Journal of labelled compounds & radiopharmaceuticals最新文献_第4页

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-26

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RETRACTION: Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum–Specific Bacteriophage 引用本文：99mtc标记的番茄青枯病特异性噬菌体通过运输和渗透跟踪加强番茄青枯病的防治。

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-26 DOI: 10.1002/jlcr.70027

{"title":"RETRACTION: Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum–Specific Bacteriophage","authors":"","doi":"10.1002/jlcr.70027","DOIUrl":"10.1002/jlcr.70027","url":null,"abstract":"RETRACTION: M. H. Abdel-Aal, Y. A. Hasanien, N. A. Younis, G. El Didamony, A. Askora, and G. Abdelaziz, “Enhanced Control of Bacterial Wilt Disease in Tomato Plant via Transport and Penetration Tracking by Aid of 99mTc-Labeled Ralstonia solanacearum–Specific Bacteriophage,” Journal of Labelled Compounds and Radiopharmaceuticals 68, no. 13 (2025): e4169, https://doi.org/10.1002/jlcr.4169.The above article, published online on 11 November 2025 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, V Derdau; and John Wiley & Sons Ltd. The retraction has been agreed upon following concerns raised by a third party. A subsequent investigation confirmed several deficiencies in the study, including the absence of essential controls, replicates, and appropriate statistical analysis. In addition, in Figure 3, the Ral 10, Ral 9, Ral 8 and Ral 7 bands appear to be duplicated, and there is evidence that Ral 10 has been spliced into the image. Furthermore, the images shown in Figures 12A and 12C are identical, despite representing untreated and treated plants. The authors cooperated with the investigation and explained that Figure 3 combines two images from separate experimental runs, as the gel tank could not hold all samples simultaneously. However, they were unable to provide the original images and did not comment on the duplicated bands. The authors also explained that the duplication in Figure 12 was an error due to figure mismanagement; they provided an alternative image for Figure 12C. However, this was not satisfactory to address all the concerns. As a result, the editors determined that the results cannot be validated and therefore the conclusions of the study are unreliable. The authors disagree with the retraction.","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"69 4-6","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jlcr.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-26

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-26

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-17

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Synthesis, Radiochemical Characterization, and Biodistribution of a 188Re Analogue of [131I]mIBG in a Neuroblastoma Xenograft Model [131I]mIBG 188Re类似物在神经母细胞瘤异种移植模型中的合成、放射化学表征和生物分布。

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-17 DOI: 10.1002/jlcr.70025

Navin Sakhare, Dheeraj Kumar, Soumen Das, Arpit Mitra, Shubhangi Mirapurkar, G. Rani, M. Sheela, Viju Chirayil, Bhabani Mohanty, Anupam Mathur, Madhava B. Mallia, Pradip Chaudhari

{"title":"Synthesis, Radiochemical Characterization, and Biodistribution of a 188Re Analogue of [131I]mIBG in a Neuroblastoma Xenograft Model","authors":"Navin Sakhare, Dheeraj Kumar, Soumen Das, Arpit Mitra, Shubhangi Mirapurkar, G. Rani, M. Sheela, Viju Chirayil, Bhabani Mohanty, Anupam Mathur, Madhava B. Mallia, Pradip Chaudhari","doi":"10.1002/jlcr.70025","DOIUrl":"10.1002/jlcr.70025","url":null,"abstract":"[131I]meta-iodobenzylguanidine (mIBG) in variable dosage forms is widely used for the therapy of neuroendocrine tumors. Our group previously reported a 99mTc analogue of [131I]mIBG that demonstrated high specificity in vitro towards norepinephrine transporter (NET)–positive neuroblastoma cells. Considering that the 99mTc/188Re pair serves as a useful theranostic combination, we herein describe the synthesis of its 188Re analogue and evaluate its potential for therapeutic applications. A benzylguanidine derivative functionalized at the meta position via an isonitrile moiety (“1”) was employed for 188Re complexation following Re-“4 + 1” chemistry. Synthesized 188Re complex 6 was evaluated in NET-positive SK-N-SH neuroblastoma cells and corresponding xenograft models. Cellular uptake studies revealed that the 188Re complex 6 exhibited ~50% of the uptake observed for [125I]mIBG. Nonetheless, it retained significant NET specificity (~60%), as confirmed by inhibition experiments using desmethylimipramine (DMI). Biodistribution studies in SK-N-SH xenograft-bearing mice demonstrated tumor uptake of 4.07 ± 0.08%ID/g at 30 min (p > 0.05), with significant retention up to 3 h (4.99 ± 0.08%ID/g). Tumor uptake was shown to be NET-specific, as pre-treatment with excess DMI significantly inhibited tracer accumulation in vivo. Bioevaluation of the synthesized 188Re complex 6 confirmed its affinity for NETs; however, limited in vivo stability restricted its suitability for therapeutic application.","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"69 3","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-17

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Synthesis and Characterization of Deuterated Detomidine for Use in Equine Medication Regulation 马用氘化德托咪定的合成与表征

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-16 DOI: 10.1002/jlcr.70023

Justin C. Holmes, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara K. Fenger, George A. Maylin, Kimberly Brewer, Thomas Tobin

{"title":"Synthesis and Characterization of Deuterated Detomidine for Use in Equine Medication Regulation","authors":"Justin C. Holmes, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara K. Fenger, George A. Maylin, Kimberly Brewer, Thomas Tobin","doi":"10.1002/jlcr.70023","DOIUrl":"10.1002/jlcr.70023","url":null,"abstract":"<div>\u0000 \u0000 Detomidine, 5-[(2,3-dimethylphenyl)methyl]-1H-imidazole, is a tranquilizer/sedative/analgesic widely used in equine medicine and regulated by several different analyte concentrations of detomidine and its hydroxydetomidine and carboxydetomidine metabolites in plasma and urine. Accurate regulatory quantitation of detomidine at low picogram/mL concentrations requires the availability of a stable isotope internal standard of detomidine; however, to the best of our knowledge, no certified deuterated internal standard of detomidine is commercially available and its synthesis has not been reported. Here, we report the first synthesis and characterization of detomidine-d, prepared in six sequential steps consisting of a deuterium–hydrogen exchange, diazotization, Grignard coupling, hydrogenolysis, and palladium-catalyzed deuterium–hydrogen exchange. This overall route gave detomidine-d in moderate chemical yield with each intermediate purified to > 90% purity as determined by RP-HPLC. Regiochemistry and isotopic enrichment were confirmed by 1H NMR and LC/MS, demonstrating a viable method for the incorporation of three deuterium atoms into the detomidine scaffold. This internal standard will allow for precise LC/MS quantitation of detomidine at regulatory threshold concentrations, enabling accurate detection and quantitation of picogram/mL concentrations in equine blood and urine samples, thereby supporting regulatory compliance for equine medication control programs.\u0000 </div>","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"69 3","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-16

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-03-16

引用次数: 0