Journal of Medical Science And clinical Research最新文献

A Study on electrographic abnormalities and troponin elevation in COVID-19 patients: A Bangladeshi Perspective 关于 COVID-19 患者电图异常和肌钙蛋白升高的研究：孟加拉国视角

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.03

Dr. Syeda Masuma Kawsar

{"title":"A Study on electrographic abnormalities and troponin elevation in COVID-19 patients: A Bangladeshi Perspective","authors":"Dr. Syeda Masuma Kawsar","doi":"10.18535/jmscr/v12i03.03","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.03","url":null,"abstract":"Background: In Bangladesh, COVID-19 patients frequently present with electrographic abnormalities and elevated troponin levels, indicative of cardiac stress. These observations highlight the virus's potential impact on cardiovascular health, necessitating vigilant monitoring and timely interventions to mitigate complications. Study Objective: This research aims to assess electrographic abnormalities and troponin elevation in COVID-19 patients within Bangladesh. Methods: Conducted retrospectively at a tertiary medical college and hospital, our study enrolled 100 consecutive adult COVID-19 patients. We analyzed baseline characteristics, lab results, and serial ECGs. Troponin I concentrations were measured using the Abbott Architect method (normal range: ≤0.05 ng/mL). Troponin levels were categorized as normal (0.00-0.05 ng/mL), mildly elevated (0.05-1 ng/mL), and significantly elevated (>1 ng/mL). ECGs were reviewed and interpreted. Results: The majority of patients (71%) were males aged 41-50. Common COVID-19 symptoms included dyspnea and cough (75%), followed by fever, fatigue, and malaise (80%). Gastrointestinal symptoms were seen in 20%, and 10% experienced anosmia or dysgeusia. Comorbidities included diabetes mellitus (65%), hypertension (60%), CKD (10%), coronary artery diseases (13%), and other cardiovascular diseases (5%). Abnormal LFTs were observed in 30%. Initial troponin levels averaged 0.18 ± 1.75 ng/mL, with a maximum of 2.55 ± 17.90 ng/mL. Mortality occurred in 25% of cases. Conclusion: Our findings suggest that ECG repolarization abnormalities may serve as markers of clinical severity, even in cases with mildly elevated troponin values in COVID-19 patients. Keywords: covid-19, electrographic abnormalities, troponin","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"91 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140225066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Clinicoetiological profile of hyponatremia patients admitted in Medical wards 内科病房收治的低钠血症患者的临床病因研究

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.07

Dr Khwaja Mohammed Usman

{"title":"Study of Clinicoetiological profile of hyponatremia patients admitted in Medical wards","authors":"Dr Khwaja Mohammed Usman","doi":"10.18535/jmscr/v12i03.07","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.07","url":null,"abstract":"Hyponatraemia is the most common electrolyte disorder in hospitalized patients. Its epidemiology depends on the serum sodium used to define hyponatraemia, which varies from study to study. It can be an early or even first sign of important underlying disease. It can be complicated by two types of neurological disorders cerebral oedema and osmotic demyelination syndrome. It is associated with increased morbidity and mortality rates in hospitalized patients, although it remains unclear whether these associations are mainly due to the underlying disease, direct effects of hyponatraemia, or a combination of both. Aims and Objectives - to study clinical profile of hyponatremia in hospitalized subjects. To study the aetiology of hyponatremia in hospitalized subjects. To assess morbidity and mortality due to hyponatremia. Materials and Methods - 100 patients with hyponatremia were studied. Most common symptoms were Lethargy and tremors, followed by headache, nausea, altered sensorium, convulsion and coma, in order. Hypervolemic hyponatremia is most common followed by euvolemic hyponatremia and hypovolemic hyponatremia. Euvolemic subjects had propensity to develop more severe and symptomatic hyponatremia. Dilutional hyponatremia is the most prevalent underlying pathophysiology of hyponatremia followed by diuretic use, SIADH, GI loss, Hypothyroidism, extra renal/GI loss and Cerebral salt wasting in order. Congestive cardiac failure was the most common cause of hypervolemic hyponatremia, followed by cirrhosis of liver and renal failure. Acute gastroenteritis was most common cause of hypovolemic hyponatremia. SIADH was the most common cause of euvolemic hyponatremia, followed by thiazide diuretics and hypothyroidism, in order.","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges in Diagnosing and Managing Pulmonary Conditions: A Case Series Highlighting Pulmonary Tuberculosis and Lung Cancer 诊断和治疗肺部疾病的挑战：以肺结核和肺癌为重点的病例系列

