Journal of Medical Primatology最新文献

{"title":"A protocol for creating endometriosis in rhesus macaques (Macaca mulatta)","authors":"Ov D. Slayden,&nbsp;Fangzhou Luo,&nbsp;Lauren D. Martin, D.V.M","doi":"10.1111/jmp.12681","DOIUrl":"10.1111/jmp.12681","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endometriosis is the presence of endometrium-like tissue outside the uterine cavity. An experimental model of endometriosis has been created in the baboon by the transcervical collection and laparoscopic inoculation of menstrual endometrium. Macaques are the preferred model for pharmaceutical development, but the complex anatomy of the macaque cervix makes the baboon method impractical. In this work, we sought to validate a surgical approach for creating endometriosis in macaques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Menstrual endometrium was collected via laparoscopic intrauterine puncture and transferred to the peritoneal cavity. We repeated this procedure during three menstruations. Endometriotic tissue was identified during laparoscopy, collected, and characterized by immunohistochemistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sham surgery-treated animals (<i>n</i> = 3) failed to develop endometriosis. We identified red, powder burnt, and white lesions in 13/14 of the treated animals; the stroma of the red lesions stained positive for ovarian steroid receptors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This surgical technique can reliably create hormone-responsive endometriosis in macaques for therapeutic studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"405-413"},"PeriodicalIF":0.7,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of age and sex on hematological and biochemical parameters in Chinese rhesus monkeys (Macaca mulatta) anesthetized with ketamine","authors":"Gaohong Zhu,&nbsp;Xuedan Liu,&nbsp;Jiaojiao Feng,&nbsp;Yun Deng,&nbsp;Yijiang Li,&nbsp;Qionglin Ma,&nbsp;Lilin Chen,&nbsp;Yulin Su,&nbsp;An Ping,&nbsp;Fei Xie,&nbsp;Tinghua Wang,&nbsp;Longbao Lv","doi":"10.1111/jmp.12677","DOIUrl":"10.1111/jmp.12677","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Rhesus monkeys are increasingly used in biomedical research, which makes their hematological and biochemical parameters increasingly important in preclinical research. Since age and sex can influence blood parameters, establishing reference intervals for such parameters based on age and sex becomes along with identifying the effect of age and sex on those parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1385 healthy Chinese rhesus monkeys (548 males and 837 females) anesthetized with ketamine were selected and segregated by age (six groups) and sex. A total of 21 hematological and 26 biochemical parameters were measured, and the effects of age and sex were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We established baseline indices for hematological and biochemical parameters based on age and sex, separately, and observed significant impacts of age, sex, and age-sex interactions on blood parameters. Among different age groups, significant differences were found in WBC, NEUT%, LYM%, EO%, LYM#, EO#, MCV, RDW-CV, PLT, MPV, PDW, PCT, TP, Alb, GLB, A/G, ALT, AST, ALP, TBIL, GGT, BUN, Cre, GLU, CK, TRIG, LDL, HCY, IL-6 FOL, Vit B12, VIT D-T, PTH, and AMH. Additionally, significant differences were observed in RBC, HGB, HCT, MPV, Alb, BUN, Cre, GLU, CHOL, TRIG, HDL, LDL, HCY, and VIT D-T between the two sexes. An age-sex interaction exerted a significant effect on WBC, NEUT#, MCV, MCHC, PDW, GLB, ALP, Cre, CHOL, TRIG, HDL, LDL, HCY, IL-6, Vit B12, VIT D-T. However, neither age, sex, and age-sex interactions exerted significant effects on MO%, MOMO#, MCH, RDW-SD, CRP, and CT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study investigated the blood parameters of rhesus monkeys to provide a reference basis for rhesus monkey-related scientific experimental research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"384-391"},"PeriodicalIF":0.7,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41132706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrotherapy in two black-tufted marmosets (Callithrix penicillata) with metabolic bone disease—Case reports (2018–2020)","authors":"Letícia Prata Juliano Dimatteu Telles,&nbsp;Matheus Rabello de Figuereido Carvalho Krüger Martins,&nbsp;Júlia Vieira Herter,&nbsp;Líria Querioz Luz Hirano","doi":"10.1111/jmp.12679","DOIUrl":"10.1111/jmp.12679","url":null,"abstract":"<p>Integrative medicine has gained space in veterinary medicine and hydrotherapy is mainly used as an adjunct on the treatment of neurological and musculoskeletal diseases. Use of this therapeutic modality in wild animals has seldom been reported. This article describes the use of hydrotherapy in two <i>Callithrix penicillata</i> patients with metabolic bone disease.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41122552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilated cardiomyopathy phenotype in Callithrix penicillata (E. Geoffroy, 1812): Case report","authors":"Melina Castilho de Souza Balbueno,&nbsp;Jéssica Amâncio Martins,&nbsp;Soraya Kezam Malaga,&nbsp;Juliana Forato,&nbsp;Cidéli de Paula Coelho","doi":"10.1111/jmp.12678","DOIUrl":"10.1111/jmp.12678","url":null,"abstract":"<p>Dilated cardiomyopathy (DCM) is a disease of the heart muscle diagnosed by alterations resulting from ventricular systolic dysfunction with enlargement of the heart chambers, which is still underdiagnosed in non-human primates. This report is the first case of the DCM phenotype diagnosed by echocardiography and confirmed by necropsy in <i>Callithrix penicillata.