Journal of Nanobiotechnology最新文献

{"title":"Correction: PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor.","authors":"Kezhi Yu, Yongquan Huang, Yuanyuan Wang, Qunyan Wu, Zihang Wang, Fei Li, Jianri Chen, Maierhaba Yibulayin, Shushan Zhang, Zhongzhen Su, Fei Yan","doi":"10.1186/s12951-025-03491-y","DOIUrl":"10.1186/s12951-025-03491-y","url":null,"abstract":"","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"394"},"PeriodicalIF":10.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRPC6-targeted dexamethasone nanobubbles with ultrasound-guided theranostics for adriamycin-induced nephropathy.","authors":"Lin Wu, Yang Liu, Ziqi Fu, Honglei Guo, Kang Liu, Jiafa Ren, Zhimin Huang, Fang Yang, Huijuan Mao","doi":"10.1186/s12951-025-03487-8","DOIUrl":"10.1186/s12951-025-03487-8","url":null,"abstract":"<p><strong>Background: </strong>Glucocorticoid (GC) intolerance and systemic toxicity pose significant challenges in the treatment of primary nephrotic syndrome (PNS), underscoring the urgent need for targeted therapies that maximize efficacy while minimizing adverse effects. To address these challenges, we developed TRPC6-targeted dexamethasone-loaded nanobubbles (Dex@NBs-TRPC6)-an innovative therapeutic platform that enables selective podocyte delivery alongside real-time monitoring capabilities.</p><p><strong>Results: </strong>The Dex@NBs-TRPC6 nanobubble system comprises polyethylene glycol-modified lipid vesicles encapsulating dexamethasone (Dex), conjugated with TRPC6-specific antibody for precise podocyte targeting delivery. Comprehensive in vivo and in vitro evaluations demonstrated the robust kidney and podocyte-targeting capabilities of Dex@NBs-TRPC6. Functional assays in mouse podocyte cells revealed that Dex@NBs-TRPC6 significantly outperformed free Dex and non-targeted nanobubbles (Dex@NBs) in mitigating cell apoptosis and inflammation. In an adriamycin-induced mouse nephropathy model, Dex@NBs-TRPC6, administered at half the dosage of free Dex, markedly alleviated proteinuria, glomerular and tubular damage, renal apoptosis, inflammation and fibrosis. Notably, Dex@NBs-TRPC6 attenuated the overexpression of hepatic gluconeogenic genes PCK1 and GCP6, a common adverse effect associated with Dex. Furthermore, leveraging the acoustic response properties of Dex@NBs-TRPC6, this delivery system integrates ultrasound imaging capabilities, enabling real-time visualization and therapeutic monitoring.</p><p><strong>Conclusions: </strong>By simultaneously enhancing therapeutic efficacy, minimizing systemic toxicity, and enabling personalized imaging-guided treatment, Dex@NBs-TRPC6 introduces a transformative approach to GC-based renal therapy.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"398"},"PeriodicalIF":10.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dots derived from Ligusticum Chuanxiong mitigate cardiac injury by disrupting the harmful oxidative stress-apoptosis cycle.","authors":"Yapeng Guo, Lei Yang, Li Yao, Chengdong Zhou, Yuanyuan Zhu, Chenxi Xu, Wenlong Wang, Jian Song, Mingzhen Zhang, Zhichao Deng","doi":"10.1186/s12951-025-03477-w","DOIUrl":"10.1186/s12951-025-03477-w","url":null,"abstract":"<p><strong>Background: </strong>Myocardial ischemia-reperfusion injury (MIRI) represents a significant complication following myocardial infarction surgery, for which preventive strategies remain limited. The primary pathological characteristics of MIRI include oxidative stress and apoptosis.</p><p><strong>Results: </strong>This study presents the synthesis of carbon dots derived from Ligusticum Chuanxiong (LC-CDs) through the application of the hydrothermal method. The LC-CDs show strong scavenging abilities for free radicals, effectively reducing oxidative stress and preventing apoptosis, which helps combat MIRI. The findings demonstrate that LC-CDs can effectively neutralize excessive ROS within cells, thereby alleviating oxidative stress, restoring mitochondrial function, and preventing DNA damage. Concurrently, LC-CDs suppress the polarization of M1-type macrophages and reduce the secretion of pro-inflammatory cytokines. Following the in situ administration of LC-CDs into the hearts of MIRI-model rats, a significant reduction in the necrotic area of the myocardium was observed, alongside the restoration of cardiac function, with no adverse reactions reported. Moreover, similar to the pharmacological effects of Ligusticum chuanxiong, LC-CDs can also inhibit apoptosis by protecting mitochondria and suppressing the expression of apoptotic proteins (Caspase3, Caspase9, and Bax).</p><p><strong>Conclusions: </strong>The intervention strategy employing LC-CDs, which targets oxidative stress and apoptosis in MIRI, holds promise as a potential model for the clinical treatment of MIRI.