Journal of Molecular Structure最新文献

{"title":"Physicochemical studies of asarylaldehyde crosslinked type-I collagen fibrils","authors":"Kuntala Banerjee ,&nbsp;Sreesaila S ,&nbsp;T Hemalatha ,&nbsp;N. Nishad Fathima","doi":"10.1016/j.molstruc.2025.142972","DOIUrl":"10.1016/j.molstruc.2025.142972","url":null,"abstract":"<div><div>The self-assembly of collagen in vitro differs from in vivo mainly in packing densities, mechanical strength, diameter and porosity depending on pH and temperature<em>.</em> The use of collagen in biomedical and pharmaceutical industry necessitates the need for tuned-assembly of collagen and understanding the mechanical and chemical properties of the tuned collagen-fibrils. In this study, we have focused on non-toxic crosslinking of collagen by introducing asarylaldehyde, a compound found in carrot seed, into the fibrillation process of type-I collagen and explored the mechanical and chemical properties of that tuned assembly. Upon interaction of collagen with asarylaldehyde, the fibrillisation process accelerated and showed highest rate of fibril formation at 1:100 molar-ratio. The tuned assembly shows thixotropy and LVR is increased up to 1:25 molar-ratio compared to native fibrils. The fibril diameter is increased and D-periodicity is decreased for 1:100 molar-ratio as observed through SEM images. The negative Gibbs free energy and binding constant values confirm there is a strong binding attraction between tropocollagen and the asarylaldehyde molecule. MTT assay and fluorescence staining displayed the biocompatible nature of the prepared scaffold. The known cell proliferation as well as bone metabolism properties of asarylaldehyde may value-add the prepared scaffold for tissue engineering applications.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142972"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and CO2 photocatalytic reduction of heterometallic one-dimensional titanium-based coordination polymers","authors":"Yuanyuan Zhang ,&nbsp;Yaomei Fu ,&nbsp;Xiaoyan Gu ,&nbsp;Liang Zhao ,&nbsp;Junning Kou ,&nbsp;Chao Qin","doi":"10.1016/j.molstruc.2025.142978","DOIUrl":"10.1016/j.molstruc.2025.142978","url":null,"abstract":"<div><div>Four new transition metal doped one-dimensional titanium-based coordination polymers, [Ti₂L₂M(phen)] (<em>M</em> = Co²⁺, Ni²⁺, Cu²⁺, Zn²⁺, <em>L</em> = Embonic acid, phen = 1,10-phenanthroline), have been synthesized under solvothermal conditions utilizing the Ti₄L₆ precursors. In the structure of [Ti₂L₂M(phen)], a dinuclear titanium cluster is formed by coordinating two Ti atoms with two L ligands. The oxygen atoms from the carboxylate groups of the L ligands, which possess vacant coordination sites, further interact with the M(phen) unit, resulting in a Z-shaped one-dimensional chain-like structure. All compounds are determined by single crystal X-ray diffraction analysis, thermogravimetric analysis, PXRD, UV–vis and IR spectra. Notably, all frameworks exhibit excellent stability and can be used as heterogeneous catalysts to reduce CO₂ to syngas (CO+H₂) under light conditions. Specifically, the total yield of syngas for Ti₂L_2<img>Co is up to 20.3 mmol g^–1 h^–1</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142978"},"PeriodicalIF":4.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allosteric inhibitors for the treatment of cancers (2021-): A review from medicinal chemistry perspectives","authors":"Fangli Ma ,&nbsp;Yumei Chen ,&nbsp;Yudie Ni ,&nbsp;Huan He,&nbsp;Oulian Ji,&nbsp;Xizheng Quan,&nbsp;Baohui Qi","doi":"10.1016/j.molstruc.2025.142985","DOIUrl":"10.1016/j.molstruc.2025.142985","url":null,"abstract":"<div><div>Dysregulation of protein allostery is associated with a broad spectrum of human diseases. Generally, allosteric sites are structurally, conformationally and functionally different from the corresponding orthosteric pockets. In comparison to traditional medicines targeting orthosteric sites, allosteric drugs have already established reputation of advantages in improving selectivity profiles, reducing off-target effects, and overcoming acquired resistance, <em>etc</em>. Therefore, great efforts have been made in the development of effective allosteric modulators since the first allosteric drug was approved. This review summarizes recent advances of allosteric inhibitors for the treatment of cancers from a medicinal chemistry perspective. Furthermore, the current design and discovery strategies were also discussed in order to provide insight into the discovery of potential allosteric inhibitors for the treatment of cancers.