Journal of Investigative Surgery最新文献_第7页

Advances in Ultrasound-Guided Fascial Plane Blocks for Perioperative Acute Pain Management. 超声引导筋膜平面阻滞治疗围手术期急性疼痛的研究进展。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-06-09 DOI: 10.1080/08941939.2026.2681992

Feng-Lei Yuan

{"title":"Advances in Ultrasound-Guided Fascial Plane Blocks for Perioperative Acute Pain Management.","authors":"Feng-Lei Yuan","doi":"10.1080/08941939.2026.2681992","DOIUrl":"10.1080/08941939.2026.2681992","url":null,"abstract":"Introduction: Perioperative acute pain remains a major challenge because conventional analgesic strategies are often limited by inadequate efficacy and opioid-related adverse effects. Ultrasound-guided fascial plane blocks (FPBs) have become important components of multimodal analgesia. This review summarizes the mechanisms, clinical efficacy, safety, and future directions of major FPBs, including transversus abdominis plane, quadratus lumborum, and serratus anterior plane blocks, and discusses the emerging role of artificial intelligence (AI).Methods: PubMed, Embase, and the Cochrane Library were searched for relevant studies published up to December 2023. Clinical trials, meta-analyses, and mechanistic studies were reviewed, with emphasis on analgesic efficacy, opioid-sparing effects, safety, and AI-assisted applications.Results: Current evidence indicates that ultrasound-guided FPBs provide effective truncal analgesia, reduce postoperative pain and opioid consumption, and may improve recovery while maintaining favorable safety profiles in selected settings. However, clinical benefits vary according to block type, surgical procedure, and comparator regimen. Adjuvants and continuous catheter techniques may prolong analgesia, whereas AI-assisted systems show promise for image interpretation and training.Conclusion: Ultrasound-guided FPBs are valuable components of perioperative multimodal analgesia and may improve analgesic quality while reducing opioid requirements.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2681992"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148205049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Edaravone Dexborneol Treatment After Intracranial Vascular Intervention on Inflammatory Factors and Oxidative Stress Level in Elderly Patients with Acute Ischemic Cerebrovascular Disease. 颅内血管介入治疗后依达拉奉右冰片对老年急性缺血性脑血管病患者炎症因子及氧化应激水平的影响

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-02-17 DOI: 10.1080/08941939.2026.2622138

Liyuan Zhang, Xi Wang, Xueji Yu, Jie Tang, Zezhao Wang, Xiaoyan Dai, Tao Qiu

{"title":"The Effect of Edaravone Dexborneol Treatment After Intracranial Vascular Intervention on Inflammatory Factors and Oxidative Stress Level in Elderly Patients with Acute Ischemic Cerebrovascular Disease.","authors":"Liyuan Zhang, Xi Wang, Xueji Yu, Jie Tang, Zezhao Wang, Xiaoyan Dai, Tao Qiu","doi":"10.1080/08941939.2026.2622138","DOIUrl":"10.1080/08941939.2026.2622138","url":null,"abstract":"Objective: We aimed to explore the effects of applying edaravone dexborneol after intracranial vascular intervention on the levels of neuron-specific enolase (NSE), homocysteine (Hcy) and neurological function in elderly patients with acute ischemic cerebrovascular disease (AICVD).Methods: The control group and study group were established. Serum levels of NSE, Hcy, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), and superoxide dismutase (SOD) activity were measured. Neurological function and hemorheological indices [plasma viscosity (PV), high-shear viscosity (HSV), low-shear viscosity (LSV)] were assessed. Adverse reactions and 6-month adverse outcomes were recorded.Results: At 14 days postoperatively, the study group exhibited lower NSE, Hcy, IL-6, TNF-α, and MDA levels and higher SOD activity than the control group (all p < 0.05). NIHSS scores, PV, HSV, and LSV decreased in both groups at 7 and 14 days postoperatively (p < 0.05), with greater improvements in the study group (p < 0.05). The study group had a lower incidence of adverse outcomes (4.00% vs. 13.33%, p < 0.05).Conclusion: Edaravone dexborneol after intracranial vascular intervention significantly reduces NSE and Hcy levels, mitigates inflammation and oxidative stress, improves neurological function and hemorheology, and lowers adverse outcome rates in elderly AICVD patients without increasing adverse reactions.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2622138"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neutrophil Percentage to Albumin Ratio as an Independent Risk Factor for Severe Consciousness Disorders and In-Hospital Mortality Following Pulmonary Surgery. 中性粒细胞百分比与白蛋白比率是肺部手术后严重意识障碍和住院死亡率的独立危险因素。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-05-29 DOI: 10.1080/08941939.2026.2648895

