Journal of Medical Virology最新文献

{"title":"The sV184A Variant in HBsAg Specific to HBV Subgenotype C2 Leads to Enhanced Viral Replication and Apoptotic Cell Death Induced by PERK-eIF2α-CHOP-Mediated ER Stress","authors":"Yu-Min Choi,&nbsp;Dong Hyun Kim,&nbsp;Eun Ju Cho,&nbsp;Ziyun Kim,&nbsp;Junghwa Jang,&nbsp;Hyunsoo Kim,&nbsp;Su Jong Yu,&nbsp;Bum-Joon Kim","doi":"10.1002/jmv.70253","DOIUrl":"https://doi.org/10.1002/jmv.70253","url":null,"abstract":"<div>\u0000 \u0000 <p>HBV genotype C, particularly subgenotype C2, is associated with an elevated risk of HCC and aggressive disease activity. We previously identified a nonsynonymous sV184A variant in the HBsAg region, predominantly in HBV subgenotype C2. This study investigates the mechanistic role of the sV184A variant in promoting liver disease progression. Analysis of 109 chronically HBV-infected patients revealed that the sV184A variant correlates with significantly elevated HBV DNA. Both patient data and public database indicated that sV184A is associated with high frequency of BCP mutations, however, the high HBV DNA in the sV184A group are independent of the presence of BCP mutations. In vitro and in vivo studies demonstrated that the sV184A variant enhances HBV replication and induces ER stress via the PERK-eIF2α-CHOP pathway, leading to apoptosis. HBV large surface (LHB)(LHB) protein was found to be a key factor, responsible for the strong ER stress, as the sV184A variant increases LHB protein stability. Pharmacological inhibition of PERK signaling or mutation of the LHB mitigated HBV proliferation and apoptosis induced by the sV184A variant. The sV184A variant specific to HBV subgenotype C2 significantly promotes HBV replication and apoptosis, serving as a driver of advanced liver disease and potentially increasing mutation rates in affected patients.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Airborne SARS-CoV-2 Omicron and Pre-Delta Variants Around Infected Patients","authors":"Carl-Johan Fraenkel,&nbsp;Sara Thuresson,&nbsp;Patrik Medstrand,&nbsp;Malin Alsved,&nbsp;Jakob Löndahl","doi":"10.1002/jmv.70258","DOIUrl":"https://doi.org/10.1002/jmv.70258","url":null,"abstract":"<p>Transmissibility has increased during the evolution of SARS-CoV-2, possibly by improved airborne transmission. An increased transmission was noted also in many hospitals. We analyzed SARS-CoV-2 in room air of hospitalized Omicron infected patients and compared results with previous findings with pre-Delta variants to study if SARS-CoV-2 was more prevalent in patient rooms after the introduction of Omicron. Only 4 of 75 (5%) air samples, from 3 of 43 included patients, were positive during the early Omicron wave, compared to 14/120 (12%), from 10 of 60 included patients during the initial wave. No certain statistical difference between virus variants could be established, but the tendency was a lower occurrence at Omicron infected patients, also when adjusting for relevant confounders. These finding do not support the initial hypothesis that increased SARS-CoV-2 aerosol emission from diagnosed patients with Omicron could explain any increased risk of hospital transmission.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large-Scale Screening of CD4+ T-Cell Epitopes From SARS-CoV-2 Proteins and the Universal Detection of SARS-CoV-2 Specific T Cells for Northeast Asian Population","authors":"Yu Zhao,&nbsp;Chengtao He,&nbsp;Min Peng,&nbsp;Min Li,&nbsp;Xiaotao Liu,&nbsp;Xuelian Han,&nbsp;Qiang Fu,&nbsp;Yandan Wu,&nbsp;Fangping Yue,&nbsp;Chunguang Yan,&nbsp;Guangyu Zhao,&nbsp;Chuanlai Shen","doi":"10.1002/jmv.70241","DOIUrl":"https://doi.org/10.1002/jmv.70241","url":null,"abstract":"<div>\u0000 \u0000 <p>The polymorphism of human leukocyte antigens in the Northeast Asian populations and the lack of broad-spectrum T-cell epitopes covering this cohort markedly limited the development of T cell-directed vaccines against SARS-CoV-2 infection, and also hampered the universal detection of SARS-CoV-2 specific T cells. In this study, 93 CD4⁺ T-cell epitopes restricted by 12 prevalent HLA-DRB1 allotypes, which covering over 80% Chinese and Northeast Asian populations, were