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"391"},"PeriodicalIF":10.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherosclerosis enhances the efficacy of liposome-encapsulated bromocriptine in reducing the incidence of prolactinemia in pituitary tumors.","authors":"Zhe Zhang, Guangyu Jia, Qi Wang, Yamei Yu, Xiaolong Tang, Heqing Zheng, Xinyu Yang, Yao Xiao, Yangrui Ou, Jingjing Jiang, Hua Guo, Ye Wang, Shiyong Li","doi":"10.1186/s12951-025-03465-0","DOIUrl":"10.1186/s12951-025-03465-0","url":null,"abstract":"<p><p>Intranasal drug delivery via nanocarriers has long been a research focus for enhancing drug concentration in the brain. However, the strategy of exploiting blood-brain barrier (BBB) alterations in atherosclerotic mouse models to enhance nanoparticle-mediated delivery of bromocriptine to the hypothalamus for the treatment of prolactinomas with hyperprolactinemia has not yet been reported. This study reveals that in patients with prolactinomas complicated by arteriosclerosis, bromocriptine therapy more effectively attenuates postoperative elevations in prolactin levels. In a mouse model, liposome-encapsulated bromocriptine efficiently traversed the nasal mucosa and entered the intracranial space. Compared with normal mice, bromocriptine-loaded liposomes delivered higher bromocriptine concentrations to the hypothalamus. Single-cell RNA sequencing revealed a significant upregulation of organic anion-transporting polypeptide 1a4 (Oatp1a4) expression in the brain endothelial cells of atherosclerotic mice. Importantly, bromocriptine-loaded liposomes more effectively reduced prolactin levels in a mouse model of prolactinoma with concurrent atherosclerosis. This study provides a theoretical foundation for the precision treatment of prolactinomas in arteriosclerosis.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"392"},"PeriodicalIF":10.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myogenic nano-adjuvant for orthopedic-related sarcopenia via mitochondrial homeostasis modulation in macrophage-myosatellite metabolic crosstalk.","authors":"Xudong Zhang, Peng Zhang, Yunliang Zhu, Jiaqing Lou, Peng Wu, Yingjie Wang, Zhengxi Wang, Quan Liu, Baoliang Lu, Qianming Li, Jiawei Mei, Chen Zhu, Wanbo Zhu, Xianzuo Zhang","doi":"10.1186/s12951-025-03480-1","DOIUrl":"10.1186/s12951-025-03480-1","url":null,"abstract":"<p><p>The decline in skeletal muscle mass and muscle strength linked to aging, also known as sarcopenia, is strongly associated with disability, traumatic injury, and metabolic disease in patients. Meanwhile, sarcopenia increases the risk of adverse orthopedic perioperative complications including implant dislocation, infection, loosening, and poor wound healing. Mitochondrial dyshomeostasis in the immune-myosatellite metabolic crosstalk is one of the major pathological factors in sarcopenia. To reduce the incidence of orthopedic perioperative complications in patients, we designed and developed a nano-adjuvant based on two-dimensional layer double hydroxide (LDH) for sustained improvement of systemic and orthopedic-related sarcopenia. Construction of MgAlCo-LDH@UA (MACL@UA) nano-adjuvant was performed by introducing cobalt in magnesium-aluminum LDH and further loading urolithin A (UA). The release of magnesium ions and UA promoted myocyte proliferation, angiogenesis and improved mitochondrial homeostasis. Al acted as an immunomodulatory adjuvant to enhance the metabolic crosstalk between macrophages and myosatellite cells, and prompted macrophage-derived glutamine nourishment. Animal experiments confirmed that vaccination with MACL@UA in systemic sarcopenia and intensive orthopedic perioperative vaccination with MACL@UA significantly enhanced quadriceps muscle mass in rats. This nano-adjuvant offers a solution for long-term improvement of sarcopenia and short-term significant reduction of orthopedic perioperative complications in patients, with promising prospects for clinical application and commercial translation.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"390"},"PeriodicalIF":10.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles from adipose-derived stromal/stem cells reprogram dendritic cells to alleviate rat TMJOA by transferring mitochondria.","authors":"Ziyi Mei, Hanyue Li, Chuling Huang, Shiyong Ma, Yuejia Li, Pingmeng Deng, Sha Zhou, Aizhuo Qian, Bin Yang, Jie Li","doi":"10.1186/s12951-025-03478-9","DOIUrl":"10.1186/s12951-025-03478-9","url":null,"abstract":"<p><p>Temporomandibular joint osteoarthritis (TMJOA) urgently needs regenerative therapies due to the limited effects of traditional treatments. