Respirology (Carlton, Vic.)最新文献

{"title":"P1‐55: Pulmonary function after nintedanib treatment in post‐COVID‐19 pulmonary fibrosis","authors":"","doi":"10.1111/resp.14150_55","DOIUrl":"https://doi.org/10.1111/resp.14150_55","url":null,"abstract":"Chest CT scan showed extensive fibrosis for which she received methylprednisolone and physical therapy, eventually weaning her off HFNC but still with persistence of dyspnea on mild exertion. 1 Philippine General Hospital, Philippines, 2 St Lukes Medical Center, Philippines Physicians worldwide have been reporting substantial cases of post-COVID-19 pulmonary fibrosis. In conclusion, Nintedanib improved pulmonary function and chest CT findings in post-COVID-19 pulmonary fibrosis. [Extracted from the article] Copyright of Respirology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all Abstracts.)","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132806602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P11‐6: Indices of endogenous intoxication in patients with COVID‐19 associated pneumonia","authors":"","doi":"10.1111/resp.14150_818","DOIUrl":"https://doi.org/10.1111/resp.14150_818","url":null,"abstract":"Background and Aims : One of the most emerging issues among sepsis survivors is new onset cardiovascular disease. It is postulated that inflammatory response and endothelial dysfunction can persist beyond acute infection and hospitalisation, hence incurring long-term cardiovascular risks. We aim to describe the incidence of delayed cardiovascular events (CVE) among sepsis survivors, its risk factors and impact on mortality. Methods : This was a single centre retrospective cohort study of sepsis patients admitted to medical ICU between July 2015 to October 2016 who were survived hospitalisation, and followed-up for one year from time of ICU admission. Primary outcome was incident CVE that occurred after hospital dis-charge. Secondary outcome was one-year all-cause mortality. Results : There were 359 sepsis survivors. 235 (65.5%) were males. Median (interquartile range, IQR) age was 67 (55-76) years old. 64 (17.8%) had one or more CVE: 5 (1.4%) acute coronary syndromes; 16 (4.5%) type 2 myocardial infarction; 10 (2.8%) coronary angiogram/revascularisation; 10 (2.8%) incident atrial fibrillation; 26 (7.2%) new or worsening heart failure; 6 (1.7%) cerebrovascular accident and 10 (2.8%) cardiovascular deaths. Factors associated with CVE in univari-ate analysis are diabetes, hypertension, hyperlipidemia, pre-existing cardiovascular disease (ischemic heart disease, heart failure, valvular heart disease and peripheral vascular dis-ease), chronic kidney disease and anemia (hemoglobin <9g/ dL). Sepsis survivors with CVE had higher one-year all-cause mortality times less likely to be discharged (OR = -111.00, p = 0.01) than those who were not intubated. The mean duration of high-flow nasal cannula therapy was also significantly higher among females ( β = 0.36, p = 0.007) and the mean duration of hospital stay was higher ( β = 0.29, p = 0.032) among those with existing respiratory comorbidities. Conclusion : High-flow nasal cannula therapy is a viable oxygenation supplementation approach with better clinical outcomes among hypoxemic, COVID-19 confirmed adult patients rather than invasive and aggressive oxygen therapy. Nonetheless, further empirical evidence is warranted to develop clinical practice guidelines on the use of high-flow nasal cannula among hypoxemic, COVID-19 confirmed adult patients. index (LIIm), the integral index of intoxication (IPI), the neutrophil-to-monocyte ratio index (ISNM), the neutrophil-to-lymphocyte ratio index (ISNL). The difference in indicators was considered statistically significant at p<0.05. This study was performed in accordance with the Declaration of Helsinki. This human study was approved by Ethics Commit-tee of Amur State Medical Academy. Results and Conclusions : In group 2, LIIm was 17.3% higher than in group 1. In group 2, an increase in the integral index of intoxication (III) by 17.8% (p<0.02) was detected. It may indicate respiratory disorders associated with EI. Group 2 patients showed a 13.6% increase in NMRI (","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133715184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐62: Evaluation of lung cell populations in severe COVID‐19 pneumonia","authors":"Shailza Verma, Yu Suzuki, Daisuke Akaneya, Takafumi, Aizawa, Hiroki Ota, Mari Aso, Hitomi Nogawa, Kazunori Moriya, Hiroki Suzuki, Dhammika Leshan, Wannigama, Euodia Guinmapang, Jose Edzel, Tamayo","doi":"10.1111/resp.14150_269","DOIUrl":"https://doi.org/10.1111/resp.14150_269","url":null,"abstract":"were 32 and 33 years old, respectively (p=0.301). Distribution of COVID-19 severity was not different between two groups. White blood cell count, CRP, and D-dimer level were significantly higher in pregnant women compared to non-pregnant women. In terms of radiological findings, air bronchogram was frequently seen in pregnant women compared to non-pregnant (28% vs 0%; p=0.064). Discussion: Clinical features of COVID-19 pregnant women were different from that of COVID-19 non-pregnant women. We will analyze above data with more patients until the presentation on the congress.