Journal of Liposome Research最新文献_第9页

Transport of hydrocortisone in targeted layers of the skin by multi-lamellar liposomes. 氢化可的松通过多层脂质体在皮肤靶层中的转运。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-09-01 DOI: 10.1080/08982104.2023.2177309

Antoine Bernasqué, Muriel Cario, Stéphanie Krisa, Sophie Lecomte, Chrystel Faure

{"title":"Transport of hydrocortisone in targeted layers of the skin by multi-lamellar liposomes.","authors":"Antoine Bernasqué, Muriel Cario, Stéphanie Krisa, Sophie Lecomte, Chrystel Faure","doi":"10.1080/08982104.2023.2177309","DOIUrl":"https://doi.org/10.1080/08982104.2023.2177309","url":null,"abstract":"Hydrocortisone (HyC), a hydrophobic pharmaceutical active, was encapsulated in multi-lamellar liposomes (MLLs) composed of P100, a mixture of phospholipids, and Tween®80. Three different HyC-loaded formulations were designed to target the stratum corneum, the living epidermis and the hypodermis. The impact of encapsulation on their size, elasticity and zeta potential, the three key factors controlling MLLs skin penetration, was studied. Raman mapping of phospholipids and HyC allowed the localisation of both components inside an artificial skin, Strat-M®, demonstrating the efficiency of the targeting. Percutaneous permeation profiles through excised human skin were performed over 48 h, supporting results on artificial skin. Their modelling revealed that HyC encapsulated in MLLs, designed to target the stratum corneum and living epidermis, exhibited a non-Fickian diffusion process. In contrast, a Fickian diffusion was found for HyC administered in solution, in a pharmaceutical cream and in transdermal MLLs. These results allowed us to propose a mechanism of interaction between HyC-containing MLLs and the skin.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 3","pages":"314-327"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A mini review for lipid-based nanovaccines: from their design to their applications. 脂质纳米疫苗的综述:从设计到应用。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-09-01 DOI: 10.1080/08982104.2023.2170408

Katerina Xekouki, Nefeli Lagopati, Costas Demetzos, Maria Gazouli, Natassa Pippa

{"title":"A mini review for lipid-based nanovaccines: from their design to their applications.","authors":"Katerina Xekouki, Nefeli Lagopati, Costas Demetzos, Maria Gazouli, Natassa Pippa","doi":"10.1080/08982104.2023.2170408","DOIUrl":"https://doi.org/10.1080/08982104.2023.2170408","url":null,"abstract":"Nanovaccines have shown to be effective, and this is the reason they are preferred than conventional vaccines. The scope of this review is to describe the role, mechanisms, and advantages of nano vaccines based on lipids, and present the most important types, their physicochemical characteristics, as well as their challenges. The most important categories of lipid nano-vaccines are liposomal nano vaccines and (virus-lipid nanoparticles (NPs)/virosomes. Examples of vaccine formulations from each category are presented and analyzed below, focusing on their structure and physicochemical characteristics. In all cases, a nanoscale platform is used, enriched with adjuvants, antigens, and other helping agents to trigger immune response process and achieve cell targeting, and eventually immunity against the desired disease. The exact mechanism of action of each vaccine is not always completely known or understood. Physicochemical characteristics, such as particle size, morphology/shape, and zeta potential are also mentioned as they seem to affect the properties and mechanism of action of the vaccine formulation.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 3","pages":"214-233"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9882484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of different ligand modification liposomes to evaluate the anti-liver tumor activity of cantharidin. 用不同配体修饰脂质体评价斑蝥素的抗肝肿瘤活性。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-09-01 DOI: 10.1080/08982104.2022.2163254

