Journal of Lipids最新文献_第10页

Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. 补充苦瓜对肥胖及代谢综合征相关并发症的有益作用。

IF 5.3

Journal of Lipids Pub Date : 2015-01-01 Epub Date: 2015-01-12 DOI: 10.1155/2015/496169

Md Ashraful Alam, Riaz Uddin, Nusrat Subhan, Md Mahbubur Rahman, Preeti Jain, Hasan Mahmud Reza

{"title":"Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.","authors":"Md Ashraful Alam, Riaz Uddin, Nusrat Subhan, Md Mahbubur Rahman, Preeti Jain, Hasan Mahmud Reza","doi":"10.1155/2015/496169","DOIUrl":"https://doi.org/10.1155/2015/496169","url":null,"abstract":"Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2015 ","pages":"496169"},"PeriodicalIF":5.3,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/496169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33353033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 102

Usefulness of lipid apheresis in the treatment of familial hypercholesterolemia. 脂质分离术治疗家族性高胆固醇血症的有效性。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-10-19 DOI: 10.1155/2014/864317

Matthew Lui, Ross Garberich, Craig Strauss, Thomas Davin, Thomas Knickelbine

{"title":"Usefulness of lipid apheresis in the treatment of familial hypercholesterolemia.","authors":"Matthew Lui, Ross Garberich, Craig Strauss, Thomas Davin, Thomas Knickelbine","doi":"10.1155/2014/864317","DOIUrl":"https://doi.org/10.1155/2014/864317","url":null,"abstract":"Lipid apheresis is used to treat patients with severe hyperlipidemia by reducing low-density lipoprotein cholesterol (LDL-C). This study examines the effect of apheresis on the lipid panel and cardiac event rates before and after apheresis. An electronic health record screen of ambulatory patients identified 11 active patients undergoing lipid apheresis with 10/11 carrying a diagnosis of FH. Baseline demographics, pre- and postapheresis lipid levels, highest recorded LDL-C, cardiac events, current medications, and first apheresis treatment were recorded. Patients completed a questionnaire and self-reported risk factors and interest in alternative treatment. There were significant reductions in mean total cholesterol (-58.4%), LDL-C (-71.9%), triglycerides (-51%), high-density lipoprotein (HDL) cholesterol (-9.3%), and non-HDL (-68.2%) values. Thirty-four cardiac events were documented in 8 patients before apheresis, compared with 9 events in 5 patients after apheresis. Our survey showed a high prevalence of statin intolerance (64%), with the majority (90%) of participants indicating an interest in alternative treatment options. Our results have shown that lipid apheresis primary effect is a marked reduction in LDL-C cholesterol levels and may reduce the recurrence of cardiac events. Apheresis should be compared to the newer alternative treatment modalities in a randomized fashion due to patient interest in alternative options. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"864317"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/864317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32806169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Spice up your life: adipose tissue and inflammation. 为您的生活增添色彩：脂肪组织与炎症。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-02-20 DOI: 10.1155/2014/182575

Anil K Agarwal

引用次数: 0

Why fish oil fails: a comprehensive 21st century lipids-based physiologic analysis. 为什么鱼油不起作用:一个全面的21世纪基于脂质的生理分析。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-01-16 DOI: 10.1155/2014/495761

B S Peskin

{"title":"Why fish oil fails: a comprehensive 21st century lipids-based physiologic analysis.","authors":"B S Peskin","doi":"10.1155/2014/495761","DOIUrl":"https://doi.org/10.1155/2014/495761","url":null,"abstract":"The medical community suffered three significant fish oil failures/setbacks in 2013. Claims that fish oil's EPA/DHA would stop the progression of heart disease were crushed when The Risk and Prevention Study Collaborative Group (Italy) released a conclusive negative finding regarding fish oil for those patients with high risk factors but no previous myocardial infarction. Fish oil failed in all measures of CVD prevention-both primary and secondary. Another major 2013 setback occurred when fish oil's DHA was shown to significantly increase prostate cancer in men, in particular, high-grade prostate cancer, in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) analysis by Brasky et al. Another monumental failure occurred in 2013 whereby fish oil's EPA/DHA failed to improve macular degeneration. In 2010, fish oil's EPA/DHA failed to help Alzheimer's victims, even those with low DHA levels. These are by no means isolated failures. The promise of fish oil and its so-called active ingredients EPA / DHA fails time and time again in clinical trials. This lipids-based physiologic review will explain precisely why there should have never been expectation for success. This review will focus on underpublicized lipid science with a focus on physiology. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"495761"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/495761","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32137841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Prevalence of Dyslipidemia and Management in the Thai Population, National Health Examination Survey IV, 2009. 泰国人群血脂异常患病率及管理，国家健康调查IV, 2009。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-03-30 DOI: 10.1155/2014/249584

