Journal of Neural Transmission - Parkinson's Disease and Dementia Section最新文献_第8页

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. 认知增强药物替尼西坦是一种通过糖基化晚期蛋白交联的抑制剂。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260940

G Münch, Y Taneli, E Schraven, U Schindler, R Schinzel, D Palm, P Riederer

引用次数: 66

Cerebrospinal monoamine metabolites and amino acid content in patients with parkinsonian syndrome and rats lesioned with MPP+. 帕金森综合征患者及MPP+损伤大鼠脑单胺代谢物及氨基酸含量。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02253436

A Espino, S Ambrosio, R Bartrons, G Bendahan, M Calopa

{"title":"Cerebrospinal monoamine metabolites and amino acid content in patients with parkinsonian syndrome and rats lesioned with MPP+.","authors":"A Espino, S Ambrosio, R Bartrons, G Bendahan, M Calopa","doi":"10.1007/BF02253436","DOIUrl":"https://doi.org/10.1007/BF02253436","url":null,"abstract":"Monoamine metabolites and amino acid concentration in cerebrospinal fluid (CSF) of 33 untreated patients with parkinsonian syndrome, and 20 control patients without specific neurological symptoms have been compared with those obtained in cerebrospinal fluid of rats intrastriatally lesioned with 1-methyl-4-phenylpyridinium ion (MPP+) and sham operated animals. Homovanillic acid content was found to be significantly lower in patients with severe parkinsonism (motor score of UPDRS > 24), but not in patients with mild symptoms (motor score < or = 24). A correlation between the loss of striatal dopamine and the decrease in cerebrospinal homovanillic acid has been established in rats treated with MPP+. The extrapolation of these results to those obtained from human patients could be important in assessing the degree of striatal dopamine loss shown by humans with parkinsonian syndrome at the moment of clinical diagnosis. No significant differences were found between the other monoamine metabolites analyzed and free amino acid content in human and rat CSF.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"7 3","pages":"167-76"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02253436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18714053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

NADPH-diaphorase/nitric oxide synthase containing neurons in normal and Parkinson's disease putamen. 正常和帕金森病壳核中含有nadph -脱氢酶/一氧化氮合酶的神经元。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1994-01-01 DOI: 10.1007/BF02260966

R Böckelmann, G Wolf, G Ransmayr, P Riederer

引用次数: 63

High affinity hippocampal [3H]-glibenclamide binding sites are preserved in Alzheimer's disease. 阿尔茨海默病保留了高亲和力海马[3H]-格列本脲结合位点。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02257672

M Ikeda, D Dewar, J McCulloch

{"title":"High affinity hippocampal [3H]-glibenclamide binding sites are preserved in Alzheimer's disease.","authors":"M Ikeda, D Dewar, J McCulloch","doi":"10.1007/BF02257672","DOIUrl":"https://doi.org/10.1007/BF02257672","url":null,"abstract":"ATP-sensitive K+ channels were examined in sections of the hippocampus from patients with Alzheimer's disease and age-matched control subjects by means of quantitative autoradiography. ATP-sensitive K+ channels were labelled with the sulfonylurea, [3H]-glibenclamide, which is a potent blocker of these channels. The density of cells in the subiculum and the activity of choline acetyltransferase were determined in the same hippocampal tissue samples. In the hippocampal formation of control subjects, the density of high affinity [3H]-glibenclamide binding sites ranged from 17.6 +/- 0.9 pmoles/g in the presubiculum to 11.6 +/- 0.6 pmoles/g in the parvo-pyramidal layer of the presubiculum. There was no difference between Alzheimer patients and controls in the level of high affinity [3H]-glibenclamide binding in any hippocampal region although there was a marked loss of subicular cells (reduced by 29% compared to controls) and a reduction in choline acetyltransferase activity (reduced by 60% compared to controls). The results suggest that ATP-sensitive K+ channels are associated with elements in the hippocampus which are preserved in Alzheimer's disease.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"5 3","pages":"177-84"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02257672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19355203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Circulating immune complexes in sera from patients with Alzheimer's disease and subjects with age-associated memory impairment. 阿尔茨海默病患者和年龄相关记忆障碍患者血清中的循环免疫复合物

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02260920

H Soininen, O Heinonen, M Hallikainen, T Hänninen, K Koivisto, S Syrjänen, S Talasniemi, P J Riekkinen

