阿尔茨海默病中高亲和力胆碱摄取载体的选择性皮质减少:3h -钬-3放射自显影研究

R Rodríguez-Puertas, A Pazos, J J Zarranz, J Pascual
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引用次数: 24

摘要

3H-HC-3结合是突触前高亲和力胆碱摄取载体(HACU)的标志物,通过放射自显影技术在17例阿尔茨海默病(AD)患者和11例匹配对照的几个脑区进行了测量。3H-HC-3结合位点在大鼠内嗅皮层、海马和额叶皮层I-III层的密度明显降低。相比之下,在AD病例的尾壳核中,3H-HC-3结合位点的数量与对照纹状体相当。这些数据与先前使用经典突触前标记物的结果一致,反映了HACU活性的丧失,从而反映了乙酰胆碱合成的丧失,这种丧失选择性地发生在阿尔茨海默病大脑皮层区域,原因是源于基底前脑的突触前胆碱能末梢的退化。然而,皮层区HACU相对较低的平均降低(-40%),以及在某些严重痴呆的AD病例中该标记物的明显补偿,表明AD痴呆不能简单地用起源于基底前脑的突触前终末的丧失来解释。这些数据似乎可以很好地解释AD患者对胆碱能替代的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Selective cortical decrease of high-affinity choline uptake carrier in Alzheimer's disease: an autoradiographic study using 3H-hemicholinium-3.

3H-hemicholinium-3 (3H-HC-3) binding, a marker of the presynaptic high-affinity choline uptake carrier (HACU), was measured by autoradiography in several brain regions of 17 Alzheimer's disease (AD) patients and of 11 matched controls. A significant decrease in the density of 3H-HC-3 binding sites was found in entorhinal cortex, hippocampus and layers I-III of the frontal cortex. By contrast, in the caudate-putamen the number of 3H-HC-3 binding sites in AD cases was comparable to that of control striata. These data concur with previous results using classical presynaptic markers and reflect the loss in the activity of HACU, and, hence, in the synthesis of acetylcholine, that selectively occurs in cortical areas of AD brains due to the degeneration of presynaptic cholinergic terminals arising from the basal forebrain. However, the relatively low mean reduction in HACU in cortical areas (-40%), together with the apparent indemnity of this marker in certain severely demented AD cases, suggest that AD dementia cannot be explained simply by the loss of presynaptic terminals originating in the basal forebrain. These data seem to be a good explanation for the poor response to cholinergic replacement in AD.

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