Anionic ligands tune the structure and bioactivity of nickel(II)-albendazole complexes

IF 4.7 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-10-02 DOI:10.1016/j.molstruc.2025.144230

Abd El-Motaleb M. Ramadan , Mohamed M. Ibrahim , Shaban Y. Shaban , Reham Wagdy , Mohamed I. Ayad , Mahmode G. Salem , Ahmed M. Fathy

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Abstract

Two novel ternary nickel(II) complexes with albendazole (L), [NiL₂Cl₂] and [NiL(NO₃)₂]·2H₂O, were synthesized and characterized. Structural analyses revealed distorted octahedral and square planar geometries, respectively, with significant electronic differences influencing biological activity. Both complexes exhibited markedly higher affinity for calf thymus DNA and human serum albumin compared to free albendazole, with binding constants up to an order of magnitude greater. Stopped-flow kinetics confirmed faster DNA association rates. The square planar complex demonstrated particularly potent in vitro anticancer activity against HepG-2, HCT-116, and MDA-MB-231 cell lines, with IC₅₀ values as low as 4.21 µM and therapeutic coefficients up to 35.1. Both complexes also showed strong antibacterial activity, with MIC values rivaling Tobramycin. These results highlight the enhanced pharmacological potential of nickel(II)-albendazole complexes.

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阴离子配体调节镍(II)-阿苯达唑配合物的结构和生物活性

合成了两种新型的与阿苯达唑(L)的三元镍（II）配合物[NiL₂Cl₂]和[NiL（NO₃）₂]·2H₂O。结构分析分别显示扭曲的八面体和正方形平面几何形状，具有显著的电子差异影响生物活性。与游离的阿苯达唑相比，这两种复合物对小牛胸腺DNA和人血清白蛋白的亲和力明显更高，结合常数高达一个数量级。停流动力学证实了更快的DNA结合率。方形平面配合物在体外对HepG-2， HCT-116和MDA-MB-231细胞系表现出特别有效的抗癌活性，IC₅₀值低至4.21µM，治疗系数高达35.1。这两种配合物也显示出很强的抗菌活性，其MIC值与妥布霉素相当。这些结果突出了镍(II)-阿苯达唑配合物增强的药理潜力。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

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