Journal of Neuroimaging最新文献

{"title":"Perfusion Territory Shifts in Cerebrovascular Diseases Measured by Super-Selective Arterial Spin Labeling","authors":"Gabriel Hoffmann,&nbsp;Miriam Reichert,&nbsp;Jens Göttler,&nbsp;Michael Helle,&nbsp;Lena Schmitzer,&nbsp;Moritz Hernandez Petzsche,&nbsp;Claus Zimmer,&nbsp;Christine Preibisch,&nbsp;Michael Kallmayer,&nbsp;Kornelia Kreiser,&nbsp;Nico Sollmann,&nbsp;Hans Liebl,&nbsp;Stephan Kaczmarz","doi":"10.1111/jon.70101","DOIUrl":"10.1111/jon.70101","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Individualized diagnostic approaches are crucial in cerebrovascular diseases, such as internal carotid artery stenosis (ICAS). To evaluate individual collateral blood supply, vessel-selective imaging has gained high relevance. However, clinically established digital subtraction angiography (DSA) exposes patients to intervention risks and radiation. Two noninvasive MRI-based alternatives are super-selective pseudo-continuous arterial spin labeling (ss-pCASL, a technique for selective labeling of arterial blood-water) for perfusion territory mapping and four-dimensional vessel-selective angiography (4D-sPACK). We hypothesized that asymptomatic atherosclerosis-induced ICAS and Moyamoya disease result in chronic malperfusion. Therefore, we aimed towards quantitative assessment of collateral blood flow by ss-pCASL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective monocentric study, we acquired data in three subgroups (<i>n</i> = 23): patients with asymptomatic unilateral atherosclerosis-induced ICAS, Moyamoya disease, and age-matched healthy controls (HCs). On the basis of vascular territories from ss-pCASL, we introduced four parameters: volume, territorial shift, overlap with an atlas, and cerebral blood flow (CBF). For patients with atherosclerosis-induced ICAS, ipsi- and contralateral hemispheres were compared (paired <i>t</i>-test), and hemispheric lateralization <i>Δ</i> was calculated subjectwise and compared between patients and HCs (unpaired <i>t</i>-test) (<i>p </i>&lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included data from 20 subjects (8 ICAS, 3 Moyamoya, 9 HC). Group-level results showed ICAS-induced shifts with significant lateralization compared to HCs (<i>Δ</i>_Volume,ICAS = 18% ± 10%, <i>p </i>&lt; 0.001; <i>Δ</i>_Shift,ICAS = 4.9% ± 5.8%, <i>p</i> = 0.027; <i>Δ</i>_Overlap,ICAS = 0.2 ± 0.3, <i>p</i> = 0.033, <i>Δ</i>_CBF,ICAS = 3 ± 3 mL/100 g/min, <i>p</i> = 0.045). Furthermore, collateral blood supply in Moyamoya disease was assessed by 4D-sPACK and showed comparable diagnostic value as DSA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Perfusion territory mapping by ss-pCASL revealed chronic malperfusion in asymptomatic ICAS that can be objectively quantified, and 4D-sPACK added diagnostic value similar to DSA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differentiating Brain Metastasis and High-Grade Glioma Using Multi-b Value Diffusion MRI and Tumor Volumetry","authors":"Tereza Kopřivová,&nbsp;Marek Dostál,&nbsp;Tomáš Jůza,&nbsp;Václav Vybíhal,&nbsp;Petra Ovesná,&nbsp;Michal Kozubek,&nbsp;Miloš Keřkovský","doi":"10.1111/jon.70103","DOIUrl":"10.1111/jon.70103","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>To evaluate feasibility of multi-<i>b</i> value diffusion magnetic resonance imaging (MRI) and volumetry in differentiating between brain metastases and high-grade gliomas (HGGs) while producing a differentiation tool.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Preoperative brain MRI consisting of both morphological and multi-<i>b</i> value diffusion sequences of patients with HGGs and brain metastases was prospectively performed. Three-dimensional masks of enhancing and non-enhancing tumor and surrounding edema were semiautomatically segmented. Multiple diffusion parameters were subsequently derived together with volumes of the particular tissues. Histogram analysis of the diffusion parameters was performed, and the parameters’ diagnostic power to differentiate between the subgroups was evaluated by receiver operating characteristic analysis and least absolute shrinkage and selection operator (LASSO) regression method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A training dataset included 97 consecutive patients (67 HGGs, 30 metastases), whereas 17 patients (9 HGGs and 8 metastases) comprised a validation group. Overall, 66 histogram diffusion parameters and tissue volumes were found to differ significantly between metastasis and HGG subgroups. LASSO regression identified 17 of these as best predictors. A decision tree