A. Torii, A. Yamada, Yuka, Shinohara, H. Niwa, Y. Kogure, Chiyoe, Kitagawa, M. Oki, T. Asakura, Shoji Suzuki, Satoshi, Okamori, Tatsuya Kusumoto, T. Ogawa, S. Uno, A. Morita, Ho Lee, H. Namkoong, H. Kamata, Yasunori Sato, Y. Uwamino, T. Nishimura, M. Ishii, K. Fukunaga, N. Hasegawa
{"title":"P5‐43: A case of hyperpyrexia of hypothalamic origin associated with severe COVID‐19 pneumonia in pregnancy","authors":"A. Torii, A. Yamada, Yuka, Shinohara, H. Niwa, Y. Kogure, Chiyoe, Kitagawa, M. Oki, T. Asakura, Shoji Suzuki, Satoshi, Okamori, Tatsuya Kusumoto, T. Ogawa, S. Uno, A. Morita, Ho Lee, H. Namkoong, H. Kamata, Yasunori Sato, Y. Uwamino, T. Nishimura, M. Ishii, K. Fukunaga, N. Hasegawa","doi":"10.1111/resp.14150_250","DOIUrl":null,"url":null,"abstract":"pital. Autopsy revealed necrotic nodules, thromboangitis and hemorrhage infarction in multiple organs including brain, lung, heart, adrenal gland and kidney. Many filamentous fungi with prominent infiltration of neutrophils were observed intravascularly in these organs. Grocott strain and genetic analysis revealed that the fungi belong to Rhizopus microsporus group. We concluded that he died of sepsis and multiple organ failure due to disseminated mucormycosis. Though steroids and IL-6 inhibitor improve survival rate of severe Covid-19 infection, it should be considered severe opportunistic infection such as disseminated fungal infection might occur under the powerful immunosuppressive treatment to modulate hyperimmunity due to COVID-19 infection.","PeriodicalId":162871,"journal":{"name":"Respirology (Carlton, Vic.)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respirology (Carlton, Vic.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/resp.14150_250","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
pital. Autopsy revealed necrotic nodules, thromboangitis and hemorrhage infarction in multiple organs including brain, lung, heart, adrenal gland and kidney. Many filamentous fungi with prominent infiltration of neutrophils were observed intravascularly in these organs. Grocott strain and genetic analysis revealed that the fungi belong to Rhizopus microsporus group. We concluded that he died of sepsis and multiple organ failure due to disseminated mucormycosis. Though steroids and IL-6 inhibitor improve survival rate of severe Covid-19 infection, it should be considered severe opportunistic infection such as disseminated fungal infection might occur under the powerful immunosuppressive treatment to modulate hyperimmunity due to COVID-19 infection.
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