Respirology (Carlton, Vic.)最新文献

{"title":"P5‐87: Time course of oxygen demand in patients with COVID‐19 pneumonia","authors":"","doi":"10.1111/resp.14150_294","DOIUrl":"https://doi.org/10.1111/resp.14150_294","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115052958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P14‐9: Lung function analysis of COVID‐19 survivors in dr. Zainoel Abidin Hospital Banda Aceh, Indonesia","authors":"","doi":"10.1111/resp.14150_884","DOIUrl":"https://doi.org/10.1111/resp.14150_884","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115220577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐111: SARS‐CoV‐2 PCR and antigen positivity continued for 3 months after treatment for severe COVID‐19: Case report","authors":"A. Suzuki, Ken Tanaka, Riko, Fukuda, S. Katayama, Y. Kozu, N. Furusho, Ryosuke Ozoe, Yusuke Jinno, Suhun Yokota, Yusuke, Kurosawa, Hiroyuki Morita, Akifumi Hirata, Shiho, Yamada, Asami Fukuda, Mari Hikichi, Hisato, Hiranuma, Reiko Ito, S. Maruoka, Y. Gon, S. Munir, Indra Yovi, Andreas, Makmur, A. Syamsu, Dewi Wijaya","doi":"10.1111/resp.14150_318","DOIUrl":"https://doi.org/10.1111/resp.14150_318","url":null,"abstract":"Background and Purpose: The SARS-CoV-2 antigen test has lower specificity and sensitivity than the PCR test proving SARS-CoV-2 nucleic acid, but has the advantage of providing test results in 15 minutes without the need for measuring equipment. Such antigen tests can be used to determine SARS-CoV-2 infection or non-infection in the general population and will provide useful information for social activities. In this study, we investigated the safety and usefulness of self-collection of nasal swab fluid and the sensitivity and specificity of the antigen test. This clinical trial was conducted with the approval of the Clinical Trial Review Committee of Seijin Hospital (Tokyo, Japan). Research design, subjects and evaluation items Subjects: 3898 office workers, participants in music concerts and sports events. PanbioTMCOVID19AgRapidTestDevice Kit for SARSCoV-2 antigen test (Abott Diagnostic Medical) was used for SARS-CoV-2 antigen test. The safety of self-collection of nasal swab fluid was determined by the presence or absence of nasal bleeding. To verify the sensitivity and specificity of the antigen test, the results from the antigen tests were compared with the PCR test (Ct value) results. Results: 1. Safety: 91 out of 3898 (2.3%) had nasal bleeding. 2. Positive and negative concordance rate of antigen test and PCR test: 92.3%. Summary and conclusions Self-specimen collection using the SARS-Cov2 antigen assay kit is safe. The concordance rate between antigen test and PCR test is 92.3%. Panbio TM COVID19 Ag Rapid Test Device Kit for SARSCoV-2 antigen test is useful not only for diagnosis of COVID-19 but also for screening asymptomatic patients. P5-111 | SARS-CoV-2 PCR and antigen positivity continued for 3 months after treatment for severe COVID-19: Case report","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116040366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐43: A case of hyperpyrexia of hypothalamic origin associated with severe COVID‐19 pneumonia in pregnancy","authors":"A. Torii, A. Yamada, Yuka, Shinohara, H. Niwa, Y. Kogure, Chiyoe, Kitagawa, M. Oki, T. Asakura, Shoji Suzuki, Satoshi, Okamori, Tatsuya Kusumoto, T. Ogawa, S. Uno, A. Morita, Ho Lee, H. Namkoong, H. Kamata, Yasunori Sato, Y. Uwamino, T. Nishimura, M. Ishii, K. Fukunaga, N. Hasegawa","doi":"10.1111/resp.14150_250","DOIUrl":"https://doi.org/10.1111/resp.14150_250","url":null,"abstract":"pital. Autopsy revealed necrotic nodules, thromboangitis and hemorrhage infarction in multiple organs including brain, lung, heart, adrenal gland and kidney. Many filamentous fungi with prominent infiltration of neutrophils were observed intravascularly in these organs. Grocott strain and genetic analysis revealed that the fungi belong to Rhizopus microsporus group. We concluded that he died of sepsis and multiple organ failure due to disseminated mucormycosis. Though steroids and IL-6 inhibitor improve survival rate of severe Covid-19 infection, it should be considered severe opportunistic infection such as disseminated fungal infection might occur under the powerful immunosuppressive treatment to modulate hyperimmunity due to COVID-19 infection.