using four parameters achieved sensitivity of 90% and 87.5% and specificity of 97% and 77.8% for the training and validation subgroups, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Multi-<i>b</i> diffusion MRI and tumor volumetry may be valuable diagnostic tools for differentiating HGG from brain metastasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion Tensor Imaging Reveals Altered Centrality of Pain-Related Regions in SCN9A-Associated Small Fiber Neuropathy","authors":"Gerhard S. Drenthen,&nbsp;Dennis Kool,&nbsp;Amir Far,&nbsp;Jaymin Upadhyay,&nbsp;David E. J. Linden,&nbsp;Raquel van Gool,&nbsp;Celine P. Goijen,&nbsp;Ingemar S. J. Merkies,&nbsp;Walter H. Backes,&nbsp;Catharina G. Faber,&nbsp;Jacobus F. A. Jansen,&nbsp;Janneke G. J. Hoeijmakers","doi":"10.1111/jon.70105","DOIUrl":"10.1111/jon.70105","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Small fiber neuropathy (SFN) is a neuropathic disorder that is associated with chronic pain. While most SFN cases are idiopathic, SFN can also have hereditary causes. For example, rare SCN9A gene mutations can impair the Na_V1.7 sodium channel, which leads to dorsal root ganglion neuron hyperexcitability, causing SFN. Although chronic pain may induce cerebral changes, the specific structural brain alterations in SCN9A-associated SFN (SFN-SCN9A) remain insufficiently characterized. Therefore, potential alterations in the structural brain network of idiopathic SFN and SFN-SCN9A were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten SFN-SCN9A patients, 20 idiopathic SFN patients, and 20 controls were included. All participants underwent 3-Tesla diffusion MRI (66 gradient directions, <i>b</i>-value = 1200 s/mm²), and the brain network was quantified using nodal importance, which describes the influence of a group of regions on the whole network.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The nodal importance of pain-associated regions (postcentral gyrus, insular cortex, anterior cingulate cortex, and thalamus) was increased in SFN-SCN9A patients compared to controls (<i>β</i> = 0.43, <i>p</i> = 0.02) and idiopathic SFN patients (<i>β</i> = 0.43, <i>p</i> = 0.02). Moreover, higher self-reported pain was associated with higher nodal importance of pain-associated regions in the SFN-SCN9A group (<i>r</i> = 0.67, <i>p</i> = 0.03), while this effect was not observed in the idiopathic SFN patients (<i>r</i> = −0.22, <i>p</i> = 0.34). As self-reported pain did not differ between the SFN groups, it is likely specific to the SCN9A-mutation and not to differences in pain intensity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Combined, these results suggest the potential involvement of a distinct structural pathway related to pain processing in SFN-SCN9A.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12604079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Myo-Inositol From Glycine in Brain MRS at 3T: A Pitfall Using Intermediate Echo Times","authors":"Seyma Alcicek,&nbsp;Georg Oeltzschner,&nbsp;Doris D. M. Lin,&nbsp;Peter B. Barker","doi":"10.1111/jon.70107","DOIUrl":"10.1111/jon.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>In in vivo magnetic resonance spectroscopy (MRS) of the brain, glycine (Gly) is traditionally separated from the overlapping signal of <i>myo</i>-inositol (mI) through the use of intermediate (e.g., 130–140 ms) or long (270–280 ms) echo times (TE). However, no quantitative comparisons have been performed to date comparing the performance of clinically available MRS sequences to differentiate mI and Gly as a function of TE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In vivo spectra recorded with two clinically available MRS pulse sequences (single voxel PRESS and semi-LASER 2D-MRSI) with short (35 ms), intermediate (135 ms), and long (280 ms) echo times in a neonate with clinically suspected nonketotic hyperglycinemia were compared to those recorded from phantoms, and spectral simulations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In vivo spectra recorded at short and intermediate TE spectra showed signals at 3.5 ppm that could arise from either mI or Gly; however, long TE spectra showed an absence of signal in this spectral region, which was consistent with the final clinical diagnosis of hypoxic-ischemic encephalopathy. Phantom data and spectral simulations demonstrated that at intermediate TE, mI has a “pseudo-singlet” appearance that is very similar to that of Gly.