Yunfei Mu, Haosong Bai, Xin Huang, Yuan Wang, Yi Yang

{"title":"The Neutrophil Percentage to Albumin Ratio as an Independent Risk Factor for Severe Consciousness Disorders and In-Hospital Mortality Following Pulmonary Surgery.","authors":"Yunfei Mu, Haosong Bai, Xin Huang, Yuan Wang, Yi Yang","doi":"10.1080/08941939.2026.2648895","DOIUrl":"10.1080/08941939.2026.2648895","url":null,"abstract":"Background: This study investigated the relationship between the neutrophil percentage to albumin ratio (NPAR) and risks of severe consciousness disorders and in-hospital mortality after pulmonary surgery.Methods: Patients undergoing pulmonary surgery and admitted to the intensive care unit were included in this retrospective study. Primary outcomes were severe consciousness disorders and in-hospital mortality. Cox proportional hazards models assessed associations between NPAR and these outcomes. Kaplan-Meier analysis demonstrated survival differences among patients with varying NPAR levels. Restricted cubic spline (RCS) analysis explored potential nonlinear associations between NPAR and outcomes. Subgroup analyses stratified by demographic characteristics, laboratory parameters, disease type, adjuvant therapy, and surgical type were performed to evaluate the consistency of results across different patient populations.Results: Among 717 included patients, severe consciousness disorder incidence was 40% and in-hospital mortality was 29%. NPAR demonstrated significant positive associations with both severe consciousness disorders (OR [95% CI]: 1.018 [1.006-1.031]; p = 0.004) and in-hospital mortality (OR [95% CI]: 1.018 [1.003-1.033]; p = 0.017). RCS analysis revealed a nonlinear relationship between NPAR and consciousness disorders, and an approximately linear relationship with in-hospital mortality. Subgroup analyses confirmed consistent findings across different patient populations.Conclusion: NPAR is an independent predictor of severe consciousness disorders and in-hospital mortality following pulmonary surgery.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2648895"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival Outcome Was Better with Liver Resection than with Percutaneous Radiofrequency Ablation in Patients with Very Early-Stage Hepatocellular Carcinoma: A Single-Center Retrospective Study. 一项单中心回顾性研究表明，极早期肝癌患者行肝切除术比经皮射频消融术生存率更高。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-02-09 DOI: 10.1080/08941939.2026.2625532

Yi-Hao Yen, Yueh-Wei Liu, Chao-Hung Hung, Chien-Hung Chen, Kwong-Ming Kee, Wei-Feng Li, Chih-Chi Wang, Sheng-Nan Lu, Tsung-Hui Hu, Jing-Houng Wang, Chih-Yun Lin

{"title":"Survival Outcome Was Better with Liver Resection than with Percutaneous Radiofrequency Ablation in Patients with Very Early-Stage Hepatocellular Carcinoma: A Single-Center Retrospective Study.","authors":"Yi-Hao Yen, Yueh-Wei Liu, Chao-Hung Hung, Chien-Hung Chen, Kwong-Ming Kee, Wei-Feng Li, Chih-Chi Wang, Sheng-Nan Lu, Tsung-Hui Hu, Jing-Houng Wang, Chih-Yun Lin","doi":"10.1080/08941939.2026.2625532","DOIUrl":"10.1080/08941939.2026.2625532","url":null,"abstract":"Background: Antiviral therapies for hepatitis B or C virus may be associated with reduced risk of tumor recurrence and mortality of patients with hepatocellular carcinoma (HCC) undergoing curative treatments, compared to untreated patients. Previous studies comparing survival outcomes between percutaneous radiofrequency ablation (RFA) and liver resection (LR) for treating patients with very early-stage HCC did not evaluate the effects of antiviral treatments on survival outcome. Our study aimed to clarify this issue.Methods: From 2011 to 2021, 265 patients undergoing LR and 269 patients undergoing RFA for very early-stage HCC (i.e., a single tumor ≤2 cm without macrovascular invasion or extrahepatic metastasis, with Eastern Cooperative Oncology Group performance status = 0 and Child-Pugh class A liver disease) were included in this retrospective study. Survival analysis was performed using the Kaplan - Meier method after propensity score matching (PSM).Results: After 1:1 PSM (n = 205 in both groups), the survival benefit of LR was significantly higher than that of RFA (five-year OS: 85% vs. 73%; p = 0.004; five-year RFS: 64% vs. 45%; p < 0.001).Conclusions: For patients with very early-stage HCC, LR was associated with superior OS and RFS compared to RFA.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2625532"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Retrospective Comparative Study of Early and Mid-to Long-Term Clinical Efficacy and Spinopelvic Sagittal Alignment After Multisegment PLIF with Different Degrees of Sagittal Correction. 不同程度矢状位矫正的多节段PLIF术后早期、中长期临床疗效及脊柱-骨盆矢状位对齐的回顾性比较研究

