Emanuele Curti, Giulio Falasconi, David Soto-Iglesias, Paula Franco-Ocaña, Federico Landra, Aldo Francisco Bellido, Dario Turturiello, Daniel Viveros, José Alderete, Fatima Zaraket, Bruno Tonello, Julio Martí-Almor, Diego Penela, Antonio Berruezo
{"title":"Computed tomography-based ganglionated plexi identification and bilateral extra-cardiac vagal stimulation streamline cardioneuroablation procedure.","authors":"Emanuele Curti, Giulio Falasconi, David Soto-Iglesias, Paula Franco-Ocaña, Federico Landra, Aldo Francisco Bellido, Dario Turturiello, Daniel Viveros, José Alderete, Fatima Zaraket, Bruno Tonello, Julio Martí-Almor, Diego Penela, Antonio Berruezo","doi":"10.1007/s10840-025-02059-y","DOIUrl":"https://doi.org/10.1007/s10840-025-02059-y","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Badertscher, Rebecca Arnet, Corinne Isenegger, Behnam Subin, Sven Knecht, Jessica Trussardi, Philipp Krisai, Felix Mahfoud, Christian Sticherling, Beat Schär, Michael Kühne
{"title":"Long-term follow up of single-chamber atrial pacing-system upgrade and Wenckebach block point behavior: potential implications for leadless AAI pacing?","authors":"Patrick Badertscher, Rebecca Arnet, Corinne Isenegger, Behnam Subin, Sven Knecht, Jessica Trussardi, Philipp Krisai, Felix Mahfoud, Christian Sticherling, Beat Schär, Michael Kühne","doi":"10.1007/s10840-025-02061-4","DOIUrl":"https://doi.org/10.1007/s10840-025-02061-4","url":null,"abstract":"<p><strong>Background: </strong>Single chamber atrial pacing (AAI) provides a disease-specific treatment for sick sinus syndrome (SSS) but has largely been replaced by DDD pacing. With the advent of leadless atrial pacemakers (PM), there is growing interest in long-term follow-up data in patients with SSS and an AAI pacemaker.</p><p><strong>Purpose: </strong>To assess the incidence of system upgrade in patients treated with AAI-PM for SSS during long-term follow-up.</p><p><strong>Methods: </strong>This is an analysis of prospectively enrolled patients undergoing implantation of an AAI-PM. Wenckebach block point (WBP) was measured at implantation and serially during follow up.</p><p><strong>Results: </strong>We included 178 patients (58% female, median age at implantation 77 [71-83] years). The median follow-up duration was 6.5 [2.0-9.7] years. Twenty-three patients (13%) received a system upgrade to a DDD system, corresponding to a yearly upgrade rate of 2.0%. Median time to system upgrade was 5.2 [1.6-8.7] years. Reasons for system upgrade were higher-degree AVB (39%), atrial arrhythmias (35%), low WBP (17%), and syncope (9%). Median WBP at implantation was 130 [120-140] bpm, showing a significant decline over time in the upgrade-group compared to the rest of the cohort with 103 [91-130] bpm vs. 130 [120-130] bpm (p = 0.011).</p><p><strong>Conclusion: </strong>In this cohort of patients undergoing AAI-PM implantation for SSS, upgrade to a DDD system was low during long-term follow-up. Therefore, AAI pacing for the treatment of SSS may be considered a patient-tailored treatment option, especially in light of novel leadless pacing therapies.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emre Oto, Sercan Okutucu, Deniz Katircioglu Öztürk, Naim Ata, Bunyamin Yavuz, Chris Gale, A John Camm, Karen S Pieper, Ajay K Kakkar, Ali Oto
{"title":"A new score with superior stroke risk prediction in atrial fibrillation: entropy-based information gain approaches in a large nationwide cohort.","authors":"Emre Oto, Sercan Okutucu, Deniz Katircioglu Öztürk, Naim Ata, Bunyamin Yavuz, Chris Gale, A John Camm, Karen S Pieper, Ajay K Kakkar, Ali Oto","doi":"10.1007/s10840-025-02053-4","DOIUrl":"https://doi.org/10.1007/s10840-025-02053-4","url":null,"abstract":"<p><strong>Background: </strong>Risk scores have been used to assess stroke risk in atrial fibrillation (AF) for reducing ischemic stroke and bleeding risk. Information gain ratio (IGR) is an entropy-based parameter that shows which clinical score is more informative for prediction of the clinical endpoint.