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A Comprehensive Network Map of Interleukin-26 Signaling Pathway. 白细胞介素-26 信号通路的综合网络图
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-04-19 DOI: 10.1089/jir.2024.0026
G P Suchitha, Shobha Dagamajalu, Thottethodi Subrahmanya Keshava Prasad, Rex Devasahayam Arokia Balaya
{"title":"A Comprehensive Network Map of Interleukin-26 Signaling Pathway.","authors":"G P Suchitha, Shobha Dagamajalu, Thottethodi Subrahmanya Keshava Prasad, Rex Devasahayam Arokia Balaya","doi":"10.1089/jir.2024.0026","DOIUrl":"10.1089/jir.2024.0026","url":null,"abstract":"<p><p>Interleukin-26 (IL-26) is a cytokine that belongs to the IL-20 subfamily and is primarily expressed in T helper 1 cells and Th17 memory CD4<sup>+</sup> cells. Its receptor complex, consisting of IL-20R1 and IL-10R2, activates a signaling pathway involving several proteins such as Janus kinase 1 and tyrosine-protein kinase, signal transducer and activator of transcription (STAT) 1, and STAT3. This leads to the initiation of downstream signaling cascades that play a crucial role in various biological processes, including inflammation, immune response regulation, atopic dermatitis, macrophage differentiation, osteoclastogenesis, antibacterial host defense, anti-apoptosis, and tumor growth. In this study, we curated literature data pertaining to IL-26 signaling. The curated map includes a total of seven activation/inhibition events, 16 catalysis events, 33 gene regulation events, 25 protein expression types, two transport events, and three molecular associations.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"408-413"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20. 解密白细胞介素-19 和白细胞介素-20 受体介导的信号传导途径。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-06 DOI: 10.1089/jir.2024.0009
Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya
{"title":"Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20.","authors":"Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya","doi":"10.1089/jir.2024.0009","DOIUrl":"10.1089/jir.2024.0009","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"388-398"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation. 抗CD138靶向干扰素-α通过直接杀伤肿瘤细胞和瘤内免疫调节对实体瘤具有广泛疗效
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI: 10.1089/jir.2024.0099
Tahmineh Safaie, Kham R Trinh, Alex Vasuthasawat, Sherie L Morrison, David R Stover
{"title":"An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation.","authors":"Tahmineh Safaie, Kham R Trinh, Alex Vasuthasawat, Sherie L Morrison, David R Stover","doi":"10.1089/jir.2024.0099","DOIUrl":"10.1089/jir.2024.0099","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"414-423"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of IL-4, IL-13, and Their Receptors in Lung Cancer. IL-4、IL-13 及其受体在肺癌中的作用
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-22 DOI: 10.1089/jir.2024.0008
Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu
{"title":"Roles of IL-4, IL-13, and Their Receptors in Lung Cancer.","authors":"Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu","doi":"10.1089/jir.2024.0008","DOIUrl":"10.1089/jir.2024.0008","url":null,"abstract":"<p><p>Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type 2 innate immune response, which can carry out specific signal transmission between multiple cells in the tumor immune microenvironment. IL-4 and IL-13 mediate signal transduction and regulate cellular functions in a variety of solid tumors through their shared receptor chain, the transmembrane heterodimer interleukin-4 receptor alpha/interleukin-13 receptor alpha-1 (type II IL-4 receptor). IL-4, IL-13, and their receptors can induce the formation of a variety of malignant tumors and play an important role in their progression, growth, and tumor immunity. In order to explore possible targets for lung cancer prediction and treatment, this review summarizes the characteristics and signal transduction pathways of IL-4 and IL-13, and their respective receptors, and discusses in depth their possible role in the occurrence and development of lung cancer.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"399-407"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β. 多发性硬化症中的替代剪接：干扰素-β治疗反应的有望生物标志物
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI: 10.1089/jir.2024.0108
Suhayl Dhib-Jalbut
{"title":"Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β.","authors":"Suhayl Dhib-Jalbut","doi":"10.1089/jir.2024.0108","DOIUrl":"10.1089/jir.2024.0108","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"335-336"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-Dependent Signature of Serum Inflammatory Cytokines in Healthy Children and Young Adults. 健康儿童和青少年血清炎症细胞因子的年龄特征
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1089/jir.2024.0053
Maarten Buytaert, Rachida El Kaddouri, Levi Hoste, Bram Meertens, Simon Jan Tavernier, Karlien Claes, Veronique Debacker, Jo Dehoorne, Filomeen Haerynck