Wichai Aekplakorn, Surasak Taneepanichskul, Pattapong Kessomboon, Virasakdi Chongsuvivatwong, Panwadee Putwatana, Piyamitr Sritara, Somkiat Sangwatanaroj, Suwat Chariyalertsak

{"title":"Prevalence of Dyslipidemia and Management in the Thai Population, National Health Examination Survey IV, 2009.","authors":"Wichai Aekplakorn, Surasak Taneepanichskul, Pattapong Kessomboon, Virasakdi Chongsuvivatwong, Panwadee Putwatana, Piyamitr Sritara, Somkiat Sangwatanaroj, Suwat Chariyalertsak","doi":"10.1155/2014/249584","DOIUrl":"https://doi.org/10.1155/2014/249584","url":null,"abstract":"This study determined the prevalence and management of dyslipidemia in Thai adults using data from the Thai National Health Examination Survey IV in 2009. Dyslipidemia was defined based on the Third Adult Treatment Panel guidelines. A total of 19,021 adults aged 20 yr and over were included. Mean (SE) levels of total cholesterol, HDL-C, LDL-C, and triglycerides were 206.4 (1.03), 46.9 (0.34), 128.7 (1.09), and 131.4 (2.20) mg/dL, respectively. Prevalence of high LDL-C, low HDL-C, and high triglycerides were 29.6 %, 47.1 %, and 38.6%, respectively. Compared with individuals in the north and northeast, residents in Bangkok and Central region had significant higher levels of LDL-C but lower level of HDL-C. Triglyceride level was the highest in the northeast residents. Overall, 66.5% of Thais had some forms of dyslipidemia. Awareness and treatment of high LDL-C among those with high LDL-C were 17.8% and 11.7%, respectively. Among individuals aware of high LDL-C, those at highest CHD risk compared with those at low risk had higher percentage of treatment (73.1% versus 51.7%, resp.) but lower percentage of control at goal (32.9% versus 76.4%, resp.). Various forms of dyslipidemia are common in Thai adults, with a low level of awareness and treatment of high LDL-C. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"249584"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/249584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32319038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Comparison of carotid intima-media thickness in pediatric patients with metabolic syndrome, heterozygous familial hyperlipidemia and normals. 代谢综合征、杂合子家族性高脂血症与正常儿童颈动脉内膜-中膜厚度的比较。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-05-14 DOI: 10.1155/2014/546863

Arvind Vijayasarathi, Stanley J Goldberg

{"title":"Comparison of carotid intima-media thickness in pediatric patients with metabolic syndrome, heterozygous familial hyperlipidemia and normals.","authors":"Arvind Vijayasarathi, Stanley J Goldberg","doi":"10.1155/2014/546863","DOIUrl":"https://doi.org/10.1155/2014/546863","url":null,"abstract":"Background. Our goal was to compare the carotid intimal-medial thickness (CIMT) of untreated pediatric patients with metabolic syndrome (MS), heterozygous familial hyperlipidemia (heFH), and MS+heFH against one another and against a control group consisting of healthy, normal body habitus children. Methods. Our population consisted of untreated pediatric patients (ages 5-20 yrs) who had CIMT measured in a standardized manner. Results. Our population included 57 with MS, 23 with heFH, and 10 with MS+heFH. The control group consisted of 84 children of the same age range. Mean CIMT for the MS group was 469.8 μ m (SD = 67), 443.8 μ m (SD = 61) for the heFH group, 478.3 μ m (SD = 70) for the MS+heFH group, and 423.2 μ m (SD = 45) for the normal control group. Significance differences between groups occurred for heFH versus MS (P = 0.022), heFH versus control (P = 0.038), MS versus control (P = 9.0E - 10), and MS+heFH versus control (P = 0.003). Analysis showed significant negative correlation between HDL and CIMT (r = -0.32, P = 0.03) but not for LDL, triglycerides, BP, waist circumference, or BMI. Conclusion. For pediatric patients, the thickest CIMT occurred for patients with MS alone or for those with MS+heFH. This indicates that MS, rather than just elevated LDL, accounts for more rapid thickening of CIMT in this population. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"546863"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/546863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32447485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Association of high density lipoprotein with platelet to lymphocyte and neutrophil to lymphocyte ratios in coronary artery disease patients. 高密度脂蛋白与冠心病患者血小板和淋巴细胞比率以及中性粒细胞和淋巴细胞比率的关系。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-11-16 DOI: 10.1155/2014/686791

