Journal of Lipids最新文献

{"title":"Dyslipidemias: Prevalence and Associated Factors among Lactating Women in a Lower- and Middle-Income Country, Ghana.","authors":"Gideon Kofi Helegbe, Saeed Jabactey Abdullah, Baba Sulemana Mohammed","doi":"10.1155/2023/6280494","DOIUrl":"https://doi.org/10.1155/2023/6280494","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia, an abnormally high level of lipids in the blood, has a negative impact on the health status of the individual and has lately emerged as a major public health concern, especially for low- and middle-income countries (LMIC) globally, including Ghana. However, it is still unclear what the burden and drivers of these lipid abnormalities are, especially among lactating women in the Upper West of Ghana. Thus, this study is aimed at determining the prevalence of dyslipidemia and its associated factors among lactating mothers in the Wa Municipality of Ghana. <i>Methodology</i>. A cross-sectional study was conducted from May to June 2020 in 8 health facilities within the Wa Municipality. Multistage and simple random sampling methods were used to select the facilities and the 200 study subjects. Sociodemographic data were collected using questionnaires, while blood samples were taken to determine the lipid profile of participants. Dietary patterns were also assessed using the Food Frequency Questionnaire (FFQ). Data were processed and analyzed using SPSS 17 software (SPSS, Inc., Chicago, IL). The chi-square test and multiple regression analysis were performed to determine the predictors associated with the various types of dyslipidemia, with statistical significance set at a <i>p</i> value < 0.05.</p><p><strong>Results: </strong>The prevalence of hypercholesterolemia (LDL-C), hypo-HDL-cholesterolemia, and hypertriglyceridemia (TG) was 57%, 59%, and 22%, respectively. Chi-square and multinomial regression analysis revealed that duration of lactation (<i>X</i>² = 3.95, <i>p</i> = 0.047), religion (AOR = 0.375, 95% CI 0.144-0.978, <i>p</i> = 0.045), low income (AOR = 0.116, 95% CI 0.026-0.514, <i>p</i> = 0.005), middle income (AOR = 0.163, 95% CI 0.044-0.600, <i>p</i> = 0.006), and alcohol intake (AOR = 6.312, 95% CI 1.108-35.949, <i>p</i> = 0.038) were associated with LDL-C, while age (AOR = 0.963, 95% CI 0.910-1.019, <i>p</i> < 0.001) and educational status (AOR = 0.365, 95% CI 0.140-0.954, <i>p</i> = 0.040) predicted HDL status.</p><p><strong>Conclusion: </strong>Dyslipidemia is common among lactating mothers of Wa Municipality, and it is predicted by lifestyle factors. Furthermore, future research to look at a larger sample size on dyslipidemia during lactation is recommended.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2023 ","pages":"6280494"},"PeriodicalIF":5.3,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-33a Expression Attenuates ABCA1-Dependent Cholesterol Efflux and Promotes Macrophage-Like Cell Transdifferentiation in Cultured Vascular Smooth Muscle Cells.","authors":"Ikechukwu C Esobi, Olanrewaju Oladosu, Jing Echesabal-Chen, Rhonda R Powell, Terri Bruce, Alexis Stamatikos","doi":"10.1155/2023/8241899","DOIUrl":"10.1155/2023/8241899","url":null,"abstract":"<p><p>Recent evidence suggests that the majority of cholesterol-laden cells found in atherosclerotic lesions are vascular smooth muscle cells (VSMC) that have transdifferentiated into macrophage-like cells (MLC). Furthermore, cholesterol-laden MLC of VSMC origin have demonstrated impaired ABCA1-dependent cholesterol efflux, but it is poorly understood why this occurs. A possible mechanism which may at least partially be attributed to cholesterol-laden MLC demonstrating attenuated ABCA1-dependent cholesterol efflux is a miR-33a expression, as a primary function of this microRNA is to silence ABCA1 expression, but this has yet to be rigorously investigated. Therefore, the VSMC line MOVAS cells were used to generate miR-33a knockout (KO) MOVAS cells, and we used KO and wild-type (WT) MOVAS cells to delineate any possible proatherogenic role of miR-33a expression in VSMC. When WT and KO MOVAS cells were cholesterol-loaded to convert into MLC, this resulted in the WT MOVAS cells to exhibit impaired ABCA1-dependent cholesterol efflux. In the cholesterol-loaded WT MOVAS MLC, we also observed a delayed restoration of the VSMC phenotype when these cells were exposed to the ABCA1 cholesterol acceptor, apoAI. These results imply that miR-33a expression in VSMC drives atherosclerosis by triggering MLC transdifferentiation via attenuated ABCA1-dependent cholesterol efflux.