Unraveling the Multifaceted Roles of Atypical Chemokine Receptors in Breast Cancer.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Qinan Yin, Yisha Yang, Zhifeng Qu, Mouna Ouchari, Li Zeng, Siya Tang, Jiayu Zheng, Shunshun Zhang, Haodi Ma, Youyou Chen, Jiayi Wang, Linlin Shi, Xuewei Zheng
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引用次数: 0

Abstract

Breast cancer (BC) remains one of the most prevalent and deadly malignancies among women globally. A deeper understanding of the molecular mechanisms driving BC progression and metastasis is essential for the development of effective therapeutic strategies. While traditional chemokine receptors are well known for their roles in immune cell migration and positioning, atypical chemokine receptors (ACKRs) have recently gained attention as key modulators in cancer-related processes. Unlike conventional receptors, ACKRs-comprising ACKR1, ACKR2, ACKR3, and ACKR4-primarily function by scavenging chemokines, regulating their availability, and modulating receptor signaling in a ligand-independent manner. This review aims to elucidate the roles of ACKRs in BC, focusing on their influence on the tumor microenvironment (TME), cancer cell proliferation, survival, metastasis, and angiogenesis. Additionally, we will explore the potential of ACKRs as diagnostic and prognostic markers and assess their viability as therapeutic targets. By synthesizing recent research findings and highlighting future research directions, this review seeks to provide a comprehensive understanding of the significance of ACKRs in BC and underscore the need for continued investigation into their therapeutic potential.

揭示非典型趋化因子受体在乳腺癌中的多重作用
乳腺癌(BC)仍然是全球妇女中发病率最高、最致命的恶性肿瘤之一。深入了解乳腺癌进展和转移的分子机制对于开发有效的治疗策略至关重要。传统的趋化因子受体因其在免疫细胞迁移和定位中的作用而广为人知,而非典型趋化因子受体(ACKRs)作为癌症相关过程中的关键调节因子最近也受到了关注。与传统受体不同,ACKRs(包括 ACKR1、ACKR2、ACKR3 和 ACKR4)主要通过清除趋化因子、调节其可用性以及以配体无关的方式调节受体信号转导来发挥作用。本综述旨在阐明 ACKRs 在 BC 中的作用,重点是它们对肿瘤微环境 (TME)、癌细胞增殖、存活、转移和血管生成的影响。此外,我们还将探索 ACKRs 作为诊断和预后标志物的潜力,并评估其作为治疗靶点的可行性。本综述综合了最近的研究成果,并强调了未来的研究方向,旨在提供对 ACKRs 在 BC 中的重要性的全面理解,并强调继续研究其治疗潜力的必要性。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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