Journal of Liposome Research最新文献_第9页

Carboxymethyl chitosan and octadecylamine-coated liposome-containing WPTS: design, optimization, and evaluation. 羧甲基壳聚糖和十八胺包覆脂质体的 WPTS：设计、优化和评估。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-08-18 DOI: 10.1080/08982104.2023.2246057

Nan Wang, Chi Zhang, Jiahui Wu, Dachuan Zhang, Junling Li, A Galvbu, Leimengyuan Tang, Yan Li, Houxier Li, Shuting Tan, Xueyong Wang

{"title":"Carboxymethyl chitosan and octadecylamine-coated liposome-containing WPTS: design, optimization, and evaluation.","authors":"Nan Wang, Chi Zhang, Jiahui Wu, Dachuan Zhang, Junling Li, A Galvbu, Leimengyuan Tang, Yan Li, Houxier Li, Shuting Tan, Xueyong Wang","doi":"10.1080/08982104.2023.2246057","DOIUrl":"10.1080/08982104.2023.2246057","url":null,"abstract":"Liposomes (LPs) are a delivery system for stabilizing pharmaceuticals with limited use due to their propensity to congregate and fuse. A proposed method of addressing these problems is polymer coating. In this study, the potential of octadecylamine (ODA)-coated liposomes and carboxymethyl chitosan (CMCS/ODA-LPs) for enhancing Wacao pentacyclic triterpene saponin (WPTS) transport capacity was investigated. CMCS/ODA-LPs were produced by electrostatic adsorption and thin-film hydration. Response surface methodology (RSM) was employed to enhance the process and encapsulation efficiency (EE) for optimum drug encapsulation efficiency. The synthesized WPTS-CMCS/ODA-LPs were uniformly dispersed in a circular shape, and during 14 days of storage at 4 °C, the particle size and morphology did not significantly change. Vesicle size, zeta potential, polydispersity index (PDI), and entrapment efficiency (%) were 179.1 ± 7.31 nm, -29.6 ± 1.35 mV, 0.188 ± 0.052, and 75.62 ± 0.43, respectively. The hemolysis test revealed that WPTS-CMCS/ODA-LPs were sufficiently biocompatible. Compared to WPTS-LPs, WPTS-CMCS/ODA-LPs consistently showed a much more significant cytotoxic effect on cancer cells. Early and WPTS-CMCS/ODA-LPs-induced apoptosis resulted in almost seven times more cell death than the control. Compared to physiological pH 7.3, the pH-sensitive CMCS coupled LPs increased drug release at acidic pH 6.5. These findings suggest the efficacy of pH-sensitive CMCS/ODA-LPs as a medication delivery method for WPTS.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"124-134"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10016611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-08-10 DOI: 10.1080/08982104.2023.2246116

引用次数: 0

Nose to brain delivery of naringin loaded transniosomes for epilepsy: formulation, characterisation, blood-brain distribution and invivo pharmacodynamic evaluation. 从鼻腔向大脑输送柚皮苷治疗癫痫：配方、特性、血脑屏障分布和体内药效学评估。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-05-22 DOI: 10.1080/08982104.2023.2214619

Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb

{"title":"Nose to brain delivery of naringin loaded transniosomes for epilepsy: formulation, characterisation, blood-brain distribution and invivo pharmacodynamic evaluation.","authors":"Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb","doi":"10.1080/08982104.2023.2214619","DOIUrl":"10.1080/08982104.2023.2214619","url":null,"abstract":"The current work limns the preparation of naringin-loaded transnioosomes (NRN-TN) to enhance NRN solubility, permeation and bioavailability via nasal mucosa for intranasal delivery. NRN-TN was created by the thin-film hydration technique, and with the BBD (Box-Behnken design), optimisation was carried out. NRN-TNopt was characterised for the vesicle size, PDI (Polydispersity index), zeta potential, entrapment efficiency (EE) and in vitro NRN release. For further assessment, nasal permeation study, study of Blood-brain distribution, TEM (Transmission Electron Microscopy), and CLSM (Confocal Scanning Laser Microscopy) were conducted withal. The NRN-TNopt exhibited spherical as well as sealed vesicles with a considerable small size of 151.3 nm, an EE of 75.23 percent, a PDI of 0.1257, and an in vitro release of 83.32 percent. CLSM investigation revealed that the new formulation allows for higher NRN permeation across nasal mucosa than the NRN solution. The blood-brain distribution investigation revealed that intranasally administered NRN-TN had a greater Cmax and AUC0-24 h than orally administered NRN-TN. Seizure activity and neuromuscular coordination as measured by the rotarod test, biochemical estimate of oxidative stress indicators, and histological investigations demonstrated that the NRN-TN has superior anti-epileptic potential in comparison to the standard diazepam. In addition, nasal toxicity studies demonstrate that the NRN-TN formulation is safer for intranasal administration. This study confirmed that the created TN vesicle formulation is a valuable carrier for the intranasal administration of NRN for the treatment of epilepsy.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"60-76"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of multivesicular liposomes for the loco-regional delivery of Vancomycin hydrochloride using active loading method: drug release and antimicrobial properties. 利用活性负载法制备用于局部区域递送盐酸万古霉素的多囊脂质体：药物释放和抗菌特性。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-06-07 DOI: 10.1080/08982104.2023.2220805

