Journal of Investigative Surgery最新文献_第7页

The Effect of Antioxidant Astaxanthin on Intestinal Ischemia Reperfusion Damage in Rats. 抗氧化剂虾青素对大鼠肠道缺血再灌注损伤的影响

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-31 Epub Date: 2023-03-05 DOI: 10.1080/08941939.2023.2182930

Arda Sakir Yilmaz, Bartu Badak, Nilufer Erkasap, Mete Ozkurt, Ertugrul Colak

{"title":"The Effect of Antioxidant Astaxanthin on Intestinal Ischemia Reperfusion Damage in Rats.","authors":"Arda Sakir Yilmaz, Bartu Badak, Nilufer Erkasap, Mete Ozkurt, Ertugrul Colak","doi":"10.1080/08941939.2023.2182930","DOIUrl":"10.1080/08941939.2023.2182930","url":null,"abstract":"Background: Mesenteric ischemia is a frequently encountered disease in surgical clinics, difficult to diagnose, and very mortal if not treated. Our study investigated the effects of astaxanthin, which is known to have potent antioxidant properties and is also known to have anti-inflammatory effects on ischemia-reperfusion (I/R) injury.Methods: A total of 32 healthy Wistar albino female rats were used in our study. Subjects were randomized and equally divided into 4 groups; control (laparotomy group only), I/R (transient mesenteric ischemia group only), astaxanthin 1 mg/kg and 10 mg/kg doses. The transient ischemia time was 60 minutes and the reperfusion time was 120 minutes. Tissue samples were taken from intracardiac blood and terminal ileum after reperfusion. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) from blood samples, interleukin-1 (IL-1), IL-6, tumor necrosis factor-α (TNFα), Caspase-3, P53 tests from terminal ileum were studied. Tissue samples were also taken for histopathological evaluation.Results: At the end of the study, both doses of astaxanthin were found to significantly reduce MDA level, CAT, and SOD enzymatic activity, whereas higher doses of astaxanthin significantly reduced MDA level, CAT, and SOD enzyme activities. In addition, cytokines such as TNFα, IL-1 and IL-6 were found to be reduced at both doses of astaxanthin, but only significantly inhibited at higher doses. We observed that inhibition of apoptosis reduced caspase-3 activity and P53 and deoxyribonucleic acid (DNA) fragmentation.Conclusion: Astaxanthin, a potent antioxidant, and anti-inflammatory, significantly reduces ischemia and reperfusion injury, especially when used at a dose of 10 mg/kg. These data need to be confirmed by larger animal series and clinical studies.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":" ","pages":"2182930"},"PeriodicalIF":1.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9083149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Mesalamine Combined with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules on Intestinal Mucosa Barrier Function and Intestinal Microbiota in Mildly Active Crohn’s Disease Patients 美沙拉明联合活复合双歧杆菌、乳杆菌和肠球菌胶囊对轻度活动性克罗恩病患者肠黏膜屏障功能和肠道微生物群的影响

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-30 DOI: 10.1080/08941939.2023.2297565

Meiqin Shen, Yingqi Shi, Zhenming Ge, Junbo Qian

引用次数: 0

Surgical Research Progress of Sentinel Lymph Node Biopsy in Melanoma. 黑色素瘤前哨淋巴结活检的外科研究进展。

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 DOI: 10.1080/08941939.2023.2225087

Haining Mou, Qian Tan

引用次数: 0

Avoiding Excessive Physical Restraints to Reduce ICU Pseudo Delirium. 避免过度肢体约束减少ICU假性谵妄。

IF 2.1 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1080/08941939.2023.2285786

Taotao Liu

引用次数: 0

Comparison between Endoscopic Submucosal Dissection and Transanal Endoscopic Microsurgery in Early Rectal Neuroendocrine Tumor Patients: A Meta-Analysis. 内镜下粘膜夹层与经肛门内镜显微手术治疗早期直肠神经内分泌肿瘤的meta分析。

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-11-16 DOI: 10.1080/08941939.2023.2278191