Manshu Zou, Yilin Xu, Peng Lin, Lili Zhou, Xinhua Xia

{"title":"Use of different ligand modification liposomes to evaluate the anti-liver tumor activity of cantharidin.","authors":"Manshu Zou, Yilin Xu, Peng Lin, Lili Zhou, Xinhua Xia","doi":"10.1080/08982104.2022.2163254","DOIUrl":"https://doi.org/10.1080/08982104.2022.2163254","url":null,"abstract":"In this study, cantharidin(CTD), a bioactive terpenoid in traditional Chinese medicine cantharidin, was selected as a model component to construct novel nano liposome delivery systems for hepatocellular carcinoma therapy. Previous studies have shown that although cantharidin has definite curative effects on primary liver cancer, it is associated with numerous toxic and side effects. Therefore, based on the glycyrrhetinic acid (GA) binding site and the asialoglycoprotein receptor (ASGPR) on the hepatocyte membrane, the surface of CTD liposomes was modified with stearyl alcohol galactoside (SA-Gal) or/and the newly synthesized 3-succinic-30-stearyl deoxyglycyrrhetinic acid (11-DGA-Suc) ligands, and the physicochemical properties, pharmacokinetics, in vivo and in vitro anti-liver tumor activity and its mechanism of modified liposomes were investigated. Compared to CTD-lip, SA-Gal-CTD-lip, and 11-DGA-Suc + SA-Gal-CTD-lip, 11-DGA-Suc-CTD-lip showed stronger cytotoxicity and increased inhibition of HepG2 cell migration had the highest apoptosis rate. The cell cycle results indicated that HepG2 cells was arrested mainly at G0/G1phase and G2/M phase. The results of in vivo pharmacokinetic experiments revealed that the distribution of modified liposomes in the liver was significantly increased compared with that of unmodified liposome. In vivo tumor inhibition experiment showed that 11-DGA-Suc-CTD-lip had excellent tumor inhibition, and the tumor inhibition rates was 80.96%. The 11-DGA-Suc-CTD-lip group also displayed the strongest proliferation inhibition with the lowest proliferation index of 7% in PCNA assay and the highest apoptotic index of 49% in TUNEL assay. Taken together, our findings provide a promising solution for improving the targeting of nano liposomes and further demonstrates the encouraging potential of poor solubility and high toxicity drugs applicable to tumor therapy.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 3","pages":"283-299"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating tumour vascular normalisation using triptolide-loaded NGR-functionalized liposomes for enhanced cancer radiotherapy. 使用雷公藤甲素负载的nrr功能化脂质体调节肿瘤血管正常化，以增强癌症放疗。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-09-01 DOI: 10.1080/08982104.2022.2161095

Ying-Ying Xu, Yan-Hong Chen, Jie Jin, Yuan Yuan, Jin-Meng Li, Xin-Jun Cai, Ruo-Ying Zhang

{"title":"Modulating tumour vascular normalisation using triptolide-loaded NGR-functionalized liposomes for enhanced cancer radiotherapy.","authors":"Ying-Ying Xu, Yan-Hong Chen, Jie Jin, Yuan Yuan, Jin-Meng Li, Xin-Jun Cai, Ruo-Ying Zhang","doi":"10.1080/08982104.2022.2161095","DOIUrl":"https://doi.org/10.1080/08982104.2022.2161095","url":null,"abstract":"Radiotherapy is an effective therapy in tumour treatment. However, the characteristics of the tumour microenvironment, including hypoxia, low pH, and interstitial fluid pressure bring about radioresistance. To improve the anti-tumour effect of radiotherapy, it has been demonstrated that antiangiogenic therapy can be employed to repair the structural and functional defects of tumour angiogenic vessels, thereby preventing radioresistance or poor therapeutic drug delivery. In this study, we prepared triptolide (TP)-loaded Asn-Gly-Arg (NGR) peptide conjugated mPEG2000-DSPE-targeted liposomes (NGR-PEG-TP-LPs) to induce tumour blood vessel normalisation, to the end of increasing the sensitivity of tumour cells to radiotherapy. Further, to quantify the tumour vessel normalisation window, the structure and functionality of tumour blood vessels post NGR-PEG-TP-LPs treatment were evaluated. Thereafter, the anti-tumour effect of radiotherapy following these treatments was evaluated using HCT116 xenograft-bearing mouse models based on the tumour vessel normalisation period window. The results obtained showed that NGR-PEG-TP-LPs could modulate tumour vascular normalisation to increase the oxygen content of the tumour microenvironment and enhance the efficacy of radiotherapy. Further, liver and kidney toxicity tests indicated that NGR-PEG-TP-LPs are safe for application in cancer treatment.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 3","pages":"251-257"},"PeriodicalIF":4.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10255704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of epi-1 modified epirubicin and curcumin encapsulated liposomes targeting-EpCAM in the inhibition of epithelial ovarian cancer cells. epi-1修饰的表柔比星和姜黄素包封脂质体靶向epcam对卵巢癌上皮细胞的抑制作用。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2153138