Melody Vatankhah, Simin Dadashzadeh, Arash Mahboubi, Azadeh Haeri, Kimia Jandaghi Alaee, Seyed Baubak Mostafavi Naeini, Zahra Abbasian

{"title":"Preparation of multivesicular liposomes for the loco-regional delivery of Vancomycin hydrochloride using active loading method: drug release and antimicrobial properties.","authors":"Melody Vatankhah, Simin Dadashzadeh, Arash Mahboubi, Azadeh Haeri, Kimia Jandaghi Alaee, Seyed Baubak Mostafavi Naeini, Zahra Abbasian","doi":"10.1080/08982104.2023.2220805","DOIUrl":"10.1080/08982104.2023.2220805","url":null,"abstract":"Over the last few years, among controlled-release delivery systems, multivesicular liposomes (MVLs) have attracted attention due to their unique benefits as a loco-regional drug delivery system. Considering the clinical limitations of the current treatment strategies for osteomyelitis, MVLs can be a suitable carrier for the local delivery of effective antibiotics. This study aimed to prepare vancomycin hydrochloride (VAN HL) loaded MVLs using the active loading method which to the best of our knowledge has not been previously reported. Empty MVLS were prepared by the double emulsion (w/o/w) method and VAN HL was loaded into the prepared liposomes by the ammonium gradient method. After full characterization, the release profile of VAN HL from MVLs was assessed at two different pH values (5.5 and 7.4), and compared with the release profile of the free drug and also passively loaded MVLs. In vitro antimicrobial activities were evaluated using the disc diffusion method. Our results demonstrated that the encapsulation efficiency was higher than 90% in the optimum actively loaded MVL. The free VAN HL was released within 6-8 h, while the passively loaded MVLs and the optimum actively loaded MVL formulation released the drug in 6 days and up to 19 days, respectively. The released drug showed effective antibacterial activity against osteomyelitis-causing pathogens. In conclusion, the prepared formulation offered the advantages of sustained-release properties, appropriate particle size as well as being composed of biocompatible materials, and thus could be a promising candidate for the loco-regional delivery of VAN HL and the management of osteomyelitis.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"77-87"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9646277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phthalocyanine-based glucose-responsive nanocochleates for dynamic prevention of β-cell damage in diabetes. 基于酞菁的葡萄糖响应性纳米偶联剂，用于动态预防糖尿病中的β细胞损伤。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2024-03-01 Epub Date: 2023-05-12 DOI: 10.1080/08982104.2023.2209642