{"title":"Age-Dependent Signature of Serum Inflammatory Cytokines in Healthy Children and Young Adults.","authors":"Maarten Buytaert, Rachida El Kaddouri, Levi Hoste, Bram Meertens, Simon Jan Tavernier, Karlien Claes, Veronique Debacker, Jo Dehoorne, Filomeen Haerynck","doi":"10.1089/jir.2024.0053","DOIUrl":"10.1089/jir.2024.0053","url":null,"abstract":"<p><p>The study of sensitive and specific biomarkers, such as blood inflammatory cytokines, could provide an answer to the challenges faced in the differential diagnosis of patients with systemic inflammation. Limited data exist on the impact of age on serum levels of inflammatory cytokines. We collected serum samples of 42 healthy children and young adults (1 month to 21 years). Serum levels of interleukin 1 receptor antagonist (IL-1Ra), IL-1β, IL-6, IL-18, tumor necrosis factor-alpha (TNF-α), CXCL9, and CXCL10 were measured. Data were analyzed for three different age groups (<6, 6-17, and 18-21 years). IL-18, TNF-α, and CXCL9 values varied significantly according to age group. Median values of IL-18 and TNF-α decline with age, whereas CXCL9 and CXCL10 are lowest at 6-17 years. IL-1Ra is stable among age groups. In the majority of cases, IL-1β and IL-6 are not measurable above the lower limit of quantification. A scoping literature review revealed highly variable data on IL-1Ra, IL-18, TNF-α, and CXCL10. For CXCL9, pediatric reference data are scarce. In conclusion, we report an age-dependent signature of multiple inflammatory cytokines measured in the serum of healthy children and young adults, suggesting the need to use age-specific reference values in future pediatric studies.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"372-378"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interplay Between Cytokines and MicroRNAs to Regulate Metabolic Disorders. 细胞因子与 MicroRNA 之间的相互作用可调节代谢紊乱。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-31 DOI: 10.1089/jir.2024.0059
Li Zhang, Li Zhang, Huan Chen, Xiangyong Xu
{"title":"The Interplay Between Cytokines and MicroRNAs to Regulate Metabolic Disorders.","authors":"Li Zhang, Li Zhang, Huan Chen, Xiangyong Xu","doi":"10.1089/jir.2024.0059","DOIUrl":"10.1089/jir.2024.0059","url":null,"abstract":"<p><p>Metabolic disorders represent significant public health challenges worldwide. Emerging evidence suggests that cytokines and microRNAs (miRNAs) play crucial roles in the pathogenesis of metabolic disorders by regulating various metabolic processes, including insulin sensitivity, lipid metabolism, and inflammation. This review provides a comprehensive overview of the intricate interplay between cytokines and miRNAs in the context of metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases. We discuss how dysregulation of cytokine-miRNA networks contributes to the development and progression of metabolic disorders and explore the therapeutic potential of targeting these interactions for disease management.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"337-348"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis. COVID-19 患者的细胞因子特征和免疫失调：转录组和血清分析
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1089/jir.2024.0083
Nikola Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, José Francisco Muñoz-Valle, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone
{"title":"Cytokine Signatures and Immune Dysregulation in COVID-19 Patients: Transcriptomic and Serum Analysis.","authors":"Nikola Ralchev, Silviya Lyubenova Bradyanova, Yana Valerieva Doneva, Nikolina Mihaylova, Elena Vikentieva Elefterova-Florova, Andrey Ivanov Tchorbanov, José Francisco Muñoz-Valle, Maria Cristina Petralia, Ferdinando Nicoletti, Paolo Fagone","doi":"10.1089/jir.2024.0083","DOIUrl":"10.1089/jir.2024.0083","url":null,"abstract":"<p><p>COVID-19, caused by the SARS-CoV-2 virus, has caused a global health crisis, necessitating a deeper understanding of its pathophysiology. In this study, we explored the immune and hematological dynamics in COVID-19 patients to gain insights into disease severity and prognosis. Our findings revealed distinct cytokine profiles in moderate and severe cases. <i>IL12A</i> was significantly upregulated in peripheral blood mononuclear cells from moderate cases, suggesting a potential role in initiating an effective immune response. Conversely, severe cases exhibited downregulation of key pro-inflammatory cytokines (<i>IL23A, TNFalpha, IL1B, and IFNG</i>) alongside an upregulation of the immunosuppressive <i>IL10</i>, indicative of a dysregulated immune environment. Serum analysis showed elevated IL6 and IL10 levels in both moderate and severe cases, emphasizing their potential as markers for disease severity. Notably, no significant differences in serum cytokines were found between recovery and lethal cases. In lethal cases of COVID-19, elevated D-dimer, urea, and creatinine correlated with IL6 and IL10. This study contributes valuable information to the ongoing efforts to understand and manage the dysregulated immune responses underlying COVID-19 pathology.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"379-385"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternative Splicing of RNA Is Excessive in Multiple Sclerosis and Not Linked to Gene Expression Levels: Dysregulation Is Corrected by IFN-β. 多发性硬化症患者的 RNA 替代剪接过多，且与基因表达水平无关：IFN-β 可纠正失调。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-05-02 DOI: 10.1089/jir.2024.0032
Anthony T Reder, Aika Goel, Tzintzuni Garcia, Xuan Feng
{"title":"Alternative Splicing of RNA Is Excessive in Multiple Sclerosis and Not Linked to Gene Expression Levels: Dysregulation Is Corrected by IFN-β.","authors":"Anthony T Reder, Aika Goel, Tzintzuni Garcia, Xuan Feng","doi":"10.1089/jir.2024.0032","DOIUrl":"10.1089/jir.2024.0032","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"355-371"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Interleukin-22 in Controlling Virus Infections at Mucosal Surfaces. 白细胞介素-22 在控制黏膜表面病毒感染中的作用
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1089/jir.2024.0097
Cuncai Guo, Steeve Boulant, Megan Lynn Stanifer
{"title":"The Role of Interleukin-22 in Controlling Virus Infections at Mucosal Surfaces.","authors":"Cuncai Guo, Steeve Boulant, Megan Lynn Stanifer","doi":"10.1089/jir.2024.0097","DOIUrl":"10.1089/jir.2024.0097","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"349-354"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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