Gaia Filiberti, Giulia Antonelli, Giulio Falasconi, Alessandro Villaschi, Stefano Figliozzi, Martina Maria Ruffo, Antonio Taormina, Guido Del Monaco, Alessia Chiara Latini, Sebastiano Carli, Kamil Stankowski, Stefano Valcher, Nicola Cesani, Francesco Amata, Alessandro Giaj Levra, Filippo Giunti, Giacomo Carella, David Soto-Iglesias, Dario Turturiello, Federico Landra, Andrea Saglietto, Emanuele Curti, Pietro Francia, Julio Martí-Almor, Diego Penela, Antonio Berruezo
{"title":"The use of cardiac imaging in patients undergoing atrial fibrillation ablation.","authors":"Gaia Filiberti, Giulia Antonelli, Giulio Falasconi, Alessandro Villaschi, Stefano Figliozzi, Martina Maria Ruffo, Antonio Taormina, Guido Del Monaco, Alessia Chiara Latini, Sebastiano Carli, Kamil Stankowski, Stefano Valcher, Nicola Cesani, Francesco Amata, Alessandro Giaj Levra, Filippo Giunti, Giacomo Carella, David Soto-Iglesias, Dario Turturiello, Federico Landra, Andrea Saglietto, Emanuele Curti, Pietro Francia, Julio Martí-Almor, Diego Penela, Antonio Berruezo","doi":"10.1007/s10840-025-02035-6","DOIUrl":"10.1007/s10840-025-02035-6","url":null,"abstract":"<p><p>Cardiac imaging (CI), including echocardiography, multidetector computed tomography (MDCT), and cardiac magnetic resonance (CMR), is gaining increasing interest to aid atrial fibrillation (AF) ablation procedures, from pre-procedural planning to intra-procedural guidance. Transthoracic echocardiography is widely used for imaging, especially for preprocedural assessment, while transesophageal and intracardiac echocardiography (ICE) are used for intraprocedural guidance during transseptal puncture. Cardiac MDCT, leveraging its high spatial resolution, offers a detailed anatomical visualization of cardiac chambers and adjacent structures; moreover, left atrial wall thickness assessed by MDCT may guide radiofrequency energy titration to enhance procedural safety and efficiency. At the same time, CMR allows for detailed myocardial tissue characterization and the detection of fibrosis. ICE, MDCT, and CMR also permit intra-procedural image integration with electroanatomical maps, allowing to be aware of a greater amount of intra-procedural real-time information regarding the anatomy and the local characteristics of the tissue in contact with the ablation catheter. One of the primary objectives of performing CI-aided AF ablations is to increase procedural safety and to permit more personalized procedures, according to the characteristics of each patient. This review offers a comprehensive overview of the current applications of CI during the different phases of AF ablation and explores the potential future applications of CI in this context.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1719-1738"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iva Minga, Kevin Lee, Lolita Golemi, Allyson Varley, Christopher Thorne, Jose Osorio, Shrinivas Hebsur, Anil Rajendra, Gustavo Morales, Saumil Oza, Anthony Magnano, Luigi Di Biase, Matthew Singleton, Paul C Zei, Benjamin Dsouza, Joshua Silverstein, Mark Metzl
{"title":"Comparative analysis of transesophageal echocardiography (TEE) and intracardiac echocardiography (ICE) in atrial fibrillation ablation: insights from the real-world experience registry.","authors":"Iva Minga, Kevin Lee, Lolita Golemi, Allyson Varley, Christopher Thorne, Jose Osorio, Shrinivas Hebsur, Anil Rajendra, Gustavo Morales, Saumil Oza, Anthony Magnano, Luigi Di Biase, Matthew Singleton, Paul C Zei, Benjamin Dsouza, Joshua Silverstein, Mark Metzl","doi":"10.1007/s10840-025-02013-y","DOIUrl":"10.1007/s10840-025-02013-y","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1695-1697"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siddharth Agarwal, Zain Ul Abideen Asad, Muhammad Bilal Munir, Alan Sugrue, Nicholas Y Tan, Freddy Del-Carpio Munoz, Siva K Mulpuru, Yong-Mei Cha, Christopher V DeSimone, Abhishek Deshmukh
