Journal of Neural Transmission - Parkinson's Disease and Dementia Section最新文献_第7页

Initiation of visual-guided random saccades and remembered saccades in parkinsonian patients with severe motor-fluctuations. 严重运动波动的帕金森病患者视觉引导随机扫视和记忆扫视的开始。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260964

C Müller, S Wenger, L Fertl, E Auff

引用次数: 17

Mitochondrial enzyme deficiencies in Down's syndrome. 唐氏综合症的线粒体酶缺乏。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260938

J Prince, S Jia, U Båve, G Annerén, L Oreland

{"title":"Mitochondrial enzyme deficiencies in Down's syndrome.","authors":"J Prince, S Jia, U Båve, G Annerén, L Oreland","doi":"10.1007/BF02260938","DOIUrl":"https://doi.org/10.1007/BF02260938","url":null,"abstract":"Defects in cytochrome oxidase (CO; complex 4) have recently been demonstrated in blood platelets and in brain tissue from patients with Alzheimer's disease (AD) with possible etiological implications. Because of pathogenetic similarities with AD, we have measured the activities of several mitochondrially localised enzymes in the blood platelets of individuals afflicted with trisomy-21 (Down's syndrome). The activities of monoamine oxidase, cytochrome oxidase, isocitrate dehydrogenase, and glutamate dehydrogenase were assayed in washed platelets from sixty caucasian, male and female control individuals (ages 18-60) and ten, young Down's Syndrome patients (ages 9-21). Significant reductions in the activities of monoamine oxidase, cytochrome oxidase, and isocitrate dehydrogenase were found. In all cases the average activities in Down's syndrome individuals were approximately two-thirds those of controls (DS/Controls = 0.68, 0.67, 0.64 respectively). The activity of the fourth enzyme studied, glutamate dehydrogenase, was found to be similar to controls. Results suggest that these reductions are a consequence of a generalised mitochondrial disturbance which may lie behind some pathogenetic aspect(s) of the disease.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"8 3","pages":"171-81"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02260938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study.

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02250920

T Brannan, A Prikhojan, M D Yahr

引用次数: 1

Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3. 阿尔茨海默病中高亲和力胆碱摄取载体的选择性皮质减少:3h -钬-3放射自显影研究

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260937

R Rodríguez-Puertas, A Pazos, J J Zarranz, J Pascual

{"title":"Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3.","authors":"R Rodríguez-Puertas, A Pazos, J J Zarranz, J Pascual","doi":"10.1007/BF02260937","DOIUrl":"https://doi.org/10.1007/BF02260937","url":null,"abstract":"3H-hemicholinium-3 (3H-HC-3) binding, a marker of the presynaptic high-affinity choline uptake carrier (HACU), was measured by autoradiography in several brain regions of 17 Alzheimer's disease (AD) patients and of 11 matched controls. A significant decrease in the density of 3H-HC-3 binding sites was found in entorhinal cortex, hippocampus and layers I-III of the frontal cortex. By contrast, in the caudate-putamen the number of 3H-HC-3 binding sites in AD cases was comparable to that of control striata. These data concur with previous results using classical presynaptic markers and reflect the loss in the activity of HACU, and, hence, in the synthesis of acetylcholine, that selectively occurs in cortical areas of AD brains due to the degeneration of presynaptic cholinergic terminals arising from the basal forebrain. However, the relatively low mean reduction in HACU in cortical areas (-40%), together with the apparent indemnity of this marker in certain severely demented AD cases, suggest that AD dementia cannot be explained simply by the loss of presynaptic terminals originating in the basal forebrain. These data seem to be a good explanation for the poor response to cholinergic replacement in AD.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"8 3","pages":"161-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02260937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

A novel anticholinesterase THB013: biochemical and behavioural studies. 一种新型抗胆碱酯酶THB013:生化和行为研究。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02250925

