Journal of Molecular Structure最新文献_第4页

Novel composite of nano-silica, l-tartaric acid, and magnesium bismuthate (SiO2/L-Tar/MgBi2O4): A versatile recoverable promoter for solvent-free synthesis of 5-(indole)-chromeno[2,3-b]pyridines

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-11 DOI: 10.1016/j.molstruc.2024.140012

{"title":"Novel composite of nano-silica, l-tartaric acid, and magnesium bismuthate (SiO2/L-Tar/MgBi2O4): A versatile recoverable promoter for solvent-free synthesis of 5-(indole)-chromeno[2,3-b]pyridines","authors":"","doi":"10.1016/j.molstruc.2024.140012","DOIUrl":"10.1016/j.molstruc.2024.140012","url":null,"abstract":"<div>In the present work, commercial amorphous nano-silica has been covered by l-tartaric acid and MgBi2O4 to obtain the nanocomposite (SiO2/L-Tar/MgBi2O4) which has been characterized by Fourier transform infrared (FT-IR), Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDAX), and X-ray diffraction (XRD) techniques. In continue, it has been utilized as an efficient, heterogeneous, and recoverable catalyst for the green and pseudo four-component synthesis of diverse 5-(indole)-chromeno[2,3-b]pyridines from the reaction of various salicylaldehydes, indoles, and malononitrile, in 1:1: 2 molar ratio, under solvent-free conditions at 50 °C. The recovery of the nanocatalyst was also examined within two runs successfully. The recovered inorganic-organic nanohybrid has been identified through FESEM and EDAX techniques. The structural parameters and thermodynamic stability of SiO2/L-Tar complexes have been investigated by density functional theory (DFT) calculations. Additionally, the nature of intermolecular hydrogen bonds has been studied by natural bond orbital (NBO) analysis. Short reaction times, simple and facile work-up procedures, and good yields are the advantages of this producer.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nickel(II) complex anchoring on anatase nanoparticles: A multifunctional approach to anticancer, anti-inflammatory, and antioxidant activities 锚定在锐钛矿纳米粒子上的镍(II)复合物：抗癌、抗炎和抗氧化的多功能方法

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-11 DOI: 10.1016/j.molstruc.2024.140034

{"title":"Nickel(II) complex anchoring on anatase nanoparticles: A multifunctional approach to anticancer, anti-inflammatory, and antioxidant activities","authors":"","doi":"10.1016/j.molstruc.2024.140034","DOIUrl":"10.1016/j.molstruc.2024.140034","url":null,"abstract":"<div>In this study, a biologically active nickel(II) complex, [Ni(bipy)3]Cl2 (where bipy = 2,2′-bipyridine), was synthesized using a straightforward precipitation method. This nickel(II) complex was subsequently grafted onto anatase (TiO2) nanoparticles (NPs) through an adsorption technique, yielding nickel(II)-complex-grafted anatase (Ni-TiO2) NPs. The Ni-TiO2 NPs were thoroughly characterized using a range of analytical methods, including X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy, UV–visible spectroscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDAX), which confirmed the successful grafting of the complex onto the TiO2 NPs and maintained the structural integrity of the composite. The anticancer activity of the Ni-TiO2 NPs was assessed on Non-Small Cell Lung Cancer (NSCLC) cell lines using the MTT assay, revealing a significant enhancement in anticancer efficacy, with a 69 % improvement in cell inhibition compared to untreated cells. Moreover, the antioxidant potential of the Ni-TiO2 NPs was evaluated using the 1-Diphenyl-2-picrylhydrazyl (DPPH) assay, and their anti-inflammatory activity was determined through the protein denaturation assay. Both assays demonstrated that the Ni-TiO2 NPs exhibited superior inhibitory effects compared to the precursor Ni(II) complex, indicating enhanced bioactivity.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ self-assembly of artesunate-β-cyclodextrin supramolecular nanomedicine as potential anti-cancer prodrug 原位自组装青蒿琥酯-β-环糊精超分子纳米药物作为潜在的抗癌原药

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-11 DOI: 10.1016/j.molstruc.2024.139976

