Clinicopathological Correlation of P53 Protein Expression in different Histological Subtypes of Gastric Carcinoma

Journal of Medical Science And clinical Research Pub Date : 2024-03-20 DOI:10.18535/jmscr/v12i03.04

Yasap Tana

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Abstract

Introduction: Gastric cancer is one of the common cancers after lung cancer worldwide, especially in the developing countries. p53 immunohistochemical expression has been proposed as a potential tool to evaluate the biological behavior of gastric cancer. However, its practical implication in gastric cancer prognosis or treatment by restoration of mutated p53 function is yet to be fully exploited. Hence, this study with the aim of assessing the yield of p53 expression in gastric carcinoma and its relationship with various clinicopathological parameters was formulated. Objectives: To assess immunohistochemical expression of p53 protein in different histological subtypes of gastric carcinoma cases and to study correlation between p53 protein expression and different clinicopathological parameters like age, gender, tumour location, gross pattern, histological types, degree of tumor differentiation and pathological staging in the above said cases. Materials and Methods: This was a hospital based cross-sectional study done over a period of 18 months on 60 cases of gastrectomies with proven histological diagnosis of gastric carcinoma. Observation and Results: Strong p53 expression was frequent among elderly male patients (>60 years) who had ulceroproliferative tumors, located at pyloric antrum belonging to pTNM stage IIIA. In 87% cases, it was expressed, predominantly in moderately differentiated intestinal type with serosal invasion. Also, cases even with no lymph node metastasis showed p53 expression. Conclusion: Few findings were contradictory to other similar studies e.g. lymph node negative cases showing P53 expression does not support the hypothesis of predicting lymph node status by p53 expression. No significant correlation between p53 expression and different clinicopathological parameters in gastric carcinoma cases was seen. Keywords: P53, immunohistochemical, clinicopathological, histological subtypes, metastasis

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不同组织学亚型胃癌中 P53 蛋白表达的临床病理学相关性

引言：胃癌是继肺癌之后全球常见的癌症之一，尤其是在发展中国家：p53 免疫组化表达已被认为是评估胃癌生物学行为的潜在工具。然而，其在胃癌预后或通过恢复突变的 p53 功能进行治疗方面的实际意义仍有待充分挖掘。因此，本研究旨在评估 p53 在胃癌中的表达量及其与各种临床病理参数的关系。研究目的评估不同组织学亚型胃癌病例中 p53 蛋白的免疫组化表达，并研究上述病例中 p53 蛋白表达与不同临床病理参数（如年龄、性别、肿瘤位置、大体形态、组织学类型、肿瘤分化程度和病理分期）之间的相关性。材料与方法：这是一项基于医院的横断面研究，历时 18 个月，对 60 例经组织学确诊为胃癌的胃切除术病例进行了研究。观察结果：在患有溃疡增生性肿瘤的老年男性患者（60 岁以上）中，p53 的强表达很常见，这些肿瘤位于幽门前部，属于 pTNM IIIA 期。在 87% 的病例中，它都有表达，主要是在有浆膜侵犯的中度分化肠型肿瘤中。此外，即使没有淋巴结转移的病例也有 p53 表达。结论一些发现与其他类似研究相矛盾，如淋巴结阴性病例显示 P53 表达并不支持通过 p53 表达预测淋巴结状态的假设。在胃癌病例中，p53表达与不同的临床病理参数之间没有明显的相关性。关键词P53、免疫组化、临床病理学、组织学亚型、转移

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Journal of Medical Science And clinical Research

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