Journal of King Saud University - Science最新文献

{"title":"Cardioprotective potential of sakuranetin to counteract polyethylene microplastics induced cardiotoxicity","authors":"Nazia Ehsan ,&nbsp;Muhammad Gulfam ,&nbsp;Ali Akbar ,&nbsp;Moazama Batool ,&nbsp;Mohammad Z. Ahmed ,&nbsp;Mian Nadeem Riaz","doi":"10.1016/j.jksus.2024.103529","DOIUrl":"10.1016/j.jksus.2024.103529","url":null,"abstract":"<div><div>Polyethylene microplastics (PEMPs) are toxic environmental contaminants which can impair multiple organs including heart. Sakuranetin (SKN) is a potential flavonoid with diverse pharmacological benefits. This research was undertaken to analyze the defensive impact of SKN to avert PEMPs-induced cardiotoxicity. 24 male albino rats were randomly allocated into 4 separate groups: control, PEMPs (1.5 mg kg⁻¹), PEMPs + SKN (1.5 mg kg⁻¹ + 10 mg kg⁻¹) and only SKN (10 mg kg⁻¹) treated group. After 30 days of treatment, our results revealed that PEMPs exposure reduced the expressions of Nrf2 and antioxidant genes while increasing Keap1 expression. Besides, PEMPs intoxication escalated the levels of cardiac markers (CPK, LDH, Troponin I &amp; CK-MB). Additionally, it lessened the activities of GSH, GST, SOD, HO-1, CAT, GSR, GPx whereas the levels of MDA and ROS were increased. Conversely, the levels of inflammatory markers i.e., COX-2 activity IL-1β, TNF-α, NF-kB &amp; IL-6 were augmented. Moreover, the expressions of apoptotic markers i.e., Bax and caspase-3 were elevated while the Bcl-2 expression was decreased. However, SKN treatment significantly restored the PEMPs-induced biochemical dysregulations. Therefore, SKN could be used as a therapeutic compound to ameliorate PEMPs-induced cardiac impairments in rats, possibly due to its tremendous pharmacotherapeutic potential.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103529"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: Merging from traditional to potential novel breast cancer biomarkers","authors":"Hanan Alismail","doi":"10.1016/j.jksus.2024.103551","DOIUrl":"10.1016/j.jksus.2024.103551","url":null,"abstract":"<div><div>Breast cancer biomarkers are the main player in decision-making in diagnosis, prognosis, and treatment. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are well-known in breast cancer management. Additionally, the Ki-67 protein is used as a tumor proliferation indicator to asses the cancer aggressiveness. Recently, the field has been rapidly integrating novel biomarkers to develop precise, personalized with high effectiveness in patient care. A group of merging biomarkers, including genomic and transcriptomic signatures, circulating tumor cells (CTCs), cell-free DNA (cfDNA), tumor-infiltrating lymphocytes (TILs), and immune checkpoint proteins such as PD-L1, all showed promising toward revealing tumor behavior, treatment response, and potential metastatic spread. microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are merging as new potential diagnostic tools. All mentioned merging innovative biomarkers showed promising results, yet challenges remain in their validation, standardization, and integration into routine clinical practice. This review will highlight the transition from traditional to novel strategies, developing more effective treatments that improve breast cancer patients’ outcomes and survival.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103551"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorimetric detection of anionic surfactant using polydiacetylene/zinc (II)/zinc oxide nanocomposites with unique yellow-to-red color transition","authors":"Watsapon Yimkaew ,&nbsp;Johannes Allwang ,&nbsp;Christine M. Papadakis ,&nbsp;Rakchart Traiphol ,&nbsp;Nisanart Traiphol","doi":"10.1016/j.jksus.2024.103557","DOIUrl":"10.1016/j.jksus.2024.103557","url":null,"abstract":"<div><div>Polydiacetylenes (PDAs) have extensively received attention as colorimetric sensors because of their stimulus-responsive properties. This contribution presents a simple technique to modify polydiacetylene/zinc (II) ion/zinc oxide (PDA/Zn²⁺/ZnO) nanocomposites for colorimetric detection of an anionic surfactant. Incorporation of cetyltrimethylammonium bromide (CTAB) into the nanocomposite structure is achieved through a simple mixing process in an aqueous medium. Interestingly, the resultant PDA/Zn²⁺/ZnO-CTAB sensors exhibit a unique yellow-to-red color change in response to the anionic surfactant, sodium dodecyl sulfate (SDS). Furthermore, the colorimetric detection of SDS at different concentrations can be achieved by varying the added CTAB concentrations. The detectable concentration range of SDS in this study extends from 0.3 to 7 mM. Our study offers a simple and low-cost method to fabricate colorimetric sensors for anionic surfactant detection using PDA materials.