Sharayu Govardhane, Pravin Shende

{"title":"Phthalocyanine-based glucose-responsive nanocochleates for dynamic prevention of β-cell damage in diabetes.","authors":"Sharayu Govardhane, Pravin Shende","doi":"10.1080/08982104.2023.2209642","DOIUrl":"10.1080/08982104.2023.2209642","url":null,"abstract":"Phthalocyanine is a blue-colored macrocyclic compound with excellent anti-oxidant and lipid-peroxidation abilities due to its intermolecular π-π stacking structure. Antioxidants inhibit intracellular reactive oxygen species formation and decrease oxidation defense ability of the enzymes in diabetes management. The present study aimed to fabricate concanavalin A conjugated phthalocyanine-loaded cochleates (Formulation PhConA) as a glucose-sensitive lipidic system and estimate its efficacy in streptozotocin-induced male Sprague Dawley diabetic rats for 28 days. Thin-film hydration and trapping methods were used in the preparation of liposomes and cochleates, respectively, whereas the surface was modified for concanavalin A conjugation using EDAC: NHS (1:1). Formulation PhConA with rod-shaped structures showed particle size of 415.7 ± 0.46 nm, PdI value of 0.435 ± 0.09, encapsulation efficiency of 85.64 ± 0.34%, and 84.55 ± 0.29% release of phthalocyanine for 56 h. The circular dichroism study displayed a slight deviation after the conjugation effect of concanavalin A to cochleates. The in-vivo studies of the formulation PhConA improved the blood glucose levels along with defensive effect on the liver to overcome the hyperlipidemic effect. The rigid structure of cochleates prolongs the drug elimination from systemic circulation and extends its effect for a longer duration by decreasing the blood glucose level. Thus, the glucose-sensitive formulation PhConA showed significant improvement in diabetic rats within the period of 28 days by improving the oxidative defense and protecting the pancreatic β-cells.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"44-59"},"PeriodicalIF":4.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astragaloside IV-induced BMSC exosomes promote neovascularization and protect cardiac function in myocardial infarction mice via the miR-411/HIF-1α axis 黄芪甲苷IV诱导的BMSC外泌体通过miR-411/HIF-1α轴促进心肌梗死小鼠的血管新生并保护心脏功能

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-12-13 DOI: 10.1080/08982104.2023.2293844

Lei Yang, Nuan Liu, Yang Yang

引用次数: 0

Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting. 用于胶质瘤靶向的具有可调内部水相的tLyP-1功能化纳米脂质体的开发。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-12-01 Epub Date: 2023-03-28 DOI: 10.1080/08982104.2023.2191718

Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang

{"title":"Development of tLyP-1 functionalized nanoliposomes with tunable internal water phase for glioma targeting.","authors":"Yajing Wang, Ziwei Ding, Shiqun Lv, Jie Liu, Jie Pan, Yingcong Yu, Jun Gao, Xianfeng Huang","doi":"10.1080/08982104.2023.2191718","DOIUrl":"10.1080/08982104.2023.2191718","url":null,"abstract":"tLyP-1 peptide is verified to recognize neuropilin (NRP) receptors overexpressed on the surface of both glioma cells and endothelial cells of angiogenic blood vessels. In the present study, tLyP-1 was conjugated with DSPE-PEG2000 to prepare tLyP-1-DSPE-PEG2000, which was further employed to prepare tLyP-1 functionalized nanoliposome (tLyP-1-Lip) to achieve enhancing target of glioblastoma. Process parameters were systematically studied to investigate the feasibility of tuning the internal water phase of nanoliposomes and encapsulating more Temozolomide (TMZ). The particle size, Zeta potential, and encapsulation efficiency of tLyP-1-Lip/TMZ were fully characterized in comparison with conventional nanoliposomes (Lip-TMZ) and PEGylated nanoliposomes (PEG-Lip/TMZ). The release behaviors of TMZ from PEG-Lip/TMZ and tLyP-1-Lip/TMZ are similar and slower than TMZ-Lip in acidic solutions. The tLyP-1-Lip/TMZ demonstrated the strongest cytotoxicity in comparison with TMZ-Lip and PEG-Lip/TMZ in both U87 and HT22 cells, and displayed the highest cellular internalization. The pharmacokinetic studies in rats revealed that tLyP-1-Lip/TMZ showed a 1.4-fold (p < 0.001) increase in AUCINF_obs and a 1.4-fold decrease (p < 0.01) in clearance compared with PEG-Lip/TMZ. We finally confirmed by in vivo imaging that tLyP-1-Lip were able to penetrate the brains and tumors of mice.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"353-367"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosticating the effect of temperature and pH parameters on size and stability of the nanoliposome system based on thermodynamic modeling. 基于热力学模型预测温度和pH参数对纳米脂质体系统大小和稳定性的影响。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-12-01 Epub Date: 2023-05-12 DOI: 10.1080/08982104.2023.2203250

Fardin Rahimi, Pari Hajizadeh, Ghassem Amoabediny, Bahman Ebrahimi, Mansoor Khaledi, Fatemeh Sameni, Hamed Afkhami, Shahriar Bakhti, Elham Rafiee Taqanaki, Mahdi Zafari

