Journal of Mathematical and Fundamental Sciences最新文献_第8页

Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database 基于印尼药用植物数据库的Janus Kinase 3 (JAK3)潜在抑制剂鉴定的分子模型

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-12-31 DOI: 10.5614/J.MATH.FUND.SCI.2020.52.3.2

M. Arba, S. N. Safitri, A. N. Hidayat, Arry Yanuar, M. Zubair, A. Djalil, D. H. Tjahjono

引用次数: 0

Stratigraphic Model of East Biak Based on Magnetotelluric Data 基于大地电磁资料的东碧亚克地层模型

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-08 DOI: 10.5614/j.math.fund.sci.2020.52.2.7

Alviyanda Alviyanda, G. Junursyah, P. Sumintadireja

{"title":"Stratigraphic Model of East Biak Based on Magnetotelluric Data","authors":"Alviyanda Alviyanda, G. Junursyah, P. Sumintadireja","doi":"10.5614/j.math.fund.sci.2020.52.2.7","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.7","url":null,"abstract":"Biak Island is thought to have originated from the Australian Continental passive margin in the Mesozoic. This passive margin underwent tectonic collision to form the bedrock of Biak Island during the Paleogene. East Biak is covered by limestone, which is an obstacle to knowing the deeper stratigraphy. This study’s aim was to identify the subsurface geology of the East Biak area based on rock resistivity values. Magnetotelluric (MT) surveying is a passive geophysical method that is able to interpret subsurface geology based on rock resistivity values at depths of up to 5 to 10 km. The MT measurements in East Biak used 25 measurement points. Cross-sectional variations in rock resistivity values generated from the MT measurements were used to identify rock types in the East Biak subsurface. Five rock units were identified. The East Biak stratigraphy model is dominated by carbonates, comprising two sequences, i.e. an Early Neogene sequence with a thickness of 1,000 to 3,000 m and a Late Neogene to Quaternary sequence with a thickness of 180 to 2,450 m. The unconformity between these two sequences is due to tectonic activity, which separated Supiori and Biak Island.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79427401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous-Like Linear Operators on Bilinear Spaces 双线性空间上的类连续线性算子

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-08 DOI: 10.5614/j.math.fund.sci.2020.52.2.8

Sabarinsyah Sabarinsyah, H. Garminia, P. Astuti

引用次数: 0

Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines N-苯氨基甲酰基苯甲酰胺的合理设计、合成及对HeLa细胞的细胞毒活性研究

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-06 DOI: 10.5614/j.math.fund.sci.2020.52.2.3

B. Purwanto, S. Siswandono, Suko Hardjono, Dian Triwidiandany

{"title":"Rational Design, Synthesis and Cytotoxic Activity of N-(Phenylcarbamoyl)Benzamide on HeLa Cell Lines","authors":"B. Purwanto, S. Siswandono, Suko Hardjono, Dian Triwidiandany","doi":"10.5614/j.math.fund.sci.2020.52.2.3","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.3","url":null,"abstract":"Urea derivatives are extensively used in the pharmaceutical industry. However, the unsatisfactory level of their membrane penetration requires further modification of the structures with stronger lipophillic properties. Phenylurea has a phenyl group that enables easier membrane penetration as a result of stronger pharmacological activity. Activity prediction was conducted by docking experiments and molecular dynamics, performed with Molegro Virtual Docker 5.5 using checkpoint kinase 1 (CHK1) enzyme with ID PDB: 2YWP. ADMET prediction was applied to collect data using the pkCSM tool. N -(phenyl carbamyol)benzamide compounds, modified by the Schotten Baumann method, were synthesized from benzoil chloride reacting with N -phenylurea. For evaluating anticancer activity, the MTT assay method on HeLa cells was used. Derived from the docking experiments, the compound rerank score of the N -(phenylcarbamoyl)benzamide was 72.0603 kcal/mol, lower than that of hydroxyurea, -32.1514 kcal/mol, causing better inhibitory activities against HeLA cell lines due to higher cytotoxic effects. ADMET Predictor was employed, indicating satisfactory compound distribution with a low, favorable metabolism, possessing good excretion and non-toxicity. The synthesized compound was 82% N- (phenyl carbamoyl)benzamide with 0.8 mM IC 80 , higher than that of hydroxyurea, 4.3 mM. In conclusion, successfully synthesized N- (phenylcarbamoyl)benzamide was proved to have higher cytotoxic effects. The satisfactory values of these compounds indicate that they are promising anticancer drug candidates.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81760949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Spectral Analysis of Proton-Irradiated Natural MoO3 Relevant for Technetium-99m Radionuclide Production 与锝-99m核素生产有关的质子辐照天然MoO3的光谱分析

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-06 DOI: 10.5614/j.math.fund.sci.2020.52.2.6

I. Kambali, Rajiman Rajiman, Parwanto Parwanto, M. Marlina, K. Kardinah, Nur Huda, Ferdi D. Listiawadi, Herta Astarina, Ratu R. Ismuha, Heranudin Heranudin, H. Suryanto

