Journal of Medical Economics最新文献

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Transcatheter aortic valve replacement and the value of increasing treatment for severe symptomatic aortic stenosis: a plain language summary. 经导管主动脉瓣置换术和增加严重症状性主动脉瓣狭窄治疗的价值:通俗易懂的摘要。
IF 2.9 4区 医学
Journal of Medical Economics Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1080/13696998.2024.2403926
J P Sevilla, Mark J Russo, Christin A Thompson, Xiayu Jiao, David E Bloom
{"title":"Transcatheter aortic valve replacement and the value of increasing treatment for severe symptomatic aortic stenosis: a plain language summary.","authors":"J P Sevilla, Mark J Russo, Christin A Thompson, Xiayu Jiao, David E Bloom","doi":"10.1080/13696998.2024.2403926","DOIUrl":"https://doi.org/10.1080/13696998.2024.2403926","url":null,"abstract":"","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"27 1","pages":"1036-1045"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness analysis of a lung cancer screening program in the netherlands: a simulation based on NELSON and NLST study outcomes. 荷兰肺癌筛查计划的成本效益分析:基于 NELSON 和 NLST 研究结果的模拟。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-19 DOI: 10.1080/13696998.2024.2404359
Hilde Ten Berge,Bo Willems,Xuanqi Pan,Evgeni Dvortsin,Joachim Aerts,Maarten J Postma,Mathias Prokop,Michel M van den Heuvel
{"title":"Cost-effectiveness analysis of a lung cancer screening program in the netherlands: a simulation based on NELSON and NLST study outcomes.","authors":"Hilde Ten Berge,Bo Willems,Xuanqi Pan,Evgeni Dvortsin,Joachim Aerts,Maarten J Postma,Mathias Prokop,Michel M van den Heuvel","doi":"10.1080/13696998.2024.2404359","DOIUrl":"https://doi.org/10.1080/13696998.2024.2404359","url":null,"abstract":"BACKGROUNDIn the Netherlands, lung cancer is the leading cause of cancer-related death, accounting for more than 10,000 annual deaths. Lung cancer screening (LCS) studies using low-dose computed tomography (LDCT) have demonstrated that early detection reduces lung cancer mortality. However, no LCS program has been implemented yet in the Netherlands. A national LCS program has the potential to enhance the health outcomes for lung cancer patients in the Netherlands.OBJECTIVE AND METHODSThis study evaluates the cost-effectiveness of LCS compared to no-screening in the Netherlands, by simulating the screening outcomes based on data from NEderlands-Leuvens Longkanker Screenings ONderzoek (NELSON) and National Lung Screening Trial (NLST). We simulated annual screening up to 74 years of age, using inclusion criteria from the respective studies. A decision tree and Markov model was used to predict the incremental costs, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratio (ICERs) for the screening population. The analysis used a lifetime horizon and a societal perspective.RESULTSCompared to no-screening, LCS resulted in an ICER of €5,169 per QALY for the NELSON simulation, and an ICER of €17,119 per QALY for the NLST simulation. The screening costs were highly impactful for the cost-effectiveness. The most influential parameter was the CT scan cost. Cost reduction for CT from €201 to €101 per scan would reduce the ICER to €2,335 using NELSON criteria. Additionally, LCS could prevent 15,115 and 12,611 premature lung cancer deaths, accompanied by 1.66 and 1.31 QALYs gained per lung cancer case for the NELSON and NLST simulations, respectively.CONCLUSIONLCS was estimated to be cost-effective in the Netherlands for both simulations at a willingness-to-pay threshold of €20,000 per QALY. Using the NELSON criteria, less than €5,500 per QALY had to be spent. Lowering the cost per CT exam would lead to a further reduction of this amount.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"26 1","pages":"1197-1211"},"PeriodicalIF":2.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-effectiveness and public health impact of using high dose quadrivalent influenza vaccine in the French older adults population 在法国老年人群中使用高剂量四价流感疫苗的成本效益和对公共卫生的影响
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-17 DOI: 10.1080/13696998.2024.2404331