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142985"},"PeriodicalIF":4.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conformational aspects of 6-N-aryl-glycosides: X-ray and vibrational spectroscopic studies","authors":"Natividad Bejarano Rengel ,&nbsp;Juliana Esteche ,&nbsp;Gustavo A. Echeverría ,&nbsp;Oscar E. Piro ,&nbsp;Mauricio F. Erben ,&nbsp;Cintia C. Santiago ,&nbsp;Agustín Ponzinibbio","doi":"10.1016/j.molstruc.2025.142975","DOIUrl":"10.1016/j.molstruc.2025.142975","url":null,"abstract":"<div><div>This study investigates the structural and conformational features of novel 6-N-aryl-galactosides, specifically 4-halo-6-deoxy-1,2:3,4-di-<em>O</em>-isopropylidene-6-N-phenylamino-α-<em><span>d</span></em>-galactopyranosides, using a combination of spectroscopic techniques. Comparative analyses were performed using single-crystal X-ray diffraction, FT-IR, and FT-Raman vibrational spectroscopy to elucidate structural similarities and differences among the derivatives. Two crystallographically independent molecules were observed in the asymmetric unit of the <em>p</em>‑chloro compound, and four in that of the <em>p</em>-fluoro compound, all exhibiting close structural resemblance. Key inter- and intramolecular interactions governing crystal packing and conformational variability were identified. The 6-C substituent displayed notable flexibility in the solid state. Unlike the typical perpendicular orientation in C1-substituted glycosides, the C6-N-galactosides exhibited a planar arrangement of the aromatic and sugar rings. The pyranose ring adopted an °S₂ twist-boat conformation, as confirmed by torsional analysis. These interactions also led to distinct supramolecular assemblies in the <em>p</em>‑chloro and <em>p</em>-fluoro derivatives.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142975"},"PeriodicalIF":4.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of Fe-doped g-C3N4 as a robust piezophotocatalyst system for degradation of organic dyes","authors":"Mohammed S. Mohammed ,&nbsp;Saad H. Ammar ,&nbsp;Yousra S. Kareem ,&nbsp;A. Al-Farraji","doi":"10.1016/j.molstruc.2025.142962","DOIUrl":"10.1016/j.molstruc.2025.142962","url":null,"abstract":"<div><div>This work involved introducing defect states into the electronic structure of g-C₃N₄ by Fe doping to create a piezoelectric effect in addition to its photocatalytic properties, thereby increasing the transfer of photoinduced charge carriers and achieving an effective piezophoto-catalytic degradation toward MB dye. Noticeably, Fe-doped g-C₃N₄ (FeCN) catalyst (with 5 % doping) possesses great piezophoto-catalytic degradation performance, decomposing 97.7 % of MB in 60 min. ^•O₂⁻ and ^•OH radicals were the key reactive components as stated by the trapping experiments. Moreover, a degradation efficiency of 92.5 % was still achieved after the fifth round, representing a good durability of assembled FeCN piezophotocatalyst has been ensured.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142962"},"PeriodicalIF":4.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, In silico studies and antitumor activity of new 4-bromo-2-(1H-1,2,4-triazol-3-yl)aniline derived schiff bases","authors":"Shivaraja G ,&nbsp;Fadzilah Adibah Abdul Majid ,&nbsp;S. Pradeep ,&nbsp;Dwi Hudiyanti ,&nbsp;Wan Mohd Norsani Wan Nik ,&nbsp;Sanay Naha ,&nbsp;B.M. Praveen","doi":"10.1016/j.molstruc.2025.142987","DOIUrl":"10.1016/j.molstruc.2025.142987","url":null,"abstract":"<div><div>In the present study, in an effort to develop an effective anticancer agents, novel series of Schiff bases derived from 4‑bromo‑2-(1H-1,2,4-triazol-3-yl) aniline have been synthesized and assessed for their anticancer activity in vitro, alongside in silico evaluations of pharmacokinetic properties. The new compounds (6a–j) were characterized using IR, NMR, spectroscopic and mass techniques. Among all, compound <strong>6c</strong> exhibited superior efficacy compared to Doxorubicin in the treatment of MiaPaca2, and A549 with IC₅₀ values of 6.74 ± 0.21 µM and 2.86± 0.11 µM respectively. Also compound <strong>6c</strong> showed good activity on HeLa and HCT116 cells with the IC₅₀ values 5.42 ± 0.35 µM and 7.37 ± 0.25 µM respectively. Furthermore, compound <strong>6g</strong> also demonstrated anticancer activity against HeLa, A549, and HCT116, with IC₅₀ values of 14.35 ± 0.33 µM, 18.04 ± 0.41 µM, and 28.91 ± 0.79 µM. The insilico studies revealed that compounds showed an appropriate pharmacokinetic profile and favorable drug-likeness characteristics. Molecular docking and MD simulation studies against a set of EGFR and HER2 proteins reveals that compound <strong>6c</strong> showed good docking energy and 100 ns MD simulation confirms that compound is stable inside the active site of EGFR. So, it can be concluded that 1,2,4-triazole based Schiff bases (<strong>6c</strong> and <strong>6g</strong>) could serve as promising candidates for further development as novel promising bioactive molecules targeting EGFR.