</p><p><strong>Objective: </strong>Herein, we aimed to generate and validate a stroke risk score based on the TuRkish Atrial Fibrillation (TRAF) data.</p><p><strong>Methods: </strong>We used a split-sample approach to develop and internally validate the new stroke risk score. Based on multivariate logistic regression analysis, we generated CHADS-F in the anticoagulation naïve TRAF cohort (274,631 patients). CHADS-F stands for Cardiac failure (1 point), hypertension (1 point), age (≥ 65-69 = 1 point, ≥ 70-74 = 2 points ≥ 75 = 3 points), diabetes (1 point), stroke (2 points), and older female (1 point) (≥ 65). External validation was performed in the \"Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF)\" Registry. Informative capacity and accuracy of the CHADS-F score was compared with CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores.</p><p><strong>Results: </strong>In anticoagulation naïve cohort, CHADS-F (IGR for all cohort: 0.7526) outperforms both the CHADS<sub>2</sub> (IGR for all cohort: 0.6340) and CHA<sub>2</sub>DS<sub>2</sub>-VASc (IGR for all cohort: 0.6969) in terms of the IGR for ischemic stroke and systemic embolism. Receiver operating characteristic curves revealed highest accuracy for the CHADS-F score [area under curve for CHADS-F: 0.743, CHADS<sub>2</sub>: 0.722, and CHA<sub>2</sub>DS<sub>2</sub>-VASc: 0.722]. CHADS-F had good discriminative abilities at predicting clinical endpoints in the GARFIELD-AF registry.</p><p><strong>Conclusion: </strong>The CHADS-F score had higher informative capacity and accuracy than the current CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores for predicting stroke and systemic embolism.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chronically jailed right ventricular implantable cardioverter defibrillator lead visualized with imaging integration prior to ventricular tachycardia ablation.","authors":"Nithi Tokavanich, Jackson Liang","doi":"10.1007/s10840-025-02054-3","DOIUrl":"https://doi.org/10.1007/s10840-025-02054-3","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Andrés Del Valle-Montero, Irene Esteve-Ruiz, María Teresa Moraleda-Salas, Pablo Moriña-Vázquez, Ana José Manovel-Sánchez, Antonio Enrique Gómez-Menchero
{"title":"Atrial septal pouch as the main cause of failed transseptal puncture in pulmonary vein isolation.","authors":"José Andrés Del Valle-Montero, Irene Esteve-Ruiz, María Teresa Moraleda-Salas, Pablo Moriña-Vázquez, Ana José Manovel-Sánchez, Antonio Enrique Gómez-Menchero","doi":"10.1007/s10840-025-02067-y","DOIUrl":"https://doi.org/10.1007/s10840-025-02067-y","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Talha Gunes, Soner Duman, Derya Demir, Evrim Simsek
{"title":"Comparison of two suturing techniques in terms of lead stabilizing efficiency in acute and chronic terms.","authors":"Mustafa Talha Gunes, Soner Duman, Derya Demir, Evrim Simsek","doi":"10.1007/s10840-025-02060-5","DOIUrl":"https://doi.org/10.1007/s10840-025-02060-5","url":null,"abstract":"<p><strong>Background and aims: </strong>Cardiac implantable electronic devices (CIED) are frequently used in the treatment of arrhythmias. Maintenance of lead position is a key element for proper functioning of the CIEDs. There are two suturing techniques that are commonly used to anchor the leads to pectoral muscle (simple knot and anchor knot techniques). While there is one in vitro study comparing lead stabilizing efficacy of these two techniques, there is no in vivo study in the literature. In this in vivo study, the efficacy of lead stabilization between these two techniques was compared.