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Long echo times are used to best discriminate Gly from mI if specialized sequences and analysis methods are not available. Quantitative spectral analysis methods may also assist in correctly assigning Gly and mI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12604077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing a Stimulator Modification for Simultaneous Noninvasive Auricular Vagus Nerve Stimulation and MRI","authors":"Vanessa Teckentrup,&nbsp;Mareike Ludwig,&nbsp;Janis Seibt,&nbsp;Renée Hartig,&nbsp;Hubert Preissl,&nbsp;Mark Schuppert,&nbsp;Nikolai I. Avdievich,&nbsp;Klaus Scheffler,&nbsp;Nikos Priovoulos,&nbsp;Maik Ehses,&nbsp;Benedikt A. Poser,&nbsp;Christopher J. Wiggins,&nbsp;Peter Trautner,&nbsp;Walter Honerbach,&nbsp;Heidi I. L. Jacobs,&nbsp;Oliver Speck,&nbsp;Dorothea Hämmerer,&nbsp;Nils B. Kroemer","doi":"10.1111/jon.70098","DOIUrl":"10.1111/jon.70098","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>The vagus nerve can be stimulated noninvasively at the ear using transcutaneous auricular vagus nerve stimulation (taVNS). Concurrent functional MRI (fMRI) permits study of taVNS-induced changes in brain dynamics, a key requisite for precision neurostimulation. However, there is no standardized protocol for how to safely apply taVNS during MRI. One major risk is temperature increase exceeding innocuous thresholds due to coupling of the emitted radio frequency (RF) pulse during imaging. Thus, we developed and tested a stimulator cable configuration with floating ground cable traps and filter plate connectors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We measured temperature, resonance of the stimulation electrodes, and current interference using unmodified and modified stimulation cables. Measurements were conducted across three sites using different 3T MRI scanner models, stimulators, and stimulation strengths with phantoms and human participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The modified compared to the unmodified cable considerably reduced RF heating as the relative temperature increase stayed well below the 2 K threshold specified by the ASTM F2182 standard. Additionally, in accordance with ASTM 2119, we can rule out potential distortion and signal loss around the electrodes due to current flow from the stimulator and demonstrate that impaired image quality in brainstem and midbrain regions is recovered using the modified cable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We show that adding floating ground cable traps to the stimulator cable allows the safe use of taVNS with fMRI and may improve image quality in functional imaging. To enable other researchers to modify their hardware in the same way, we provide details of the modifications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ghost Penumbra Pattern in Acute Ischemic Stroke: Characterization and Prognostic Significance","authors":"Mercedes de Lera Alfonso,&nbsp;Alicia Sierra-Gómez,&nbsp;Ana I. Calleja,&nbsp;Elisa Cortijo,&nbsp;Gonzalo Valle,&nbsp;Beatriz Gómez-Vicente,&nbsp;Mario Martínez-Galdámez,&nbsp;Jorge Galván,&nbsp;Miguel Schüller,&nbsp;Lorenzo Pérez,&nbsp;Alirio Millán,&nbsp;Ignacio Eiros,&nbsp;Juan F. Arenillas","doi":"10.1111/jon.70100","DOIUrl":"https://doi.org/10.1111/jon.70100","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>We studied the so-called ghost penumbra pattern (GPP), characterized by an underestimation of ischemic core volume on computed tomography perfusion (CTP) as compared with noncontrast CT (NCCT). We aimed to describe its frequency, to characterize the baseline factors associated with its presence, and to investigate its impact on clinical and radiological outcomes in acute ischemic stroke (AIS) patients treated with endovascular therapy (EVT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A consecutive series of AIS patients with proximal anterior circulation large vessel occlusion (LVO) treated with EVT and achieving successful reperfusion were included. All underwent NCCT, multiphase CT angiography (CTA), and CTP, which were analyzed with RAPID software. Ischemic core volumes were compared between CT and CTP. GPP was defined by a CT core/CTP core ratio &gt;1.5. Collateral status and thrombus migration were assessed. Parenchymal hematoma (PH) and hypodensity volume were measured at 24 h. Functional outcome was evaluated at 90 days using the modified Rankin Scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From June 2020 to December 2021, a total of 173 AIS patients were included in the study (mean age was 73; 52% women; median National Institutes of Health Stroke Scale [NIHSS] 16). GPP was detected in 100 (58%) patients. Good collateral circulation (OR 2.8 [1.5–5.4]; <i>p</i> = 0.001) and lower NIHSS (OR 0.9 [0.8–0.9]; <i>p</i> = 0.02) were independently associated with GPP. The GPP predicted a lower risk of PH (OR 0.43 [0.19–0.97]; <i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GPP was observed in about half of the included AIS patients and was associated with better collateral circulation and thrombus migration. Endovascular reperfusion in this group was safe.