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1345 ","pages":"Article 142987"},"PeriodicalIF":4.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of low-bandgap D-A copolymers based on dithienopyrrole with fluorinated benzothiadiazole for organic solar cells: Experimental and computational studies","authors":"Bakhet A. Alqurashy ,&nbsp;Ohoud S. Al-Qurashi ,&nbsp;Mouslim Messali ,&nbsp;Ahmed Iraqi","doi":"10.1016/j.molstruc.2025.142980","DOIUrl":"10.1016/j.molstruc.2025.142980","url":null,"abstract":"<div><div>Two new alternating copolymers were synthesized as electron-donors for use in polymeric solar cells, using hexylphenyl substituted-dithienopyrrole coupled with mono and di-fluorinated benzothiadiazole to produce <strong>DTPBT1F</strong> and <strong>DTPBT2F</strong>. Fluorine substitution effects on the two narrow band gap copolymers have been investigated. The molecular weights of the di-fluorinated polymer (<strong>DTPBT2F</strong>) and the mono-fluorinated polymer (<strong>DTPBT2F</strong>) are found to be 3818 and 3851 Da, respectively, by using GPC. Both copolymers showed two distinct absorption bands in thin films, with their respective optical band gaps being 1.35 eV for <strong>DTPBT1F</strong> and 1.43 eV for <strong>DTPBT2F</strong>. Furthermore, UV–vis studies revealed that the λ_max of <strong>DTPBT2F</strong> in solution and thin film was blue-shifted than <strong>DTPBT1F</strong>. According to CV analysis, the HOMO energy level of <strong>DTPBT2F</strong> (-5.00 eV) is lower than <strong>DTPBT1F</strong> (-4.72 eV), caused by the greater number of fluorine atoms attached to the benzothiadiazole moiety. TGA showed that <strong>DTPBT1F</strong>’s degradation temperature is 265 °C, while <strong>DTPBT2F</strong>’s has a relatively higher value of 314 °C. Based on XRD studies, both polymers displayed similar pattern curves with sharp and intense peaks. They also exhibited a small π-π stacking distance of 3.48 Å, indicating semi-crystalline structures. In addition, DFT was carried out to find reorganization energies and photovoltaic parameters. The calculated short-circuit current are 26.45 and 25.85 mAcm^-2 for <strong>H-DTPBT1F</strong> and <strong>H-DTPBT2F</strong>, respectively, whereas opposite trend is found for Voc. The predicted power conversion efficiencies were found to range between 17.23 % and 11.25 %.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142980"},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel ionic liquid–Schiff base grafted on NH2-MIL-53(Al) hybrid sensor for selective and sensitive Zn2+ fluorescent sensing in complex matrices","authors":"Shaimaa K. Mohamed,&nbsp;Asmaa A. Wagdy,&nbsp;Reda F.M. Elshaarawy,&nbsp;Fathy K. Awad,&nbsp;Rasha M. Kamel","doi":"10.1016/j.molstruc.2025.142983","DOIUrl":"10.1016/j.molstruc.2025.142983","url":null,"abstract":"<div><div>A novel hybrid sensor was constructed by grafting 1-(salicyl)-2,4-lutidinium hexafluorophosphate (Sal(lut⁺PF₆⁻) onto NH₂−MIL-53(Al) via a Schiff base reaction (Sal@MIL) for the highly selective and sensitive detection of Zn²⁺ ions. The chemical structure of Sal (Lut⁺PF₆⁻) was confirmed using ¹H, ¹³C, ³¹P, ¹⁹F NMR and FT-IR spectroscopy, while NH₂−MIL-53(Al) and the Sal@MIL sensor were characterized using XRD, BET surface area analysis, FT-IR, SEM, and XPS techniques. The Sal@MIL sensor exhibited a broad Zn²⁺ recognition capability. Under optimal conditions, it achieved a remarkable low limit of detection (0.11 ppb) and limit of quantification (0.36 ppb), along with excellent selectivity against potentially interfering metal ions. The sensing mechanism relies on the inhibition and destruction of C<img>N isomerization and excited-state intramolecular proton transfer (ESIPT) upon Zn²⁺ binding, resulting in a significant fluorescence response. Practical applications were successfully demonstrated through accurate Zn²⁺ quantification in diverse real-world matrices including tap water, seawater, human blood serum, and various medications with results rigorously validated by ICP-MS analysis. The Sal@MIL sensor offers a high sensitivity, selectivity, and rapid response for Zn²⁺ ion detection in complex matrices.