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Journal of Interferon and Cytokine Research最新文献

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Experts Speak: A Conversation with Professor Stefan Rose-John. 专家发言：与斯特凡-罗斯-约翰教授对话。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI: 10.1089/jir.2024.0153
David L Woodland
{"title":"Experts Speak: A Conversation with Professor Stefan Rose-John.","authors":"David L Woodland","doi":"10.1089/jir.2024.0153","DOIUrl":"10.1089/jir.2024.0153","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"425-429"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experts Speak: A Conversation with Professor Laura Mackay. 专家发言：与劳拉-麦凯教授对话。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1089/jir.2024.0155
David L Woodland
{"title":"Experts Speak: A Conversation with Professor Laura Mackay.","authors":"David L Woodland","doi":"10.1089/jir.2024.0155","DOIUrl":"10.1089/jir.2024.0155","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"430-432"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-22 Promotes Cell Proliferation to Combat Virus Infection in Human Intestinal Epithelial Cells. 白细胞介素-22 促进细胞增殖以对抗人类肠上皮细胞的病毒感染
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1089/jir.2024.0096
Cuncai Guo, Ashwini Kumar Sharma, José Guzmán, Carl Herrmann, Steeve Boulant, Megan L Stanifer
{"title":"Interleukin-22 Promotes Cell Proliferation to Combat Virus Infection in Human Intestinal Epithelial Cells.","authors":"Cuncai Guo, Ashwini Kumar Sharma, José Guzmán, Carl Herrmann, Steeve Boulant, Megan L Stanifer","doi":"10.1089/jir.2024.0096","DOIUrl":"10.1089/jir.2024.0096","url":null,"abstract":"<p><p>Interferon lambdas (IFN-λs) are crucial to control virus infections at mucosal surfaces. Interleukin-22 (IL-22) was reported to help IFN-λ control rotavirus infection in the intestinal epithelium of mice either by aiding in the induction of interferon-stimulated genes (ISGs) or by increasing cell proliferation thereby clearing virally infected cells. We investigated whether IL-22 and IFN-λs exhibit similar synergistic effects in human intestinal epithelial cells (IECs) models. Our results showed that co-treatment of IL-22 and IFN-λ induced more phosphorylation of STAT1 than either cytokine used alone. However, this increased STAT1 activation did not translate to increased ISGs production or antiviral protection. Transcriptomics analysis revealed that despite sharing a common subunit (IL-10Rb) within their heterodimeric receptors and activating similar STATs, the signaling generated by IL-22 and IFN-λs is independent, with IFN-λ signaling inducing ISGs and IL-22 signaling inducing cell proliferation genes. Using human intestinal organoids, we confirmed that IL-22 increased the size of the organoids through increased cell proliferation and expression of the stem cell marker (OLFM4). These findings suggest that in human intestinal cells, IFN-λs and IL-22 act independently to clear virus infections. IFN-λs induce ISGs to control virus replication and spread, whereas IL-22 increases cell proliferation to eliminate infected cells and repair the damage epithelium. Although these two cytokines do not act synergistically, each plays a key function in the protection of human IECs.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"438-452"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-17 Genotypes in Egyptian Asthmatic Children at Zagazig University Hospitals. 扎加齐格大学医院埃及哮喘儿童的白细胞介素-17 基因型
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-07-27 DOI: 10.1089/jir.2024.0098
Abdallah S Abdelazem, Azza Ali Khalil, Dalia Ghareeb, Ahmad Sallam Soliman, Hanaa M El Maghraby, Nagwan A Ismail, Samia Hussein
{"title":"<i>Interleukin-17</i> Genotypes in Egyptian Asthmatic Children at Zagazig University Hospitals.","authors":"Abdallah S Abdelazem, Azza Ali Khalil, Dalia Ghareeb, Ahmad Sallam Soliman, Hanaa M El Maghraby, Nagwan A Ismail, Samia Hussein","doi":"10.1089/jir.2024.0098","DOIUrl":"10.1089/jir.2024.0098","url":null,"abstract":"<p><p>Bronchial asthma (BA) is increasing among Egyptian children. It is affected by multiple factors including genetic ones. In the current study, we assessed the relationship between <i>interleukin-17</i> (<i>IL-17</i>) genotypes and the occurrence of BA among Egyptian children. This case-control study included 100 participants. Group I (the control group) comprised 50 healthy subjects. Group II (the asthmatic group) comprised 50 subjects diagnosed with atopic asthma according to the Global Initiative for Asthma. Measurement of serum Ig E and eosinophilic count was performed. Detection of single nucleotide polymorphism <i>rs2275913 of IL-17</i> gene by restriction fragment length polymorphism-polymerase chain reaction was conducted. GA and AA genotypes were more frequent in the asthmatic group compared to the control group (<i>P</i> = 0.03 and 0.01, respectively). Subjects carrying GA and AA genotypes were more susceptible to have asthma [odds ratio (OR) = 2.21, 95% confidence interval (CI) = 1.14-9.94, <i>P</i> = 0.03; OR = 7.78, 95% CI = 1.59-38.3, <i>P</i> = 0.01, respectively]. The A allele was higher in the asthmatic group (33%) compared to the control group (10%). A allele carriers were more susceptible to have asthma (OR = 4.43, 95% CI = 2.04-9.82 and <i>P</i> < 0.001). Immunoglobulin E (IgE) levels and eosinophil percentages were higher among the carriers of GA and AA genotypes when compared with the GG genotype. All pulmonary function tests were significantly lower among carriers of AA genotype compared with GG genotype. An A allele carrier, AA genotype, increased IgE level, and eosinophil level were significant predictors for occurrence of asthma (<i>P</i> = 0.01, 0.02, 0.004, and 0.01). In conclusion, AA genotype carriers and A allele carriers of the <i>IL-17</i> gene are more likely to have asthma compared with controls.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"461-466"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experts Speak: A Conversation with Professor Susan Kaech. 与苏珊-凯奇教授对话。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1089/jir.2024.0162