F.P Alvarez, L. Allard, F. Bianic, H. Bricout, P. Crépey, J. Gaillat, G. Gavazzi, A. Mosnier, O. Launay, MC Levant, D. Proshenska, C. deCourville
{"title":"Cost-effectiveness and public health impact of using high dose quadrivalent influenza vaccine in the French older adults population","authors":"F.P Alvarez, L. Allard, F. Bianic, H. Bricout, P. Crépey, J. Gaillat, G. Gavazzi, A. Mosnier, O. Launay, MC Levant, D. Proshenska, C. deCourville","doi":"10.1080/13696998.2024.2404331","DOIUrl":"https://doi.org/10.1080/13696998.2024.2404331","url":null,"abstract":"Seasonal influenza outbreaks in France cause a surge in patients, exacerbating the overburdened healthcare system each winter. Older adults are particularly vulnerable to serious events related to ...","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"20 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-time continuous glucose monitoring vs. self-monitoring of blood glucose: cost-utility in South Korean type 2 diabetes patients on intensive insulin. 实时连续血糖监测与自我血糖监测:使用强化胰岛素的韩国 2 型糖尿病患者的成本效益。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-14 DOI: 10.1080/13696998.2024.2405293
Ji Yoon Kim,Sabrina Ilham,Hamza Alshannaq,Richard F Pollock,Waqas Ahmed,Gregory J Norman,Sang-Man Jin,Jae Hyeon Kim
{"title":"Real-time continuous glucose monitoring vs. self-monitoring of blood glucose: cost-utility in South Korean type 2 diabetes patients on intensive insulin.","authors":"Ji Yoon Kim,Sabrina Ilham,Hamza Alshannaq,Richard F Pollock,Waqas Ahmed,Gregory J Norman,Sang-Man Jin,Jae Hyeon Kim","doi":"10.1080/13696998.2024.2405293","DOIUrl":"https://doi.org/10.1080/13696998.2024.2405293","url":null,"abstract":"AIMSThis study investigated the cost-utility of real-time continuous glucose monitoring (rt-CGM) versus self-monitoring of blood glucose (SMBG) in people with type 2 diabetes (T2D) receiving intensive insulin therapy in South Korea.METHODSThe IQVIA Core Diabetes Model (CDM v9.5) was used, with clinical effectiveness data obtained from a large-scale real world study. Costs were obtained from South Korean sources and inflated to 2022 South Korean Won (KRW). A South Korean payer perspective was adopted over a lifetime horizon, with future costs and effects discounted at 4.5% per annum. Baseline characteristics included a mean baseline HbA1c level of 8.6% (71 mmol/mol), and a mean age of 64.4 years. A willingness-to-pay (WTP) threshold of KRW 46.0 million was used.RESULTSRt-CGM led to an increase of 0.683 quality-adjusted life years (QALYs) versus SMBG (7.526 QALYs for rt-CGM versus 6.843 QALYs for SMBG). An increase in costs of KRW 16.4 million (from KRW 90.4 million to KRW 106.8 million) was associated with rt-CGM. The incremental cost-utility ratio was KRW 24.0 million per QALY gained, significantly lower than the KRW 46 million threshold.CONCLUSIONSFor individuals with T2D managed by intensive insulin therapy in South Korea, rt-CGM is cost-effective relative to SMBG.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"46 1","pages":"1-39"},"PeriodicalIF":2.4,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizational and budget impact model (OBIM) of same™ a new autotransfusion medical device 新型自动输血医疗设备 Same™ 的组织和预算影响模型 (OBIM)
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-13 DOI: 10.1080/13696998.2024.2404361
H. Moutier, T. Martin, N. Martelli, J. Placer, S. Bourguignon
{"title":"Organizational and budget impact model (OBIM) of same™ a new autotransfusion medical device","authors":"H. Moutier, T. Martin, N. Martelli, J. Placer, S. Bourguignon","doi":"10.1080/13696998.2024.2404361","DOIUrl":"https://doi.org/10.1080/13696998.2024.2404361","url":null,"abstract":"Objectives: This study aimed to assess the budget and organizational impact of progressively replacing the intraoperative cell salvage centrifugation-based systems currently installed in French hos...","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"1 1","pages":"1-11"},"PeriodicalIF":2.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Narrative review of value frameworks in urothelial carcinoma and positioning of enfortumab vedotin. 对尿路上皮癌价值框架和恩福单抗维多汀定位的叙述性回顾。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-11 DOI: 10.1080/13696998.2024.2403351