{"title":"In situ self-assembly of artesunate-β-cyclodextrin supramolecular nanomedicine as potential anti-cancer prodrug","authors":"","doi":"10.1016/j.molstruc.2024.139976","DOIUrl":"10.1016/j.molstruc.2024.139976","url":null,"abstract":"<div>Supramolecular nanomedicines have drawn great interest in cancer therapy, but their potential immunotoxicities restrict application in clinical translation. Herein, we constructed a supramolecular nanomedicine CD-Artesunate (CD-ATS) in situ by supramolecular polymerization and orthogonal self-assembly. The nanostructure was meticulously characterized using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy, Mass spectrometry, Transmission Electron Microscopy (TEM), and particle size distribution analysis. β-cyclodextrin (β-CD) hosts are conjugated with artesunate (ATS) by click chemistry to improve the solubility and antitumor activity of ATS. Supramolecular nanomedicine was prepared through orthogonal self-assembly driven by host−guest complexation and hydrogen bonds. The results showed that the aqueous solubility of CD-ATS was 30 times better than that of free ATS. Furthermore, CD-ATS displayed a superior antitumor effect against HCT116 tumor cells compared to the first-line drug Taxol. This enhanced effect was attributed to the induction of excessive reactive oxygen species (ROS) generation, which subsequently triggered apoptosis.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanostructured hexagonal S-doped CeO2 for effective Rh-B and MB dye degradation

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-11 DOI: 10.1016/j.molstruc.2024.140016

{"title":"Nanostructured hexagonal S-doped CeO2 for effective Rh-B and MB dye degradation","authors":"","doi":"10.1016/j.molstruc.2024.140016","DOIUrl":"10.1016/j.molstruc.2024.140016","url":null,"abstract":"<div>The photocatalytic efficiency of CeO2−xSx (x = 0.05, 0.1, 0.2, 0.3, 0.5) hexagonal nanoparticles (HNPs) prepared through the hydrothermal method were tested by performing the degradation of Rhodamine-B and Methylene blue dyes under UV light irradiation. These compounds were thoroughly characterised using XRD, FESEM, EDX, HRTEM, XPS, ESR, FTIR, Raman, UV–vis DRS, BET and PL techniques. XRD analysis verified the cubic crystal structure of S-doped and pure CeO2 HNPs. HRTEM images clearly affirmed that S-doped CeO2 is made from HNPs. Over 94 % of Rh-B and 72 % of MB dyes were degraded by S-doped CeO2 for 180 min under UV light exposure, demonstrating its efficacy towards the photocatalytic activity (PCA). S-doped CeO2 HNPs have enhanced the PCA due to the reduction in the recombination rate of photo-generated electron-hole pairs, the rise in oxygen vacancy (Ov) and the narrowed optical band-gap. The photoluminescence findings clearly validated the increased PCA of S-doped CeO2. The scavenger tests confirmed the OH• and •O2− radicals participation in the quick degradation of both Rh-B and MB dyes.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bismuth doped g-C3N4 composites for enhanced photocatalytic degradation of ciprofloxacin 用于增强环丙沙星光催化降解的掺铋 g-C3N4 复合材料

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.140013

{"title":"Bismuth doped g-C3N4 composites for enhanced photocatalytic degradation of ciprofloxacin","authors":"","doi":"10.1016/j.molstruc.2024.140013","DOIUrl":"10.1016/j.molstruc.2024.140013","url":null,"abstract":"<div>There is an increase in presence of various contaminants particularly related to antibiotics in the water sources affecting the environment. This study focusses on designing and development of innovative bismuth doped g-C3N4 for photocatalytic degradation of ciprofloxacin. Diverse Bi doped g-C3N4 catalysts, with metal loadings ranging from (0.5 – 2 wt%), were synthesized and characterized using advanced techniques. The introduction of Bi doped g-C3N4 drastically lowered the bandgap, with the introduction of Bi loadings. A highest ∼79% degradation was observed in 60 min using 1 wt% Bi doped g-C3N4, drastically outperforming bare g-C3N4 (∼63%). Kinetic studies were carried in the temperature range of (10 – 25°C), revealing an activation energy of 23.1 kJ/mol. Scavenging tests were carried with different additives (EDTA, IPA, AgNO3), among these lowest degradation (∼45%) was observed with EDTA which confirms that the h+ species controlling the degradation mechanism. Overall, this study reveals an improved photocatalytic activity attributed to better charge transfer and synergetic effects among Bi and g-C3N4, demonstrating the potential for pollutant removal present in wastewater.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel carboxylic functionalized ionic liquid grafted on carbonized polymer dots as highly efficient corrosion inhibitors