Yu-Jia Wang, Ling Tang, Xu-Hong Lu, Ji-Tao Liu, Yuan-Yuan Wang, Hong-Xia Geng, Xue-Tao Li, Quan An

{"title":"Efficacy of epi-1 modified epirubicin and curcumin encapsulated liposomes targeting-EpCAM in the inhibition of epithelial ovarian cancer cells.","authors":"Yu-Jia Wang, Ling Tang, Xu-Hong Lu, Ji-Tao Liu, Yuan-Yuan Wang, Hong-Xia Geng, Xue-Tao Li, Quan An","doi":"10.1080/08982104.2022.2153138","DOIUrl":"https://doi.org/10.1080/08982104.2022.2153138","url":null,"abstract":"Treatment of epithelial ovarian cancer (EOC) is a challenge because it still leads to unsatisfactory clinical prognosis. This is due to the toxicity and poor targeting of chemotherapeutic agents, as well as metastasis of the tumor. In this study, we designed a targeted liposome with nanostructures to overcome these problems. In the liposomes, epirubicin and curcumin were encapsulated to achieve their synergistic antitumor efficacy, while Epi-1 was modified on the liposomal surface to target epithelial cell adhesion molecule (EpCAM). Epi-1, a macrocyclic peptide, exhibits active targeting for enhanced cellular uptake and potent cytotoxicity against tumor cells. The encapsulation of epirubicin and curcumin synergistically inhibited the formation of neovascularization and vasculogenic mimicry (VM) channels, thereby suppressing tumor metastasis on SKOV3 cells. The dual drug loaded Epi-1-liposomes also induced apoptosis and downregulated metastasis-related proteins for effective antitumor in vitro. In vivo studies showed that dual drug loaded Epi-1-liposomes prolonged circulation time in the blood and increased the selective accumulation of drug at the tumor site. H&E staining and immunohistochemistry with Ki-67 also showed that targeted liposomes elevated antitumor activity. Also, targeted liposomes downregulated angiogenesis-related proteins to inhibit angiogenesis and thus tumor metastasis. In conclusion, the production of dual drug loaded Epi-1-liposomes is an effective strategy for the treatment of EOC.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"197-213"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9620083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes. 新型抗脑缺血纳米材料:龙脑当归多糖脂质体的制备与应用。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2106240

Huang Ding, Ke Wang, Lin-Qin He, Xiao-Yu Yang, Hai-Hong Huang, Wen-Long Liu, Chen Xiao, Ze-Xuan Du, Lian- Yu, Wei Zhang

{"title":"A novel nano material for anti-cerebral ischaemia: preparation and application of borneol angelica polysaccharide liposomes.","authors":"Huang Ding, Ke Wang, Lin-Qin He, Xiao-Yu Yang, Hai-Hong Huang, Wen-Long Liu, Chen Xiao, Ze-Xuan Du, Lian- Yu, Wei Zhang","doi":"10.1080/08982104.2022.2106240","DOIUrl":"https://doi.org/10.1080/08982104.2022.2106240","url":null,"abstract":"Objective: To investigate the preparation of novel nanoliposomes (Borneol Angelica Polysaccharide Liposomes, BAPL) for anti-cerebral ischaemia and verify its curative effects and mechanism.Methods: By applying a uniform experiment design to investigate the fitting combination of BAPL. Encapsulation Efficiency Evaluation of BAPL Preparation; Particle Size and Surface Potential Evaluation of BAPL Biological activity; Cerebral ischaemia models of rats Evaluation of BAPL curative effects and mechanism.Results: (1) The fitting combination of lecithin, Cholesterol, AP mass and the borneol mass was 60 mg, 60 mg, 45 mg and 5 mg. the highest encapsulation efficiency was 80.4%, the particle size was 179.1 nm, and the surface zeta potential was -17.2 mV. It conforms to the nano-material standards. (2) The results of animal experiments show that: In the BAPL group, the infarct volume of TTC staining was significantly decreased, and the expression levels of NF-κBp65, TLR-4, IL-8, IL-6, IL-1β in brain tissue were significantly decreased, while the expression levels of ZO-1, ZO-2, IL-10 were significantly increased after cerebral ischaemia-reperfusion.Conclusion: BAPL is a novel nano and effective material for anti-cerebral ischaemia.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"144-153"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9984125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables. 替莫唑胺脂质体的微流体和膜挤压制备研究:配方和工艺变量的影响。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2139844