Aurora Ortiz Nunez,Judit Gonzalez Portela,Néboa Zozaya,Irene Fernández
{"title":"Narrative review of value frameworks in urothelial carcinoma and positioning of enfortumab vedotin.","authors":"Aurora Ortiz Nunez,Judit Gonzalez Portela,Néboa Zozaya,Irene Fernández","doi":"10.1080/13696998.2024.2403351","DOIUrl":"https://doi.org/10.1080/13696998.2024.2403351","url":null,"abstract":"AIMSEvaluate existing oncology value frameworks in terms of their methodology, structure, characteristics, and functionality using the example of enfortumab vedotin, an approved therapy for urothelial carcinoma.METHODSA search of PubMed, grey literature, and official websites of relevant international organizations was performed from January 2022 to March 2023.RESULTSSix frameworks were identified and analyzed, including the American Society of Clinical Oncology's assessment framework, European Society for Medical Oncology's Magnitude of Clinical Benefit Scale, the National Comprehensive Cancer Network's Evidence Blocks, Memorial Sloan Kettering Cancer Center's DrugAbacus, Institute for Clinical and Economic Review's assessment framework, and the Drug Assessment Framework. Comparisons across frameworks were challenging, owing to differing approaches, objectives, perspectives, methodology, and criteria. Based on the results of the EV-301 study (NCT03474107), the European Society for Medical Oncology's Magnitude of Clinical Benefit Scale assigned a score of 4 out of 5 to enfortumab vedotin administered after chemotherapy and immunotherapy. The National Comprehensive Cancer Network's Evidence Blocks enabled assessment of enfortumab vedotin compared with other treatments for locally advanced or metastatic urothelial carcinoma, resulting in the positioning of enfortumab vedotin as a preferred regimen after chemotherapy and immunotherapy.CONCLUSIONSApplication of value frameworks in oncology can contribute to informed value-based decision-making. However, comparisons across frameworks should be made with caution and limited to the same lines of treatment. Enfortumab vedotin may contribute to optimizing outcomes in patients previously treated with chemotherapy and immunotherapy for locally advanced or metastatic urothelial carcinoma.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"44 1","pages":"1-38"},"PeriodicalIF":2.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Budget impact of dostarlimab plus carboplatin-paclitaxel for primary advanced or recurrent endometrial cancer from a third-party US payer perspective. 从美国第三方支付机构的角度看多司他单抗联合卡铂-紫杉醇治疗原发性晚期或复发性子宫内膜癌的预算影响。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-10 DOI: 10.1080/13696998.2024.2403278
Solomon J Lubinga,Lydia Walder,Mark Burton,Qin Shen
{"title":"Budget impact of dostarlimab plus carboplatin-paclitaxel for primary advanced or recurrent endometrial cancer from a third-party US payer perspective.","authors":"Solomon J Lubinga,Lydia Walder,Mark Burton,Qin Shen","doi":"10.1080/13696998.2024.2403278","DOIUrl":"https://doi.org/10.1080/13696998.2024.2403278","url":null,"abstract":"AIMDostarlimab plus carboplatin-paclitaxel (CP) significantly increased progression-free survival in patients with primary advanced or recurrent endometrial cancer (pA/rEC) vs CP alone in the RUBY trial (NCT03981796). This analysis estimated the per-member-per-month (PMPM) costs of introducing dostarlimab + CP as a treatment alternative from a third-party US payer perspective.MATERIALS AND METHODSA budget impact model was developed to estimate the costs of introducing dostarlimab + CP into commercial and Medicare health plans over a 3-year time horizon (2023-2025). Costs were sourced from relevant literature and US-specific databases and were calculated using epidemiology data, clinical inputs, treatment costs, and market share estimates. Clinical inputs were sourced from primary clinical trials for each respective treatment (ie, dostarlimab + CP, CP, pembrolizumab, pembrolizumab plus lenvatinib, bevacizumab + CP, and pembrolizumab + CP). Current and future market shares assumed dostarlimab + CP reduced the market share of CP only. Analyses