脑脊液中神经元特异性烯醇化酶:痴呆患者神经元变性的生化标志物?

K Blennow, A Wallin, R Ekman
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引用次数: 48

摘要

阿尔茨海默病(AD)是最常见的导致痴呆症的疾病。目前对AD的临床诊断多采用排除法,没有生化标志物辅助临床诊断。我们研究了脑脊液(CSF)中神经元特异性烯醇化酶(NSE)作为AD诊断标志物的潜力。采用单克隆抗体双位点免疫放射测定法(IRMA)检测45例“疑似阿尔茨海默病(AD)”患者、19例血管性痴呆(VAD)患者和33例年龄匹配的健康人的血清(S)和脑脊液(CSF)样本中的NSE。S- nse与CSF- nse之间、CSF/S白蛋白比与CSF- nse之间无显著相关性,提示CSF- nse的主要部分是鞘内产生的,单独分析CSF- nse(不附带血清分析)就足够了。AD组CSF-NSE显著升高(4.7 +/- 2.7 ng/mL;p < 0.0001), VAD组(4.5 +/- 2.5 ng/mL;p < 0.001),与对照组(2.2 +/- 1.0 ng/mL)相比,AD组和VAD组之间无显著差异。这些发现提示CSF-NSE有潜力作为痴呆障碍中神经元变性的非疾病特异性标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuron specific enolase in cerebrospinal fluid: a biochemical marker for neuronal degeneration in dementia disorders?

Alzheimer's disease (AD) is the most common disease causing dementia. Today the clinical diagnosis of AD is made by way of exclusion, and no biochemical markers are available to assist the clinical diagnosis. We examined the potential of neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) as a diagnostic marker for AD. NSE was determined with a monoclonal antibody two-site immunoradiometric assay (IRMA) in serum (S) and cerebrospinal fluid (CSF) samples from 45 patients with "probable Alzheimer's disease (AD)", 19 patients with vascular dementia (VAD) and 33 age-matched healthy individuals. There was no significant correlation between S-NSE and CSF-NSE, or between CSF/S albumin ratio and CSF-NSE, findings suggesting that the major portion of CSF-NSE is intrathecally produced and that analysis of CSF-NSE alone (without accompanying analysis of serum) is sufficient. CSF-NSE was significantly higher in the AD group (4.7 +/- 2.7 ng/mL; p < 0.0001) and in VAD group (4.5 +/- 2.5 ng/mL; p < 0.001) as compared with the control group (2.2 +/- 1.0 ng/mL), while it did not differ significantly between the AD and the VAD group. These findings suggest that CSF-NSE have a potential as a non-disease specific marker for the neuronal degeneration in dementia disorders.

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