Fu-Gang Wang, Ying Jiang, Chao Liu, Hong Qi

{"title":"Comparison between Endoscopic Submucosal Dissection and Transanal Endoscopic Microsurgery in Early Rectal Neuroendocrine Tumor Patients: A Meta-Analysis.","authors":"Fu-Gang Wang, Ying Jiang, Chao Liu, Hong Qi","doi":"10.1080/08941939.2023.2278191","DOIUrl":"10.1080/08941939.2023.2278191","url":null,"abstract":"Purpose: To compare the effectiveness, safety and cost-effectiveness of endoscopic submucosal dissection (ESD) with transanal endoscopic microsurgery (TEM) in early rectal neuroendocrine tumor (RNET) patients. This article will provide reliable evidence for surgeons in regards to clinical decision-making.Methods: Systematic literature retrieval was performed in Pubmed, Embase and Cochrane database from 2013/4/30 to 2023/4/30. Methodology validation was performed by using the Newcastle-Ottawa Scale (NOS). Data-analysis was conducted by using the Review manager version 5.3 software.Results: A total of three retrospective studies were included in our meta-analysis. All eligible studies were considered to be high quality. By comparing baseline characteristics between TEM and ESD, patients in the TEM group seemed to be characterized by a larger tumor size and lower tumor level, even though no statistical significance was found. Clear statistical significance favoring TEM was identified in terms of R0 resection rate, procedure time and hospital stay. No statistical significance was found in terms of recurrence rate, adverse events rate and additional treatment rate.Conclusions: Compared with ESD, TEM was a more effective treatment modality for early RNET patients; it was associated with a relatively higher R0 resection rate and a similar degree of safety. However, the relatively higher cost and complicated manipulation restricted the promotion of TEM. Surgeons should opt for TEM as a primary treatment in patients with a larger tumor size and deeper degree of tumorous infiltration if the financial condition and hospital facility permit.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"36 1","pages":"2278191"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136397784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral Neck System versus Three Cannulated Screws for Fixation of Femoral Neck Fractures in Younger Patients: A Retrospective Cohort Study. 股骨颈系统与三枚空心螺钉固定年轻患者股骨颈骨折的比较：一项回顾性队列研究。

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI: 10.1080/08941939.2023.2266752

Shuang G Yan, Yiliang Cui, Di Li, Fanxiao Liu, Xingyi Hua, Florian Schmidutz

{"title":"Femoral Neck System versus Three Cannulated Screws for Fixation of Femoral Neck Fractures in Younger Patients: A Retrospective Cohort Study.","authors":"Shuang G Yan, Yiliang Cui, Di Li, Fanxiao Liu, Xingyi Hua, Florian Schmidutz","doi":"10.1080/08941939.2023.2266752","DOIUrl":"10.1080/08941939.2023.2266752","url":null,"abstract":"Objective: To compare the clinical results of a new femoral neck system (FNS) and cannulated compression screws (CCS) for the treatment of femoral neck fractures in younger patients.Methods: Retrospective study was performed in younger patients with femoral neck fractures that were treated with FNS or CCS from August 2017 to August 2022. The hip functional outcomes were assessed with the Harris hip score (HHS). Secondary outcomes included the surgical time, surgical blood loss, satisfaction visual analog scale (VAS), fluoroscopy frequency, fracture healing time and complications.Results: A total of 49 patients (22 FNS and 27 CCS) with a minimum follow-up of 12 months were included. There was also no significant difference in HHSs (p = 0.27) and satisfaction VAS (p = 0.10) between them. Patients with FNS had more blood loss (50.45 ± 5.28 mL vs. 20.67 ± 4.71 ml, p < 0.01), lower fluoroscopy frequency (16.64 ± 3.32 vs. 23.59 ± 3.39, p < 0.01) and lower fracture healing time (3.76 ± 0.42 vs. 4.46 ± 0.59 months, p < 0.01). The femoral neck shortening and incidence of nail withdrawal in the FNS group was significantly lower than CCS group (2.91 ± 1.95 vs. 4.44 ± 1.52 mm, p < 0.01; 4.5% vs. 22.2%, p = 0.03).Conclusions: The FNS and CCS get similar hip functions. The FNS can reduce fluoroscopy exposure and the complications such as femoral neck shortening and nail withdrawal. Thus, FNS can be an alternative to CCS for the fixation of femoral neck fractures in younger patients.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"36 1","pages":"2266752"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41182786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Patients with Chronic Liver Disease in the Perioperative Period. 慢性肝病患者围手术期的管理。

IF 2.1 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 DOI: 10.1080/08941939.2022.2156346