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2023 ","pages":"8241899"},"PeriodicalIF":5.3,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10289877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10036542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cardiovascular Disease Risk in Females with Subclinical Hypothyroidism","authors":"A. Lamichhane, Pabitra Bista, Sushant Pokhrel, Kalasha Bolakhe, G. Joshi, Suraj Aryal, M. Chhusyabaga, Jyotsna Shakya, M. Bhatt","doi":"10.1155/2023/4440275","DOIUrl":"https://doi.org/10.1155/2023/4440275","url":null,"abstract":"Background. Subclinical hypothyroidism (SCH) is a common endocrine disorder prevalent in the Nepalese female population. Dyslipidemia, a prerequisite to the development of cardiovascular disease, links the thyroid profile and cardiovascular disease risk. This study is aimed at assessing the cardiovascular disease risk in females with SCH. Methods. This laboratory-based cross-sectional study was carried out at Manmohan Memorial Teaching Hospital, Kathmandu, Nepal, where 100 females with SCH and 100 euthyroid controls were included. Estimates of thyroid and lipid profiles were made, and lipid variables were used to calculate lipid indices. Results. In comparison to controls, females with SCH had significantly higher lipid profiles, thyroid profiles, and lipid indices but significantly lower HDL-C. The TSH (\u0000 \u0000 p\u0000 <\u0000 0.001\u0000 \u0000 ), TG (\u0000 \u0000 p\u0000 =\u0000 0.039\u0000 \u0000 ), VLDL (\u0000 \u0000 p\u0000 =\u0000 0.039\u0000 \u0000 ), and AIP (\u0000 \u0000 p\u0000 =\u0000 0.031\u0000 \u0000 ) were significantly associated with mild and severe SCH. AIP was significantly correlated with TSH (\u0000 \u0000 r\u0000 =\u0000 0.256\u0000 \u0000 , \u0000 \u0000 p\u0000 =\u0000 0.010\u0000 \u0000 ) among SCH females. Conclusion. Our findings suggest that women with SCH are more likely to get CVD. Hence, timely monitoring of cardiovascular status among females with SCH is crucial, and it can be performed using simple lipid indices like AIP, AI, and LCI.","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"13 1","pages":""},"PeriodicalIF":5.3,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91328003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics, Safety, Cost-Effectiveness, and Accessibility of Injectable Lipid-Lowering Agents: A Narrative Review.","authors":"Abdulmajeed Abdulghani A Sindi","doi":"10.1155/2023/2025490","DOIUrl":"10.1155/2023/2025490","url":null,"abstract":"<p><p>Cardiovascular disease causes significant personal, financial, and societal burden and is a major cause of mortality and morbidity globally. Dyslipidemia has proven to be a major factor that contributes to its increased incidence; thus, since a long time, low-density lipoprotein cholesterol-lowering therapies have been employed to reduce coronary artery disease-associated mortality. The first-line therapy for hyperlipidemia and dyslipidemia is statins. Evidence showed that statins decrease the level of LDL-C resulting in a lower risk of CVD (20-25% for every decrease of 1 mmol/L). However, due to statin intolerance in some patients and despite using maximal doses, they have not been successful in lowering cardiovascular-associated mortality. Moreover, bococizumab was recently suspended due to its higher immunogenicity with time, resulting in less efficacy with long-term use. Alternatives to statins are PCSK9 inhibitors which are administered subcutaneously every two or four weeks. They are injectables with considerable lipid-lowering properties. This narrative review discusses their genetics, safety, tolerability, and cost-effectiveness. It also quantifies their benefit in certain subgroups by analyzing the findings from recent randomized clinical trials. Current data from phase 2 and 3 trials (ORION, ODYSSEY, and FOURIER) suggest a favorable profile for evolocumab, alirocumab, and inclisiran with minimal tolerable side effects and superior efficacy in statin-intolerant patients. Their cost-effectiveness has not yet been established clearly, but future outcomes seem promising.