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.140011

{"title":"Novel carboxylic functionalized ionic liquid grafted on carbonized polymer dots as highly efficient corrosion inhibitors","authors":"","doi":"10.1016/j.molstruc.2024.140011","DOIUrl":"10.1016/j.molstruc.2024.140011","url":null,"abstract":"<div>A one-step hydrothermal synthesis of ionic liquid grafted carbonized polymer dots (CPDs) from l-cysteine and carboxylic acid functionalized ionic liquid is presented. The obtained CPDs have been characterized by various methods, found multiples functional groups have been detected on the CPD surfaces from FT-IR and XPS and 13C NMR, and ionic liquid serves as both the reaction medium and the reaction precursor for the grafting, endows a charged surface and can prevent the aggregation of carbon dots, whose sizes are around 100 nm from HRTEM. The CPDs exhibit excellent corrosion inhibition efficiency of 94.07 % to carbon steel at 50 mg·L-1 in 0.5 mol·L-1 H2SO4 solution, and low surface roughness can be observed on the inhibited steel surface by SEM, and a mixed adsorption of CPD on steel surface, including chemisorption and physisorption, can be demonstrated by XPS, and finally molecular dynamic study shows that the parallel adsorption mode is preferred to ensure nice inhibiting efficiency. This work provides a promising preparation strategy for CPDs, with ionic liquid grafted, for effective corrosion inhibition. which ensures multiple surface adsorption sites.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the role of potent thiadiazole based Schiff base derivatives in targeting type-II diabetes: A combine in-vitro and in-silico approaches

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.140000

{"title":"Insights into the role of potent thiadiazole based Schiff base derivatives in targeting type-II diabetes: A combine in-vitro and in-silico approaches","authors":"","doi":"10.1016/j.molstruc.2024.140000","DOIUrl":"10.1016/j.molstruc.2024.140000","url":null,"abstract":"<div>A novel series of varied substituted thiadiazole based Schiff base analogues (1–21) were designed and characterized using NMR (13C, 1H) and HREI-mass spectrometry, and secerned against the enzymes responsible for hyperglycemia i-e α-amylase and α-glucosidase. Newly designed analogues demonstrated distinct inhibitory activities having IC50= 1.10 ± 0.50 to 21.40 ± 0.20 µM (for alpha-amylase) and 2.50 ± 0.05 to 21.40 ± 0.10 µM (for alpha-glucosidase) in contrast to acarbose a well-known marketed drug (IC50 = 3.16 ± 0.22 & 4.8 ± 0.21 µM for α-amylase and α-glucosidase, respectively). Compound (20) with tri-fluoromethyl at para position of aromatic ring revealed as lead candidate among the members of synthesized series, having effective inhibitory activity against enzymes α-amylase and α-glucosidase. The excellent activity of compound (20) might be due to involvement of fluoro atom interacting via H-bonding with the active sites of enzymes α-amylase and α-glucosidase being targeted. Furthermore, for exploration of binding interactions of potent drugs, molecular docking was performed. For investigation of drug likeness and toxicity, ADME analysis was also conducted.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the impact of CuCl2 modification on structural variations and dielectric constant in bismuth borate tellurite glasses

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.140019

{"title":"Exploring the impact of CuCl2 modification on structural variations and dielectric constant in bismuth borate tellurite glasses","authors":"","doi":"10.1016/j.molstruc.2024.140019","DOIUrl":"10.1016/j.molstruc.2024.140019","url":null,"abstract":"<div>Copper chloride doped boro-tellurite-based glass series with compositions 60TeO2-(25-x) Bi2O3–15B2O3-xCuCl2 (x = 0, 5, 10, 15, and 20) were synthesized using the traditional melt-quench procedure. The X-ray diffraction patterns of the examined glasses reveal their amorphous nature. The effect of CuCl2 addition on the glass network/structural units was studied using vibrational (FTIR/Raman) spectroscopy, and CuCl2 inclusion in the glass matrix resulted in a transformation from compact TeO4 to TeO3 structural units This shows that copper chloride acts as a modifier in the examined glass series, resulting in the creation of non-bridging oxygen (NBOs), meaning that the loosening of the glass network is further supported by a decrease in the glass transition temperature as CuCl2 content increases. UV–Vis DRS spectra of examined glasses reveal an absorption band corresponding to the typical transition of Cu2+ ions from 2B1g → 2B2g, situated in deformed octahedral sites in absorption spectra. As Cu+ concentration rises, the indirect optical band gap values drop from 2.94 eV to 1.75 eV. The metallization criterion values lie between 0.383 and 0.300 suggesting that these glasses are potential candidates for nonlinear optical applications. With an increase in Cu+ concentration, the values of molar refractive index (Rm) and molar electronic polarizability <math><msub><mi>α</mi><mi>m</mi></msub></math> increases from 22.412 to 26.205 and 8.894 to 10.398 respectively, which correlate with increasing dielectric constant (ε′) values as the Cu+ amount increases. Further dielectric studies reveal non-Debye-type relaxation behaviour.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin-cyclodextrin inclusion complexes embedded in intrinsically active nano-assemblies: Preparation, characterization, antibacterial and antibiofilm activity against ESKAPE pathogens