{"title":"Regional differences in the outcomes of leadless pacemaker implantation in the USA.","authors":"Siddharth Agarwal, Zain Ul Abideen Asad, Muhammad Bilal Munir, Alan Sugrue, Nicholas Y Tan, Freddy Del-Carpio Munoz, Siva K Mulpuru, Yong-Mei Cha, Christopher V DeSimone, Abhishek Deshmukh","doi":"10.1007/s10840-025-02023-w","DOIUrl":"10.1007/s10840-025-02023-w","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1699-1702"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Arslan Ul Hassan, Sana Mushtaq, Tao Li, Zhen Yang, Abdul Rehman, Al-Qaisi Mohammed Abdulkarem
{"title":"Correlation between diagnosis-to-ablation time and atrial fibrillation recurrence: a systematic review and meta-analysis.","authors":"Muhammad Arslan Ul Hassan, Sana Mushtaq, Tao Li, Zhen Yang, Abdul Rehman, Al-Qaisi Mohammed Abdulkarem","doi":"10.1007/s10840-025-02015-w","DOIUrl":"10.1007/s10840-025-02015-w","url":null,"abstract":"<p><strong>Background: </strong>The time from the initial diagnosis of atrial fibrillation (AF) to the index ablation procedure, known as diagnosis-to-ablation time (DAT), is a modifiable risk factor that is correlated to affect the recurrence of AF. The objective of this meta-analysis was to examine the correlation between diagnosis-to-ablation time and AF recurrence.</p><p><strong>Methods: </strong>A systematic search was performed in PubMed, Google Scholar, and Cochrane Library from database inception till June 2024. Studies reporting diagnosis-to-ablation time and its relation with AF recurrence were included. The primary analysis evaluated outcomes segregated by DAT ≤ 1 year versus > 1 year. Random-effects model with the Mantel-Haenszel method was used to evaluate AF recurrence.</p><p><strong>Results: </strong>Of the 9177 articles, only 6 observational studies got through the inclusion criteria with a total participant count of 14,862. DAT of greater than 1 year was associated with increased risk of AF recurrence in all the included studies while DAT of ≤ 1 year was correlated with lower risk of AF recurrence (RR, 0.76 (95% CI, 0.73-0.79); P < 0.01). Similarly, DAT of ≤ 3 years was correlated with lower AF recurrence risk (RR, 0.82 (95% CI, 0.79-0.85); P < 0.01).</p><p><strong>Conclusion: </strong>Evidence from observational cohorts suggests that the optimum time for ablation in AF patients is less than 1 year and a DAT of ≤ 1 year is linked to 24% lower chances of recurrence in AF patients, compared to DAT of ≥ 1 year.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1711-1717"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emre Oto, Sercan Okutucu, Deniz Katircioglu Öztürk, Naim Ata, Bunyamin Yavuz, Chris Gale, A John Camm, Karen S Pieper, Ajay K Kakkar, Ali Oto
{"title":"A new score with superior stroke risk prediction in atrial fibrillation: entropy-based information gain approaches in a large nationwide cohort.","authors":"Emre Oto, Sercan Okutucu, Deniz Katircioglu Öztürk, Naim Ata, Bunyamin Yavuz, Chris Gale, A John Camm, Karen S Pieper, Ajay K Kakkar, Ali Oto","doi":"10.1007/s10840-025-02053-4","DOIUrl":"10.1007/s10840-025-02053-4","url":null,"abstract":"<p><strong>Background: </strong>Risk scores have been used to assess stroke risk in atrial fibrillation (AF) for reducing ischemic stroke and bleeding risk. Information gain ratio (IGR) is an entropy-based parameter that shows which clinical score is more informative for prediction of the clinical endpoint.