Tejashree Waghule, Ranendra Narayan Saha, Gautam Singhvi

{"title":"Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables.","authors":"Tejashree Waghule, Ranendra Narayan Saha, Gautam Singhvi","doi":"10.1080/08982104.2022.2139844","DOIUrl":"https://doi.org/10.1080/08982104.2022.2139844","url":null,"abstract":"Liposomes have gained much attention in drug delivery since the entry of liposomal Doxorubicin (Doxil®) into the market. Liposomes can entrap lipophilic, hydrophilic as well as amphiphilic drug molecules due to their distinctive structural features. Yet the clinical translation of liposomes is limited due to the reproducibility issues owing to a lack of information related to the impact of process parameters and formulation variables on designed liposomes. Recently, preparation techniques like membrane extrusion and microfluidics have been reported to produce liposomes in a reproducible manner. The present research study selected an amphiphilic drug Temozolomide (TMZ). It has a short half-life in the plasma due to its pH-dependent stability. Various critical and non-critical parameters affecting the critical quality attributes were identified and studied using risk-based assessment. The effect of various material attributes and process parameters on the critical quality attributes of the temozolomide-loaded liposomes prepared by microfluidics and membrane extrusion techniques were investigated in detail. Liposomes in the size range of 100-150 nm were targeted. Both techniques were optimized with a minimum number of critical process parameters. The obtained information will be beneficial to formulation scientists for designing liposomes for an amphiphilic drug on a large scale.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"170-182"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10001268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Experimental design, formulation, and in-vivo evaluation of novel anticoagulant Rivaroxaban loaded cubosomes in rats model. 新型抗凝药物利伐沙班在大鼠模型中的实验设计、配方和体内评价。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2153137

Hadeer A El-Hashemy, Abeer Salama, Amira Rashad

{"title":"Experimental design, formulation, and in-vivo evaluation of novel anticoagulant Rivaroxaban loaded cubosomes in rats model.","authors":"Hadeer A El-Hashemy, Abeer Salama, Amira Rashad","doi":"10.1080/08982104.2022.2153137","DOIUrl":"https://doi.org/10.1080/08982104.2022.2153137","url":null,"abstract":"The aim of this study was to develop novel cubosomes as an oral delivery system to improve the permeation and anti-clotting activity of Rivaroxaban (RX). The experimental design (23 full factorial design) was employed to study individual and combined impacts of the assigned formulation variables. The variables RX amount (X1), Poloxamer (PX): GMO (GMO) ratio (X2) and PX/GMO: water ratio (X3) were taken as independent factors, and their effect was examined on entrapment efficiency (Y1), particle size (Y2), and zeta potential. (Y3). The cubosomal vesicle RX-C 3 composed of RX (20 mg), PX: GMO (1:0.5 % w/w), and PX/GMO: water (1:5% w/w) is the optimised formula achieving the required prerequisites. RX-C 3 had shown a vesicle size of 91.2 ± 1.3 nm, entrapment efficiency of 96.27 ± 0.12 %, and zeta potential of -24.1 ± 0.2 mV. The in-vivo studies showed revealed good inhibition of blood clotting, where RX-C 3 significantly increased clotting time by 35% and prothrombin time by 29% compared to Rivarospire®. In conclusion, the present study suggested that oral cubosomes formulations provide prolonged delivery of Rivaroxaban.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"189-196"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9626146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer. qbd辅助开发依西美坦抗乳腺癌雌激素活性的脂质纳米胶囊。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2108441

Priya Singh, Alka, Priyanka Maurya, Raquibun Nisha, Neelu Singh, Poonam Parashar, Nidhi Mishra, Ravi Raj Pal, Shubhini A Saraf