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-08-03 DOI: 10.1080/08941939.2026.2696123

Chengyue Wang, Haifu Sun, Tianci Fang, Hao Liu

{"title":"A Retrospective Comparative Study of Early and Mid-to Long-Term Clinical Efficacy and Spinopelvic Sagittal Alignment After Multisegment PLIF with Different Degrees of Sagittal Correction.","authors":"Chengyue Wang, Haifu Sun, Tianci Fang, Hao Liu","doi":"10.1080/08941939.2026.2696123","DOIUrl":"https://doi.org/10.1080/08941939.2026.2696123","url":null,"abstract":"Objective: This study compared radiographic spinopelvic alignment parameters and clinical outcomes after multisegment posterior lumbar interbody fusion (PLIF) with different degrees of sagittal correction in multilevel degenerative lumbar spine disease.Methods: We retrospectively reviewed adults who underwent three-segment PLIF (L2-L5 or L3-S1) between January 2020 and August 2021. Patients were stratified post hoc by achieved change in fused-segment lordosis (ΔSL) from preoperative to early postoperative radiographs (ΔSL ≤5° vs >5°). Spinopelvic parameters (SL, lumbar lordosis [LL], pelvic tilt [PT], sacral slope [SS], pelvic incidence [PI], PI-LL) and patient-reported outcomes (Visual Analog Scale [VAS], Oswestry Disability Index [ODI]) were assessed preoperatively and at follow-up (≥2 years).Results: A total of 157 patients were included (Group A, n = 85; Group B, n = 72) with comparable baseline parameters. At 1 month and 1 year, SL was higher in Group B. At final follow-up, Group B showed more favorable alignment (higher SL/LL and lower PT/PI-LL) and better VAS/ODI than Group A (all p < 0.05). Postoperative complications were similar, except for a higher ileus rate in Group B (p = 0.024).Conclusions: A larger achieved ΔSL was associated with improved mid-to long-term spinopelvic alignment parameters and better final follow-up patient-reported outcomes. This potential benefit may occur at the expense of worse early postoperative symptoms; prospective studies with predefined correction targets are warranted.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2696123"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Lesion Shrinkage and Factors Influencing Shrinkage Following Radiofrequency Ablation of Breast Nodules: An Observational Study. 乳房结节射频消融后病灶缩小及影响因素分析：一项观察性研究。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-07-15 DOI: 10.1080/08941939.2026.2696115

Xiaoyin Tang, Bingwei Lu, Min Ding, Yan Lin, Ping Li

{"title":"Analysis of Lesion Shrinkage and Factors Influencing Shrinkage Following Radiofrequency Ablation of Breast Nodules: An Observational Study.","authors":"Xiaoyin Tang, Bingwei Lu, Min Ding, Yan Lin, Ping Li","doi":"10.1080/08941939.2026.2696115","DOIUrl":"10.1080/08941939.2026.2696115","url":null,"abstract":"Purpose: To evaluate the reduction in ablated lesion volume after ultrasound-guided percutaneous radiofrequency ablation (RFA) for benign breast tumors and identify factors associated with shrinkage.Methods: This retrospective study included 64 patients (244 benign breast tumors) treated with RFA from December 2014 to February 2021. All tumors were biopsy confirmed before ablation. Follow-up at 1, 3, 6, and 12 months measured nodule volume changes and recorded complications, with analyses at the individual nodule level.Results: All patients were discharged within 24h without major events. Grade I pain occurred in two patients (3.13%), with no higher-grade complications observed. The complete ablation rate at 1 month was 98.77% (241/244). At 12 months, lesion volume decreased significantly (p < 0.001), with a mean volume reduction ratio (VRR) of 97.14% and a complete sonographic disappearance rate of 81.97% (200/244). Multiple mixed-effect linear regression showed that lesions with a maximum diameter > 20 mm and an absence of blood vessels within 5 mm of the nodule were significantly associated with a lower 12-month VRR.Conclusions: Ultrasound-guided RFA is safe and effective for benign breast tumors. Ablated lesions effectively shrink, with nodule size and the presence of blood vessels around the nodules being associated with the 12-month VRR.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2696115"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: "The Effect of Moxibustion at the Dazhui Point on Hypothermia and Maternal Comfort During Cesarean Delivery: A Randomized Controlled Trial." 致编辑的信：“艾灸大椎穴对剖宫产产妇体温降低和舒适度的影响：一项随机对照试验。”