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117041533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P1‐79: Diaphragm dysfunction developed after COVID‐19 infection without pneumonia","authors":"Evgeniya Afanas, Eva, A. Ilyin, J. Perelman, I. Tsujino, Y. Nagata, T. Nishizawa, Ryosuke Ozoe, K. Hayashi, Yasuo Asai, Y. Nakagawa, K. Ogawa, Tetsuo Shimizu, Yutaka Suzuki, Y. Gon, G. Idor, J. E. Tamayo","doi":"10.1111/resp.14150_79","DOIUrl":"https://doi.org/10.1111/resp.14150_79","url":null,"abstract":"We reported a 50-year-old patient with no bad habits and no significant medical history except for obesity (BMI 32.7 kg/m) complained of progressive shortness of breath aggravated in a supine position. One month ago the patient suffered from mild COVID-19 with positive PCR test but no abnormalities on chest CT scan. At the moment of examination his oxygen saturation was decreased to 89% and 78% in standing and supine position correspondingly. Pulmonary embolism was excluded. Orthopnea and paradoxical abdominal wall movement during breathing in supine position were observed. Spirometry showed restrictive disorders (FVC 49%, FEV1 48%, FEV1/FVC ratio 0.78). In supine position FVC declined to 19%. Gas transfer for carbon monoxide (TLCO) was reduced to 4.81 mmol/min/kPa (49%) but KCO was normal. Patient was characterized by reduced lung volumes (TLC 74%), preserved RV (117%) and normal airway resistance (Reff < 30 кПа*s/l). Maximal inspiratory pressure was decreased (25 cmH20). Ultrasonography showed no diaphragm thickening with inspiration. CT scan of the chest revealed elevated diaphragmatic domes with significantly thinned diaphragmatic cruras and bibasilar atelectasis. Electromyography of the diaphragm was not performed as this method was unavailable neither in our clinic nor in the other regional medical institutions. Thus, the patient was diagnosed with bilateral diaphragm dysfunction that we believe may be a complication of COVID-19 infection. The underlying pathological mechanism of this disorder needs to be further elucidated.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124609227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐33: Impacts of the COVID‐19 pandemic on hospitalizations for pneumonia in Brazil","authors":"Mariana Cavalcante, Pedro Portugal, A. Rios, G. V. Boas, M. Souza, Marilyn Ong-Mateo, T. Nomizo, H. Kita, Koichi, Hasegawa, H. Fukada, Yasukiyo Nakamura, T. Murayama","doi":"10.1111/resp.14150_240","DOIUrl":"https://doi.org/10.1111/resp.14150_240","url":null,"abstract":"351 COVID-19 patients (178 males and 173 females, mean age 59.3 years) admitted to our hospital between April 3, 2020, and May 31, 2021. According to the severity of illness classification by the National Institutes of Health (NIH), USA, the cases were classified into four groups (mild, moderate, severe, and critical). A comparative study was conducted on background factors such as underlying diseases, clinical test values, and the spread of opacity in computed tomography (CT) chest imaging. Results: Exacerbation factors included age, underlying diseases (diabetes mellitus, interstitial pneumonia), low lymphocyte count, high D-dimer values, and the extent of opacity on CT chest imaging. Multivariate analysis revealed concomitant diabetes mellitus and a wider area of opacity on CT chest imaging as independent exacerbation factors. Conclusion: Concomitant diabetes mellitus and the extent of opacity on CT chest imaging were associated with exacerbation in COVID-19 patients.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123401952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐93: Therapeutic effectiveness and tolerability of favipiravir in mild COVID‐19: Real world experience from India","authors":"K. Venugopal, A. Vora, Anil Daxini, P. Dadhich, S. Bhagat, Saiprasad Patil, H. Barkate, N. Goto, Y. Ikuyama, Jumpei, Akahane, Makoto Kosaka, A. Ushiki, Yoshiaki, Kitaguchi, Masanori Yasuo, Hiroshi Yamamoto, Akemi, Matsuo, Tsutomu Hachiya, Gen Ideura, Yoshitaka, Yamazaki, Masayuki Hanaoka, Katherina Koesling, Firaz, Charfare, Musab Ahmad, Syed Ahmad, Yussef Haider","doi":"10.1111/resp.14150_300","DOIUrl":"https://doi.org/10.1111/resp.14150_300","url":null,"abstract":"Background & Aims: Favipiravir is approved in India for mildmoderate COVID-19. We aimed to observe effectiveness & safety of favipiravir in mild COVID-19 in real world setting. Methods: Retrospective cohort study was conducted in favipiravir treated mild COVID-19 patients(SpO2≥94) at 4 Indian centres after ethics committee approval. Medical records from Oct 2020 Feb 2021 were analyzed to capture required details. Results: 283 mild COVID-19 patients received favipiravir. Mean age was 50.5 16.7 years, M:F=1.4:1. 