Alexis Poitrasson-Rivière PhD , Michael D. Vanderver MSA, CNMT , Tomoe Hagio PhD , Liliana Arida-Moody BS , Jonathan B. Moody PhD , Jennifer M. Renaud MSc , Edward P. Ficaro PhD, FASNC , Venkatesh L. Murthy MD, PhD, FASNC
{"title":"Automated Segmentation of Cardiac Inflammatory FDG PET Using a 3D-UNET Deep Learning Model","authors":"Alexis Poitrasson-Rivière PhD , Michael D. Vanderver MSA, CNMT , Tomoe Hagio PhD , Liliana Arida-Moody BS , Jonathan B. Moody PhD , Jennifer M. Renaud MSc , Edward P. Ficaro PhD, FASNC , Venkatesh L. Murthy MD, PhD, FASNC","doi":"10.1016/j.nuclcard.2024.101978","DOIUrl":"10.1016/j.nuclcard.2024.101978","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Explainable deep-learning-based ischemia detection using hybrid O-15 H2O perfusion positron emission tomography and computed tomography imaging with clinical data","authors":"","doi":"10.1016/j.nuclcard.2024.101889","DOIUrl":"10.1016/j.nuclcard.2024.101889","url":null,"abstract":"<div><h3>Background</h3><p>We developed an explainable deep-learning (DL)-based classifier to identify flow-limiting coronary artery disease (CAD) by O-15 H<sub>2</sub>O perfusion positron emission tomography computed tomography (PET/CT) and coronary CT angiography (CTA) imaging. The classifier uses polar map images with numerical data and visualizes data findings.</p></div><div><h3>Methods</h3><p>A DLmodel was implemented and evaluated on 138 individuals, consisting of a combined image—and data-based classifier considering 35 clinical, CTA, and PET variables. Data from invasive coronary angiography were used as reference. Performance was evaluated with clinical classification using accuracy (ACC), area under the receiver operating characteristic curve (AUC), F1 score (F1S), sensitivity (SEN), specificity (SPE), precision (PRE), net benefit, and Cohen's Kappa. Statistical testing was conducted using McNemar's test.</p></div><div><h3>Results</h3><p>The DL model had a median ACC = 0.8478, AUC = 0.8481, F1S = 0.8293, SEN = 0.8500, SPE = 0.8846, and PRE = 0.8500. Improved detection of true-positive and false-negative cases, increased net benefit in thresholds up to 34%, and comparable Cohen's kappa was seen, reaching similar performance to clinical reading. Statistical testing revealed no significant differences between DL model and clinical reading.</p></div><div><h3>Conclusions</h3><p>The combined DL model is a feasible and an effective method in detection of CAD, allowing to highlight important data findings individually in interpretable manner.</p></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1071358124005439/pdfft?md5=adce7e98b2a6be739c07fab348a3af7c&pid=1-s2.0-S1071358124005439-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica M.C. Becker PhD Student , Felipe A. Mourato PhD , João M.D. R. Sobrinho Student , Roberto O. Buril PhD Student , Diego R.F. Berenguer Master , Brivaldo M. Filho PhD , Simone C.S. Brandão PhD
{"title":"Assessing Cardiac Glucose Metabolism and Global Longitudinal Strain As Predictive Biomarkers of Chemotherapy-Induced Cardiotoxicity in Lymphoma Patients","authors":"Monica M.C. Becker PhD Student , Felipe A. Mourato PhD , João M.D. R. Sobrinho Student , Roberto O. Buril PhD Student , Diego R.F. Berenguer Master , Brivaldo M. Filho PhD , Simone C.S. Brandão PhD","doi":"10.1016/j.nuclcard.2024.101971","DOIUrl":"10.1016/j.nuclcard.2024.101971","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}