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2023 ","pages":"2025490"},"PeriodicalIF":5.9,"publicationDate":"2023-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9498357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and Pathological Functions of TMEM30A: An Essential Subunit of P4-ATPase Phospholipid Flippases.","authors":"Jingyi Li,&nbsp;Yue Zhao,&nbsp;Na Wang","doi":"10.1155/2023/4625567","DOIUrl":"https://doi.org/10.1155/2023/4625567","url":null,"abstract":"<p><p>Phospholipids are asymmetrically distributed across mammalian plasma membrane. The function of P4-ATPases is to maintain the abundance of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in the inner leaflet as lipid flippases. Transmembrane protein 30A (TMEM30A, also named CDC50A), as an essential <i>β</i> subunit of most P4-ATPases, facilitates their transport and functions. With TMEM30A knockout mice or cell lines, it is found that the loss of TMEM30A has huge influences on the survival of mice and cells because of PS exposure-triggered apoptosis signaling. TMEM30A is a promising target for drug discovery due to its significant roles in various systems and diseases. In this review, we summarize the functions of TMEM30A in different systems, present current understanding of the protein structures and mechanisms of TMEM30A-P4-ATPase complexes, and discuss how these fundamental aspects of TMEM30A may be applied to disease treatment.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2023 ","pages":"4625567"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9491001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19.","authors":"Jafar Mohammadshahi,&nbsp;Hassan Ghobadi,&nbsp;Golchin Matinfar,&nbsp;Mohammad Hossein Boskabady,&nbsp;Mohammad Reza Aslani","doi":"10.1155/2023/6329873","DOIUrl":"https://doi.org/10.1155/2023/6329873","url":null,"abstract":"Background Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood glucose (FBG)/HDL-C ratio are valuable indicators that have been studied in various disorders to predict mortality. The present study was conducted with the aim of investigating the role of lipid profile ratios in predicting mortality in COVID-19 patients. Methods At the beginning of hospitalization, laboratory tests were taken from all patients (n = 300). The ability of lipid profile ratios to determine the COVID-19 severity was evaluated using receiver-operating characteristic (ROC). In addition, survival probability was determined with the average of Kaplan-Meier curves, so that the end point was death. Results In deceased patients, TG, TC, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C parameters were significantly lower than those of surviving patients, while WBC/HDL-C and FBG/HDL-C were significantly higher. TC (HR = 3.178, 95%CI = 1.064 to 9.491, P < 0.05), TG (HR = 3.276, 95%CI = 1.111 to 9.655, P < 0.05), LDL-C (HR = 3.207, 95%CI = 1.104 to 9.316, P < 0.05), and HDL-C (HR = 3.690, 95%CI = 1.290 to 10.554, P < 0.05), as well as TC/HDL-C (HR = 3.860, 95%CI = 1.289 to 11.558, P < 0.05), TG/HDL-C (HR = 3.860, 95%CI = 1.289 to 11.558, P < 0.05), LDL-C/HDL-C (HR = 3.915, 95%CI = 1.305 to 11.739, P < 0.05), WBC/HDL-C (HR = 3.232, 95%CI = 1.176 to 8.885, P < 0.05), and FBG/HDL-C ratios (HR = 4.474, 95%CI = 1.567 to 12.777, P < 0.01), were detectably related to survival. The multivariate Cox regression models showed that only FBG/HDL-C ratio (HR = 5.477, 95%CI = 1.488 to 20.153, P < 0.01) was significantly related to survival. Conclusion The results suggested that FBG/HDL-C ratio in hospital-admitted COVID-19 patients was a reliable predictor of mortality.","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2023 ","pages":"6329873"},"PeriodicalIF":5.