51.6% had co-morbidities, with hypertension (40%) and diabetes (35.7%) as frequent ones. 26.1% had multiple (≥2) co-morbidities. Mean SpO2 & RR at baseline was 96.9 1.5% & 21.5 12/min respectively. Overall CRP (30.3 46.3), d-Dimer (433.5 746.4), serum ferritin (321.8 329.5 and LDH (234.4 99.7) were raised at baseline. Fever (90.8%), cough (59.4%), myalgia (32.5%) and fatigue (30.4%) were common presenting symptoms. 55.1% required hospitalization. Favipiravir was prescribed for median duration of 14 days. 12.4% received systemic steroids. Fever resolution occurred in median duration of 4 days(1-10 d). Fever resolved in 86.2% and 90.8% by day 7 and 10. Median time to clinical cure was 5 days (1-13 days). Clinical cure rate at day 7, 10 and 14 was 79.2%, 90.5% and 94.7%. At Baseline 47 (16.6%) patients were on respiratory support which reduced from day 3 (n=34) (12%) to day 14 (n=2) (0.7%). (n=15) 5.3% had disease progression with mortality in 2. TEAEs were observed in (n=23)8.1%. Elevation of liver transaminases 14 (5%), loosemotion 5 (1.8%) weremost frequent TEAEs. Conclusion: Favipiravir was found effective in majority of mild COVID-19 patients despite high risk association. It was well tolerated and no new safety signals were detected.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124443145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐37: Community‐acquired respiratory virus cases mimic COVID‐19 on lung computed tomography","authors":"","doi":"10.1111/resp.14150_244","DOIUrl":"https://doi.org/10.1111/resp.14150_244","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"590 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125250690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P5‐67: Predictors of mortality in severe COVID‐19 pneumonia: An interim analysis from a single Tertiary Care Centre in Central Sri Lanka","authors":"Anuradha Kolombage, Nuwani, Nissanka, Disnie Ranathunge, Ruwan Buddhi, Sameera, Wasala, Arjuna Madegama, Kris Ray Dumaguin","doi":"10.1111/resp.14150_274","DOIUrl":"https://doi.org/10.1111/resp.14150_274","url":null,"abstract":"the clinical and microbiologic characteristics, and their relationship with adverse clinical outcomes among patients with Ventilator Associated Pneumonia (VAP) admitted in Critical Care Unit in San Juan de Dios Hospital from 2016-2019. Method and Outcome Measures: The study used a retrospective cohort analysis which includes adult patients 18 years old and above admitted or transferred at critical care unit who were intubated and were diagnosed and treated as ventilator associated pneumonia (VAP). The relationship of the clinical characteristics of patients with VAP, antimicrobial resistance pattern and patient’s outcome including prolonged hospital stay (>21 days), ventilator dependence and mortality were measured. Results: A total of 164 patients were included. Mean time of hospital stay is 40 days in the MDR group (p-value 0.03). Presence of chronic lung disease is a significant risk factor in the development of VAP (p value 0.03). Mortality among patients with VAP is 53.7% and is significant in the MDR group (p value 0.05). Antibiotic use within the previous 90 days showed significance in mortality (OR 2.72; p value 0.003). Presence of chronic kidney disease is significant in developing ventilator dependence (OR 0.42, p value 0.05). Prolonged hospital stay of >21 days was significant among patients with previous antibiotic use (OR 3.2; p value 0.01). Conclusion: Recognition of the risk factors in the development of mortality among patients with VAP are significant to reduce adverse clinical outcomes. Avoiding adverse clinical outcomes requires the early use of appropriate antimicrobial therapy with broad coverage among the common pathogens based on local microbiologic data per institution.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115773321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P11‐13: Diffuse pulmonary hemorrhage, a catastrophic outcome of a 57‐year‐old venezuelan, with COVID‐19 pneumonia, who developed multiple thrombosis and aman‐variant GBS","authors":"","doi":"10.1111/resp.14150_825","DOIUrl":"https://doi.org/10.1111/resp.14150_825","url":null,"abstract":"","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134035422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}