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103557"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic farming innovations: Cultivation of wheatgrass microgreens in soil enriched with fruit peels and antimicrobial assessment","authors":"Krithika R,&nbsp;Raajeswari P.A","doi":"10.1016/j.jksus.2024.103511","DOIUrl":"10.1016/j.jksus.2024.103511","url":null,"abstract":"<div><h3>Objective</h3><div>This study explores the viability of fruit peel-enriched soils as a sustainable growth medium, acting as a biofertilizer for wheatgrass microgreens. Additionally, the research seeks to evaluate the antimicrobial properties of fruit peels, typically considered agricultural waste, to determine their influence on plant growth parameters.</div></div><div><h3>Methods</h3><div>Fruit peels from pomegranate, orange, and sweet lime were collected and processed into powder, and diluted with water to create enriched soil. Wheatgrass microgreens were cultivated in conventional potting soil and soil enriched with fruit peel powder. Growth parameters, including germination rates, shoot and root length, and total yield of wheatgrass microgreens, were monitored over a 15-day growth cycle. Antimicrobial analysis was conducted on selected fruit peels, assessing their impact on <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> compared to a control (Rifampicin).</div></div><div><h3>Results</h3><div>The results, analyzed through ANOVA and Tukey (post hoc) tests, indicate significant differences among fruit peel-enriched soils. Pomegranate peel emerged as a particularly effective enhancer of wheatgrass microgreen growth. Furthermore, the antimicrobial analysis revealed that pomegranate and sweet lime peels exhibited superior properties, with a notable zone of inhibition effects on <em>Staphylococcus aureus</em> and <em>Escherichia coli</em> compared to the control (Rifampicin).</div></div><div><h3>Conclusion</h3><div>This study demonstrates the potential of fruit peels as effective biofertilizers to promote wheatgrass microgreen growth in sustainable agricultural practices. The multifaceted benefits include enhanced crop development and the discovery of natural antimicrobial agents, particularly in pomegranate and sweet lime peels. These findings support the broader adoption of environmentally conscious approaches in agriculture, emphasizing the value of utilizing agricultural waste for plant growth promotion and the development of natural alternatives to synthetic antimicrobial agents.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103511"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Interferon-stimulated gene (ISG12a) suppresses hepatitis B virus replication in Huh 7 cells line” [J. King Saud Univ. Sci. 36(9) (2024) 103377]","authors":"Hafiz Ullah ,&nbsp;Amin Ullah ,&nbsp;Hadia Gul ,&nbsp;Rahat Ullah Khan ,&nbsp;Junaid Ahmad ,&nbsp;Rafa Almeer ,&nbsp;Khurshid Alam ,&nbsp;Muhammad Ayaz ,&nbsp;Muhammad Ajmal Khan ,&nbsp;Zafar Abbass Shah","doi":"10.1016/j.jksus.2024.103554","DOIUrl":"10.1016/j.jksus.2024.103554","url":null,"abstract":"","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103554"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cloud spot instance price forecasting multi-headed models tuned using modified PSO","authors":"Mohamed Salb ,&nbsp;Luka Jovanovic ,&nbsp;Ali Elsadai ,&nbsp;Nebojsa Bacanin ,&nbsp;Vladimir Simic ,&nbsp;Dragan Pamucar ,&nbsp;Miodrag Zivkovic","doi":"10.1016/j.jksus.2024.103473","DOIUrl":"10.1016/j.jksus.2024.103473","url":null,"abstract":"<div><div>The increasing dependence and demands on cloud infrastructure have brought to light challenges associated with cloud instance pricing. The often unpredictable nature of demand as well as changing costs of supplying a reliable instance can leave companies struggling to appropriately budget to support a healthy cash flow while maintaining operating costs. This work explores the potential of multi-headed recurrent architectures to forecast cloud instance prices based on historical and instance data. Two architectures are explored, long short-term memory (LSTM) and gated recurrent unit (GRU) networks. A modified optimizer is introduced and tested on a publicly available Amazon elastic compute cloud dataset. The GRU model, enhanced by the proposed modified approach, had the most impressive outcomes with an MAE score of 0.000801. Results have undergone meticulous statistical validation with the best-performing models further analyzed using explainable artificial intelligence techniques to provide further insight into model reasoning and information on feature importance.