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Arginase-2 mRNA Levels by <i>ω</i>-3 PUFAs and Aspirin in Asthmatic Human Lung Fibroblasts.","authors":"Vamsee K Duggirala,&nbsp;Kyla Geary,&nbsp;Donald Hasenmayer,&nbsp;Farzaneh Daghigh","doi":"10.1155/2022/3062274","DOIUrl":"https://doi.org/10.1155/2022/3062274","url":null,"abstract":"<p><p>Airway remodeling (AR) increases disease severity, and morbidity of asthmatic patients by contributing to irreversible airflow obstruction and progressive declines in lung function. Arginase isoenzymes and the downstream enzymes ornithine decarboxylase (ODC) and ornithine aminotransferase (OAT) have been implicated in the hyperplastic and fibrotic changes of AR, respectively. Omega-3 polyunsaturated fatty acids (<i>ω</i>-3 PUFAs) and resolvin metabolites have anti-AR effects, but whether they are mediated through the arginase pathway is unclear. Our study intended to determine the effects of the <i>ω</i>-3 PUFAs eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), resolvin D1 (RvD1), T_H1 cytokines, acetylsalicylic acid (ASA), cAMP, and dexamethasone (DEX) on the expression of arginase isoenzymes arginase 1 (ARG1) and arginase 2 (ARG2), ODC, and OAT in human lung fibroblasts (HLF) from normal (NHLF) and diseased (DHLF) asthmatic donors using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR). Our data showed that EPA and EPA+DHA downregulated ARG2 mRNA 2-fold in both types of HLF. DHA, RvD1, and DEX did not alter mRNA levels for any of the genes studied. EPA lowered the ARG2 protein levels in DHLF, but did not affect those levels in NHLF. ASA upregulated ARG2 mRNA 5-fold and 7-fold in NHLF and DHLF, respectively, T_H1 cytokines downregulated ARG2, ODC, and OAT mRNA in DHLF 10-fold, 2-fold, and 2.5-fold, respectively, and cAMP downregulated ARG2 mRNA 2-fold in DHLF. These results are the first to show a direct effect of <i>ω</i>-3 PUFAs on ARG2 mRNA levels and provide further evidence for a role of <i>ω</i>-3 PUFAs in AR.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":" ","pages":"3062274"},"PeriodicalIF":5.3,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40347742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Characterization and Antibacterial Properties of <i>Fontitrygon margarita</i> (Günther, 1870) Liver Oil.","authors":"Boris Simo Noutsa,&nbsp;Sammuel Raymond Tchabong,&nbsp;Arlette Danelle Deutchoua Djitieu,&nbsp;Fabrice Fabien Dongho Dongmo,&nbsp;Fabrice Hervé Njike Ngamga,&nbsp;Ronice Zokou,&nbsp;Ousman Tamgue,&nbsp;Rosalie Anne Ngono Ngane,&nbsp;François Tchoumbougnang","doi":"10.1155/2022/9369387","DOIUrl":"https://doi.org/10.1155/2022/9369387","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the chemical characteristics and antibacterial activity of <i>Fontitrygon margarita</i> liver oil against the bacteria responsible for food poisoning.</p><p><strong>Methods: </strong>Oils were extracted from <i>F. margarita</i> liver using two methods (exudation and cooking-pressing) and analyses by Fourier transform infrared (FTIR) spectroscopy. Quality indexes were determined using standard methods and the fatty acid profile was carried out by gas chromatography with a flame ionization detector (GC-FID). Antibacterial activities of these oils, their emulsion, and their interactions with common antibiotics were evaluated by the broth microdilution method.</p><p><strong>Results: </strong>Extraction yield was higher with cooking-pressing (16.90%) compared to exudation (14.49%). The quality indexes of both oils were conformed to Codex Alimentarius Standard. Thiobarbituric acid index was higher with exudation compared to cooking-pressing (3.20 ± 0.14 and 2.36 ± 0.14 <i>μ</i>mol MDA/kg, respectively) while acid, iodine, peroxide, and anisidine values did not significantly vary with the extraction methods (2.15-2.30 mgKOH/g, 102.42-106.65 gI₂/100 g, 3.34-3.57 meqO₂/kg, and 2.85-3.32 respectively). FTIR analyses clearly show that the two spectra are similar (no differences in the frequency and absorbance of their bands). The fatty acid profile revealed that, regardless of the extraction methods, <i>F. margarita</i> oil is richer in monounsaturated (55.97-55.41%) followed by polyunsaturated (28.17-28.52%) and saturated fatty acids (15.86-16.07%). Moreover, these oils showed antibacterial activity on all the bacteria strains tested with MICs between 16 and 256 mg/ml. Regardless of the extraction methods, emulsions showed higher activity (6.25 ≤ MIC ≤25 mg/ml) compared to crude oils. Additionally, <i>F. margarita</i> liver oil potentiated the antibacterial activity of ciprofloxacin, tetracycline, gentamicin, amoxicillin, and chloramphenicol.</p><p><strong>Conclusion: </strong>These results showed the effectiveness of <i>Fontitrygon margarita</i> liver oil against some bacteria responsible for food poisoning, thus demonstrating their antibacterial properties which could be due to their chemical composition.