Journal of Interferon and Cytokine Research最新文献_第6页

Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20. 解密白细胞介素-19 和白细胞介素-20 受体介导的信号传导途径。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-06 DOI: 10.1089/jir.2024.0009

Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya

引用次数: 0

An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation. 抗CD138靶向干扰素-α通过直接杀伤肿瘤细胞和瘤内免疫调节对实体瘤具有广泛疗效

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI: 10.1089/jir.2024.0099

Tahmineh Safaie, Kham R Trinh, Alex Vasuthasawat, Sherie L Morrison, David R Stover

引用次数: 0

Roles of IL-4, IL-13, and Their Receptors in Lung Cancer. IL-4、IL-13 及其受体在肺癌中的作用

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-22 DOI: 10.1089/jir.2024.0008

Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu

引用次数: 0

Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β. 多发性硬化症中的替代剪接：干扰素-β治疗反应的有望生物标志物

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI: 10.1089/jir.2024.0108

Suhayl Dhib-Jalbut

引用次数: 0

Age-Dependent Signature of Serum Inflammatory Cytokines in Healthy Children and Young Adults. 健康儿童和青少年血清炎症细胞因子的年龄特征

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1089/jir.2024.0053

Maarten Buytaert, Rachida El Kaddouri, Levi Hoste, Bram Meertens, Simon Jan Tavernier, Karlien Claes, Veronique Debacker, Jo Dehoorne, Filomeen Haerynck

{"title":"Age-Dependent Signature of Serum Inflammatory Cytokines in Healthy Children and Young Adults.","authors":"Maarten Buytaert, Rachida El Kaddouri, Levi Hoste, Bram Meertens, Simon Jan Tavernier, Karlien Claes, Veronique Debacker, Jo Dehoorne, Filomeen Haerynck","doi":"10.1089/jir.2024.0053","DOIUrl":"10.1089/jir.2024.0053","url":null,"abstract":"The study of sensitive and specific biomarkers, such as blood inflammatory cytokines, could provide an answer to the challenges faced in the differential diagnosis of patients with systemic inflammation. Limited data exist on the impact of age on serum levels of inflammatory cytokines. We collected serum samples of 42 healthy children and young adults (1 month to 21 years). Serum levels of interleukin 1 receptor antagonist (IL-1Ra), IL-1β, IL-6, IL-18, tumor necrosis factor-alpha (TNF-α), CXCL9, and CXCL10 were measured. Data were analyzed for three different age groups (<6, 6-17, and 18-21 years). IL-18, TNF-α, and CXCL9 values varied significantly according to age group. Median values of IL-18 and TNF-α decline with age, whereas CXCL9 and CXCL10 are lowest at 6-17 years. IL-1Ra is stable among age groups. In the majority of cases, IL-1β and IL-6 are not measurable above the lower limit of quantification. A scoping literature review revealed highly variable data on IL-1Ra, IL-18, TNF-α, and CXCL10. For CXCL9, pediatric reference data are scarce. In conclusion, we report an age-dependent signature of multiple inflammatory cytokines measured in the serum of healthy children and young adults, suggesting the need to use age-specific reference values in future pediatric studies.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"372-378"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay Between Cytokines and MicroRNAs to Regulate Metabolic Disorders. 细胞因子与 MicroRNA 之间的相互作用可调节代谢紊乱。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-31 DOI: 10.1089/jir.2024.0059

Li Zhang, Li Zhang, Huan Chen, Xiangyong Xu

引用次数: 0

Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis. COVID-19 患者的细胞因子特征和免疫失调：转录组和血清分析

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1089/jir.2024.0083

Nikola Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, José Francisco Muñoz-Valle, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone

