Journal of labelled compounds & radiopharmaceuticals最新文献_第2页

A 64Cu-Labeled Oxopurine Derivative for Translocator Protein–Targeted Inflammation Imaging 用于转位蛋白靶向炎症成像的64cu标记的氧嘌呤衍生物。

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-06-02 DOI: 10.1002/jlcr.70032

Undram Ochirsukh, Iqra Bibi, Ho Young Kim, In Ok Ko, Kyung Jun Kang, Hyun Ji Lee, Kwang Il Kim, Ji-Ae Park, Jung Young Kim

{"title":"A 64Cu-Labeled Oxopurine Derivative for Translocator Protein–Targeted Inflammation Imaging","authors":"Undram Ochirsukh, Iqra Bibi, Ho Young Kim, In Ok Ko, Kyung Jun Kang, Hyun Ji Lee, Kwang Il Kim, Ji-Ae Park, Jung Young Kim","doi":"10.1002/jlcr.70032","DOIUrl":"10.1002/jlcr.70032","url":null,"abstract":"<div>\u0000 \u0000 The translocator protein (TSPO) is a mitochondrial biomarker overexpressed in activated immune cells and various tumors that is an attractive target for positron emission tomography (PET) imaging of inflammation and the tumor microenvironment. We designed and evaluated the novel TSPO-targeted PET tracer, 64Cu-purine ([64Cu]5), constructed from a purine scaffold conjugated to a NOTA chelator. Molecular docking analysis indicated that the DOTA analog exhibited slightly higher TSPO binding affinity than did the NOTA derivative; however, the NOTA chelator was selected for 64Cu labeling due to its superior radiochemical yield and stability. [64Cu]5 demonstrated high radiochemical purity, excellent in vitro and in vivo stability, and moderate lipophilicity, which minimized nonspecific uptake. In vitro, [64Cu]5 showed significantly higher uptake in inflammatory macrophages than in tumor cells. In vivo PET imaging and biodistribution studies revealed preferential accumulation in inflamed and tumor tissues, with reduced uptake following PK11195 administration. Autoradiography and immunohistochemistry confirmed tracer accumulation in both inflamed and tumor tissues, reflecting the presence of inflammation within the tumor microenvironment. Overall, these findings suggest that [64Cu]5 is a promising TSPO-targeting PET radiotracer for imaging inflammation-associated processes in tumors.\u0000 </div>","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"69 7-8","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fully Automated Production of Multiple 11C-Labeled PET Tracers Using a Self-Cleaning TracerMaker Radiosynthesizer 全自动生产多个11c标记PET示踪剂使用自清洁示踪机放射性合成器。

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-05-15 DOI: 10.1002/jlcr.70031

Bao Hu, Wenchao Qu, Ramin Parsey, Mark Slifstein, Peter Larsen

{"title":"Fully Automated Production of Multiple 11C-Labeled PET Tracers Using a Self-Cleaning TracerMaker Radiosynthesizer","authors":"Bao Hu, Wenchao Qu, Ramin Parsey, Mark Slifstein, Peter Larsen","doi":"10.1002/jlcr.70031","DOIUrl":"10.1002/jlcr.70031","url":null,"abstract":"<div>\u0000 \u0000 The rapid translation of carbon-11 PET radiotracers into clinical and preclinical research requires automated synthesis modules capable of fast, reliable, and reproducible production. Here, we report the development and application of a fully automated TracerMaker radiosynthesizer for routine production of multiple 11C-labeled PET tracers at the PET Research Core, Stony Brook University. The system integrates automated Sep-Pak preconditioning, in-line sterile filter integrity testing, and a fully automated postproduction cleaning protocol that significantly reduces operator workload and radiation exposure. Using this module, three radiotracers with high clinical research interest, (E)-3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-11C-methyl-oxime ((E)-[11C]ABP688), 5-(4-(Methoxy-11C)phenyl)-1-(4-methoxyphenyl)-3-(2,2,2-trifluoroethoxy)-1H-1,2,4-triazole ([11C]PS13), and 11C-labeled Pittsburgh Compound B ([11C]PiB) were successfully produced without hardware modification. The automated cleaning protocol enables rapid turnaround between runs and supports high-throughput sequential production. These results demonstrate that the TracerMaker module provides a robust, flexible, and cost-effective platform for the routine clinical production of carbon-11 radiopharmaceuticals.\u0000 </div>","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"69 4-6","pages":""},"PeriodicalIF":0.9,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-05-15

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-05-15

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-04-21

引用次数: 0

IF 0.9 4区医学

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2026-04-21