{"title":"Spectral Analysis of Proton-Irradiated Natural MoO3 Relevant for Technetium-99m Radionuclide Production","authors":"I. Kambali, Rajiman Rajiman, Parwanto Parwanto, M. Marlina, K. Kardinah, Nur Huda, Ferdi D. Listiawadi, Herta Astarina, Ratu R. Ismuha, Heranudin Heranudin, H. Suryanto","doi":"10.5614/j.math.fund.sci.2020.52.2.6","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.6","url":null,"abstract":"Due to the declining number of available nuclear reactors capable of Tc-99m production and tight regulations related to uranium enrichment, cyclotron-based Tc-99m production has recently been suggested as a new method to help ease Tc-99m supply shortages. In this investigation, a solid natural MoO 3 target was irradiated using 11-MeV proton beams at variable proton doses. The proton doses were varied by varying the irradiation time while keeping the proton beam current constant at 20 µA. At the end of the bombardment, the post-irradiated solid MoO 3 targets were analyzed for their radioactive contents using a portable gamma-ray spectroscopy system. The analysis was also performed for the post-irradiated targets after dissolving the solid MoO 3 in a 6M NaOH solution. The experimental results indicated that as much as 75.71% of Tc-99m radioactivity was directly generated via a 100 Mo(p,2n) 99m Tc nuclear reaction, while the rest of the Tc-99m radioactivity was a result of a 98 Mo(n,γ) 99 Mo→ 99m Tc nuclear reaction. Apart from Tc-99m and Mo-99 radionuclides, some other radionuclides such as N-13, Tc-96, and Nb-96 were also recorded following temporal observation of the NaOH-dissolved MoO 3 . These experimental results open up the possibility of direct production of Tc-99m using a proton-accelerating cyclotron.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90042745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Classification and Dynamics of Class of ξ(as)-QSO ξ(as)-QSO类的分类与动力学

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-06 DOI: 10.5614/j.math.fund.sci.2020.52.2.2

Hamza Abd El-Qader, A. T. A. Ghani, I. Qaralleh

引用次数: 1

Hankel Inequalities for a Subclass of Bi-Univalent Functions based on Salagean type q-Difference Operator 基于Salagean型q-差分算子的双一元函数子类的Hankel不等式

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-06 DOI: 10.5614/j.math.fund.sci.2020.52.2.4

S. Yalçın, Ş. Altınkaya, G. Murugusundaramoorthy, K. Vijaya

引用次数: 3

Restricted Size Ramsey Number Involving Matching and Graph of Order Five 涉及匹配的受限大小Ramsey数与五阶图

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-01 DOI: 10.5614/j.math.fund.sci.2020.52.2.1

D. R. Silaban, E. Baskoro, S. Uttunggadewa

引用次数: 3

Synthesis of Oligosuccinimide and Evaluation of Its Corrosion Inhibition Performance on Carbon Steel in CO2-Saturated 1% NaCl Solution 低聚琥珀酰亚胺的合成及其在co2饱和1% NaCl溶液中对碳钢缓蚀性能的评价

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-09-01 DOI: 10.5614/j.math.fund.sci.2020.52.2.5

M. J. Baari, B. Bundjali, D. Wahyuningrum

{"title":"Synthesis of Oligosuccinimide and Evaluation of Its Corrosion Inhibition Performance on Carbon Steel in CO2-Saturated 1% NaCl Solution","authors":"M. J. Baari, B. Bundjali, D. Wahyuningrum","doi":"10.5614/j.math.fund.sci.2020.52.2.5","DOIUrl":"https://doi.org/10.5614/j.math.fund.sci.2020.52.2.5","url":null,"abstract":"Oligosuccinimide (OSI) is an oligomer with several repeating units of succinimide. In this study, OSI was synthesized by thermal condensation between maleic anhydride and ammonium carbonate. The chemical structure of the synthesized compound was confirmed by FTIR and NMR spectroscopy as well as LC-MS characterization. Evaluation of its performance as corrosion inhibitor and the adsorption mechanism on a carbon steel surface in CO 2 -saturated 1% (w/v) NaCl solution was performed using electrochemical techniques (electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization) and weight-loss methods. These tests were simultaneously carried out for all fractions without separation. The EIS results showed that the inhibition efficiency (IE) of the OSI increased with increasing concentration but decreased at higher temperatures. The potentiodynamic polarization data indicated that the OSI acted as a mixed inhibitor. Adsorption of OSI on the carbon steel generally obeys the Langmuir adsorption isotherm according to curve linearity, which relates the degree of surface coverage to the inhibitor concentration. The standard Gibbs free energy of the adsorption values (∆ G° ads ) were negative within the range of -33.14 to -38.73 kJ.mol -1 , which indicates the spontaneity of the adsorption process on the carbon steel surface and that OSI molecules interacted with the carbon steel through semi-physisorption.","PeriodicalId":16255,"journal":{"name":"Journal of Mathematical and Fundamental Sciences","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73179688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A New Hybrid Approach for Solving Large-scale Monotone Nonlinear Equations 求解大规模单调非线性方程的一种新的混合方法

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Journal of Mathematical and Fundamental Sciences Pub Date : 2020-04-30 DOI: 10.5614/j.math.fund.sci.2020.52.1.2

J. Sabi’u, A. Shah, M. Waziri, M. K. Dauda

引用次数: 7