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Meningeal Artery Lidocaine Infusion for Refractory Migraine: Angiographic Dose Response and 3-Month Outcomes","authors":"Rami Fakih,&nbsp;Nived Jayaraj Ranjini,&nbsp;Syed A. Gillani,&nbsp;Kimberley Pfeiffer,&nbsp;Camilo R. Gomez,&nbsp;Alexander Sirakov,&nbsp;M. Fareed K. Suri,&nbsp;Paul Bhogal,&nbsp;Adnan I. Qureshi","doi":"10.1111/jon.70096","DOIUrl":"https://doi.org/10.1111/jon.70096","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Several studies have demonstrated the amelioration of refractory migraines with middle meningeal artery (MMA) intra-arterial lidocaine infusion, but the durability beyond 1 month is not well studied, and the angiographic dose response of lidocaine infusion was not previously evaluated. We aimed to assess the efficacy of middle meningeal artery lidocaine infusion in the treatment of refractory migraines at a 3-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We quantified the response to intra-arterial lidocaine infusion (maximum dose of 150 mg) in patients with refractory migraine using the Migraine Disability Assessment (MIDAS) evaluated pre- and posttreatment. At 3 months, We determined the MIDAS score changes, the proportion of responders (≥50% MIDAS reduction), the proportion of patients with “no disability” (MIDAS Grade 1), and the cessation of opioid medication for headache management measured at the last known follow-up. An angiographic dose response was quantified.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eight patients were included in our analysis (mean age of 49.1 ± 13.2 years; 87.5% were women). The cohort comprised equal numbers of unilateral and bilateral MMA lidocaine infusions (4 each), with doses titrated from 50 to 150 mg per procedure. At 3 months posttreatment, the mean MIDAS score improved from 86.3 ± 40.1 to 23.5 ± 26.8 (<i>p</i> = 0.001, paired <i>t</i>-test), and 62.5% of the patients showed 50% MIDAS score reduction. The disability pre-treatment was classified as “severe disability” in all patients, and 50% achieved “no disability” (MIDAS Grade 1) at 3 months posttreatment. No adverse events were reported in any of the procedures. At last known follow-up of a median period of 9.8 months [range 4–21 months], three out of the four patients who were on opioid medication pre-treatment discontinued their opioid medications following MMA lidocaine infusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Intra-arterial lidocaine infusion was associated with sustained improvement at 3 months posttreatment in 50% of patients with refractory migraines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Neuromuscular Ultrasound for Carpal Tunnel Syndrome: A Real-World Study","authors":"Ujjawal Roy,&nbsp;Michael S. Cartwright,&nbsp;Achal Kumar Srivastava,&nbsp;Abhishek Dixit,&nbsp;Ajay Panwar,&nbsp;Meenakshi Vanchi,&nbsp;Guhan Ramamurthy,&nbsp;M. M. Arun Shivaraman,&nbsp;Saankritya Ayan,&nbsp;Saket Verma,&nbsp;Prabhat Kumar Lal","doi":"10.1111/jon.70102","DOIUrl":"https://doi.org/10.1111/jon.70102","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>To determine the diagnostic accuracy of median nerve ultrasound in suspected cases of carpal tunnel syndrome (CTS) in a prospective, real-world study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study was carried out over one year at Roy Neuro Care Centre, Ranchi, Jharkhand, India. The clinical, electrophysiologic, and ultrasonographic findings in suspected cases of CTS were collected. A history and physical examination consistent with CTS were considered the gold standard for diagnosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 134 patients with symptoms suggestive of CTS were enrolled, and both wrists were examined. The diagnostic accuracy of various ultrasound parameters including maximum cross-sectional area (CSA) of the median nerve in the tunnel, difference between CSA at the level of the pronator quadratus compared to the carpal tunnel, and wrist-to-forearm ratio were evaluated by individual, parallel, and serial testing strategies using optimal cut-off values determined by the Youden Index. Parallel testing provided the highest sensitivity, making it suitable for screening, whereas serial testing produced the highest overall accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Median nerve ultrasound is an accurate diagnostic tool for CTS in a real-world setting.