Jakob Lüker, Marc Strik, Jason G Andrade, Alexandre Raymond-Paquin, Mohamed Hassan Elrefai, Paul R Roberts, Óscar Cano Pérez, Jordana Kron, Jayanthi Koneru, Hilton Franqui-Rivera, Arian Sultan, Angela Ernst, Jörn Schmitt, Alexander Pott, Christian Veltmann, Neil T Srinivasan, Jason Collinson, Antonius M W van Stipdonk, Dominik Linz, Nina Fluschnik, Tobias Tönnis, Andreas Haeberlin, Sylvain Ploux, Daniel Steven
{"title":"Incidence of premature battery depletion in subcutaneous cardioverter-defibrillator patients: insights from a multicenter registry.","authors":"Jakob Lüker, Marc Strik, Jason G Andrade, Alexandre Raymond-Paquin, Mohamed Hassan Elrefai, Paul R Roberts, Óscar Cano Pérez, Jordana Kron, Jayanthi Koneru, Hilton Franqui-Rivera, Arian Sultan, Angela Ernst, Jörn Schmitt, Alexander Pott, Christian Veltmann, Neil T Srinivasan, Jason Collinson, Antonius M W van Stipdonk, Dominik Linz, Nina Fluschnik, Tobias Tönnis, Andreas Haeberlin, Sylvain Ploux, Daniel Steven","doi":"10.1007/s10840-023-01468-1","DOIUrl":"10.1007/s10840-023-01468-1","url":null,"abstract":"<p><strong>Background: </strong>The subcutaneous ICD established its role in the prevention of sudden cardiac death in recent years. The occurrence of premature battery depletion in a large subset of potentially affected devices has been a cause of concern. The incidence of premature battery depletion has not been studied systematically beyond manufacturer-reported data.</p><p><strong>Methods: </strong>Retrospective data and the most recent follow-up data on S-ICD devices from fourteen centers in Europe, the US, and Canada was studied. The incidence of generator removal or failure was reported to investigate the incidence of premature S-ICD battery depletion, defined as battery failure within 60 months or less.</p><p><strong>Results: </strong>Data from 1054 devices was analyzed. Premature battery depletion occurred in 3.5% of potentially affected devices over an observation period of 49 months.</p><p><strong>Conclusions: </strong>The incidence of premature battery depletion of S-ICD potentially affected by a battery advisory was around 3.5% after 4 years in this study. Premature depletion occurred exclusively in devices under advisory. This is in line with the most recently published reports from the manufacturer.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT04767516 .</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1409-1415"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10541584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Calvert, Mark T Mills, Ben Murray, Jonathan Kendall, Justin Ratnasingham, Vishal Luther, Dhiraj Gupta
{"title":"Feasibility of pulsed field ablation for atrial fibrillation under mild conscious sedation.","authors":"Peter Calvert, Mark T Mills, Ben Murray, Jonathan Kendall, Justin Ratnasingham, Vishal Luther, Dhiraj Gupta","doi":"10.1007/s10840-024-01961-1","DOIUrl":"10.1007/s10840-024-01961-1","url":null,"abstract":"<p><strong>Background: </strong>Pulsed field ablation (PFA) is a new modality for pulmonary vein isolation (PVI) for atrial fibrillation (AF). PFA is performed under general anaesthetic (GA) or deep sedation with propofol, but this requires anaesthetic support in many countries, restricting use. No study has tested the feasibility of PFA under mild conscious sedation (MCS).</p><p><strong>Methods: </strong>We prospectively recruited patients undergoing PFA PVI, offered the option of MCS delivered by electrophysiologists, and compared these with patients who opted for GA. MCS comprised intravenous midazolam and fentanyl. All procedures were performed under anaesthetic supervision in case of requirement to convert to GA, which formed the primary outcome.</p><p><strong>Results: </strong>Twenty-three patients were recruited (8 MCS, 15 GA). One patient (1/8 [12.5%]) required conversion from MCS to GA. Total procedural times were similar between groups (MCS 92 ± 12.4 min vs. GA 101 ± 17.3 min; p = 0.199). High mean sedative doses were required in the MCS group (5.12 ± 0.83 mg midazolam and 209 ± 40 mcg fentanyl). Median intraprocedural pain perception by the patient, rated from 0 to 100 was 45 (IQR 22.5-72.5) in the MCS group. Post-procedural groin pain (0 [0-0] vs. 5 [0-35]; p = 0.027) and throat pain (0 [0-0] vs. 10 [5-40]; p = 0.001) were lower in the MCS group.</p><p><strong>Conclusion: </strong>PFA under MCS is feasible in selected patients but pain and tolerance may be suboptimal, and high sedative doses are required.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1429-1436"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giacomo Mugnai, Bruna Bolzan, Elena Franchi, Sofia Capocci, Nicolò Pellegrini, Flavio Luciano Ribichini, Luca Tomasi