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-09-22 DOI: 10.1080/08941939.2026.2734635

Xinyi Hu, Lin Huang, Qiongying Shen

引用次数: 0

Survival Nomogram for Stage IV (M1a-c) Melanoma: A Population-Based Study Highlighting the Prognostic Correlates of Surgery in Pre-Immunotherapy and Early Immunotherapy Eras. IV期（M1a-c）黑色素瘤的生存图：一项基于人群的研究，突出了免疫治疗前和早期免疫治疗时期手术与预后的相关性。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-07-14 DOI: 10.1080/08941939.2026.2702186

Dun-Chang Mo, Jian-Feng Huang, Peng-Hui Luo, Peng Lin, Shang-Xiao Huang, Han-Lei Wang, Xiu-Juan Liang

{"title":"Survival Nomogram for Stage IV (M1a-c) Melanoma: A Population-Based Study Highlighting the Prognostic Correlates of Surgery in Pre-Immunotherapy and Early Immunotherapy Eras.","authors":"Dun-Chang Mo, Jian-Feng Huang, Peng-Hui Luo, Peng Lin, Shang-Xiao Huang, Han-Lei Wang, Xiu-Juan Liang","doi":"10.1080/08941939.2026.2702186","DOIUrl":"10.1080/08941939.2026.2702186","url":null,"abstract":"Objective: Metastatic melanoma has a poor prognosis. This study aimed to develop and validate era-specific nomograms for Stage IV (M1a-c) melanoma and assess the survival impact of surgery across two eras.Methods: This retrospective Surveillance, Epidemiology, and End Results (SEER) study included 3,319 stage IV melanoma patients divided into pre-immunotherapy era (2001-2005, n = 622) and early immunotherapy era (2011-2015, n = 2,697) cohorts. Cox regression identified overall survival (OS) prognostic factors. Era-specific nomograms predicting 1-, 3-, and 5-year OS were constructed and validated. The survival benefit of surgery was assessed using Kaplan-Meier analysis.Results: Age, M-stage, lactate dehydrogenase, chemotherapy, and surgery were consistent independent prognostic factors in both eras. The nomograms showed good calibration yet limited discriminatory capacity only slightly exceeding the 0.5 random threshold (C-index: 0.649 and 0.641 for pre- and early immunotherapy eras, respectively). Surgery showed longer OS in patients of the overall immunotherapy cohort: median OS was 17 vs. 6 months for surgical vs. non-surgical patients (p < 0.001). The benefit was pronounced in the M1a (40.5 vs. 20.0 months, p < 0.001) and M1c (11 vs. 5 months, p < 0.001) subgroups. Patients in the early immunotherapy era had longer OS (8 vs. 6 months, p < 0.001).Conclusions: We constructed population-based era-specific nomograms for stage IV melanoma. Within the immunotherapy cohort, surgery correlates with prolonged survival, suggesting surgical evaluation for selected metastatic melanoma patients.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2702186"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of a TrachoSpray Device and Manual Lidocaine Spray on Hemodynamic Stability and Postoperative Sore Throat in Patients Undergoing Double-Lumen Tube Intubation: A Randomized Controlled Trial. 气管放射装置和手动利多卡因喷雾对双腔管插管患者血流动力学稳定性和术后喉咙痛的比较：一项随机对照试验。

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-03-09 DOI: 10.1080/08941939.2025.2586017

Murat Tümer, Fatih Doğu Geyik, Mesut Buz, Kübra Taşkın, Muhammet Selman Söğüt, Banu Çevik, Recep Demirhan