David L Woodland
{"title":"Experts Speak: A Conversation with Professor Susan Kaech.","authors":"David L Woodland","doi":"10.1089/jir.2024.0162","DOIUrl":"10.1089/jir.2024.0162","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"433-437"},"PeriodicalIF":1.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comprehensive Network Map of Interleukin-26 Signaling Pathway. 白细胞介素-26 信号通路的综合网络图
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-04-19 DOI: 10.1089/jir.2024.0026
G P Suchitha, Shobha Dagamajalu, Thottethodi Subrahmanya Keshava Prasad, Rex Devasahayam Arokia Balaya
{"title":"A Comprehensive Network Map of Interleukin-26 Signaling Pathway.","authors":"G P Suchitha, Shobha Dagamajalu, Thottethodi Subrahmanya Keshava Prasad, Rex Devasahayam Arokia Balaya","doi":"10.1089/jir.2024.0026","DOIUrl":"10.1089/jir.2024.0026","url":null,"abstract":"<p><p>Interleukin-26 (IL-26) is a cytokine that belongs to the IL-20 subfamily and is primarily expressed in T helper 1 cells and Th17 memory CD4<sup>+</sup> cells. Its receptor complex, consisting of IL-20R1 and IL-10R2, activates a signaling pathway involving several proteins such as Janus kinase 1 and tyrosine-protein kinase, signal transducer and activator of transcription (STAT) 1, and STAT3. This leads to the initiation of downstream signaling cascades that play a crucial role in various biological processes, including inflammation, immune response regulation, atopic dermatitis, macrophage differentiation, osteoclastogenesis, antibacterial host defense, anti-apoptosis, and tumor growth. In this study, we curated literature data pertaining to IL-26 signaling. The curated map includes a total of seven activation/inhibition events, 16 catalysis events, 33 gene regulation events, 25 protein expression types, two transport events, and three molecular associations.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"408-413"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20. 解密白细胞介素-19 和白细胞介素-20 受体介导的信号传导途径。
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-06 DOI: 10.1089/jir.2024.0009
Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya
{"title":"Deciphering the Receptor-Mediated Signaling Pathways of Interleukin-19 and Interleukin-20.","authors":"Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya","doi":"10.1089/jir.2024.0009","DOIUrl":"10.1089/jir.2024.0009","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"388-398"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation. 抗CD138靶向干扰素-α通过直接杀伤肿瘤细胞和瘤内免疫调节对实体瘤具有广泛疗效
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI: 10.1089/jir.2024.0099
Tahmineh Safaie, Kham R Trinh, Alex Vasuthasawat, Sherie L Morrison, David R Stover
{"title":"An Anti-CD138-Targeted Interferon-Alpha Has Broad Efficacy in Solid Tumors Through Direct Tumor Cell Killing and Intratumoral Immune Modulation.","authors":"Tahmineh Safaie, Kham R Trinh, Alex Vasuthasawat, Sherie L Morrison, David R Stover","doi":"10.1089/jir.2024.0099","DOIUrl":"10.1089/jir.2024.0099","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"414-423"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of IL-4, IL-13, and Their Receptors in Lung Cancer. IL-4、IL-13 及其受体在肺癌中的作用
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-09-01 Epub Date: 2024-03-22 DOI: 10.1089/jir.2024.0008
Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu
{"title":"Roles of IL-4, IL-13, and Their Receptors in Lung Cancer.","authors":"Yao Zhang, Kangle Zhu, Xiao Wang, Yi Zhao, Jingwei Shi, Zhengcheng Liu","doi":"10.1089/jir.2024.0008","DOIUrl":"10.1089/jir.2024.0008","url":null,"abstract":"<p><p>Interleukin (IL)-4 and IL-13 are the main effectors of innate lymphoid cells (ILC2) of the type 2 innate immune response, which can carry out specific signal transmission between multiple cells in the tumor immune microenvironment. IL-4 and IL-13 mediate signal transduction and regulate cellular functions in a variety of solid tumors through their shared receptor chain, the transmembrane heterodimer interleukin-4 receptor alpha/interleukin-13 receptor alpha-1 (type II IL-4 receptor). IL-4, IL-13, and their receptors can induce the formation of a variety of malignant tumors and play an important role in their progression, growth, and tumor immunity. In order to explore possible targets for lung cancer prediction and treatment, this review summarizes the characteristics and signal transduction pathways of IL-4 and IL-13, and their respective receptors, and discusses in depth their possible role in the occurrence and development of lung cancer.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"399-407"},"PeriodicalIF":1.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β. 多发性硬化症中的替代剪接：干扰素-β治疗反应的有望生物标志物
IF 1.9 4区 医学
Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-05-27 DOI: 10.1089/jir.2024.0108
Suhayl Dhib-Jalbut
{"title":"Alternative Splicing in Multiple Sclerosis: A Promising Biomarker of Therapeutic Response to Interferon-β.","authors":"Suhayl Dhib-Jalbut","doi":"10.1089/jir.2024.0108","DOIUrl":"10.1089/jir.2024.0108","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":" ","pages":"335-336"},"PeriodicalIF":1.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141155214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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