were performed in mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) and overall populations using a US 2023 cost year.RESULTSFor a commercial plan, the model estimated (dMMR/MSI-H and overall populations) that 7 and 26 patients would be treated with dostarlimab + CP, respectively; average annual budget impacts per patient treated were $118,257 and $116,094; average budget impacts per patient treated per month (PPPM) were $9,855 and $9,675; average budget impacts PMPM were $0.02 and $0.06. For a Medicare plan, the model estimated that 28 and 93 patients, respectively, would be treated with dostarlimab + CP. Average annual budget impacts per patient treated and PPPM were the same as those for the commercial plan in both populations; average budget impacts PMPM were $0.07 and $0.22, respectively.CONCLUSIONSIntroducing dostarlimab + CP as a first-line treatment for patients with pA/rEC results in minimal budget impact PMPM from a US third-party payers' perspective. Together with the efficacy and safety results from RUBY, these results support the use of dostarlimab + CP as a treatment option.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"61 1","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment patterns, healthcare resource utilization, and costs in Medicare patients with diffuse large B-cell lymphoma: A retrospective claims analysis (2015-2020). 弥漫大 B 细胞淋巴瘤医保患者的治疗模式、医疗资源利用率和费用:回顾性索赔分析(2015-2020 年)。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-10 DOI: 10.1080/13696998.2024.2399435
Monika P Jun,Alex Mutebi,Anindit Chhibber,Chenxue Liang,Allison Keshishian,Anthony Wang,Fernando Rivas Navarro,Anupama Kalsekar,Jing He,Tongsheng Wang
{"title":"Treatment patterns, healthcare resource utilization, and costs in Medicare patients with diffuse large B-cell lymphoma: A retrospective claims analysis (2015-2020).","authors":"Monika P Jun,Alex Mutebi,Anindit Chhibber,Chenxue Liang,Allison Keshishian,Anthony Wang,Fernando Rivas Navarro,Anupama Kalsekar,Jing He,Tongsheng Wang","doi":"10.1080/13696998.2024.2399435","DOIUrl":"https://doi.org/10.1080/13696998.2024.2399435","url":null,"abstract":"AIMSTo understand treatment patterns, healthcare resource utilization (HCRU), and economic burden of diffuse large B-cell lymphoma (DLBCL) in elderly adults in the US.MATERIALS AND METHODSThis retrospective database analysis utilized US Centers for Medicare and Medicaid Services Medicare fee-for-service administrative claims data from 2015 to 2020 to describe DLBCL patient characteristics, treatment patterns, HCRU, and costs among patients aged ≥66 years. Patients were indexed at DLBCL diagnosis and required to have continuous enrollment from 12 months pre-index until 3 months post-index. HCRU and costs (USD 2022) are reported as per-patient per-month (PPPM) estimates.RESULTSA total of 11,893 patients received ≥1-line (L) therapy; 1633 and 391 received ≥2L and ≥3L therapy, respectively. Median (Q1, Q3) age at 1L, 2L, and 3L initiation, respectively, was 76 (71, 81), 77 (72, 82), and 77 (72, 82) years. The most common therapy was R-CHOP (70.9%) for 1L and bendamustine ± rituximab for 2L (18.7%) and 3L (17.4%). CAR T was used by 14.8% of patients in 3L. Overall, 39.6% (1L), 42.1% (2L), and 47.8% (3L) of patients had all-cause hospitalizations. All-cause mean (median [Q1-Q3]) costs PPPM during each line were $22,060 ($20,121 [$16,676-$24,597]) in 1L, $30,027 ($20,868 [$13,416-$31,016]) in 2L, and $47,064 ($25,689 [$15,555-$44,149]) in 3L, with increasing costs driven primarily by inpatient expenses. Total all-cause 3L mean (median [Q1-Q3]) costs PPPM for patients with and without CAR T were $153,847 ($100,768 [$26,534-$253,630]) and $28,466 ($23,696 [$15,466-$39,107]), respectively.CONCLUSIONSNo clear standard of care exists in 3L therapy for older adults with relapsed/refractory DLBCL. The economic burden of DLBCL intensifies with each progressing line of therapy, thus underscoring the need for additional therapeutic options.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"31 1","pages":"1-15"},"PeriodicalIF":2.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Foslevodopa/foscarbidopa (LDp/CDp) in advanced Parkinson’s Disease (aPD): demonstration of savings from a societal perspective in the UK 晚期帕金森病(aPD)患者服用磷左多巴/磷卡比多巴(LDp/CDp):从英国社会角度看节省费用的证明