{"title":"Comparison of a TrachoSpray Device and Manual Lidocaine Spray on Hemodynamic Stability and Postoperative Sore Throat in Patients Undergoing Double-Lumen Tube Intubation: A Randomized Controlled Trial.","authors":"Murat Tümer, Fatih Doğu Geyik, Mesut Buz, Kübra Taşkın, Muhammet Selman Söğüt, Banu Çevik, Recep Demirhan","doi":"10.1080/08941939.2025.2586017","DOIUrl":"10.1080/08941939.2025.2586017","url":null,"abstract":"Background: Postoperative sore throat (POST) is an distressing complication following endotracheal intubation, particularly with double-lumen tube (DLT) intubation. Study evaluated the effects of two local anesthetic techniques on hemodynamic responses and POST in DLT-intubated patients.Methods: A randomized controlled study was conducted with 60 patients scheduled for elective thoracic surgery. Participants were randomized into three groups: TrachoSpray group (2 mL of 10% lidocaine), Manual spray group (10% lidocaine) and, Control group (0.9% saline). Hemodynamic parameters, including systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), were monitored preoperatively, intraoperatively, and postoperatively. POST was assessed using a visual analog scale at 2, 6, 12, and 24 h post-extubation.Results: Both lidocaine groups demonstrated significant reductions in SBP, DBP, and MAP at key time points compared to control group. Post-extubation, MAP was significantly higher in TrachoSpray group than lidocaine group (p = 0.04). No statistically significant differences in POST scores were observed between groups.Conclusions: TrachoSpray device and manual lidocaine spray improved hemodynamic stability in DLT-intubated patients; however, neither method resulted in a significant reduction in POST scores. Further research is needed to confirm these hemodynamic benefits and to explore potential effects on long-term outcomes.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2586017"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Postoperative Nutritional Management Under a Validated Diabetes-Specific Enhanced Recovery After Surgery Protocol in Patients With Lumbar Spinal Stenosis and Type 2 Diabetes Mellitus. 腰椎管狭窄合并2型糖尿病患者手术后糖尿病特异性增强恢复方案下早期术后营养管理

IF 2.7 4区医学

Journal of Investigative Surgery Pub Date : 2026-12-01 Epub Date: 2026-08-22 DOI: 10.1080/08941939.2026.2717479

Yanxuan Chen, Baiqiu Ke, Li Zhou, Ganqing Li, Kaitao Xu, Honglian Qin

{"title":"Early Postoperative Nutritional Management Under a Validated Diabetes-Specific Enhanced Recovery After Surgery Protocol in Patients With Lumbar Spinal Stenosis and Type 2 Diabetes Mellitus.","authors":"Yanxuan Chen, Baiqiu Ke, Li Zhou, Ganqing Li, Kaitao Xu, Honglian Qin","doi":"10.1080/08941939.2026.2717479","DOIUrl":"https://doi.org/10.1080/08941939.2026.2717479","url":null,"abstract":"Objective: To evaluate early postoperative nutritional management with a diabetes-specific enhanced recovery after surgery (DS-ERAS) pathway in patients with lumbar spinal stenosis (LSS) and type 2 diabetes mellitus (T2DM).Methods: This retrospective cohort study compared a DS-ERAS nutritional pathway with conventional perioperative care in LSS patients with T2DM. Outcomes included postoperative recovery, nutritional status, glycemic control, inflammation, complications, and hospital stay. Effect size metrics (relative risk reduction [RRR], absolute risk difference [ARD], number needed to treat [NNT]), subgroup analyses, and multivariable linear regression were performed.Results: The DS-ERAS group demonstrated faster gastrointestinal recovery, improved nutritional status and glycemic control, reduced inflammatory and shorter hospital stay (p < 0.001). The complication rate was lower (10.0% vs. 23.3%; p = 0.016), with a relative risk reduction of 57.1% and absolute risk difference of 13.3%. Subgroup analyses demonstrated consistent benefits across age, sex, body mass index (BMI), diabetes duration, and surgical segments (all P for interaction > 0.05). Multivariable regression show that DS-ERAS was associated with a mean reduction in hospital stay of 1.57 days.Conclusion: Early postoperative nutritional management within the DS-ERAS pathway was associated with improved perioperative recovery in LSS patients with T2DM, with favorable nutritional , metabolic, inflammatory, and clinical outcomes.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"39 1","pages":"2717479"},"PeriodicalIF":2.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0