Journal of Molecular Evolution最新文献_第2页

The De Novo Emergence of Two Brain Genes in the Human Lineage Appears to be Unsupported. 两个大脑基因在人类谱系中的从头出现似乎是不支持的。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2024-12-27 DOI: 10.1007/s00239-024-10227-3

Joseph Hannon Bozorgmehr

引用次数: 0

Evolutionary Nonindependence Between Human piRNAs and Their Potential Target Sites in Protein-Coding Genes. 人类pirna及其在蛋白质编码基因中的潜在靶点之间的进化非独立性。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2024-12-02 DOI: 10.1007/s00239-024-10220-w

Chong He, Hao Zhu

{"title":"Evolutionary Nonindependence Between Human piRNAs and Their Potential Target Sites in Protein-Coding Genes.","authors":"Chong He, Hao Zhu","doi":"10.1007/s00239-024-10220-w","DOIUrl":"10.1007/s00239-024-10220-w","url":null,"abstract":"PIWI-interacting RNAs (piRNAs) are the most diverse small RNAs in animals. These small RNAs have been known to play an important role in the suppression of transposable elements (TEs). Protein-coding genes (PCGs) are the most well-recognized functional genes in genomes. In the present study, we designed and performed a set of statistics-based evolutionary analyses to reveal nonrandom phenomena in the evolution of human piRNA-PCG targeting relationships. Through analyzing the occurrence of single nucleotide variants (SNVs) in potential piRNA target sites in human PCGs, we provide evidence that there exists a mutational force biased to strengthen piRNA-PCG targeting relationships. Through analyzing the allele frequencies of SNVs in potential piRNA target sites in human PCGs, we provide evidence that there exists a piRNA-dependent selective force acting on potential piRNA target sites in human PCGs. Because of these nonrandom evolutionary forces, human piRNAs and their potential target sites in PCGs are not independent in evolution. Additionally, we found evidence that potential piRNA target sites in human PCGs are particularly likely to be present in regions derived from Alu elements. This finding suggests that the aforementioned evolutionary forces acting on piRNA-PCG targeting relationships could be particularly prone to affect Alu-derived regions in human PCGs. Collectively, our findings provide new insights into the evolutionary interplay between piRNAs, PCGs, and Alu elements in the evolution of the human genome.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"83-99"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Amphibian Major Histocompatibility Complex-A Review and Future Outlook. 两栖动物主要组织相容性复合体——综述与展望。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI: 10.1007/s00239-024-10223-7

Joana Sabino-Pinto, Martine E Maan

{"title":"The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.","authors":"Joana Sabino-Pinto, Martine E Maan","doi":"10.1007/s00239-024-10223-7","DOIUrl":"10.1007/s00239-024-10223-7","url":null,"abstract":"The major histocompatibility complex (MHC) is a cluster of functionally related genes encoding proteins which, among other functions, mediate immune system activation. While the MHC of many vertebrates has been extensively studied, less is known about the amphibian MHC. This represents an important knowledge gap because amphibians mark the evolutionary transition from an aquatic to a terrestrial lifestyle and often maintain a biphasic lifestyle. Hence, they tend to be exposed to both aquatic and terrestrial pathogen communities, providing opportunities to gain fundamental insights into how the immune system responds to different environmental challenges. Moreover, amphibians are globally threatened by invasive pathogens and the MHC may play a role in combating population decline. In this review, we summarize the current state of knowledge regarding the amphibian MHC and identify the major differences with other vertebrates. We also review how the number of MHC gene copies varies across amphibian groups and how MHC-based variation relates to amphibian ontogeny, behaviour, disease, and phylogeography. We conclude by identifying knowledge gaps and proposing priorities for future research.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"38-61"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Riboviruses: A Comprehensive Study. 人类核病毒：一项综合研究。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI: 10.1007/s00239-024-10221-9

Gauravya Mohan, Akangkha Choudhury, Jeevika Bhat, Rajendra Phartyal, Rup Lal, Mansi Verma

{"title":"Human Riboviruses: A Comprehensive Study.","authors":"Gauravya Mohan, Akangkha Choudhury, Jeevika Bhat, Rajendra Phartyal, Rup Lal, Mansi Verma","doi":"10.1007/s00239-024-10221-9","DOIUrl":"10.1007/s00239-024-10221-9","url":null,"abstract":"The urgency to understand the complex interactions between viruses, their animal reservoirs, and human populations has been necessitated by the continuous spread of zoonotic viral diseases as evidenced in epidemics and pandemics throughout human history. Riboviruses are involved in some of the most prevalent human diseases, responsible for causing epidemics and pandemics. These viruses have an animal origin and have been known to cross the inter-species barrier time and time again, eventually infecting human beings. Their evolution has been a long road to harbour important adaptations for increasing fitness, mutability and virulence; a result of natural selection and mutation pressure, making these viruses highly infectious and difficult to counter. Accumulating favourable mutations in the course, they imitate the GC content and codon usage patterns of the host for maximising the chances of infection. A myriad of viral and host factors determine the fate of specific viral infections, which may include virus protein and host receptor compatibility, host restriction factors and others. Thus, understanding the biology, transmission and molecular mechanisms of Riboviruses is essential for the development of effective antiviral treatments, vaccine development and strategies to prevent and control viral infections. Keeping these aspects in mind, this review aims to provide a holistic approach towards understanding Riboviruses.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"11-37"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations. 灵长类内源性逆转录病毒整合的2-LTR定年中的突变率变异和其他挑战。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2024-12-23 DOI: 10.1007/s00239-024-10225-5