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-10 DOI: 10.1080/13696998.2024.2400857
K Ray Chaudhuri, Lars Bergmann, Jonathan Belsey, Trishal Boodhna, Emanuele Leoncini
{"title":"Foslevodopa/foscarbidopa (LDp/CDp) in advanced Parkinson’s Disease (aPD): demonstration of savings from a societal perspective in the UK","authors":"K Ray Chaudhuri, Lars Bergmann, Jonathan Belsey, Trishal Boodhna, Emanuele Leoncini","doi":"10.1080/13696998.2024.2400857","DOIUrl":"https://doi.org/10.1080/13696998.2024.2400857","url":null,"abstract":"In advanced Parkinson’s disease (aPD), adequate 24-hour control of OFF-time may not be achievable using oral/transdermal therapies. Clinical trials of foslevodopa/foscarbidopa (LDp/CDP) demonstrate...","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"1 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and economic impact of first-line or drug-naïve catheter ablation and delayed second-line catheter ablation for atrial fibrillation using a patient-level simulation model. 利用患者层面的模拟模型,分析心房颤动一线或药物无效导管消融术和延迟二线导管消融术的临床和经济影响。
IF 2.4 4区 医学
Journal of Medical Economics Pub Date : 2024-09-10 DOI: 10.1080/13696998.2024.2399438
Elena Arbelo,Roberto De Ponti,Lucas Cohen,Laura Pastor,Graca Costa,Marike Hempel,Daniel Grima
{"title":"Clinical and economic impact of first-line or drug-naïve catheter ablation and delayed second-line catheter ablation for atrial fibrillation using a patient-level simulation model.","authors":"Elena Arbelo,Roberto De Ponti,Lucas Cohen,Laura Pastor,Graca Costa,Marike Hempel,Daniel Grima","doi":"10.1080/13696998.2024.2399438","DOIUrl":"https://doi.org/10.1080/13696998.2024.2399438","url":null,"abstract":"AIMSTo determine the clinical and economic implications of first-line or drug-naïve catheter ablation compared to antiarrhythmic drugs (AADs), or shorter AADs-to-Ablation time (AAT) in atrial fibrillation (AF) patients in France and Italy, using a patient level-simulation model.MATERIALS AND METHODSA patient-level simulation model was used to simulate clinical pathways for AF patients using published data and expert opinion. The probabilities of adverse events (AEs) were dependent on treatment and/or disease status. Analysis 1 compared scenarios of treating 0%, 25%, 50%, 75% or 100% of patients with first-line ablation and the remainder with AADs. In Analysis 2, scenarios compared the impact of delaying transition to second-line ablation by 1 or 2 years.RESULTSOver 10 years, increasing first-line ablation from 0% to 100% (versus AAD treatment) decreased stroke by 12%, HF hospitalization by 29%, and cardioversions by 45% in both countries. As the rate of first-line ablation increased from 0% to 100%, the overall 10-year per-patient costs increased from €13,034 to €14,450 in Italy and from €11,944 to €16,942 in France. For both countries, the scenario with no delay in second-line ablation had fewer AEs compared to the scenarios where ablation was delayed after AAD failure. Increasing rates of first-line or drug-naïve catheter ablation, and shorter AAT, resulted in higher cumulative controlled patient years on rhythm control therapy.LIMITATIONSThe model includes assumptions based on the best available clinical data, which may differ from real-world results, however, sensitivity analyses were included to combat parameter ambiguity. Additionally, the model represents a payer perspective and does not include societal costs, providing a conservative approach.CONCLUSIONIncreased first-line or drug-naïve catheter ablation, and shorter AAT, could increase the proportion of patients with controlled AF and reduce AEs, offsetting the small investment required in total AF costs over 10 years in Italy and France.","PeriodicalId":16229,"journal":{"name":"Journal of Medical Economics","volume":"8 1","pages":"1-17"},"PeriodicalIF":2.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142189216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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