</p><p><strong>Methods: </strong>Twenty rabbits were included in this study, and they were divided into two equal groups. The anchor knot technique was used in one group, whereas the simple knot technique was used in the other group. The rabbits were followed up for 2 weeks and 4 weeks (acute term and chronic term, respectively). At the end of the acute term, the leads were evaluated for spontaneous dislocation and resistance to at least 10 N of traction force. Whether the leads maintained their position in the sleeve was evaluated by measurement. At the end of 4 weeks, in addition to aforementioned criteria, whether necrosis had occurred was evaluated on pectoral muscle biopsy specimens that included the area where suture was taken. Additionally, the two suturing techniques were also compared for procedural time on the last two rabbits of each group.</p><p><strong>Results: </strong>Seven and nine rabbits were evaluated for outcomes throughout acute and chronic terms, respectively. Four rabbits died during follow-up, two of which due to anesthetic complications. No lead- or suture-related complications were observed at postmortem examinations of these rabbits. All leads stabilized by using the anchor knot technique maintained their position in the sleeve and were resistant to at least 10 N of traction force in acute and chronic terms. The leads stabilized by the simple knot technique (three rabbits) maintained their position in the acute term, two of them were dislocated under traction and only one of them was found to be partially resistant to at least 10 N of traction force. 0.5 cm of dislocation was observed between that lead and its sleeve after applying traction. Only two leads (50%) stabilized by using the simple knot technique in chronic term remained their position. Lead and sleeve dislocated together in one subject, while the other lead was found separately dislocated from its sleeve. One of the two other leads was resistant to at least 10 N of traction force and that lead remained in stable in sleeve. Muscle biopsy specimens of eight rabbits were evaluated for necrosis. Two of the three samples were found to have necrosis in the simple knot technique group; however, none of the five rabbits in the anchor knot group had necrosis. The time required for the complete stabilization process in the last two rabbits of each suturing technique group was 21","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ting-Wei Ernie Liao, Lingyu Xu, Mirmilad Pourmousavi Khoshknab, Paul J Mather, Paco E Bravo, Benoit Desjardins, Saman Nazarian
{"title":"Quantitative cardiac magnetic resonance standardized signal intensity comparison in dilated cardiomyopathy vs. cardiac sarcoidosis.","authors":"Ting-Wei Ernie Liao, Lingyu Xu, Mirmilad Pourmousavi Khoshknab, Paul J Mather, Paco E Bravo, Benoit Desjardins, Saman Nazarian","doi":"10.1007/s10840-025-02042-7","DOIUrl":"https://doi.org/10.1007/s10840-025-02042-7","url":null,"abstract":"<p><strong>Background: </strong>Dilated cardiomyopathy (DCM) and cardiac sarcoidosis (CS) manifest unique late gadolinium enhancement (LGE) patterns on cardiac magnetic resonance (CMR), indicative of different myocardial scar distributions. However, the overlap in these patterns due to their lack of specificity complicates differentiation. This study introduces a novel quantitative method employing z-score analysis of LGE-CMR intensity to objectively compare the spatial distribution of LGE intensity between DCM and CS.</p><p><strong>Methods: </strong>This retrospective study included 22 NICM patients (13 DCM, 9 CS) who underwent CMR before electrophysiology study from November 2018 to May 2023. LGE images were delineated into sub-endocardial, mid-myocardial, and sub-epicardial layers across anterior, lateral, inferior, and septal walls using the AHA 17-segment model. CMR signal intensities were standardized to z-scores (z = (x - μ)/σ), with x as the signal intensity for a specific myocardial segment, and μ and σ as the mean and SD for all LV myocardial segments, to map regional intensity variations.