Age-Dependent Signature of Serum Inflammatory Cytokines in Healthy Children and Young Adults.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI:10.1089/jir.2024.0053
Maarten Buytaert, Rachida El Kaddouri, Levi Hoste, Bram Meertens, Simon Jan Tavernier, Karlien Claes, Veronique Debacker, Jo Dehoorne, Filomeen Haerynck
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引用次数: 0

Abstract

The study of sensitive and specific biomarkers, such as blood inflammatory cytokines, could provide an answer to the challenges faced in the differential diagnosis of patients with systemic inflammation. Limited data exist on the impact of age on serum levels of inflammatory cytokines. We collected serum samples of 42 healthy children and young adults (1 month to 21 years). Serum levels of interleukin 1 receptor antagonist (IL-1Ra), IL-1β, IL-6, IL-18, tumor necrosis factor-alpha (TNF-α), CXCL9, and CXCL10 were measured. Data were analyzed for three different age groups (<6, 6-17, and 18-21 years). IL-18, TNF-α, and CXCL9 values varied significantly according to age group. Median values of IL-18 and TNF-α decline with age, whereas CXCL9 and CXCL10 are lowest at 6-17 years. IL-1Ra is stable among age groups. In the majority of cases, IL-1β and IL-6 are not measurable above the lower limit of quantification. A scoping literature review revealed highly variable data on IL-1Ra, IL-18, TNF-α, and CXCL10. For CXCL9, pediatric reference data are scarce. In conclusion, we report an age-dependent signature of multiple inflammatory cytokines measured in the serum of healthy children and young adults, suggesting the need to use age-specific reference values in future pediatric studies.

健康儿童和青少年血清炎症细胞因子的年龄特征
对血液炎症细胞因子等敏感而特异的生物标志物进行研究,可以为全身性炎症患者的鉴别诊断提供答案。关于年龄对血清中炎症细胞因子水平影响的数据十分有限。我们采集了 42 名健康儿童和年轻人(1 个月至 21 岁)的血清样本。测量了血清中白细胞介素 1 受体拮抗剂(IL-1Ra)、IL-1β、IL-6、IL-18、肿瘤坏死因子-α(TNF-α)、CXCL9 和 CXCL10 的水平。对三个不同年龄组 (
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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