Acta pharmaceutica Sinica最新文献

Medicinal chemistry strategies in seeking coronavirus inhibitors 寻找冠状病毒抑制剂的药物化学策略

Acta pharmaceutica Sinica Pub Date : 2020-04-01 DOI: 10.16438/J.0513-4870.2020-0131

Jing Li, Xiangyi Jiang, Shujing Xu, Q. Cui, Ruikun Du, Dongwei Kang, P. Zhan, L. Rong, Xin Liu

引用次数: 0

Analysis of chemical drugs applied for clinical trial for the treatment of COVID-19 新冠肺炎临床试验化学药物应用分析

Acta pharmaceutica Sinica Pub Date : 2020-03-01 DOI: 10.16438/J.0513-4870.2020-0151

Chao Zhang, S. Chen, Jie Zhang, Ying Guo

{"title":"Analysis of chemical drugs applied for clinical trial for the treatment of COVID-19","authors":"Chao Zhang, S. Chen, Jie Zhang, Ying Guo","doi":"10.16438/J.0513-4870.2020-0151","DOIUrl":"https://doi.org/10.16438/J.0513-4870.2020-0151","url":null,"abstract":"The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout China and many other countries around the world. The antivirals are important measures to this epidemic; however, there is no drug approved for against coronavirus yet. With the continuously rising number of confirmed/suspected cases of COVID-19, it is urgent to obtain antiviral drugs for the clinical treatment. In response to this situation, drug repurposing strategy becomes one of the best approaches for anti-SARS-CoV-2 drug discovery. By retrieving the clinical trials registered in Chinese Clinical Trial Registry and ClinicalTrials.gov, a total of 14 chemical drugs were registered for COVID-19. In this review, we summarize and analyze the 14 drugs' indications, targets, and research basis related to the activities against viral infections, esp. coronavirus infections. We are making efforts to understand the evidence basis of these drugs for the treatment of SARS-CoV-2 infection applied by various research and clinical institutions in response to this COVID-19 outbreak, and also providing clues for quick response to possible epidemic in future and reasonable expansion of the indications of drugs.","PeriodicalId":7092,"journal":{"name":"Acta pharmaceutica Sinica","volume":"33 1","pages":"355-365"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90595048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

[Synthesis and biological evaluation of novel pleuromutilin derivatives with nitrogen-containing heterocycles as antibacterial agents]. [含氮杂环的新型胸腺嘧啶衍生物作为抗菌剂的合成和生物学评价]。

Acta pharmaceutica Sinica Pub Date : 2015-10-01

Xin-yang Wang, Min Chen, Duo Wang, Xiang-dong Chen, Yong Ling, Xiao-li Wang, Hui Wang

引用次数: 0

[Effect of WS070117M1 on chronic obstructive pulmonary disease in mice and the underling mechanisms of anti-inflammation]. [WS070117M1对小鼠慢性阻塞性肺病的影响及抗炎的内在机制]。

Acta pharmaceutica Sinica Pub Date : 2015-08-01

Shu-hua Cao, Ling-ling Xuan, Dong-mei Wang, Jian-lin Xie, Ren-tao Jiang, Jin-ye Bai, Song Wu, Qi Hou

{"title":"[Effect of WS070117M1 on chronic obstructive pulmonary disease in mice and the underling mechanisms of anti-inflammation].","authors":"Shu-hua Cao, Ling-ling Xuan, Dong-mei Wang, Jian-lin Xie, Ren-tao Jiang, Jin-ye Bai, Song Wu, Qi Hou","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this study is to investigate the anti-inflammatory effect of the adenosine derivative N6-(3-hydroxylaniline) adenosine (WS070117M1) on cigarette smoke plus LPS (lipopolysaccharide)-induced chronic obstructive pulmonary disease (COPD) in mice and its mechanism. COPD model was established by exposing male BALB/c mice to cigarette smoke and challenged with LPS inhalation. Supernatants of bronchoalveolar lavage fluid (BALF) were harvested and IL-1β, IL-6, IL-8 and TGF-β1 levels were measured by ELISA (enzyme-linked immunesorbent assay). The number of total white blood cells and neutrophils in bronchoalveolar lavage fluid was counted separately. Lung tissue was stained with Mayer 's hematoxylin and eosin for histopathologic examination. pAMPKa protein expression and distribution of lung tissue were analyzed by immunohistochemistry method. In vitro, levels of AMPKα phosphorylation in phorbol-12- myristate-13-acetate (PMA) differentiated THP-1 cells was detected by immunohistochemistry, IL-8 level in supernatants of cigarette smoke condensate stimulating PMA differentiated THP-1 cells was measured by ELISA. The results showed that WS070117M1 treatment significantly activated AMPKa in the lung tissue. It also resulted in down regulation of IL-1β, IL-6, IL-8 and TGF-β1 levels in bronchoalveolar lavage fluid and IL-8 level in cigarette smoke condensate stimulating PMA differentiated THP-1 cells. In addition, WS070117M1 could inhibit the recruitment of total white blood cells and neutrophils. These results suggest that WS070117M1 may alleviate the airway inflammation by activating AMPK in the lung tissue.</p>","PeriodicalId":7092,"journal":{"name":"Acta pharmaceutica Sinica","volume":"50 8","pages":"986-92"},"PeriodicalIF":0.0,"publicationDate":"2015-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138794633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A new flavonol glycoside from Baeckea Frutescens L]. [一种新的黄酮醇苷，来自白花蛇舌草）。

Acta pharmaceutica Sinica Pub Date : 2008-10-01

Wen-jie Lu, Qi-kang Ya, Jia-yuan Chen, Bu-ming Liu

引用次数: 0

Advances in chromatography 色谱法研究进展

Acta pharmaceutica Sinica Pub Date : 1983-12-01 DOI: 10.1201/crcadvchroma

Zhou Th

引用次数: 0