identified from the S, E, M, N and RdRp proteins of SARS-CoV-2 by in silico prediction, DC-peptide-PBL coculture experiment, and immunization in HLA-A2/DR1 transgenic mice. Furthermore, by using validated 215 CD8⁺ T cell epitope peptides and 123 CD4⁺ T-cell epitope peptides covering Northeast Asian cohort, the universal ELISpot detection systems of SARS-CoV-2 specific CD8⁺ T cells and CD4⁺ T cells were established, for the first time, and followed by the tests for 50 unexposed and 100 convalescent samples. The median of spot-forming units for CD8⁺ T cells and CD4⁺ T cells were 68 and 15, respectively, in the unexposed donors, but were 137 and 52 in the convalescent donors 6 months after recovery while 128 and 47 in the convalescent donors 18 months after recovery. This work initially provided the broad-spectrum CD4⁺ T-cell epitope library of SARS-CoV-2 for the design of T cell-directed vaccines and the universal T cell detection tool tailoring to Northeast Asian population, and confirmed the long-term memory T cell immunity after SARS-CoV-2 infection.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Spatial-Temporal Dynamics and Time Series Prediction of HFRS in Mainland China: A Long-Term Retrospective Study”","authors":"","doi":"10.1002/jmv.70223","DOIUrl":"https://doi.org/10.1002/jmv.70223","url":null,"abstract":"<p>J. He, Y. Wang, X. Wei, et al., “Spatial-Temporal Dynamics and Time Series Prediction of HFRS in Mainland China: A Long-Term Retrospective Study,” <i>Journal of Medical Virology</i> 95 (2022): e28269, https://doi.org/10.1002/jmv.28269.</p><p>In the original version of this article, the authors realized that there was an error in Figure 3. The images were incorrectly assembled, and the study periods in the lower left corner were not arranged in the correct order.</p><p>The authors have now prepared an updated version of Figure 3, which includes the correct sequence of the periods. This correction does not affect the overall results or conclusions of the study.</p><p>The authors apologize for this error and any inconvenience this may have caused.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of Clinical and Molecular Features in Cancer Patients Associated With Major Human Oncoviruses","authors":"Ahmed Osman Mohamed,&nbsp;Rongzhuo Long,&nbsp;Yin He,&nbsp;Xiaosheng Wang","doi":"10.1002/jmv.70239","DOIUrl":"https://doi.org/10.1002/jmv.70239","url":null,"abstract":"<div>\u0000 \u0000 <p>Viral infections contribute to a higher incidence of cancer than any other individual risk factor. This study aimed to compare the clinical and molecular features of four viral-associated cancers: stomach adenocarcinoma (STAD), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), and cervical squamous cell carcinoma (CESC). Patients were categorized based on viral infection status, as provided in the clinical data, into virus-associated and non-virus-associated groups, followed by a comprehensive comparison of clinical and molecular features. Our analysis disclosed that viral infections confer unique clinical and molecular signatures to their associated tumors. Specifically, human papillomavirus-associated (HPV+) HNSC and hepatitis B virus-associated (HBV+) LIHC patients were predominantly male, younger, and exhibited better clinical prognoses. Virus-associated tumors displayed enhanced immune microenvironments and high DNA damage response scores, while non-virus-associated tumors were enriched in stromal signatures. HPV+ HNSC and Epstein-Barr virus-associated (EBV+) STAD showed similarities across multi-omics features, including better responses to immunotherapy, lower <i>TP53</i> mutation rates, tumor mutation burden (TMB), and copy number alteration (CNA). Conversely, HBV+, Hepatitis C virus-associated (HCV+) LIHCs and HPV+ CESC were more genomically unstable due to high <i>TP53</i> mutation rates, TMB, and CNA. At the protein level, <i>Caspase-7</i> and <i>Syk</i> were upregulated in HPV+ HNSC and EBV+ STAD, and positively correlated with the enrichment levels of CD8 + T cell, PD-L1, and cytolytic activity. Patient stratification based on infection status has significant clinical implications, particularly for patient prognosis and drug response.