Assessment of Cardiovascular Disease Risk in Females with Subclinical Hypothyroidism

IF 5.9 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Lipids Pub Date : 2023-04-28 DOI:10.1155/2023/4440275

A. Lamichhane, Pabitra Bista, Sushant Pokhrel, Kalasha Bolakhe, G. Joshi, Suraj Aryal, M. Chhusyabaga, Jyotsna Shakya, M. Bhatt

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Abstract

Background. Subclinical hypothyroidism (SCH) is a common endocrine disorder prevalent in the Nepalese female population. Dyslipidemia, a prerequisite to the development of cardiovascular disease, links the thyroid profile and cardiovascular disease risk. This study is aimed at assessing the cardiovascular disease risk in females with SCH. Methods. This laboratory-based cross-sectional study was carried out at Manmohan Memorial Teaching Hospital, Kathmandu, Nepal, where 100 females with SCH and 100 euthyroid controls were included. Estimates of thyroid and lipid profiles were made, and lipid variables were used to calculate lipid indices. Results. In comparison to controls, females with SCH had significantly higher lipid profiles, thyroid profiles, and lipid indices but significantly lower HDL-C. The TSH ( p < 0.001 ), TG ( p = 0.039 ), VLDL ( p = 0.039 ), and AIP ( p = 0.031 ) were significantly associated with mild and severe SCH. AIP was significantly correlated with TSH ( r = 0.256 , p = 0.010 ) among SCH females. Conclusion. Our findings suggest that women with SCH are more likely to get CVD. Hence, timely monitoring of cardiovascular status among females with SCH is crucial, and it can be performed using simple lipid indices like AIP, AI, and LCI.

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亚临床甲状腺功能减退症女性心血管疾病风险评估

背景。亚临床甲状腺功能减退症(SCH)是尼泊尔女性人群中常见的内分泌疾病。血脂异常是心血管疾病发展的先决条件，将甲状腺特征与心血管疾病风险联系起来。本研究旨在评估女性SCH患者的心血管疾病风险。这项以实验室为基础的横断面研究在尼泊尔加德满都的曼莫汉纪念教学医院进行，其中包括100名患有SCH的女性和100名甲状腺功能正常的对照组。估计甲状腺和脂质分布，并使用脂质变量计算脂质指数。结果。与对照组相比，患有SCH的女性的脂质谱、甲状腺谱和脂质指数显著升高，但HDL-C显著降低。TSH (p < 0.001)、TG (p = 0.039)、VLDL (p = 0.039)、AIP (p = 0.031)与轻度和重度SCH相关，AIP与TSH相关(r = 0.256, p = 0.010)。结论。我们的研究结果表明，患有SCH的女性更容易患心血管疾病。因此，及时监测女性SCH患者的心血管状况至关重要，可通过简单的脂质指标如AIP、AI、LCI进行监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Lipids BIOCHEMISTRY & MOLECULAR BIOLOGY-

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Journal of Lipids is a peer-reviewed, Open Access journal that publishes original research articles and review articles related to all aspects of lipids, including their biochemistry, synthesis, function in health and disease, and nutrition. As an interdisciplinary journal, Journal of Lipids aims to provide a forum for scientists, physicians, nutritionists, and other relevant health professionals.