</p><p><strong>Objective: </strong>Herein, we aimed to generate and validate a stroke risk score based on the TuRkish Atrial Fibrillation (TRAF) data.</p><p><strong>Methods: </strong>We used a split-sample approach to develop and internally validate the new stroke risk score. Based on multivariate logistic regression analysis, we generated CHADS-F in the anticoagulation naïve TRAF cohort (274,631 patients). CHADS-F stands for Cardiac failure (1 point), hypertension (1 point), age (≥ 65-69 = 1 point, ≥ 70-74 = 2 points ≥ 75 = 3 points), diabetes (1 point), stroke (2 points), and older female (1 point) (≥ 65). External validation was performed in the \"Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF)\" Registry. Informative capacity and accuracy of the CHADS-F score was compared with CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores.</p><p><strong>Results: </strong>In anticoagulation naïve cohort, CHADS-F (IGR for all cohort: 0.7526) outperforms both the CHADS<sub>2</sub> (IGR for all cohort: 0.6340) and CHA<sub>2</sub>DS<sub>2</sub>-VASc (IGR for all cohort: 0.6969) in terms of the IGR for ischemic stroke and systemic embolism. Receiver operating characteristic curves revealed highest accuracy for the CHADS-F score [area under curve for CHADS-F: 0.743, CHADS<sub>2</sub>: 0.722, and CHA<sub>2</sub>DS<sub>2</sub>-VASc: 0.722]. CHADS-F had good discriminative abilities at predicting clinical endpoints in the GARFIELD-AF registry.</p><p><strong>Conclusion: </strong>The CHADS-F score had higher informative capacity and accuracy than the current CHADS<sub>2</sub> and CHA<sub>2</sub>DS<sub>2</sub>-VASc scores for predicting stroke and systemic embolism.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1739-1748"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameer A Kunte, Lurdes Y T Inoue, William T Abraham, John G F Cleland, Anne B Curtis, Daniel J Friedman, Michael R Gold, Valentina Kutyifa, Cecilia Linde, Anthony S Tang, Gillian D Sanders, Sana M Al-Khatib
{"title":"Clinical phenotypes and outcomes associated with improved left ventricular ejection fraction after biventricular pacing.","authors":"Sameer A Kunte, Lurdes Y T Inoue, William T Abraham, John G F Cleland, Anne B Curtis, Daniel J Friedman, Michael R Gold, Valentina Kutyifa, Cecilia Linde, Anthony S Tang, Gillian D Sanders, Sana M Al-Khatib","doi":"10.1007/s10840-025-02040-9","DOIUrl":"10.1007/s10840-025-02040-9","url":null,"abstract":"<p><strong>Background: </strong>In some patients who receive a cardiac resynchronization therapy (CRT) device, the left ventricular ejection fraction (LVEF) does not improve.</p><p><strong>Methods: </strong>We analyzed patients enrolled in the REVERSE, MADIT-CRT, and BLOCK-HF trials, restricting the analysis to those who received CRT. Characteristics of patients with or without improved LVEF were compared using two sample t-tests and Pearson's chi-square tests. Kaplan-Meier survival curves were constructed to display time-to-event data. A log-rank test was used to compare event rates for patients with or without improved LVEF. Mixed effects Cox Proportional-Hazards models adjusting for covariates were used to analyze time to death or heart failure hospitalization (HFH) and time to death.</p><p><strong>Results: </strong>Of 1065 included patients, 75% (802) were men, 87% (793) were White, 11% (118) were Black, and 7% (72) were Hispanic. LVEF improved in 910 (85%) patients and did not in 155 (15%). Patients with an improved LVEF were less likely to have ischemic cardiomyopathy (ICM) (54% vs 76%; p = 0.004), more likely to have LBBB (73% vs 53%; p = < 0.001), and had longer QRS duration (159 vs 150 ms; p = < 0.001). In adjusted analyses, improved LVEF was associated with a longer time to HFH or death (HR 0.40; 95% CI 0.26-0.62; p < 0.001) or death alone (HR 0.27; 95% CI 0.15-0.48; p < 0.001).