Antoinette Cornelia van der Kuyl

{"title":"Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations.","authors":"Antoinette Cornelia van der Kuyl","doi":"10.1007/s00239-024-10225-5","DOIUrl":"10.1007/s00239-024-10225-5","url":null,"abstract":"The time of integration of germline-targeting Long Terminal Repeat (LTR) retroposons, such as endogenous retroviruses (ERVs), can be estimated by assessing the nucleotide divergence between the LTR sequences flanking the viral genes. Due to the viral replication mechanism, both LTRs are identical at the moment of integration, when the provirus becomes part of the host genome. After that time, proviral sequences evolve within the host DNA. When the mutation rate is known, nucleotide divergence between the LTRs would then be a measure of time elapsed since integration. Though frequently used, the approach has been complicated by the choice of host mutation rate and, to a lesser extent, by the method selected to estimate nucleotide divergence. As a result, outcomes can be incompatible with, for instance, speciation events identified from the fossil record. The review will give an overview of research reporting LTR-retroposon dating, and a summary of important factors to consider, including the quality, assembly, and alignment of sequences, the mutation rate of foreign DNA in host genomes, and the choice of a distance estimation method. Primates will here be the focus of the analysis because their genomes, ERVs, and fossil record have been extensively studied. However, most of the factors discussed have a wide applicability in the vertebrate field.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"62-82"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Structural Plastome Evolution in Asterales: Insights from Off-Target Hybrid Enrichment Data on the Small Single-Copy Region. 探索Asterales结构质体进化：来自小单拷贝区脱靶杂交富集数据的见解。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2024-12-26 DOI: 10.1007/s00239-024-10224-6

Adriana Benítez-Villaseñor, Matthias Jost, Carolina Granados Mendoza, Stefan Wanke, Rubi N Meza-Lázaro, Marcia Peñafiel Cevallos, Efraín Freire, Susana Magallón

{"title":"Exploring Structural Plastome Evolution in Asterales: Insights from Off-Target Hybrid Enrichment Data on the Small Single-Copy Region.","authors":"Adriana Benítez-Villaseñor, Matthias Jost, Carolina Granados Mendoza, Stefan Wanke, Rubi N Meza-Lázaro, Marcia Peñafiel Cevallos, Efraín Freire, Susana Magallón","doi":"10.1007/s00239-024-10224-6","DOIUrl":"10.1007/s00239-024-10224-6","url":null,"abstract":"The massive increase in the amount of plastid genome data have allowed researchers to address a variety of evolutionary questions within a wide range of plant groups. While plastome structure is generally conserved, some angiosperm lineages exhibit structural changes. Such is the case of the megadiverse order Asterales, where rearrangements in plastome structure have been documented. This study investigates the possibility of recovering plastid loci from off-target reads obtained through hybrid enrichment techniques. Our sampling includes 63 species from the eleven currently recognized families in Asterales derived from previously published studies. We assembled and annotated complete and partial plastomes using custom pipelines and estimate phylogenomic relationships. We retrieved plastid information from 60 of the 63 sampled species including a complete plastome from Tithonia tubaeformis (Asteraceae), circular partial (with gaps) plastomes from seven species, and non-circular partial plastomes from other 52 species. We focused on the small single-copy region because it could be recovered for over 29 species. Within the small single-copy region, we assessed intron losses and presence of putative pseudogenes. Comparative genomics revealed a relocated fragment of ~ 6500 bp in two Campanulaceae lineages (i. e. subfamily Lobelioideae and Pseudonemacladus oppositifolium), involving the genes rbcL, atpB, atpE, trnM-CAU, and trnV-UAC. Obtained phylogenetic hypotheses were congruent across the applied methods and consistent with previously published results. Our study demonstrates the feasibility of recovering plastid information, both complete and partial, from off-target hybrid enrichment data and provides insights on the structural plastome changes that have occurred throughout the evolution of the order Asterales.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"111-123"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Stochastic Epigenetic Modification and Evolution of Sex Determination in Vertebrates. 修正：脊椎动物性别决定的随机表观遗传修饰和进化。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 DOI: 10.1007/s00239-024-10229-1

