Roles of IL-4, IL-13, and Their Receptors in Lung Cancer.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-22 DOI:10.1089/jir.2024.0008
Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu
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引用次数: 0

Abstract

Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type 2 innate immune response, which can carry out specific signal transmission between multiple cells in the tumor immune microenvironment. IL-4 and IL-13 mediate signal transduction and regulate cellular functions in a variety of solid tumors through their shared receptor chain, the transmembrane heterodimer interleukin-4 receptor alpha/interleukin-13 receptor alpha-1 (type II IL-4 receptor). IL-4, IL-13, and their receptors can induce the formation of a variety of malignant tumors and play an important role in their progression, growth, and tumor immunity. In order to explore possible targets for lung cancer prediction and treatment, this review summarizes the characteristics and signal transduction pathways of IL-4 and IL-13, and their respective receptors, and discusses in depth their possible role in the occurrence and development of lung cancer.

IL-4、IL-13 及其受体在肺癌中的作用
白细胞介素(IL)-4和IL-13是2型先天性免疫反应中先天性淋巴细胞(ILC2)的主要效应物,可在肿瘤免疫微环境中的多个细胞之间进行特异性信号传递。IL-4和IL-13通过它们共有的受体链--跨膜异源二聚体白细胞介素-4受体α/白细胞介素-13受体α-1(II型IL-4受体)--介导信号转导并调节多种实体瘤中的细胞功能。IL-4、IL-13 及其受体可诱导多种恶性肿瘤的形成,并在肿瘤的进展、生长和肿瘤免疫中发挥重要作用。为了探索肺癌预测和治疗的可能靶点,本综述总结了IL-4和IL-13及其各自受体的特点和信号转导途径,并深入探讨了它们在肺癌发生和发展中可能扮演的角色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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