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":" ","pages":"9369387"},"PeriodicalIF":5.3,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40612245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LipoxinA4 as a Potential Prognostic Marker of COVID-19.","authors":"Farzaneh Jamali,&nbsp;Bita Shahrami,&nbsp;Amirmahdi Mojtahedzadeh,&nbsp;Farhad Najmeddin,&nbsp;Amir Ahmad Arabzadeh,&nbsp;Azar Hadadi,&nbsp;Mohammad Sharifzadeh,&nbsp;Mojtaba Mojtahedzadeh","doi":"10.1155/2022/8527305","DOIUrl":"https://doi.org/10.1155/2022/8527305","url":null,"abstract":"<p><p>This pilot study aimed to determine early changes of LXA₄ levels among the hospitalized patients confirmed as COVID-19 cases following the clinical management and its correlation with commonly used inflammatory markers, including erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and ferritin. Thirty-one adult hospitalized patients infected with the non-severe COVID-19 were included. LXA₄ levels were measured at the baseline and 48-72 hours after hospitalization. Accordingly, ESR and CRP levels were collected on the first day of hospitalization. Moreover, the maximum serum ferritin levels were determined during the five days. LXA₄ levels significantly increased at 48-72 hours compared to the baseline. ESR, CRP, and ferritin levels were positively correlated with the increased LXA4. In contrast, aging was shown to negatively correlate with the increased LXA₄ levels. LXA₄ may be known as a valuable marker to assess the treatment response among non-elderly patients with non-severe COVID-19. Furthermore, LXA₄ could be considered as a potential treatment option under inflammatory conditions. Further studies are necessary to clarify LXA₄ role in COVID-19 pathogenesis, as well as the balance between such pro-resolving mediators and inflammatory parameters.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":" ","pages":"8527305"},"PeriodicalIF":5.3,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40580262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Dimorphism and Sex-2D : 4D Interactions on Fasting Lipid Variables in an Adult Ghanaian Population.","authors":"Moses Banyeh,&nbsp;Nafiu Amidu,&nbsp;Draman Abdul-Wahab,&nbsp;Abdul-Salim Zakaria","doi":"10.1155/2022/3303588","DOIUrl":"https://doi.org/10.1155/2022/3303588","url":null,"abstract":"<p><p>Prenatal hormone exposure has been suggested as a correlate of adult circulating estrogen and testosterone. If this observation is true, then prenatal hormone exposure may have an association with lipid homeostasis in adulthood. The study sought to investigate sexual dimorphism and the interactions between the putative marker of prenatal hormone exposure (2D : 4D) and sex on adult fasting plasma lipid variables. The study was cross-sectional from June to December 2021 at the University for Development Studies. The participants were between 18 and 30 years of age and consisted of 206 healthy persons (female = 93, male = 113). The right hand (2D : 4DR), the left hand (2D : 4DL), and the right-left 2D : 4D difference (Dr-l) were measured using computer-assisted analysis. Fasting venous blood samples were collected and analyzed for lipid variables including total cholesterol (TCHOL) and high-density lipoprotein cholesterol (HDL-C). There were no significant differences in the 2D : 4D ratio and lipid variables between males and females. However, after adjusting for age and BMI, the 2D : 4DR (<i>P</i> = 0.014) and the 2D : 4DL (<i>P</i> = 0.007) increased with increasing fasting plasma HDL-C on average. Moreover, there were significant interactions between sex and the 2D : 4DR (<i>P</i> = 0.002) and also, the 2D : 4DL (<i>P</i> = 0.005) on fasting plasma HDL-C. The relationship between HDL-C and the 2D : 4D ratio was positive in females but negative in males. The 2D : 4DR accounted for about 54.9% and 46.0% while the 2D : 4DL accounted for about 48.2% and 14.0% of the variabilities in fasting plasma HDL-C in females and males, respectively. Prenatal hormone exposure may partly account for the sexual dimorphism in adult lipid homeostasis.</p>","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":" ","pages":"3303588"},"PeriodicalIF":5.3,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}