{"title":"Prognosticating the effect of temperature and pH parameters on size and stability of the nanoliposome system based on thermodynamic modeling.","authors":"Fardin Rahimi, Pari Hajizadeh, Ghassem Amoabediny, Bahman Ebrahimi, Mansoor Khaledi, Fatemeh Sameni, Hamed Afkhami, Shahriar Bakhti, Elham Rafiee Taqanaki, Mahdi Zafari","doi":"10.1080/08982104.2023.2203250","DOIUrl":"10.1080/08982104.2023.2203250","url":null,"abstract":"The main challenge of using nanoliposome systems is controlling their size and stability. In order to overcome this challenge, according to the research conducted at the Research Centre for New Technologies of Biological Engineering, University of Tehran, a model for predicting the size and stability of nanoliposome systems based on thermodynamic relations has been presented. In this model, by using the presented equations and without performing many experiments in the laboratory environment, the effect of temperature, ionic power and different pH can be considered simultaneously whereas examining the components of size, stability and any feature were considered before. Synthesis and application of liposomal nanocarriers in different operating conditions can be investigated and predicted, and due to the change in temperature and pH, the smallest size of th system can be obtained. In this study, we were able to model the synthesis and storage conditions of liposomal nanocarriers at different temperatures and acidic, neutral and alkaline pHs, based on the calculation of mathematical equations. This model also indicates that with increasing temperature, the radius increases but with increasing pH, the radius first increases and then decreases. Therefore, this model can be used to predict size and stability in different operating conditions. In fact, with this modelling method, there is no need to study through laboratory methods and analysis to determine the size, stability and surface loads, and in terms of Accuracy, time and cost savings are affordable.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"392-409"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9452464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MC3/SAINT-O-Somes, a novel liposomal delivery system for efficient and safe delivery of siRNA into endothelial cells. MC3/SAINT-O-Somes是一种新型脂质体递送系统，可高效、安全地将siRNA递送至内皮细胞。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-12-01 Epub Date: 2023-03-15 DOI: 10.1080/08982104.2023.2187821

Yutong He, Mees Barlag, Josée A Plantinga, Grietje Molema, Jan A A M Kamps

{"title":"MC3/SAINT-O-Somes, a novel liposomal delivery system for efficient and safe delivery of siRNA into endothelial cells.","authors":"Yutong He, Mees Barlag, Josée A Plantinga, Grietje Molema, Jan A A M Kamps","doi":"10.1080/08982104.2023.2187821","DOIUrl":"10.1080/08982104.2023.2187821","url":null,"abstract":"Increased understanding of chronic inflammatory diseases and the role of endothelial cell (EC) activation herein, have urged interest in sophisticated strategies to therapeutically intervene in activated EC to treat these diseases. Liposome-mediated delivery of therapeutic siRNA in inflammation-activated EC is such a strategy. In this study, we describe the design and characterisation of two liposomal siRNA delivery systems formulated with the cationic MC3 lipid or MC3/SAINT mixed lipids, referred to as MC3-O-Somes (MOS) and MC3/SAINT-O-Somes (MSS). The two formulations showed comparable physicochemical properties, except for better siRNA encapsulation efficiency in the MSS formulation. Antibody-mediated VCAM-1 targeting (AbVCAM-1) increased the association of the targeted MOS and MSS with activated EC, although the targeted MOS showed a significantly higher VCAM-1 specific association than the targeted MSS. AbVCAM-1 MSS containing RelA siRNA achieved significant downregulation of RelA expression, while AbVCAM-1 MOS containing RelA siRNA did not downregulate RelA expression in activated EC. Additionally, AbVCAM-1 MSS containing RelA siRNA showed low cytotoxicity in EC and at the same time prohibited endothelial inflammatory activation by reducing expression of cell adhesion molecules. The AbVCAM-1 MSS formulation is a novel siRNA delivery system based on a combination of the cationic lipids MC3 and SAINT, that shows good physicochemical characteristics, enhanced endothelial cell association, improved transfection activity, low toxicity and significant anti-inflammatory effect, thereby complying with the requirements for future in vivo investigations.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"328-337"},"PeriodicalIF":4.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9114679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Liposomal drug delivery to the lungs: a post covid-19 scenario. 肺脂质体药物递送:后covid-19情景

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-12-01 Epub Date: 2023-04-19 DOI: 10.1080/08982104.2023.2199068

S Swathi Krishna, M S Sudheesh, Vidya Viswanad

引用次数: 0