A Adem, A H Mohammed, B Winblad, B E Henriksson

引用次数: 3

Effects of trihexyphenidyl and L-dopa on brain muscarinic cholinergic receptor binding measured by positron emission tomography. 正电子发射断层扫描测定三己苯和左旋多巴对脑毒菌碱胆碱能受体结合的影响。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02252661

H Shinotoh, M Asahina, O Inoue, T Suhara, K Hirayama, Y Tateno

引用次数: 13

Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy. 帕金森病、阿尔茨海默病和多系统萎缩患者的脑脊液铁蛋白水平。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260965

M A Kuiper, C Mulder, G J van Kamp, P Scheltens, E C Wolters

引用次数: 49

MPTP-induced behavioural and biochemical deficits: a parametric analysis. mptp诱导的行为和生化缺陷:参数分析。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260967

A Fredriksson, T Archer

{"title":"MPTP-induced behavioural and biochemical deficits: a parametric analysis.","authors":"A Fredriksson, T Archer","doi":"10.1007/BF02260967","DOIUrl":"https://doi.org/10.1007/BF02260967","url":null,"abstract":"Two experiments were performed to study the parametric effects of long-term administration of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), as a functional model of parkinsonism in mice. The behavioural deficits induced by different doses of MPTP (5, 10, 20, 30 or 40 mg/kg, s.c., each injected on two occasions) at a 3-week or a 3-month treatment-testing interval were evidenced by significant reductions of spontaneous motor activity, from the 10 mg/kg dosages upwards at the 3-week interval and from 30-40 mg/kg at the 3-month interval. Significant dopamine (DA) reductions in the mouse striatum were obtained at these dose levels and intervals. The behavioural deficit of the 40 mg/kg dose (injected on two occasions) and tested at the 3-, 6-, 12-, 24- and 40-week intervals (separate as well as repeated testing groups) indicated marked and relatively comparable reductions of all three parameters of motor activity, locomotion, rearing and total activity. DA depletions were severe at all five test intervals. These results offer functional and neurochemical evidence that MPTP treatment produces permanent damage to the nigrostriatal motor system in mice.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"7 2","pages":"123-32"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02260967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18712915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 82

Role of D1 receptor mechanisms in the potentiation of motor responses to L-dopa and apomorphine by MK 801 in the reserpine-treated mouse. D1受体机制在利血平处理小鼠MK 801增强左旋多巴和阿波啡运动反应中的作用。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02250921

S Kaur, M S Starr, B S Starr

引用次数: 11

Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders? 脑脊液中神经元特异性烯醇化酶:痴呆患者神经元变性的生化标志物?

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260939

K Blennow, A Wallin, R Ekman

{"title":"Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders?","authors":"K Blennow, A Wallin, R Ekman","doi":"10.1007/BF02260939","DOIUrl":"https://doi.org/10.1007/BF02260939","url":null,"abstract":"Alzheimer's disease (AD) is the most common disease causing dementia. Today the clinical diagnosis of AD is made by way of exclusion, and no biochemical markers are available to assist the clinical diagnosis. We examined the potential of neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) as a diagnostic marker for AD. NSE was determined with a monoclonal antibody two-site immunoradiometric assay (IRMA) in serum (S) and cerebrospinal fluid (CSF) samples from 45 patients with \"probable Alzheimer's disease (AD)\", 19 patients with vascular dementia (VAD) and 33 age-matched healthy individuals. There was no significant correlation between S-NSE and CSF-NSE, or between CSF/S albumin ratio and CSF-NSE, findings suggesting that the major portion of CSF-NSE is intrathecally produced and that analysis of CSF-NSE alone (without accompanying analysis of serum) is sufficient. CSF-NSE was significantly higher in the AD group (4.7 +/- 2.7 ng/mL; p < 0.0001) and in VAD group (4.5 +/- 2.5 ng/mL; p < 0.001) as compared with the control group (2.2 +/- 1.0 ng/mL), while it did not differ significantly between the AD and the VAD group. These findings suggest that CSF-NSE have a potential as a non-disease specific marker for the neuronal degeneration in dementia disorders.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"8 3","pages":"183-91"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02260939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 48