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Severity Predictors of Pediatric Adenovirus Infections","authors":"Sheng-Yuan Ho,&nbsp;Yu-Ting Zhou,&nbsp;Shu-Yuan Ho,&nbsp;Ya-Li Hu,&nbsp;Ting-Yu Yen,&nbsp;Kuan-Ying A. Huang,&nbsp;Chun-Yi Lu,&nbsp;Li-Min Huang,&nbsp;Luan-Yin Chang","doi":"10.1002/jmv.70248","DOIUrl":"https://doi.org/10.1002/jmv.70248","url":null,"abstract":"<div>\u0000 \u0000 <p>Adenovirus infections impose a significant disease burden on children and can result in poor clinical outcomes, thus requiring intensive care and potentially leading to fatality. We retrospectively analyzed pediatric adenovirus cases from 2018 to 2023 at a children's hospital in Taiwan and collected data regarding patients' clinical symptoms, imaging results, and laboratory findings. Multiple logistic regression was used to identify predictors of severe cases requiring intensive care. Our study revealed that adenovirus cases were more common in the winter, with a post-COVID-19 surge observed in 2023. A total of 576 pediatric adenovirus cases were collected, including 27 (4.7%) severe cases and 3 (0.5%) fatal cases. Severe cases were younger and exhibited higher frequencies of dyspnea, decreased activity, and diagnoses of bronchopneumonia/pneumonia and genetic disorders. Compared with nonsevere cases, severe cases also demonstrated more patchy opacity, lobar consolidation, pleural effusion, and bacterial coinfection. Multivariable analysis revealed that the most significant predictors of severe cases were dyspnea (aOR 18.5 [95% CI 3.792–90.257]), patchy opacity (3.391 [1.150–9.994]), lobar consolidation (116.388 [8.555–1583.393]), pleural effusion (9.117 [0.917–90.630]), and invasive bacterial coinfection (60.469 [4.047–903.555]), which are newly recognized predictors, thus highlighting the need for increased clinical vigilance.</p>\u0000 </div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Investigation of Long Noncoding RNA-NRAV and Long Noncoding RNA-Lethe Expression in Crimean−Congo Hemorrhagic Fever”","authors":"","doi":"10.1002/jmv.70245","DOIUrl":"https://doi.org/10.1002/jmv.70245","url":null,"abstract":"<p>Baysal AÇ, Kıymaz YÇ, Şahin NÖ, Bakır M. Investigation of Long Noncoding RNA-NRAV and Long Noncoding RNA-Lethe Expression in Crimean-Congo Hemorrhagic Fever. <i>J Med Virol.</i> 2024 Dec;96(12):e70142. doi:10.1002/jmv.70142.</p><p>In the “ethical statement” section, the text “Non-Clinical Research Ethics Committee” was incorrect. This should have been “Non-Interventional Clinical Ethics Committee.”</p><p>Because this is a clinical research and approval was received from a clinical ethics committee.</p><p>We apologize for this error.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Nutritional Risk Index Plays Important Role in Predicting In-Hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome: A Multi-Center Observational Study","authors":"Tingyu Zhang,&nbsp;Yanli Xu,&nbsp;Ziruo Ge,&nbsp;Di Tian,&nbsp;Chenxi Zhao,&nbsp;Qi Zhao,&nbsp;Ling Lin,&nbsp;Zhensheng Liu,&nbsp;Zhihai Chen","doi":"10.1002/jmv.70252","DOIUrl":"https://doi.org/10.1002/jmv.70252","url":null,"abstract":"<p>Geriatric nutritional risk index (GNRI) has been proposed as a reliable indicator of nutritional state and, when decreased, is closely associated with the severity and mortality risk of infectious disease. The current study retrospectively recruited patients who were admitted for SFTS from January 1, 2011 to January 1, 2024 at six medical centers. Two hundred and eighty-two patients with SFTS who met the study protocol were finally enrolled in this study. Sixty patients suffered in-hospital death during hospitalization, with a mortality rate of 21.3%. After adjustment of multiple models, GNRI remained a significant predictor of in-hospital death, either examining HR by evaluating 1-unit decrease of GNRI or by taking the higher median of GNRI as reference (all <i>p</i> &lt; 0.05). GNRI displayed a moderate-to-high strength in predicting in-hospital death, with an area under the receiver operating characteristic curve (AUC) of 0.791 [95% confidence interval (CI) 0.725–0.857, <i>p</i> &lt; 0.001]. The addition of GNRI to a former established model exhibited significant improvement in the predictive value for in-hospital death. GNRI, an important indicator simply calculated from ALB and BMI, is significantly and independently related to the risk of in-hospital death in patients with SFTS.