</p><p><strong>Conclusions: </strong>Patients with improvement in LVEF post-CRT implantation are less likely to have ICM and more likely to have LBBB and a longer QRS interval. Improvement in LVEF was associated with better outcomes.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1555-1562"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unintended isolation of the left atrial appendage: a rare complication of pulsed-field ablation.","authors":"Yuki Takai, Yuya Nakamura, Taku Asano, Toshiro Shinke","doi":"10.1007/s10840-025-02055-2","DOIUrl":"10.1007/s10840-025-02055-2","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1549-1550"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrick Badertscher, Rebecca Arnet, Corinne Isenegger, Behnam Subin, Sven Knecht, Jessica Trussardi, Philipp Krisai, Felix Mahfoud, Christian Sticherling, Beat Schär, Michael Kühne
{"title":"Long-term follow up of single-chamber atrial pacing-system upgrade and Wenckebach block point behavior: potential implications for leadless AAI pacing?","authors":"Patrick Badertscher, Rebecca Arnet, Corinne Isenegger, Behnam Subin, Sven Knecht, Jessica Trussardi, Philipp Krisai, Felix Mahfoud, Christian Sticherling, Beat Schär, Michael Kühne","doi":"10.1007/s10840-025-02061-4","DOIUrl":"10.1007/s10840-025-02061-4","url":null,"abstract":"<p><strong>Background: </strong>Single chamber atrial pacing (AAI) provides a disease-specific treatment for sick sinus syndrome (SSS) but has largely been replaced by DDD pacing. With the advent of leadless atrial pacemakers (PM), there is growing interest in long-term follow-up data in patients with SSS and an AAI pacemaker.</p><p><strong>Purpose: </strong>To assess the incidence of system upgrade in patients treated with AAI-PM for SSS during long-term follow-up.</p><p><strong>Methods: </strong>This is an analysis of prospectively enrolled patients undergoing implantation of an AAI-PM. Wenckebach block point (WBP) was measured at implantation and serially during follow up.</p><p><strong>Results: </strong>We included 178 patients (58% female, median age at implantation 77 [71-83] years). The median follow-up duration was 6.5 [2.0-9.7] years. Twenty-three patients (13%) received a system upgrade to a DDD system, corresponding to a yearly upgrade rate of 2.0%. Median time to system upgrade was 5.2 [1.6-8.7] years. Reasons for system upgrade were higher-degree AVB (39%), atrial arrhythmias (35%), low WBP (17%), and syncope (9%). Median WBP at implantation was 130 [120-140] bpm, showing a significant decline over time in the upgrade-group compared to the rest of the cohort with 103 [91-130] bpm vs. 130 [120-130] bpm (p = 0.011).</p><p><strong>Conclusion: </strong>In this cohort of patients undergoing AAI-PM implantation for SSS, upgrade to a DDD system was low during long-term follow-up. Therefore, AAI pacing for the treatment of SSS may be considered a patient-tailored treatment option, especially in light of novel leadless pacing therapies.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1605-1612"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Andrés Del Valle-Montero, Irene Esteve-Ruiz, María Teresa Moraleda-Salas, Pablo Moriña-Vázquez, Ana José Manovel-Sánchez, Antonio Enrique Gómez-Menchero