</p><p><strong>Results: </strong>Compared to DCM, CS patients exhibited significantly higher CMR signal intensity z-scores in the septum (β = 0.32, p = 0.009), particularly in the endocardial third of the right ventricular (RV) side (β = 0.56, p = 0.001). A z-score greater than 0.40 in this area was associated with a CS diagnosis, with an area under the ROC curve of 0.692 in fivefold cross-validation.</p><p><strong>Conclusion: </strong>Patients with CS exhibit higher affinity for contrast in the septum, particularly on the RV endocardium. Standardized analysis of CMR signal intensities provides a novel, quantitative method for distinguishing CS from DCM, with the former exhibiting higher CMR signal intensity z-scores in the septum.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Auroa Badin, Sreedhar R Billakanty, David M Nemer, Ankur N Shah, Andrea K Robinson, Allyson Farrah, Nagesh Chopra, Elizabeth Richards, Anish K Amin
{"title":"Learning curve of pulsed field ablation for atrial fibrillation: insights from a United States center.","authors":"Auroa Badin, Sreedhar R Billakanty, David M Nemer, Ankur N Shah, Andrea K Robinson, Allyson Farrah, Nagesh Chopra, Elizabeth Richards, Anish K Amin","doi":"10.1007/s10840-025-02043-6","DOIUrl":"https://doi.org/10.1007/s10840-025-02043-6","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simplification of left bundle branch area pacing using a novel modified 3-lead pacing system analyzer electrocardiogram technique in the non-electrophysiology laboratory.","authors":"Ugur Canpolat, Mert Dogan, Kudret Aytemir","doi":"10.1007/s10840-025-02057-0","DOIUrl":"https://doi.org/10.1007/s10840-025-02057-0","url":null,"abstract":"<p><strong>Background: </strong>An electrophysiology (EP) recording system is recommended throughout the left bundle branch area pacing (LBBaP) procedure. However, the requirement of an EP recording system limits the wide adoption of LBBaP in non-EP laboratory settings. Thus, in this study, we proposed a novel set-up in non-EP laboratories using manufacturer pacing system analyzer (PSA)-derived electrogram guidance and fluoroscopy of the angiography system for LBBaP.</p><p><strong>Methods: </strong>Our study prospectively enrolled consecutive patients who underwent LBBaP for bradyarrhythmia indications. LBBaP was performed using a stylet-driven lead (SDL) delivered through a dedicated delivery sheath. Procedural characteristics were recorded at the implant. The agreement of measurements on the modified 3-lead ECG of PSA and standard 12-lead ECG was analyzed.</p><p><strong>Results: </strong>A total of 83 patients were enrolled (mean age 65.4 ± 11.8 years, 55.4% male). The LBBaP with an SDL was successful for all patients. The pacing response was observed as LBBP in 69.9% of cases, while 30.1% were classified as left ventricular septal pacing. The mean paced QRS duration (pQRSd) and the stimulus to left ventricular activation time (LVAT) were measured at 117.6 ± 11.4 ms and 68 ± 17 ms using a modified 3-lead ECG of PSA, compared to 118.5 ± 11.8 ms and 70 ± 13 ms using the standard 12-lead ECG, with agreements of 0.89 and 0.93, respectively. SDL-LBBaP resulted in low unipolar and bipolar pacing thresholds (0.7 ± 0.2 V at 0.4 ms and 0.8 ± 0.2 V at 0.4 ms), which remained stable at a median 12-month follow-up (p > 0.05). An atrial lead revision was needed for one (1.2%) patient during the first-month visit. Acute interventricular septal perforation occurred in two (2.4%) patients as a specific complication of LBBaP.</p><p><strong>Conclusion: </strong>Our novel setting in non-EP laboratories, utilizing fluoroscopy from the angiography system and manufacturer-modified 3-lead ECG and EGM of PSA during LBBaP, is feasible, reliable, and widely available. LBB capture was confirmed by both the standard EP recording system and new modified PSA 3-lead ECG measurements, which showed good agreement. Further large-scale data is needed to validate our findings.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}