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.05

Dr Rajendra Tatu Nanavare

{"title":"Challenges in Diagnosing and Managing Pulmonary Conditions: A Case Series Highlighting Pulmonary Tuberculosis and Lung Cancer","authors":"Dr Rajendra Tatu Nanavare","doi":"10.18535/jmscr/v12i03.05","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.05","url":null,"abstract":"This study delves into the intricate challenges encountered in diagnosing and managing pulmonary conditions, focusing on tuberculosis (TB) and lung cancer, especially in individuals with a history of cancer treatment and tobacco use. Through a detailed analysis of clinical cases, we explore the complexities associated with TB reactivation post-cancer therapy and the hurdles in timely diagnosing lung cancer in tobacco users. Three cases are presented: A 60-year-old male with a history of pulmonary TB, bidi smoking, and a diagnosis of adenocarcinoma after presenting with persistent cough and imaging findings suggestive of lung cancer. A 57-year-old male, post-cancer treatment, presenting with cough, diagnosed with TB after immunosuppression, highlighting diagnostic challenges in this population. A 63-year-old female with a prolonged cough and blood streaks in sputum, not responding to anti-TB treatment, ultimately diagnosed with lung cancer due to tobacco use. These cases underscore the need for vigilant monitoring and early intervention in post-cancer individuals vulnerable to latent TB reactivation, comprehensive diagnostic approaches for immunocompromised patients, and heightened awareness of the association between tobacco use and lung cancer. The study emphasizes the importance of thorough assessments, timely interventions, and collaborative efforts among healthcare providers to optimize outcomes in patients with overlapping health concerns. In conclusion, this study sheds light on the complexities of managing patients with a history of cancer, TB, and tobacco use, advocating for a holistic approach in diagnosis and management to improve patient outcomes and quality of life. Further research and clinical guidelines are warranted to refine treatment strategies and enhance the care of individuals facing these dual health challenges. Keywords: Lung Cancer, Pulmonary Tuberculosis, Lung Cancer and Pulmonary.","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"15 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumoral Calcinosis (TC) of iliac Crest in a 70 year-Old Female: A Case Report 一名 70 岁女性的髂嵴肿瘤性钙化 (TC)：病例报告

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.01

Supriya Mehrotra

引用次数: 0

Clinicopathological Correlation of P53 Protein Expression in different Histological Subtypes of Gastric Carcinoma 不同组织学亚型胃癌中 P53 蛋白表达的临床病理学相关性