</i></p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41103232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Presentations","authors":"","doi":"10.1111/jmp.12673","DOIUrl":"https://doi.org/10.1111/jmp.12673","url":null,"abstract":"","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 5","pages":"298-343"},"PeriodicalIF":0.7,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50138142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of fine-needle aspiration techniques","authors":"Jason P. Dufour,&nbsp;Carolina Allers,&nbsp;Faith Schiro,&nbsp;Kathrine P. Falkenstein,&nbsp;Kayleigh K. Gregoire,&nbsp;Colin D. Glover,&nbsp;Alayna N. Chamel,&nbsp;Adrienne Woods,&nbsp;Jonah P. Phillippi,&nbsp;Taylor M. Gideon,&nbsp;Amitinder Kaur","doi":"10.1111/jmp.12676","DOIUrl":"10.1111/jmp.12676","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Fine-needle aspiration (FNA) has been reported since 1912 beginning with the use of trocars and other specialized instruments that were impractical. Since then, FNA has proven to be a successful alternative technique to excisional biopsy for some assays despite a few limitations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we compared four different techniques for FNA in rhesus macaques by evaluating total live cells recovered and cell viability using a standard 6 mL syringe and 1.5-inch 22-gauge needle.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Technique B which was the only technique in which the needle was removed from the syringe after collection of the sample to allow forced air through the needle to expel the contents into media followed by flushing of the syringe and needle resulted in the highest total cell count and second highest cell viability in recovered cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on our results, Technique B appears to be the superior method.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"400-404"},"PeriodicalIF":0.7,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematology and blood biochemistry in a declining population of mantled howler monkeys (Alouatta palliata palliata) at La Pacifica, Costa Rica","authors":"Lisa C. Corewyn,&nbsp;Mary A. Kelaita,&nbsp;Jenny Nollman,&nbsp;Isabel Hagnauer,&nbsp;Kinndle Blanco-Peña,&nbsp;Robert G. Lessnau,&nbsp;Jonathan B. Clayton,&nbsp;Robin Shields-Cutler,&nbsp;Kari Brossard Stoos","doi":"10.1111/jmp.12669","DOIUrl":"10.1111/jmp.12669","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Alouatta palliata palliata</i> are an ecologically flexible howler monkey subspecies that has recently been relisted as Endangered. Populations are declining through much of the subspecies' range, including at our study site at La Pacifica, Costa Rica. Our objectives were to screen blood hematology and biochemistry samples collected from this wild population to elucidate their baseline health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected blood samples from 38 adult individuals from across the study site and analyzed 13 hematology and 14 biochemistry parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Most hematology and blood biochemistry parameter values were similar between males and females. However, mean hemoglobin was significantly lower, and mean white blood cell count was significantly higher in females; and mean calcium and mean creatinine were significantly lower in females compared to males.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Overall, the La Pacifica population appeared healthy based on the blood parameters analyzed from sampled individuals. Our results were also largely consistent with published data available from other populations of <i>A. p. palliata</i>, and with reference values for captive <i>Alouatta caraya</i>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"353-360"},"PeriodicalIF":0.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10132563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice","authors":"James Z. Curlin,&nbsp;Kimberly Schmitt,&nbsp;Leila Remling-Mulder,&nbsp;Corina Valencia Tibbitts,&nbsp;Shelby O'Connor,&nbsp;Preston Marx,&nbsp;Ramesh Akkina","doi":"10.1111/jmp.12675","DOIUrl":"10.1111/jmp.12675","url":null,"abstract":"<p>HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4⁺ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 5","pages":"294-297"},"PeriodicalIF":0.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice","authors":"James Z. Curlin,&nbsp;Kimberly Schmitt,&nbsp;Leila Remling-Mulder,&nbsp;Corina Valencia Tibbitts,&nbsp;Shelby O'Connor,&nbsp;Preston Marx,&nbsp;Ramesh Akkina","doi":"10.1111/jmp.12674","DOIUrl":"10.1111/jmp.12674","url":null,"abstract":"<p>HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4⁺ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 5","pages":"290-293"},"PeriodicalIF":0.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10652354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of spontaneous hepatic fibrosarcoma in a white-tufted marmoset (Callithrix jacchus) kept in captivity","authors":"Soraya Kezam Malaga,&nbsp;Melina Castilho de Souza Balbueno,&nbsp;Jéssica Amâncio Martins,&nbsp;Leonardo Dourado da Costa,&nbsp;Maria Luiza de Sousa Barbosa,&nbsp;Cidéli de Paula Coelho","doi":"10.1111/jmp.12671","DOIUrl":"10.1111/jmp.12671","url":null,"abstract":"<p>Reports of sarcomas in nonhuman primates are scarce and, specifically, primary hepatic sarcomas are rare, as in humans. This is the first report of an aggressive hepatic fibrosarcoma in a young adult <i>Callithrix jacchus.</i> The final postmortem diagnosis was obtained by means of immunohistochemical analysis, which confirmed the tumor histogenesis.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}