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.139990

{"title":"Curcumin-cyclodextrin inclusion complexes embedded in intrinsically active nano-assemblies: Preparation, characterization, antibacterial and antibiofilm activity against ESKAPE pathogens","authors":"","doi":"10.1016/j.molstruc.2024.139990","DOIUrl":"10.1016/j.molstruc.2024.139990","url":null,"abstract":"<div>Curcumin loaded β-CD inclusion complexes (CCDs) embedded in intrinsically active rhamnosomes (CCDRs) were developed as alternative antimicrobials at the nano-scale to control ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens. The physicochemical analysis of CCDRs demonstrated that the addition of glycolipids (rhamnolipids) during the development of liposomes (phospholipids based) provided stability while the average size (158±5 nm) and polydispersity index (PDI) values of 0.2 demonstrated homogenous population of rhamnosomes. The incorporation of rhamnolipids with phospholipids increased the zeta potential to -45±1 mV with 76±1 % encapsulation efficiency for curcumin with enhanced photochemical and storage stability. In vitro, release studies demonstrated sustained release of curcumin due to its incorporation in β-CD molecular buckets, which were loaded in the aqueous liposomal core. These CCDRs with intrinsic antibacterial and antibiofilm potential enhanced the antimicrobial spectrum against ESKAPE pathogens demonstrating synergism between curcumin and rhamnolipids, by targeting multiple sites of bacterial cells and biofilms as compared to conventional antibiotics. Our study outlines that rhamnolipids and curcumin loaded inclusion complexes together offer an exciting potential for functionalized liposomal delivery systems that would be promising for the development of effective alternative therapeutics against ESKAPE pathogens.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and photoluminescence properties of Ce3+/Tb3+ and Eu3+ ions doped GdB3O6/Ca10(PO4)6(OH)2 Core/Shell particles as well as its cytotoxicity against colon cancer cells 掺杂 Ce3+/Tb3+ 和 Eu3+ 离子的 GdB3O6/Ca10(PO4)6(OH)2 核/壳粒子的合成、光致发光特性及其对结肠癌细胞的细胞毒性

IF 4 2区化学

Journal of Molecular Structure Pub Date : 2024-09-10 DOI: 10.1016/j.molstruc.2024.139921

{"title":"Synthesis and photoluminescence properties of Ce3+/Tb3+ and Eu3+ ions doped GdB3O6/Ca10(PO4)6(OH)2 Core/Shell particles as well as its cytotoxicity against colon cancer cells","authors":"","doi":"10.1016/j.molstruc.2024.139921","DOIUrl":"10.1016/j.molstruc.2024.139921","url":null,"abstract":"<div>In this study, Ce3+/Tb3+ co-doped, Eu3+ doped GdB3O6 phosphor particles were synthesized by sol-gel method, coated with hydroxyapatite (HAP) and loaded with doxorubicin. Different chelating agents and surfactants (Cetyltrimethylammonium bromide (CTAB), citric acid, glycine, ethylenediaminetetraacetic acid (EDTA) and tartaric acid) were used in the synthesis in order to see their effect on the structure. While single phase Gadolinium triborate, GdB3O6 was obtained by using CTAB in precursor solution in the synthesis and Gadolinium orthoborate, GdBO3 produced when EDTA was used in precursor solution. Other organic molecules added to precursor solution produced mixtures of both phases. The highest photoluminescence intensity was obtained in the Gd0.95Ce0.025Tb0.025B3O6 and Gd0.825Eu0.175B3O6. In order to increase the drug loading efficiency, The Gd0.825Eu0.175B3O6 core was coated with Calcium hydroxyapatite, HAP. The core had an average size of 458.65 nm which increased to 616.85 nm after coating as seen with dynamic light scattering (DLS). Gd0.825Eu0.175B3O6@HAP particles were loaded with 7.82 % ± 0.80 wt doxorubicin and the release was studied at 37 °C in pH 7.4 phosphate-buffered saline (PBS) and pH 5.5 acetate buffer solutions. The total number of moles of drug released versus luminescence intensity was measured during the release studies and real-time imaging studies were carried out. Finally, cytotoxicity experiments were performed on HCT-116 colon cancer cells.</div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0