{"title":"Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis.","authors":"Nikola Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, José Francisco Muñoz-Valle, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone","doi":"10.1089/jir.2024.0083","DOIUrl":"10.1089/jir.2024.0083","url":null,"abstract":"COVID-19, caused by the SARS-CoV-2 virus, has caused a global health crisis, necessitating a deeper understanding of its pathophysiology. In this study, we explored the immune and hematological dynamics in COVID-19 patients to gain insights into disease severity and prognosis. Our findings revealed distinct cytokine profiles in moderate and severe cases. IL12A was significantly upregulated in peripheral blood mononuclear cells from moderate cases, suggesting a potential role in initiating an effective immune response. Conversely, severe cases exhibited downregulation of key pro-inflammatory cytokines (IL23A, TNFalpha, IL1B, and IFNG) alongside an upregulation of the immunosuppressive IL10, indicative of a dysregulated immune environment. Serum analysis showed elevated IL6 and IL10 levels in both moderate and severe cases, emphasizing their potential as markers for disease severity. Notably, no significant differences in serum cytokines were found between recovery and lethal cases. In lethal cases of COVID-19, elevated D-dimer, urea, and creatinine correlated with IL6 and IL10. This study contributes valuable information to the ongoing efforts to understand and manage the dysregulated immune responses underlying COVID-19 pathology.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"379-385"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alternative Splicing of RNA Is Excessive in Multiple Sclerosis and Not Linked to Gene Expression Levels: Dysregulation Is Corrected by IFN-β. 多发性硬化症患者的 RNA 替代剪接过多，且与基因表达水平无关：IFN-β 可纠正失调。

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-05-02 DOI: 10.1089/jir.2024.0032

Anthony T Reder, Aika Goel, Tzintzuni Garcia, Xuan Feng

引用次数: 0

The Role of Interleukin-22 in Controlling Virus Infections at Mucosal Surfaces. 白细胞介素-22 在控制黏膜表面病毒感染中的作用

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1089/jir.2024.0097

Cuncai Guo, Steeve Boulant, Megan Lynn Stanifer

引用次数: 0

The Effective Inhibitory Concentration of Interferon-β Correlates with Infectivity and Replication Fitness of SARS-CoV-2 Variants. 干扰素-β的有效抑制浓度与SARS-CoV-2变体的感染性和复制能力有关

IF 1.9 4区医学

Journal of Interferon and Cytokine Research Pub Date : 2024-07-01 Epub Date: 2024-04-01 DOI: 10.1089/jir.2024.0016

Janmejay Singh, Anbalagan Anantharaj, Parveen Kumar, Rajesh Pandey, Anil Kumar Pandey, Guruprasad R Medigeshi

{"title":"The Effective Inhibitory Concentration of Interferon-β Correlates with Infectivity and Replication Fitness of SARS-CoV-2 Variants.","authors":"Janmejay Singh, Anbalagan Anantharaj, Parveen Kumar, Rajesh Pandey, Anil Kumar Pandey, Guruprasad R Medigeshi","doi":"10.1089/jir.2024.0016","DOIUrl":"10.1089/jir.2024.0016","url":null,"abstract":"India saw a spike in COVID-19 cases in early 2023, and this wave of infection was attributed to XBB sublineages of SARS-CoV-2 Omicron variant. The impact of XBB wave was significantly shorter with low burden of severe cases or hospitalization as compared with previous SARS-CoV-2 variants of concern. Although a combination of old and new mutations in the spike region of XBB.1.16 variant led to a drastic reduction in the ability of antibodies from prior immunity to neutralize this virus, additional nonspike mutations suggested a possible change in its ability to suppress innate immune responses. In this study, we tested the sensitivity of Delta, BA.2.75, and XBB.1.16 variants to interferon-β (IFN-β) treatment and found that XBB.1.16 variant was most sensitive to IFN-β. We next tested the ability of serum antibodies from healthy individuals to neutralize XBB.1.16. We showed that most of the individuals with hybrid immunity maintained a low but significant level of neutralizing antibodies to XBB.1.16 variant. Therefore, our observations indicated that both hybrid immunity because of natural infection and enhanced sensitivity to IFNs may have contributed to the low impact of XBB.1.16 infections in India.","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"325-333"},"PeriodicalIF":1.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0