{"title":"Empirical disconnection of left posterior fascicle: a new paradigm in catheter ablation of ventricular fibrillation.","authors":"Giacomo Mugnai, Bruna Bolzan, Elena Franchi, Sofia Capocci, Nicolò Pellegrini, Flavio Luciano Ribichini, Luca Tomasi","doi":"10.1007/s10840-025-02010-1","DOIUrl":"10.1007/s10840-025-02010-1","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1543-1547"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johan van Koll, Madelon D E A Engels, Jesse H J Rijks, Madelon Salari, Jelle Luijten, Joost Lumens, Vanessa P M van Empel, Sjoerd W Westra, Antonius M W van Stipdonk, Theo A R Lankveld, Sevasti M Chaldoupi, Jacqueline Joza, Rypko J Beukema, Justin G L M Luermans, Dominik K Linz, Kevin Vernooy
{"title":"Long-term outcomes of pace-and-ablate strategy in patients with atrial fibrillation.","authors":"Johan van Koll, Madelon D E A Engels, Jesse H J Rijks, Madelon Salari, Jelle Luijten, Joost Lumens, Vanessa P M van Empel, Sjoerd W Westra, Antonius M W van Stipdonk, Theo A R Lankveld, Sevasti M Chaldoupi, Jacqueline Joza, Rypko J Beukema, Justin G L M Luermans, Dominik K Linz, Kevin Vernooy","doi":"10.1007/s10840-025-02038-3","DOIUrl":"10.1007/s10840-025-02038-3","url":null,"abstract":"<p><strong>Background: </strong>The pace-and-ablate strategy is second -line therapy to obtain rate control in patients with persistent symptomatic atrial fibrillation (AF) when other treatment options fail. This study aims to evaluate long-term effects on clinical outcomes following pace-and-ablate strategy in AF patients.</p><p><strong>Methods: </strong>This retrospective study includes patients who underwent successful pacemaker implantation (right ventricular pacing (RVP) or cardiac re-synchronization therapy (CRT)) followed by atrioventricular node ablation (AVNA) between 2010 and 2020. Patients were treated according to the prevailing guidelines. The primary endpoint was a composite of all-cause mortality and heart failure hospitalization (HFH). Secondary endpoints were individual outcomes of all-cause mortality, HFH, and left-ventricular ejection fraction (LVEF) change.</p><p><strong>Results: </strong>Two hundred ninety-eight patients were included, 162 undergoing RVP, and 136 receiving CRT, with a median follow-up of 5.8 years [4.1-8.0]. The primary endpoint occured in 47% of the RVP group and 49% of the CRT group (p = 0.206). All-cause mortality occurred in 36% of the RVP group and in 45% of the CRT group (p = 0.005). HFH occurred in 22% of the RVP group and in 15% of the CRT group (p = 0.328), with 17(10%) upgrades to CRT in the RVP group. Median LVEF in the RVP group remained stable (56% [49-60] to 53% [43-57]; p = 0.081), while it improved in the CRT group (31% [22-38] to 43% [32-51]; p < 0.001).</p><p><strong>Conclusion: </strong>Mortality and HFH in patients with AF managed through a pace-and-ablate strategy are high. Reassuringly, LVEF deterioration requiring upgrade to CRT is uncommon in patients undergoing RVP with normal baseline LVEF before AVNA. CRT improves LVEF in patients with reduced LVEF before AVNA.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1487-1495"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian M Petzl, Michael I Gurin, Francis E Marchlinski
{"title":"Right bundle branch block pattern with right ventricular pacing in arrhythmogenic right ventricular cardiomyopathy.","authors":"Adrian M Petzl, Michael I Gurin, Francis E Marchlinski","doi":"10.1007/s10840-025-02051-6","DOIUrl":"10.1007/s10840-025-02051-6","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1383-1385"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Panteleimon E Papakonstantinou, Kifayat Qazalbash, Gabor Szeplaki
{"title":"Breaking barriers in atrial ablations: pulsed field ablation over left atrial scar lesions.","authors":"Panteleimon E Papakonstantinou, Kifayat Qazalbash, Gabor Szeplaki","doi":"10.1007/s10840-025-02032-9","DOIUrl":"10.1007/s10840-025-02032-9","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1381-1382"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linear and spiral ablation catheters for ventricular pulsed field ablation.","authors":"Nicholas Y Tan, Christopher V DeSimone","doi":"10.1007/s10840-023-01719-1","DOIUrl":"10.1007/s10840-023-01719-1","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1373-1374"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138830143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bilawal Nadeem, Surik Sedrakyan, Amel Fatima, Mirza Mehmood Ali Baig, Ali Ahmed, Mifrah Rahat Khan Sherwani, John Wylie