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142983"},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPTS-catalyzed metal-free synthesis of poly-substituted pyridines: their in silico / in vitro evaluation against SIRT1","authors":"Burra Sathish Kumar ,&nbsp;L. Vaikunta Rao ,&nbsp;G. Dhananjaya ,&nbsp;Ravikumar Kapavarapu ,&nbsp;Manojit Pal","doi":"10.1016/j.molstruc.2025.142976","DOIUrl":"10.1016/j.molstruc.2025.142976","url":null,"abstract":"<div><div>The poly-substituted pyridine derivatives were explored as potential inhibitors of SIRT1. One-pot synthesis of these compounds was carried out <em>via</em> PPTS-catalyzed 3-component reaction (3-CR) of <em>β</em>-keto esters (or 1,3-diketones), 2-ylidenemalononitriles and anilines. This metal-free reaction proceeded in aqueous EtOH at room temperature to give the desired product within 3 h. A variety of reactants was employed in this environmentally friendly 3-CR where water seemed to be the only by-product. This straightforward and easy to operate methodology provided a series of desired products in good to high (85-92%) yields. A majority of these compounds showed good interactions with a number of residues when docked into SIRT1 <em>in silico</em>. Most of them including the top three molecules in terms of binding affinity i.e. <strong>4c, 4e</strong> and <strong>4k</strong> participated in the key H-bonds with ILE347 and ASP348 <em>via</em> their –CN moiety. Indeed, a comparison of the active site and binding poses of <strong>4c, 4e</strong> and <strong>4k</strong> along with native ligand EX527a in SIRT1 showed that they were aligned well. The high binding affinity of <strong>4e</strong> was aided by its participation in two H-bonds with ILE347 and ASP348 <em>via</em> its CN moiety and three H-bonding with GLY319 and GLN320 through its NO₂ group. The <em>in silico</em> studies also predicted probable selectivity of <strong>4c, 4e</strong> and <strong>4k</strong> towards SIRT1 over SIRT2. When tested <em>in vitro</em> at 10 µM, these three compounds showed encouraging inhibition of SIRT1 (IC₅₀ ∼ 2.7-3.5 µM) when <strong>4e</strong> emerged as the best active molecule. According to the SAR analysis, the promising activities were observed when the aryl group at C-4 was chosen as the 4-NCC₆H₄ or 4-O₂NC₆H₄ moiety, the group at C-3 was –CO₂Et and the amine substituent at C-6 was 2-MeC₆H₄NH- moiety. However, an <em>i</em>-butyl group at C-4 was found to be less effective. Based on <em>in silico</em> and <em>in vitro</em> studies along with ADME predictions the compound <strong>4c, 4e</strong> and <strong>4k</strong> were identified as preliminary hits for further pharmacological evaluation.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142976"},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring the edge defects and morphology of g-C3N4 for efficient CO2 conversion to cyclic carbonates","authors":"Jiale Ni,&nbsp;Zicheng Yang,&nbsp;Binxuan Hong,&nbsp;Yi Feng,&nbsp;Jianfeng Yao","doi":"10.1016/j.molstruc.2025.142982","DOIUrl":"10.1016/j.molstruc.2025.142982","url":null,"abstract":"<div><div>This research endeavors to optimize the morphology and edge defects of g-C₃N₄ through straightforward pyrolysis of rationally chosen precursors, with the objective of increasing the CO₂ conversion efficiency. Our findings reveal that employing melamine and urea as precursors yields tubular g-C₃N₄ (CN tube), featuring an increased surface area and a greater density of edge defects than melamine-derived bulk g-C₃N₄ and urea-derived layered g-C₃N₄. As a result, the obtained CN tube can deliver an impressive yield of 98 % for CO₂ cycloaddition with epichlorohydrin at 12 h under mild conditions of 80 °C and 0.1 MPa CO₂ pressure, significantly outperforming those derived from melamine (53 %) or urea (66 %) alone. This investigation demonstrated the pivotal role of a tubular architecture and enriched edge defects in facilitating the thermally driven CO₂ fixation process to produce cyclic carbonates.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1344 ","pages":"Article 142982"},"PeriodicalIF":4.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}