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103473"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics and pathways analyses in traumatic brain injury animal model","authors":"Faleh Alqahtani ,&nbsp;Thamer H. Albekairi ,&nbsp;Shereen M. Aleidi ,&nbsp;Reem H. AlMalki ,&nbsp;Yousif S. Mohamed Ali ,&nbsp;Mohammed M. Almutairi ,&nbsp;Musaad A Alshammari ,&nbsp;Abdullah K. Alshememry ,&nbsp;Anas M. Abdel Rahman","doi":"10.1016/j.jksus.2024.103470","DOIUrl":"10.1016/j.jksus.2024.103470","url":null,"abstract":"<div><div>Traumatic brain injury (TBI), a progressive neurological disease caused by physical injury to the brain tissue, impacting its functions. This study employed metabolomics based on untargeted mass spectrometry method to examine plasma specimens from well-established mouse models with induced TBI (n = 6) and control mice (n = 6). The objective was to assess the metabolomics profile and the associated biochemical pathways in TBI. There was a noticeable segregation between TBI and reference groups (Q2 = 0.342, R2 = 0.993), according to orthogonal partial least square-discriminant analysis, indicating significant difference in metabolic expression. Moreover, 102 metabolites were significantly altered in TBI mice; 59 were upregulated, while 43 were downregulated in TBI mice. Correspondingly, the TBI model showed a significant dysregulation in number of key metabolic pathways, including metabolism of glycerophospholipids, linoleic acid, glycine, serine, threonine, pyrimidine, tryptophan, nicotinate and nicotinamide. Additionally, isoleucyl-asparagine, 2′-deoxyinosine triphosphate, diglycosyl diacylglycerols (25:0/26/2), and phosphatidylethanolamine (24:0/22:4) demonstrated excellent performance for TBI detection with an area under the curve ≥ 0.8. This study identified putative plasma biomarkers of TBI and highlighted the dysregulated biochemical pathways, providing valuable clinical insights into TBI research.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103470"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomedicine potential of Cymbopogon citratus Linn. –Biogenic synthesized silver nanoparticles: A study on antimicrobial and anticancer efficacy","authors":"Manikandan Ramasamy ,&nbsp;Ponmurugan Karuppiah ,&nbsp;Harini Ranganathan ,&nbsp;Sinouvassane Djearamane ,&nbsp;Ezhumalai Muthukrishnan ,&nbsp;Saminathan Kayarohanam ,&nbsp;Natarajan Arumugam ,&nbsp;Abdulrahaman I. Almansour ,&nbsp;Ling Shing Wong","doi":"10.1016/j.jksus.2024.103533","DOIUrl":"10.1016/j.jksus.2024.103533","url":null,"abstract":"<div><div>Green synthesis methods for making nanoparticles using plant extracts have gained considerable attention in recent years, particularly because of their potential applications in nanomedicine. Plant biosynthesized nanoparticles have shown noteworthy biomedical uses in comparison. The silver nanoparticle (AgNP) synthesized using extracts from the leaves and flowers of <em>Cymbopogon citratus Linn</em> was investigated for its antibacterial and anticancer properties. The biosynthesized AgNPs were characterized using UV–Vis, FTIR, DLS, EDX and SEM. The presence of alcohol, alkene, and phytochemicals in the AgNPs was confirmed using FTIR analysis. The investigation using SEM with EDX spectroscopy confirmed that the AgNPs were both pure and in the form of nanocrystals. Furthermore, AgNPs demonstrated significant antibacterial activity by efficiently suppressing bacterial growth. The biosynthesized AgNPs exhibited a concentration-dependent reduction in the lung cancer-A549 cell growth. The ethanolic extracts of <em>C. citratus</em> flower-synthesized AgNPs contain a wide range of phytochemical constituents. These components have been shown to effectively modulate antibacterial and anticancer activities, superior to<!--> <!-->the effects of leaf extracts synthesized AgNPs. Consequently, additional research is required to investigate the potential biomedical applications of these biosynthesized AgNPs.