{"title":"Outcomes of concurrent and delayed leadless pacemaker implantation following extraction of infected cardiovascular implantable electronic device.","authors":"Bilawal Nadeem, Surik Sedrakyan, Amel Fatima, Mirza Mehmood Ali Baig, Ali Ahmed, Mifrah Rahat Khan Sherwani, John Wylie","doi":"10.1007/s10840-024-01960-2","DOIUrl":"10.1007/s10840-024-01960-2","url":null,"abstract":"<p><strong>Introduction: </strong>The optimal reimplantation strategies following the removal of infected cardiovascular implantable electronic devices (CIEDs) remain inadequately understood. Given the limitations and risks associated with traditional approaches, the investigation of alternative devices, such as leadless pacemakers (LPs), has gained attention due to their potentially lower infection risk.</p><p><strong>Methods: </strong>We reviewed literature sources including PubMed, Scopus, and Embase, utilizing a combination of search terms. The inclusion criterion was leadless pacemaker (LP) implantation following lead removal (LR) of infected CIEDs, while the exclusion criterion was LR for noninfectious indications. Study endpoints encompassed patient outcomes during follow-up.</p><p><strong>Results: </strong>Our literature review yielded 827 articles, of which 22 met the inclusion criteria, encompassing a cohort of 657 patients who underwent LR followed by LP implantation. A total of 295 (44.9%) patients underwent concurrent LP implantation during the LR procedure. The rest underwent delayed procedures, and the overall duration between LR of infected CIED and LP implantation was 4.32 ± 3.9 days. A total of 194 (29.5%) patients had systemic CIED infections, whereas 153 (23.3%) had isolated pocket infections. In our patient cohort, procedural complications were scarce. Over a mean follow-up period of 13.3 ± 9.4 months, pacemaker syndrome was observed in 4 patients (0.61%), and 3 patients (0.46%) experienced persistent or recurrent infections.</p><p><strong>Conclusion: </strong>Our review finds both concurrent and delayed LP implantation after infected CIED extraction to be safe, with low reinfection rates and minimal complications. LPs could also serve as a bridge to CRT re-implantation minimizing the use of temporary pacing systems.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1523-1529"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Pepplinkhuizen, N Kors, J A de Veld, L A Dijkshoorn, N R Bijsterveld, A de Weger, L Smeding, A A M Wilde, L R A Olde Nordkamp, R E Knops
{"title":"Antithrombotic therapy and the risk of pocket hematoma after subcutaneous implantable cardioverter-defibrillator implantation.","authors":"S Pepplinkhuizen, N Kors, J A de Veld, L A Dijkshoorn, N R Bijsterveld, A de Weger, L Smeding, A A M Wilde, L R A Olde Nordkamp, R E Knops","doi":"10.1007/s10840-024-01973-x","DOIUrl":"10.1007/s10840-024-01973-x","url":null,"abstract":"<p><strong>Background: </strong>Little data exists regarding the optimal antithrombotic strategy during S-ICD implantation to prevent pocket hematomas. This study explores the association between perioperative antithrombotic management and the occurrence of pocket hematoma following S-ICD implantation.</p><p><strong>Methods: </strong>All patients who underwent de novo S-ICD implantation between February 2009 and January 2023 at Amsterdam UMC were included. Data was collected retrospectively from electronic patient records. Clinically significant pocket hematomas were defined as an accumulation of blood at the pocket site within 30 days after implantation.</p><p><strong>Results: </strong>A total of 347 patients were included of which 224 (64.6%) patients used antithrombotic therapy pre-implantation. The median age at implantation was 50 years (IQR 36-61 years), 33.4% of the patients were female, and the majority of implants were intermuscular (90.2%). A total of 18 patients (5.2%) developed a clinically significant pocket hematoma. There were significantly more pocket hematomas in patients with continued vitamin K antagonists (VKA) compared to patients with interrupted VKA (27.3% (6/22) vs. 4.3% (2/47), respectively, p = 0.01), and continuation of VKA was an independent predictor for pocket hematoma formation in the VKA group (p = 0.04). Moreover, continuation of dual antiplatelet therapy (DAPT) with ticagrelor was associated with significantly more pocket hematomas post-implantation compared to continuation of DAPT with clopidogrel (4/12 vs. 1/28, respectively, p = 0.02).</p><p><strong>Conclusion: </strong>Continuation of VKA during S-ICD implantation was associated with an increased risk of pocket hematoma formation compared to interruption of VKA. This supports the need for specific perioperative antithrombotic therapy guidelines for S-ICD implantations to reduce the risk of pocket hematomas.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1437-1446"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatima M Ezzeddine, Qiying Dai, Nathaniel E Davis, Jingjing Chen, Alan Sugrue, Ammar Killu, Malini Madhavan, Siva K Mulpuru, Paul Friedman, Yong-Mei Cha
{"title":"Predictors of cardiac resynchronization with conduction system pacing.","authors":"Fatima M Ezzeddine, Qiying Dai, Nathaniel E Davis, Jingjing Chen, Alan Sugrue, Ammar Killu, Malini Madhavan, Siva K Mulpuru, Paul Friedman, Yong-Mei Cha","doi":"10.1007/s10840-025-02012-z","DOIUrl":"10.1007/s10840-025-02012-z","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1509-1511"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}