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.04

Yasap Tana

{"title":"Clinicopathological Correlation of P53 Protein Expression in different Histological Subtypes of Gastric Carcinoma","authors":"Yasap Tana","doi":"10.18535/jmscr/v12i03.04","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.04","url":null,"abstract":"Introduction: Gastric cancer is one of the common cancers after lung cancer worldwide, especially in the developing countries. p53 immunohistochemical expression has been proposed as a potential tool to evaluate the biological behavior of gastric cancer. However, its practical implication in gastric cancer prognosis or treatment by restoration of mutated p53 function is yet to be fully exploited. Hence, this study with the aim of assessing the yield of p53 expression in gastric carcinoma and its relationship with various clinicopathological parameters was formulated. Objectives: To assess immunohistochemical expression of p53 protein in different histological subtypes of gastric carcinoma cases and to study correlation between p53 protein expression and different clinicopathological parameters like age, gender, tumour location, gross pattern, histological types, degree of tumor differentiation and pathological staging in the above said cases. Materials and Methods: This was a hospital based cross-sectional study done over a period of 18 months on 60 cases of gastrectomies with proven histological diagnosis of gastric carcinoma. Observation and Results: Strong p53 expression was frequent among elderly male patients (>60 years) who had ulceroproliferative tumors, located at pyloric antrum belonging to pTNM stage IIIA. In 87% cases, it was expressed, predominantly in moderately differentiated intestinal type with serosal invasion. Also, cases even with no lymph node metastasis showed p53 expression. Conclusion: Few findings were contradictory to other similar studies e.g. lymph node negative cases showing P53 expression does not support the hypothesis of predicting lymph node status by p53 expression. No significant correlation between p53 expression and different clinicopathological parameters in gastric carcinoma cases was seen. Keywords: P53, immunohistochemical, clinicopathological, histological subtypes, metastasis","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"28 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Glutathione: A Promising Therapy for the Alcoholic Liver Disease 静脉注射谷胱甘肽：治疗酒精性肝病的有效疗法

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.02

D. Ck

{"title":"Intravenous Glutathione: A Promising Therapy for the Alcoholic Liver Disease","authors":"D. Ck","doi":"10.18535/jmscr/v12i03.02","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.02","url":null,"abstract":"Alcoholic liver disease (ALD) and sepsis are life-threatening conditions marked by severe oxidative stress. Chronic alcohol use triggers oxidative stress and inflammation that damages liver cells. Glutathione (GSH), a tripeptide consisting of gamma glutamyl cysteinyl glycine possesses a thiol group and participates in oxidation reduction reactions, acting as a principal cellular scavenger of free radicles. GSH is present in large concentrations in the liver, and its endogenous levels are depleted in ALD, exacerbating the condition. Intravenous GSH supplementation has shown promising results in improving liver function and reducing fibrosis markers in ALD patients. Intravenous GSH treatment has demonstrated the potential to reduce oxidative injury and mortality rates in patients with sepsis in the intensive care unit. The versatility of GSH in mitigating oxidative stress, inflammation, and tissue damage and proven safety and tolerability profile make it a valuable adjunct to current treatments. Further research is imperative to comprehensively unravel the therapeutic benefits of GSH injection adjunct to standard of care in patients with ALD and sepsis. Keywords: Glutathione, Alcoholic liver disease, Sepsis, Antioxidants, Intensive care unit, Intravenous","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"23 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140226934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Critical Care Nurses' Compliance with the External Ventricular Drain Care Bundle for Critically ill Patients at Kenyatta National Hospital 评估肯雅塔国立医院重症监护护士对重症患者室外引流护理包的遵从情况

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI: 10.18535/jmscr/v12i03.06

Leah Nambiro Nanyanga

{"title":"Evaluation of Critical Care Nurses' Compliance with the External Ventricular Drain Care Bundle for Critically ill Patients at Kenyatta National Hospital","authors":"Leah Nambiro Nanyanga","doi":"10.18535/jmscr/v12i03.06","DOIUrl":"https://doi.org/10.18535/jmscr/v12i03.06","url":null,"abstract":"ntroduction: The External Ventricular Drain (EVD) care bundle involves insertion, maintenance, troubleshooting, and monitoring for issues related to EVD, which is primarily the responsibility of nurses. Despite significant efforts to address external ventricular drain-related infections (ERIs) in CCUs and other critical care units, current studies suggest a high prevalence rate of external ventricular-related infections, particularly in LMICs and low-resource settings. Material and Method: A mixed-method study was conducted at KNH Critical Care Units with a sample of 81 nurses. Data analysis of Quantitative continuous data was summarized using medians and interquartile ranges, and Categorical data was summarized using frequencies and proportions. Qualitative data was analyzed using manual thematic analysis. Results: Most respondents were between 30 and 40 years old, 43.2%, females were 75.3%, higher diplomas were 54.3%, and 4.9% specialized in EVD care. 48.1% had good knowledge of the EVD care bundle, 46.9% had fair knowledge, and 5% had poor knowledge. Binary logistic regression and chisquare tests showed no factors associated with knowledge of the EVD care bundle (P>0.05 chi-square). A basic diploma and no specialization in EVD care were associated with higher odds of a poor or fair knowledge of the EVD care bundle. Conclusion: Most nurses exhibited fair practice of EVD care bundle but Lacked continuous medical education on EVD care, poor supervision and feedback on EVD care practice, and guidelines on EVD care not being easily accessible and understandable emerged as substantial perceived barriers to EVD care bundle utilization.","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"35 S142","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of physicien attire on consultation outcomes in primary health care, National Guard, Riyadh 医生着装对初级保健咨询结果的影响，利雅得国民警卫队