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N′Djamena: Insights Into Chad's COVID-19 Epicenter","authors":"Mathiew Hota,&nbsp;Andrillene L. D. Wondeu,&nbsp;Mahamat F. Abakar,&nbsp;Koutaya Dezoumbe,&nbsp;Fatima Abdelrazakh,&nbsp;Sabrina Atturo,&nbsp;Nathan Naïbeï,&nbsp;Giulia Cappelli,&nbsp;Franck Mennechet,&nbsp;Fissou H. Yandai,&nbsp;Djamal H. Abdallah,&nbsp;Zongo R. F. Edgard,&nbsp;Abdoulaye Boukar,&nbsp;Choroma A. Moussa,&nbsp;Issa M. Yaya,&nbsp;Mahamat I. Hamad,&nbsp;Nontegyol Armand,&nbsp;Netalar Honorine,&nbsp;Kayanlengar Frederic,&nbsp;Adam A. Moustapha,&nbsp;Yanda M. Daniel,&nbsp;Adam M. Alim,&nbsp;Mahamat Grene,&nbsp;Oumaima Djarma,&nbsp;Noubaramadji Y. Suitombaye,&nbsp;Amine Akouya,&nbsp;Ouchemi Choua,&nbsp;Guy R. T. Dzomo,&nbsp;Djallaye Djimtoïbaye,&nbsp;Vittorio Colizzi,&nbsp;Mahamat A. Moussa,&nbsp;Marta Giovanetti","doi":"10.1002/jmv.70234","DOIUrl":"https://doi.org/10.1002/jmv.70234","url":null,"abstract":"<p>The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.</p>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.70234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Human Papillomavirus Prevalence and Infection Patterns Among Women Aged 35–65 in Fujian Province, China: A Nine-Year Retrospective Observational Study","authors":"Zhen Lu,&nbsp;Binhua Dong,&nbsp;Peng Yao,&nbsp;Ying Huang,&nbsp;Leiwen Fu,&nbsp;Bingyi Wang,&nbsp;Xinxin Huang,&nbsp;Xiaodan Mao,&nbsp;Shuxia Xu,&nbsp;Siyang Liu,&nbsp;Pengming Sun,&nbsp;Huachun Zou","doi":"10.1002/jmv.70238","DOIUrl":"https://doi.org/10.1002/jmv.70238","url":null,"abstract":"<div>\u0000 \u0000 <p>The assessment of human papillomavirus (HPV) genotype distribution could inform targeted cervical cancer prevention strategies. The epidemiology of HPV genotypes in terms of age and cervical lesions in Fujian Province, China has not been well described. This 9-year retrospective study aimed to delineate the prevalence pattern and trend of HPV genotypes among a large-scale community-based population. Deidentified data were retrieved from the national cervical cancer screening program in China. We included eligible women aged 35–65 years who underwent cervical cancer screening between 2014 and 2022 in Fujian Province. The HPV prevalence within distinct subpopulations was calculated, and trends in HPV prevalence over the years and across age groups were examined using the Cochran-Armitage trend test. A total of 551 604 women (median age 49 years [42, 54]; 0.10% with cervical cancer) were included in this study. The overall HPV prevalence was 11.72% (95% CI: 11.63%–11.80%), with HR-HPV (high-risk HPV) and HPV 16/18 prevalence at 10.02% (9.94%–10.10%) and 1.74% (1.71%–1.78%), respectively. HPV-52, 58, 16, 39, 51, and 68 were the most predominant genotypes in the general population. Nearly all genotypes, except for HPV-39 and 66, showed a decreasing trend in prevalence over the years, while a relatively high prevalence of HR-HPV was observed across all age groups. As lesion severity increased, HR-HPV and 9v-HPV prevalence also increased. Our study underscores the importance of ongoing surveillance of HPV prevalence in China. While the overall decline in HPV infections over the years is encouraging, the relatively high prevalence of HR-HPV warrants continued attention. Strengthening public health strategies—including prioritizing and promoting the current 9-valent vaccination, extending HPV testing and cervical cancer screening to older women where feasible, and developing future vaccines targeting more HR-HPV genotypes—will be crucial in eliminating cervical cancer and HPV-related disease in China and beyond.</p></div>","PeriodicalId":16354,"journal":{"name":"Journal of Medical Virology","volume":"97 2","pages":""},"PeriodicalIF":6.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}