{"title":"Circulating immune complexes in sera from patients with Alzheimer's disease and subjects with age-associated memory impairment.","authors":"H Soininen, O Heinonen, M Hallikainen, T Hänninen, K Koivisto, S Syrjänen, S Talasniemi, P J Riekkinen","doi":"10.1007/BF02260920","DOIUrl":"https://doi.org/10.1007/BF02260920","url":null,"abstract":"Before, we reported a higher frequency of circulating immune complexes (CIC) in the sera from institutionalized Alzheimer's disease (AD), multi-infarct dementia and Down's syndrome patients than from age-matched controls. In this study, we tested the presence of CIC in the sera from an extended series of hospitalized AD patients, AD patients living in the community, from age-associated memory impairment (AAMI) subjects as well as from nursing home and community controls. We used two methods to measure CIC, C1q binding Elisa (C1qB-Elisa) and conglutinin binding (KgB-Elisa). The AD patients showed the highest frequency of positive findings and differed from the controls in KgB (42% vs. 17%) (Chi-square, p = 0.01) and C1qB (30% vs. 11%) (p < 0.05). In severe AD, 14/19 patients were KgB positive and 11/19 were C1qB positive and differed from controls. The frequency of CIC for the patients with moderate or mild dementia, the AAMI subjects and controls was similar. In the multivariate linear regression analysis, high CIC values of the AD patients significantly associated with a long disease duration and a history of recurrent urinary infections but not with age, sex, hospitalization, or the Mini-Mental Status score. We conclude that AD patients with severe dementia frequently show CIC but those with mild or moderate disease do not. The CIC relate to a long disease duration and a history of recurrent urinary infections.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"6 3","pages":"179-88"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02260920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19115169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Sequencing of exons 16 and 17 of the beta-amyloid precursor protein gene reveals the beta-amyloid sequence to be normal in cases of the parkinson dementia complex of Guam. 对β -淀粉样蛋白前体蛋白基因外显子16和17的测序显示，关岛帕金森痴呆复合体患者的β -淀粉样蛋白序列是正常的。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02260915

M C Harlin, F Crawford, D P Perl, J Steele, J Hardy

引用次数: 6

Disturbance of colour perception in Parkinson's disease. 帕金森病的色彩知觉障碍。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02252618

T Büttner, W Kuhn, P Klotz, R Steinberg, L Voss, D Bulgaru, H Przuntek

引用次数: 43

Attenuation of haloperidol-induced catalepsy by noradrenaline and L-threo-DOPS. 去甲肾上腺素和l-三苯胺对氟哌啶醇致猝厥的抑制作用。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02252619

W D Verhagen-Kamerbeek, I Hazemeijer, J Korf, J P Lakke

{"title":"Attenuation of haloperidol-induced catalepsy by noradrenaline and L-threo-DOPS.","authors":"W D Verhagen-Kamerbeek, I Hazemeijer, J Korf, J P Lakke","doi":"10.1007/BF02252619","DOIUrl":"https://doi.org/10.1007/BF02252619","url":null,"abstract":"In addition to impaired dopaminergic neurotransmission a dysfunctional noradrenergic system has been demonstrated in Parkinson's disease. L-threo-3,4-dihydroxyphenylserine (DOPS), a synthetic precursor of noradrenaline (NA), appears to be effective in the treatment of some akinetic symptoms in parkinsonian patients. In the present study the possible effect of DOPS was studied in rats, in which catalepsy was induced with haloperidol as a model for parkinsonian akinesia. Intravenous infusion of NA (1.5 and 15 micrograms/kg) or DOPS (2 and 4 mg/kg) in male Wistar rats (240-290 g) significantly decreased catalepsy. The effect of DOPS was abolished by pretreatment with the peripheral decarboxylase inhibitor benserazide (2 mg/kg). Pretreatment with Ro 40-7592, a catechol-O-methyltransferase inhibitor, potentiated and prolonged the anticataleptic effect of DOPS. The findings suggest a peripheral site of NA mediated anticataleptic action. Therapy with DOPS may be successful only without a peripheral decarboxylase inhibitor. Moreover, the therapeutic effect of DOPS may be potentiated by COMT inhibition.","PeriodicalId":16466,"journal":{"name":"Journal of Neural Transmission - Parkinson's Disease and Dementia Section","volume":"6 1","pages":"17-26"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02252619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19206117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Effect of phosphatidylserine on free radical susceptibility in human diploid fibroblasts. 磷脂酰丝氨酸对人二倍体成纤维细胞自由基敏感性的影响。

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02252625

S Latorraca, P Piersanti, G Tesco, S Piacentini, L Amaducci, S Sorbi

引用次数: 15

The relationship of cerebrospinal fluid monoamine metabolites with clinical response to tetrahydroaminoacridine in patients with Alzheimer's disease. 阿尔茨海默病患者脑脊液单胺代谢物与四氢胺吖啶临床反应的关系

Journal of Neural Transmission - Parkinson's Disease and Dementia Section Pub Date : 1993-01-01 DOI: 10.1007/BF02257673

K Alhainen, E L Helkala, K Reinikainen, P Riekkinen

引用次数: 24