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103533"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile bio-inspired fabrication of AgNPs from Salvia elegans leaf extract and determination of their cytotoxic DNA photocleavage potential","authors":"Mufarreh Asmari ,&nbsp;A.H. Shridhar ,&nbsp;Joy H. Hoskeri ,&nbsp;B. Vinay Kumar ,&nbsp;Nayef Abdulaziz Aldabaan ,&nbsp;Ibrahim Ahmed Shaikh ,&nbsp;Abdulaziz Hassan Alhasaniah ,&nbsp;Mater H. Mahnashi ,&nbsp;Arun Shettar ,&nbsp;Basheerahmed Abdulaziz Mannasaheb ,&nbsp;Aejaz Abdullatif Khan ,&nbsp;Amal Bahafi ,&nbsp;Uday M. Muddapur ,&nbsp;S.M.Shakeel Iqubal","doi":"10.1016/j.jksus.2024.103536","DOIUrl":"10.1016/j.jksus.2024.103536","url":null,"abstract":"<div><div>This study introduces a sustainable method for producing silver nanoparticles (AgNPs), focusing on sustainability and environmental protection. The technique includes the use of <em>Salvia elegans</em> aqueous leaf extract as a reducing agent. In addition, the research investigates the dose-dependent degradation of pUC19 DNA by silver nanoparticles, which is facilitated by the generation of singlet oxygen. The presence of <em>S. elegans</em> extract results in significant color changes, going from a colorless state to a dark brown hue, serving as an indication of the synthesis of AgNPs. A range of experimental methods were employed to analyze the biogenic AgNPs, such as UV–visible absorption spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The meticulously produced AgNPs demonstrate a high level of uniformity, featuring a spherical shape and a particle size of 60 nm. DNA photo-cleavage studies show that singlet oxygen plays a crucial role in triggering DNA damage caused by AgNPs, indicating their potential as powerful cytotoxic agents specifically aimed at cancer cells. Additional studies are required to clarify the effectiveness and specificity of AgNPs against various cancer cell types to assess their therapeutic potential. The cytotoxic effects of AgNPs, particularly in relation to DNA photocleavage, are of considerable interest in cancer research. This research holds promise for developing novel and sustainable cancer therapies based on the unique properties of biogenic silver nanoparticles.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103536"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of phosphorous fertilizer on mineral nutrition and yield attributes of wheat: Acquisition with PSTOL1 gene for arid environment","authors":"Muhammad Iqbal Makhdum ,&nbsp;Muhammad Abid ,&nbsp;Rashida Hameed ,&nbsp;Sidra Balooch ,&nbsp;Sibgha Noreen ,&nbsp;Muhammad Salim Akhter ,&nbsp;Ummar Iqbal ,&nbsp;Adeel Abbas ,&nbsp;Mohammad Abul Farah ,&nbsp;Rattandeep Singh","doi":"10.1016/j.jksus.2024.103485","DOIUrl":"10.1016/j.jksus.2024.103485","url":null,"abstract":"<div><div>To boost agricultural yields, understanding mineral nutrition’s reliance on fertilizers is crucial, underscoring the need to evaluate nutrient-use efficiency for optimal fertilization. In this regard, a field study was conducted to elaborate the role of phosphorus fertilizer in enhancing growth, yield and marginal rate of return in four wheat varieties; two Zn-biofortified (Zincol-2016 and Akbar-2019) and two standard types (Anaj-2017 and FSD-2008). The study revealed that application of phosphorus significantly enhanced the uptake of nitrogen (N), phosphorous (P) and potassium (K) contents in straw (13 %, 59 % and 79 %) and grains (63 %, 92 % and 28 %) respectively. Similarly, the contents of Zinc (Zn) and iron (Fe) were reduced in straw (23 % and 19 %) and grains (19 % and 18 %) respectively after application of 80 and 120 kg P₂O₅, however at 40 kg P₂O₅ the contents of Zn and Fe were slightly enhanced. The grain yield (21 %) and harvest index (11 %) was maximum at 80 kg P₂O₅ as compared to 40 and 120 kg P₂O₅. The Marginal rate of return over investment (MRR) in P₂O₅ was maximum (241 %) in Akbar-2019 when P-fertilizer was applied at the rate of 80 kg P₂O₅ per ha⁻¹. Regression analysis showed a positive correlation between grain yield and its determinants. Biofortified wheat varieties responded better to 80 kg P₂O₅, outperforming standard varieties in yield. Additionally, our findings demonstrate a significant upregulation of <em>PSTOL1</em> gene expression at 80 kg P₂O₅ level. Concludingly the application of P-fertilizer at the rate of 80 kg P₂O₅ per ha⁻¹ enhanced growth, yield and rate of return of testing wheat varieties especially the biofortified ones; Zincol-2016 and Akbar-2019.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103485"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142551957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}