Journal of Medical Science And clinical Research Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.06

Joud Abdulshakur Basfar

{"title":"The effects of physicien attire on consultation outcomes in primary health care, National Guard, Riyadh","authors":"Joud Abdulshakur Basfar","doi":"10.18535/jmscr/v12i02.06","DOIUrl":"https://doi.org/10.18535/jmscr/v12i02.06","url":null,"abstract":"Introduction A good Physician- patient relationship is the core of a successful primary health care. It is characterized by a two way interactions between the physician and the patient, where the patient is involved in the decision making(1) . The relationship between the physician and the patient can interfere significantly with the treatment adherence(2) . So it is necessary for the physician to work on building and preserving a good relationship from the first moment. The first impression is important to optimize healthcare outcomes(3) . Physician appearances, gender, nationality, age, speech and posture were found to affect patient’s first impression(3) . Also, it is found that once the first impression been developed, it will remain unchanged – most of the times- (3) . Gender preferences found to increase patient satisfaction in some settings(4) . For the intimate, and psychosocial issues, it is found to be preferred to have a physician of the same gender as a patient (4) . For the age preference, some studies found that patients preferred the physician to be between 30- 50 years (5) . Physician appearances is also an important factor affecting patient perception of the care provided (1)","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Signal Processing Approaches in the field of Genomics: A Recent Trend 基因组学领域的数字信号处理方法：最新趋势

Journal of Medical Science And clinical Research Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.10

Shivani Saxena

{"title":"Digital Signal Processing Approaches in the field of Genomics: A Recent Trend","authors":"Shivani Saxena","doi":"10.18535/jmscr/v12i02.10","DOIUrl":"https://doi.org/10.18535/jmscr/v12i02.10","url":null,"abstract":"Digital signal processing (DSP) techniques have emerged as powerful tools in the field of genomics, enabling researchers to extract valuable insights from complex genetic data. This research paper presents a comprehensive analysis of the recent trends and advance- ments in applying DSP approaches to genomics. The objective is to provide an overview of the transformative role of DSP in genomic data analysis, variant calling, and interpretation. By leveraging DSP methods such as filtering, feature extraction, time-frequency analysis, and machine learning algorithms, researchers can enhance the quality of genetic signals, identify genetic variants, and gain a deeper understanding of genomic processes. The paper highlights key applications of DSP in genomics, including DNA sequence analysis, RNA expression pro- filing, epigenetics, and genome-wide association studies. Additionally, the challenges associated with applying DSP techniques in genomics, such as signal noise, data in- tegration, and computational complexity, are discussed. This research paper serves as a valuable resource for researchers, bioinformaticians, and geneticists seeking to harness the power of DSP in genomics, advancing our knowledge of genetic diseases and paving the way for personalized medicine and precision healthcare. Keywords: Digital signal processing, Genome analysis, Feature extraction, DNA sequence analysis, RNA expression profiling.","PeriodicalId":16362,"journal":{"name":"Journal of Medical Science And clinical Research","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis of EMA negative PR negative Microcystic Meningioma: A Case Report EMA 阴性 PR 阴性微囊性脑膜瘤的发病机制：病例报告

Journal of Medical Science And clinical Research Pub Date : 2024-02-28 DOI: 10.18535/jmscr/v12i02.01

Supriya Mehrotra

引用次数: 0