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132259892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P15‐16: Modified dose thrombolysis in a COVID‐19 related massive acute pulmonary embolism: A case report","authors":"","doi":"10.1111/resp.14150_907","DOIUrl":"https://doi.org/10.1111/resp.14150_907","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114937620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P16‐97: Secondary organizing pneumonia following COVID‐19 infection","authors":"","doi":"10.1111/resp.14150_1006","DOIUrl":"https://doi.org/10.1111/resp.14150_1006","url":null,"abstract":"Background : Coronavirus disease 2019 (COVID-19) is associated with a wide spectrum radiological pulmonary manifestations. We report an asymptomatic 81-year-old man who tested positive for PCR SARS-CoV2 RNA He developed respiratory symptoms and radiological consolida-tion 3 weeks later. We diagnosed secondary organizing pneumonia (OP) by transbronchial lung biopsy and he responded to treatment with steroids","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114970014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐42: Assessment of outcome and risk categorization of COVID‐19 exposed healthcare workers using a risk assessment tool in a Tertiary Care Hospital, Sri Lanka","authors":"W. Kami, W. Arakaki, Hiroe, Hashioka, H. Oki, D. Motooka, Shota, Nakamura, J. Fujita, S. Ranasinghe, Geetha., Nanayakkara, G. L. A. Lakruwan, A. Ranasinghe, Lalith Abeywardhane, B. Rathnayake, Santh, Jayasinghe, U. Rathnayake, A. Rodrigo, L. Dassanayake, A. Fernando, A. Sadikeen, G. Somasundaram","doi":"10.1111/resp.14150_249","DOIUrl":"https://doi.org/10.1111/resp.14150_249","url":null,"abstract":"pital. Autopsy revealed necrotic nodules, thromboangitis and hemorrhage infarction in multiple organs including brain, lung, heart, adrenal gland and kidney. Many filamentous fungi with prominent infiltration of neutrophils were observed intravascularly in these organs. Grocott strain and genetic analysis revealed that the fungi belong to Rhizopus microsporus group. We concluded that he died of sepsis and multiple organ failure due to disseminated mucormycosis. Though steroids and IL-6 inhibitor improve survival rate of severe Covid-19 infection, it should be considered severe opportunistic infection such as disseminated fungal infection might occur under the powerful immunosuppressive treatment to modulate hyperimmunity due to COVID-19 infection.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"153 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120841405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P11‐11: Bilateral iliopsoas hematomas in a severe COVID‐19 patient treated with unfractionated heparin: A case report and review of literature","authors":"","doi":"10.1111/resp.14150_823","DOIUrl":"https://doi.org/10.1111/resp.14150_823","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124036538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐11: Vaccine‐induced immune thrombotic thrombocytopenia (VITT) after ChAdOx1 nCoV‐19 vaccination","authors":"","doi":"10.1111/resp.14150_218","DOIUrl":"https://doi.org/10.1111/resp.14150_218","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129746678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐106: Japanese, multicenter, phase II trial of combination therapy with favipiravir and methylprednisolone for COVID‐19 patients with non‐critical respiratory failure: the J‐critical trial","authors":"Yasuhiro Kondoh, Akiko Kada, Yohei, Doi, Keisuke Tomii, Hiroshi Mukae, Naohiko Murata, Ryosuke Imai, Masaki Okamoto, Y. Yamano, Y. Miyazaki, Masahiro Shinoda, Hiromichi Aso, S. Izumi, H. Ishii, Ryota Ito, Akiko Saito, Toshiki Saito, Yoshinori Hasegawa, T. Saraya","doi":"10.1111/resp.14150_313","DOIUrl":"https://doi.org/10.1111/resp.14150_313","url":null,"abstract":"lymphocytopenia compared to those with mild-moderate degree. Platelet Lymphocyte Ratio (PLR) is a marker of inflammation for predicting severity and death in COVID-19. This study assessed the relationship between platelet count, lymphocyte count, and PLR with severity of disease in COVID-19 patients admitted at Dr. Saiful Anwar Malang Hospital. Method: Observational analysis with a cross sectional approach in 59 confirmed COVID-19 patients admitted in the Dr. Saiful Anwar Malang Hospital between April May 2020. Statistical analysis was performed by using the T test for numerical variables. Result: There were 38 patients (64%) with severe degree and 21 patients (36%) with mild to moderate degree. It was found that the mean value of platelets in patients with severe was lower than in patients with mild to moderate (250236.84 94887 vs 281619.05 94169), but it was not statistically significant (p = 0.288). Lymphocyte mean in patients with severe was lower than in patients with mild (1067.63 430.96 vs 1708.3 1370) but it was not statistically significant (p = 0.053). The mean PLR in patients with severe was 306.2 379.21, while in patients with mildmoderate it was 206.21 88.22, but it was not statistically significant (p = 0.106). Conclusion: There is a decrease in platelets and lymphocyte count, and an increase in PLR in patients with severe COVID-19, although not statistically significant.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"75 2 Suppl 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128456112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐47: Safety and efficacy of remdesivir, baricitinib and high‐dose steroid combination therapy in patients hospitalized with COVID‐19","authors":"","doi":"10.1111/resp.14150_254","DOIUrl":"https://doi.org/10.1111/resp.14150_254","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127180127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}