Sergio Branciamore, Andrei S Rodin, Arthur D Riggs

引用次数: 0

Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria. 细菌丝氨酸消旋酶同源物的进化和功能多样化。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2025-01-17 DOI: 10.1007/s00239-024-10231-7

Kouji Uda, Rie Nishimura, Yuexuan Li, Eisaku Shimoda, Tetsuya Miyamoto, Luke A Moe

{"title":"Evolution and Functional Diversification of Serine Racemase Homologs in Bacteria.","authors":"Kouji Uda, Rie Nishimura, Yuexuan Li, Eisaku Shimoda, Tetsuya Miyamoto, Luke A Moe","doi":"10.1007/s00239-024-10231-7","DOIUrl":"10.1007/s00239-024-10231-7","url":null,"abstract":"Amino acid racemases catalyze the interconversion of L- and D-amino acids, maintaining intracellular levels of both D- and L-amino acids. While alanine and glutamate racemases are widespread in bacteria, serine racemase (SerR) is predominantly found in animals. Recently, homologs of animal SerR were reported in some bacterial genomes, but their evolutionary distribution and functional roles remain poorly understood. In this study, we cloned and expressed 20 SerR homologous genes from 13 bacterial species spanning five phyla and characterized their enzymatic activity. Six homologs exhibited serine dehydratase activity, while the remaining showed racemase activity with serine, aspartate, asparagine, or arginine. Notably, the SerR homologs from Parafannyhessea umbonata (Actinomycetota), Clostridium aceticum, Anaerovirgula multivorans, Alkaliphilus oremlandii (Bacillota), Acetomicrobium mobile, and Thermovirga lienii (Synergistota) demonstrated strong arginine racemase activity, with Km values ranging from 0.167 to 0.885 mM and kcat values ranging from 5.86 to 61.5 s-1 for L-arginine. Phylogenetic analysis revealed that bacterial and eukaryotic SerR homologs share a common ancestral gene, and substrate specificity has independently changed multiple times during evolution. Amino acid sequence alignment and analysis of site-directed mutants revealed that residues at positions 146 to 148 and surrounding regions, located near the substrate-binding site, play a crucial role in substrate specificity and/or catalytic activity. These results highlight the evolutionary processes that drive functional diversification in serine racemase homologs.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"149-162"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Fit-Seq2.0: An Improved Software for High-Throughput Fitness Measurements Using Pooled Competition Assays.

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 DOI: 10.1007/s00239-025-10232-0

Fangfei Li, Jason Tarkington, Gavin Sherlock

引用次数: 0

Common Ancestry of the Id Locus: Chromosomal Rearrangement and Polygenic Possibilities. Id位点的共同祖先：染色体重排和多基因可能性。

IF 2.1 3区生物学

Journal of Molecular Evolution Pub Date : 2025-02-01 Epub Date: 2025-01-17 DOI: 10.1007/s00239-025-10233-z

Ashutosh Sharma, Nagarjun Vijay

{"title":"Common Ancestry of the Id Locus: Chromosomal Rearrangement and Polygenic Possibilities.","authors":"Ashutosh Sharma, Nagarjun Vijay","doi":"10.1007/s00239-025-10233-z","DOIUrl":"10.1007/s00239-025-10233-z","url":null,"abstract":"The diversity in dermal pigmentation and plumage color among domestic chickens is striking, with Black Bone Chickens (BBC) particularly notable for their intense melanin hyperpigmentation. This unique trait is driven by a complex chromosomal rearrangement on chromosome 20 at the Fm locus, resulting in the overexpression of the EDN3 (a gene central to melanocyte regulation). In contrast, the inhibition of dermal pigmentation is regulated by the Id locus. Although prior studies using genetic crosses, GWAS, and gene expression analysis have investigated the genetic underpinnings of the Id locus, its precise location and functional details remain elusive. Our study aims to precisely locate the Id locus, identify associated chromosomal rearrangements and candidate genes influencing dermal pigmentation, and examine the ancestral status of the Id locus in BBC breeds. Using public genomic data from BBC and non-BBC breeds, we refined the Id locus to a ~1.6 Mb region that co-localizes with Z amplicon repeat units at the distal end of the q-arm of chromosome Z within a 10.36 Mb inversion in Silkie BBC. Phylogenetic and population structure analyses reveal that the Id locus shares a common ancestry across all BBC breeds, much like the Fm locus. Selection signatures and highly differentiated BBC-specific SNPs within the MTAP gene position it as the prime candidate for the Id locus with CCDC112 and additional genes, suggesting a possible polygenic nature. Our results suggest that the Id locus is shared among BBC breeds and may function as a supergene cluster in shank and dermal pigmentation variation.","PeriodicalId":16366,"journal":{"name":"Journal of Molecular Evolution","volume":" ","pages":"163-180"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0