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edge-Guided Deep Learning Model to Predict Fetal Brain Age Using MRI","authors":"Haitao Gan,&nbsp;Qingsong Gao,&nbsp;Zhi Yang,&nbsp;Yiyuan Zhou,&nbsp;Ran Zhou,&nbsp;Yu Guo,&nbsp;Wei Xia","doi":"10.1111/jon.70099","DOIUrl":"https://doi.org/10.1111/jon.70099","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Deep learning enables fast fetal brain age prediction from MRI. However, most models emphasize global features while ignoring local edge details. To improve accuracy, we propose a novel model incorporating global edge information, achieving performance comparable to that of experienced clinicians.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective collection of 1630 fetal brain coronal T2-weighted MR images from 207 singleton pregnancies with brain ages ranging from 22 to 38 weeks from June 2019 to July 2023 was performed. The fetal MRI dataset was divided into two independent subsets: a training dataset for optimizing model parameters and a test dataset for evaluating the model's performance relative to a reference standard. Four-fifths of the dataset were allocated as training data and one-fifth as test data. We trained a neural network that incorporates global edge information and continuously optimized it using performance indicators such as mean absolute error (MAE) and <i>r</i>-square (<i>R</i>²) to achieve the desired results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In a retrospective study involving 1630 fetal brain MR images from 207 subjects, the edge-guided deep learning model achieved higher accuracy in predicting fetal age compared to existing methods, with an MAE of 0.79 weeks and an <i>R</i>² value of 0.94, and can promote regression models to produce more stable and reliable predictions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Compared to existing methods for predicting fetal brain age, our method demonstrates superior performance and is helpful for accurately assessing the fetal brain development in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 6","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145429405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Nature of Arachnoid Granulations During Acute Changes in Intracranial Pressure: A Pilot Study","authors":"Andrew Wai Kei Ko,&nbsp;Dipakkumar Thakor,&nbsp;Nada Aboudahab,&nbsp;Ali Sheikhy,&nbsp;M. Reza Taheri","doi":"10.1111/jon.70097","DOIUrl":"10.1111/jon.70097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Arachnoid granulations (AGs) are cerebrospinal fluid drainage structures whose number and size may vary with intracranial pressure (ICP). Although changes in AG size following lumbar puncture have been reported, longitudinal changes in patients with and without acute ICP alterations have not been studied. This study evaluated AG number and volume over time in patients with and without acute ICP changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively reviewed head and neck computed tomography angiography scans over a 10-year period. Subjects had two consecutive scans with visible AGs. Controls had no acute intracranial pathology, whereas cases had acute hydrocephalus with decompression and ICP monitoring via extraventricular drains. AG volume was measured in both groups; AG number was assessed in controls only. Wilcoxon signed rank tests and paired <i>t</i>-tests were used to assess within-group differences. Welch's <i>t</i>-test and Type III analysis of variance were used for between-group differences and interaction effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 88 controls, AG volumes had a statistically significant change over time (<i>p</i> = 0.010). In four hydrocephalus cases, AG volume decreased by 29.9 mm³ (<i>p</i> = 0.030) after ICP reduction. Between-group analysis showed a significant point estimate difference (<i>p</i> = 0.020) and interaction (<i>p</i> &lt; 0.0001), indicating differing AG responses to acute ICP changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AGs are dynamic structures exhibiting measurable changes in number and volume over time. AG volume appears responsive to acute ICP alterations, supporting their function in ICP regulation and suggesting a potential role as an imaging biomarker for ICP dynamics in acute hydrocephalus.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}