{"title":"QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer.","authors":"Priya Singh, Alka, Priyanka Maurya, Raquibun Nisha, Neelu Singh, Poonam Parashar, Nidhi Mishra, Ravi Raj Pal, Shubhini A Saraf","doi":"10.1080/08982104.2022.2108441","DOIUrl":"https://doi.org/10.1080/08982104.2022.2108441","url":null,"abstract":"Some breast cancers are caused by hormonal imbalances, such as estrogen and progesterone. These hormones play a function in directing the growth of cancer cells. The hormone receptors in hormone receptor-positive breast cancer lead breast cells to proliferate out of control. Cancer therapy such as hormonal, targeted, radiation is still unsatisfactory because of these challenges namely multiple drug resistance (MDR), off-targeting, severe adverse effects. A novel aromatase inhibitor exemestane (Exe) exhibits promising therapy in breast cancer. This study aims to develop and optimize Exe-loaded lipid nanocapsules (LNCs) by using DSPC, PF68 and olive oil as lipid, surfactant and oil phase, respectively and to characterize the same. The prepared nanocapsules were investigated via in vitro cell culture and in vivo animal models. The LNCs exhibited cytotoxicity in MCF-7 cell lines and enhanced anti-cancer activity and reduced cardiotoxicity in DMBA-induced animal model when compared to the drug. Additionally, in vivo pharmacokinetics revealed a 4.2-fold increased oral bioavailability when compared with Exe suspension. This study demonstrated that oral administration of Exe-loaded LNCs holds promise for the antiestrogenic activity of exemestane in breast cancer.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"154-169"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9628838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel Hyaluronic Acid ethosomes based gel formulation for topical use with reduced toxicity, better skin permeation, deposition, and improved pharmacodynamics. 新型透明质酸脂质体凝胶配方用于局部使用，毒性降低，更好的皮肤渗透，沉积，改善药效学。

IF 4.4 4区医学

Journal of Liposome Research Pub Date : 2023-06-01 DOI: 10.1080/08982104.2022.2087675

Tushit Sharma, Shubham Thakur, Manjot Kaur, Amrinder Singh, Subheet Kumar Jain

{"title":"Novel Hyaluronic Acid ethosomes based gel formulation for topical use with reduced toxicity, better skin permeation, deposition, and improved pharmacodynamics.","authors":"Tushit Sharma, Shubham Thakur, Manjot Kaur, Amrinder Singh, Subheet Kumar Jain","doi":"10.1080/08982104.2022.2087675","DOIUrl":"https://doi.org/10.1080/08982104.2022.2087675","url":null,"abstract":"Hyaluronic Acid (HA) has been applied as an anti-ageing molecule in the form of topical products. Current topical commercial formulations of HA face the limitations of very small and stagnant skin permeation, thereby demanding enduring administration of the formulation to sustain its action. In this study, Lipid-based nanocarriers in the form of ethosomes were formulated in a 1% w/w HA strength and were extensively evaluated in vitro, ex-vivo, and in vivo parameters along with a comparison to it's commercial counterpart. The optimised ethosomes-based HA gel formulation revealed required pH (6.9 ± 0.2), small globule size (1024 ± 9 nm), zeta potential of -6.39 ± 0.2 mV, and 98 ± 1.1% HA content. The ex vivo skin permeation and deposition potenwere conferred on synthetic membrane Strat-M, Human cadaver skin, mice skin, rat skin, and pig skin, and both parameters were found to be much higher in comparison to the commercial topical formulation. Skin deposition capacity of the optimised HA formulation was further confirmed by Scan Electron Microscopy (SEM) and Confocal Laser Scanning Microscopy (CLSM) and it was observed that the developed ethosomal gel formulation got deposited more on the treated skin. The in vivo anti-ageing effect of optimised ethosomal gel on rats was found to be greater when compared to commercial formulation of HA and the developed carrier-based system proved to deliver the HA molecule in very small amounts into the systemic circulation. The results endorse the ethosomal carrier-based formulation of HA as a attractive technique for better local bioavailability of HA.","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":"33 2","pages":"129-143"},"PeriodicalIF":4.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5