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are considered a potent alternative for MSC therapy for the treatment of TMJOA. However, the specific mechanisms remain inadequately investigated. In this study, we explored how EVs from adipose-derived stromal/stem cells (ASCs) influence the TMJOA model triggered by Complete Freund's Adjuvant in rats and their impact on the state of dendritic cells (DCs) under pathological conditions. Subsequently, we conducted transcriptomic and metabolomic analyses to elucidate the specific mechanisms by which EVs affect DCs. Mechanistically, we demonstrate that EVs transferred functional mitochondria to DCs, which reverses their metabolic states. The internalized functional mitochondria from EVs activate the MAPK/ERK1/2/FoxO1/autophagy pathway, which causes the metabolic reprogramming of DCs and facilitates the achievement of therapeutic effects. These findings provide a mechanistic rationale for utilizing ASCs-EVs as cell-free alternatives to MSC transplantation in TMJOA therapy.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"389"},"PeriodicalIF":10.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Double-sided protector\" Janus hydrogels for skin and mucosal wound repair: applications, mechanisms, and prospects.","authors":"Laijun Xu, Junyi Zhang, Junsi Luo, Yiteng Cui, Jinhong Chen, Bin Zeng, Zhiyuan Deng, Longquan Shao","doi":"10.1186/s12951-025-03438-3","DOIUrl":"10.1186/s12951-025-03438-3","url":null,"abstract":"<p><p>Skin and mucous membranes serve as crucial barrier tissues within the human body. Defective wound healing not only inflicts pain but also heightens the risk of infection and impairs immune function. Janus hydrogels possess two-sided distinct asymmetric structures that endow them with diverse properties such as high water absorbency, flexibility, anti-adhesion ability etc. These hydrogels also exhibit great potential in biofluid transport, drug delivery and promoting tissue repair. Currently, research efforts predominantly concentrate on the preparation techniques, properties, and biomedical applications. This review summarized its structural characteristics and different forms of designations, and focused on the possible mechanisms, the existing problems and improvement strategies for the skin and mucous tissues wound, aiming to provide new design ideas for repairing complex skin and mucous membrane tissue defects.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"387"},"PeriodicalIF":10.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary hazards of nanoplastic particles: a study using polystyrene in in vitro models of the alveolar and bronchial epithelium.","authors":"Sara Michelini, Safaa Mawas, Ema Kurešepi, Francesco Barbero, Katarina Šimunović, Dorian Miremont, Stéphanie Devineau, Martin Schicht, Victor Ganin, Øyvind Pernell Haugen, Anani Komlavi Afanou, Charlotte Izabelle, Shan Zienolddiny-Narui, Katharina Jüngert, Neža Repar, Ivana Fenoglio, Barbara Šetina Batić, Friedrich Paulsen, Ines Mandić-Mulec, Sonja Boland, Andreja Erman, Damjana Drobne","doi":"10.1186/s12951-025-03419-6","DOIUrl":"10.1186/s12951-025-03419-6","url":null,"abstract":"<p><strong>Background: </strong>Nanoplastics (NPs) are released into the environment through the degradation of plastic objects, leading to human exposure. Due to their small size, concerns have been raised about the potential hazards to the respiratory tract, as ultrafine and nanoparticles are known to penetrate till the alveolar regions of the lungs, potentially impairing their functions. Thus, in the present study, we used model polystyrene nanoparticles doped with the fluorescent metal europium (PS-Eu) to enhance the understanding of NPs hazard and investigate adverse outcomes associated with exposure in human lungs using alveolar (A549) and bronchial (Calu-3) cell models grown in 2D and 3D submerged conditions or quasi air-liquid interface (ALI) conditions (3D).</p><p><strong>Results: </strong>Briefly, after in-dept physicochemical characterization of the particles, we assessed their impact on ROS production, cell viability (AlamarBlue and lactate dehydrogenase assays) and barrier integrity (lucifer yellow assay and TEER measurement), finding no negative effects in either model. However, in alveolar cells, particles increased acidic organelle activity. Transmission electron microscopy and Raman microscopy showed, in both models, a dose- and cell-dependent particle uptake with PS-Eu accumulating in numerous and large endo-lysosomes, which, in transwells-grown A549 cells, often contained also lamellar bodies (LBs), organelles involved in surfactants storage and secretion. After extensively quantifying surfactant proteins (SP) in the pellet and supernatant fractions of treated A549 cells, we observed a significant reduction in several members of this family, including surfactant protein B, which is crucial for lamellar body formation and surface tension regulation in the lungs. In quasi-ALI Calu-3 cultures instead, PS-Eu significantly upregulated interleukin 6 (IL-6) and increased transforming growth factor beta β (TGF-β), zonula occludens 1 (ZO-1), and mucin (MUC) 5B mRNA expressions causing a moderate proinflammatory response.