帕金森病、阿尔茨海默病和多系统萎缩患者的脑脊液铁蛋白水平。

M A Kuiper, C Mulder, G J van Kamp, P Scheltens, E C Wolters
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引用次数: 49

摘要

铁被认为在帕金森病(PD)和阿尔茨海默病(AD)的发病机制中发挥作用。我们测量了PD、AD和多系统萎缩(MSA)患者以及对照组脑脊液中的铁蛋白,铁蛋白被认为是铁储存蛋白。我们发现,与PD和年龄匹配的对照组相比,AD患者脑脊液铁蛋白显著增加。PD合并痴呆(PDD)患者与非痴呆PD患者之间无显著差异。对于非痴呆性PD患者,脑脊液铁蛋白与年龄呈正相关。我们的结果可能表明铁在阿尔茨海默病的病理生理中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebrospinal fluid ferritin levels of patients with Parkinson's disease, Alzheimer's disease, and multiple system atrophy.

Iron is believed to play a role in the pathogenesis of both Parkinson's disease (PD) and Alzheimer's disease (AD). We measured ferritin, which is considered to be the iron storage protein, in CSF of patients with PD, AD, and multiple system atrophy (MSA) as well as control subjects. We found a significant increase in CSF ferritin in AD compared with both PD and age-matched controls. No significant differences were found between PD patients with dementia (PDD) and non-demented PD patients. For non-demented PD patients a positive correlation between CSF ferritin and age was found. Our results may indicate that iron has a role in the pathophysiology of AD.

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