Jayesh H Prajapati, Sibasis Sahoo, Tushar Nikam, Komal H Shah, Bhumika Maheriya, Meena Parmar

{"title":"Association of high density lipoprotein with platelet to lymphocyte and neutrophil to lymphocyte ratios in coronary artery disease patients.","authors":"Jayesh H Prajapati, Sibasis Sahoo, Tushar Nikam, Komal H Shah, Bhumika Maheriya, Meena Parmar","doi":"10.1155/2014/686791","DOIUrl":"10.1155/2014/686791","url":null,"abstract":"Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients. Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected. Results. We have observed significant association between HDL and PLR (P = 0.008) and NLR (P = 0.009); however no significant relationship was obtained with HDL and isolated platelet (P = 0.488), neutrophil (P = 0.407), and lymphocyte (P = 0.952) counts in CAD patients. The association was subjected to gender specific variation as in males PLR (P = 0.024) and NLR (P = 0.03) were highly elevated in low HDL patients, whereas in females the elevation could not reach the statistically significant level. The PLR (217.47 versus 190.3; P = 0.01) and NLR (6.33 versus 5.10; P = 0.01) were significantly higher among the patients with acute coronary syndrome. In young patients the PLR (P = 0.007) and NLR (P = 0.001) were inversely associated with HDL, whereas in older population only NLR (P = 0.05) had showed a significant association. Conclusion. We conclude that PLR and NLR are significantly elevated in CAD patients having low HDL levels. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"686791"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32884600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical characteristics of citrus seed oils from kerman, iran. 伊朗克尔曼柑橘籽油的理化特性。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-07-17 DOI: 10.1155/2014/174954

Mohammad Reazai, Issa Mohammadpourfard, Shahrokh Nazmara, Mahdi Jahanbakhsh, Leila Shiri

引用次数: 20

Retracted: why fish oil fails: a comprehensive 21st century lipids-based physiologic analysis. 撤回:为什么鱼油失败:一个全面的21世纪基于脂质的生理分析。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-11-05 DOI: 10.1155/2014/832729

Journal Of Lipids

引用次数: 0

Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C. 血清PCSK9水平可区分对高剂量他汀类药物治疗无反应的个体，并可降低LDL-C。

IF 5.3

Journal of Lipids Pub Date : 2014-01-01 Epub Date: 2014-07-17 DOI: 10.1155/2014/140723

Beth A Taylor, Gregory Panza, Linda S Pescatello, Stuart Chipkin, Daniel Gipe, Weiping Shao, C Michael White, Paul D Thompson

{"title":"Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C.","authors":"Beth A Taylor, Gregory Panza, Linda S Pescatello, Stuart Chipkin, Daniel Gipe, Weiping Shao, C Michael White, Paul D Thompson","doi":"10.1155/2014/140723","DOIUrl":"https://doi.org/10.1155/2014/140723","url":null,"abstract":"The purpose of the present report was to examine whether proprotein convertase subtilisin/kexin type 9 (PCSK9) levels differ in individuals who do not exhibit expected reductions in low density lipoprotein cholesterol (LDL-C) with statin therapy. Eighteen nonresponder subjects treated with 80 mg atorvastatin treatment for 6 months without substantial reductions in LDL-C (ΔLDL-C: 2.6 ± 11.4%) were compared to age- and gender-matched atorvastatin responders (ΔLDL-C: 50.7 ± 8.5%) and placebo-treated subjects (ΔLDL-C: 9.9 ± 21.5%). Free PCSK9 was marginally higher in nonresponders at baseline (P = 0.07) and significantly higher in atorvastatin responders after 6 months of treatment (P = 0.04). The change in free PCSK9 over 6 months with statin treatment was higher (P < 0.01) in atorvastatin responders (134.2 ± 131.5 ng/mL post- versus prestudy) than in either the nonresponders (39.9 ± 87.8 ng/mL) or placebo subjects (27.8 ± 97.6 ng/mL). Drug compliance was not lower in the nonresponders as assessed by pill counts and poststudy plasma atorvastatin levels. Serum PCSK9 levels, both at baseline and in response to statin therapy, may differentiate individuals who do versus those who do not respond to statin treatment. ","PeriodicalId":16274,"journal":{"name":"Journal of Lipids","volume":"2014 ","pages":"140723"},"PeriodicalIF":5.3,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/140723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32596867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11