</p><p><strong>Conclusion: </strong>Our results show that PS-Eu exposure does not induce acute cytotoxicity in these models, but affects cell-specific functions like surfactant, mucin, and cytokine production. This underscores the limitations of relying solely on standard cytotoxicity tests for particle hazard assessment and highlights the importance of investigating cell function-specific signaling pathways. To support researchers in hazard assessment, we propose specific classes of biomarkers to test in in vitro lung models.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"388"},"PeriodicalIF":10.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent induction of pyroptosis and immunogenic cell death by capsaicin/graphene nanocomplex for enhanced breast cancer immunotherapy.","authors":"Silu Li, Xin Jin, Yumo Zhang, Jidan Huang, Haiqiang Wang, Huan Meng, Jiulong Li, Lin Zhu","doi":"10.1186/s12951-025-03439-2","DOIUrl":"10.1186/s12951-025-03439-2","url":null,"abstract":"<p><p>Inducing immunogenic cell death (ICD) has emerged as a promising strategy for targeting immunologically \"cold\" tumors. However, most current therapies focus on a single mechanism, limiting their efficacy. In this study, we propose a nano-enabled approach that synergistically activates two complementary immunogenic killing mechanisms: pyroptosis, which elicits a potent inflammatory response, and ICD, characterized by the presentation of 'eat-me' signals and tumor antigens to the immune system. Capsaicin, a naturally occurring compound, was employed to induce pyroptosis via ROS-mediated gasdermin E (GSDME) cleavage, resulting in cell membrane blebbing and subsequent cell death. To simultaneously trigger ICD, we incorporated 2D graphene oxide (GO) engineered with optimized physicochemical properties to induce robust ICD under near-infrared irradiation. Our in vitro and in vivo experiments demonstrated that the combined treatment of capsaicin and GO not only enhanced cancer cell killing but also promoted immune cell infiltration and potentiated anti-tumor immunity, leading to significant tumor suppression. Moreover, the dual-trigger mechanism of pyroptosis and ICD yielded superior anti-tumor efficacy compared to single-modality treatments while maintaining a favorable biosafety profile. These findings highlight the potential of a synergistic nano-enabled strategy for improving cancer immunotherapy.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"386"},"PeriodicalIF":10.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA binding effects of LDH nanozyme for aseptic osteolysis mitigation through STING pathway modulation.","authors":"Zi Fu, Meng Zhang, Ying Huang, Han Wang, Wanting Hao, Zeyang Liu, Haiyan Guo, Dalong Ni","doi":"10.1186/s12951-025-03458-z","DOIUrl":"10.1186/s12951-025-03458-z","url":null,"abstract":"<p><p>Persistent and intense inflammation is recognized as the primary cause of wear-particle-induced aseptic osteolysis, which ultimately resulting in aseptic prosthesis loosening. Reducing inflammation plays a significant role in mitigating osteolysis, and the STING pathway has emerged as a promising therapeutic target for its prevention. Specifically, damaged periprosthetic cells of aseptic osteolysis release double-stranded DNA (dsDNA) into the osteolytic microenvironment, serving as a specific stimulus for the STING pathway. Herein, we found that layered double hydroxide (LDH) nanozyme exhibited a robust DNA-binding capacity primarily mediated by van der Waals interactions, which showed superior performance in inhibiting dsDNA-induced inflammation of aseptic osteolysis. Importantly, such binding capability enabled effective co-loading LDH with STING inhibitor C176, thus facilitating inhibition of the STING pathway. Such synergistic actions contributed to ameliorate the inflammatory milieu and remodel the osteolysis microenvironment successfully to reduce cranial bone damage, which was confirmed on animal model of osteolysis. Collectively, this strategy demonstrated an effective approach by utilizing synergistic effects to establish a positive feedback loop in the treatment of osteolysis, thereby alleviating TiPs-induced periprosthetic osteolysis and preventing postoperative complications.</p>","PeriodicalId":16383,"journal":{"name":"Journal of Nanobiotechnology","volume":"23 1","pages":"384"},"PeriodicalIF":10.6,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}