{"title":"Atrial septal pouch as the main cause of failed transseptal puncture in pulmonary vein isolation.","authors":"José Andrés Del Valle-Montero, Irene Esteve-Ruiz, María Teresa Moraleda-Salas, Pablo Moriña-Vázquez, Ana José Manovel-Sánchez, Antonio Enrique Gómez-Menchero","doi":"10.1007/s10840-025-02067-y","DOIUrl":"10.1007/s10840-025-02067-y","url":null,"abstract":"","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1551-1552"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antoine Da Costa, Lucas Ovache, Sarah Chellali, Jean Baptiste Guichard, Cécile Romeyer, Cedric Yvorel, Karim Benali
{"title":"Preoperative skin antiseptics for the prevention of cardiac implantable electronic device infections: chlorhexidine-alcohol versus povidone-iodine-alcohol.","authors":"Antoine Da Costa, Lucas Ovache, Sarah Chellali, Jean Baptiste Guichard, Cécile Romeyer, Cedric Yvorel, Karim Benali","doi":"10.1007/s10840-025-02049-0","DOIUrl":"10.1007/s10840-025-02049-0","url":null,"abstract":"<p><strong>Background: </strong>Skin antisepsis plays a key role in the prevention of cardiac implantable electronic device (CIED) infections. Moreover, skin antisepsis by chlorhexidine-alcohol has not yet been fully evaluated.</p><p><strong>Objectives: </strong>This single-center controlled study sought (1) to conduct a prospective observational analysis comparing two antiseptic skin preparations over two similar consecutive time periods, one conducted over a 1-year period using a povidone-iodine-alcohol solution (group I) and the other over the following year with a chlorhexidine-alcohol solution (group II) and (2) to determine real-life CIED infection predictive factors using the Prevention of Arrhythmia Device Infection Trial (PADIT) score.</p><p><strong>Methods and results: </strong>CIED implantations were performed in 1689 patients. A total of 17 patients (1.01%) developed a CIED infection. Long-term follow-up (16 ± 13 months) revealed no significant differences between groups: infections were observed in 9/844 patients (1.07%) in group I versus 8/845 patients (0.95%) in group II (p = 0.99). Univariate and multivariate logistic regression analyses were performed to identify infectious risk factors. Adjusted odds ratios (ORs) and hazard ratios (HRs) were calculated. Univariate analyses revealed that infection occurrence was positively correlated with acute heart failure (OR: 3.55; 95%CI [1.24-9.37]; p = 0.01 and HR: 3.37; 95% CI [1.28-8.87]; p = 0.014), renal failure (OR: 2.71; 95% CI [0.88-8.42]; p = 0.08 and HR: 2.99; 95% CI [0.97-9.17]; p = 0.05), use of temporary pacing before the implantation procedure (OR: 4.45; 95% CI [1.003-20.3]; p = 0.04 and HR: 4.35; 95% CI [0.99-19.05]; p = 0.05), PADIT score (OR: 1.3; 95% CI [1.064-1.54]; p = 0.009 and HR: 1.27; 95% CI [1.052-1.53]; p = 0.013), and PADIT score ≥ 5 (OR: 4.185; 95% CI [1.6-10.9]; p = 0.003 and HR: 3.91; 95% CI [1.51-10.149]; p = 0.005). No clear significant difference was found regarding the antiseptic skin preparation choice (OR: 0.88; 95% CI [0.34-2.3]; p = 0.8 and HR: 1.11; 95% CI [0.416-2.98]; p = 0.82). In multivariate analysis, the PADIT score ≥ 5 (OR: 3.18; 95% CI [1.125-8.99]; p = 0.003 and HR: 3.052; 95% CI [1.089-8.55]; p = 0.034) and use of temporary pacing before the implantation procedure (OR: 8.44; 95% CI [1.68-42.34]; p = 0.01 and HR: 8.49; 95% CI [1.732-41.69]; p = 0.008) were negatively correlated with the device infection risk.</p><p><strong>Conclusion: </strong>This study found that chlorhexidine-alcohol and povidone-iodine-alcohol solutions displayed similar antiseptic effects regarding CIED infection prevention. Both use of temporary pacing before the implantation procedure and PADIT score ≥ 5 correlated with the device infection risk.</p>","PeriodicalId":16202,"journal":{"name":"Journal of Interventional Cardiac Electrophysiology","volume":" ","pages":"1563-1572"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}