Joseph B Oliver, Aziz M Merchant, Baburao Koneru

引用次数: 0

Comparison of Intraoperative Endplate Injury between Mini-Open Lateral Lumbar Interbody Fusion (LLIF) and Transforaminal Lumbar Interbody Fusion (TLIF) and Analysis of Risk Factors: A Retrospective Study. 微创外侧腰椎椎间融合术(LLIF)与椎间孔腰椎椎间融合术(TLIF)术中终板损伤的比较及危险因素分析:一项回顾性研究

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1080/08941939.2023.2285787

Xiaowei Jing, Zhiyuan Gong, Ning Zhang, Zhengkuan Xu, Xiaowen Qiu, Fangcai Li, Wei Liu, Qingfeng Hu, Qixin Chen

{"title":"Comparison of Intraoperative Endplate Injury between Mini-Open Lateral Lumbar Interbody Fusion (LLIF) and Transforaminal Lumbar Interbody Fusion (TLIF) and Analysis of Risk Factors: A Retrospective Study.","authors":"Xiaowei Jing, Zhiyuan Gong, Ning Zhang, Zhengkuan Xu, Xiaowen Qiu, Fangcai Li, Wei Liu, Qingfeng Hu, Qixin Chen","doi":"10.1080/08941939.2023.2285787","DOIUrl":"10.1080/08941939.2023.2285787","url":null,"abstract":"Objective: The study aimed to compare the incidence of intraoperative endplate injury in patients who underwent Transforaminal interbody fusion (TLIF) and mini-open lumbar interbody fusion (LLIF) surgery. The independent risk factors related to endplate injury in LLIF procedure were analyzed.Methods: A total of 199 patients who underwent LLIF (n = 106) or TLIF (n = 93) surgery from June 2019 to September 2021 were reviewed. The endplate injury was assessed by postoperative sagittal CT scan. A binary logistic analysis model were used to identify independent risk factors related to LLIF endplate injury based on univariate analysis.Results: There was an obvious difference in the occurrence of intraoperative endplate injury between LLIF (42/106, 39.6%) and TLIF group (26/93, 28%), although it did not reach the significant level. L1 CT value (OR = 0.985, 95% CI = 0.972-0.998), cage position (OR = 3.881, 95% CI = 1.398-10.771) and height variance (OR = 1.263, 95% CI = 1.013-1.575) were independent risk factors for endplate injury in LLIF procedure. According to the cage settlement patterns, there 5 types of A to E. The severity of the facet joint degeneration was positively related to the occurrence of endplate injury.Conclusions: The incidence of intraoperative endplate injury is higher in LLIF than in TLIF procedures. Low bone quantity, cage posterior position and larger height variance are risk factors to induce endplate injury in LLIF surgery. The facet joint degeneration may be related to severe endplate injuries and even fractures.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"36 1","pages":"2285787"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-Review: Tendon-Exposed Wound Treatments. 迷你评论：肌腱暴露伤口治疗。

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-10-09 DOI: 10.1080/08941939.2023.2266758

Zhuan Deng, Zhi-Sheng Long, Gang Chen

引用次数: 0

Percutaneous Functional Spinal Unit Cementoplasty versus Posterior Spinal Fixation with Vertebroplasty for Symptomatic Chronic Osteoporotic Vertebral Fractures: A Retrospective Study with a 2-Year Follow up. 经皮功能性脊椎骨水泥成形术与椎体成形术后固定治疗症状性慢性骨质疏松性脊椎骨折：一项2年随访的回顾性研究。

IF 1.9 4区医学

Journal of Investigative Surgery Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI: 10.1080/08941939.2023.2257780

Youdi Xue, Zhifa Lun, Jie Feng, Weixiang Dai

{"title":"Percutaneous Functional Spinal Unit Cementoplasty versus Posterior Spinal Fixation with Vertebroplasty for Symptomatic Chronic Osteoporotic Vertebral Fractures: A Retrospective Study with a 2-Year Follow up.","authors":"Youdi Xue, Zhifa Lun, Jie Feng, Weixiang Dai","doi":"10.1080/08941939.2023.2257780","DOIUrl":"10.1080/08941939.2023.2257780","url":null,"abstract":"Purpose: To compare the clinical efficacy of percutaneous functional spinal unit cementoplasty (PFSUP) and posterior spinal fixation combined with vertebroplasty (PSF + VP) for the treatment of symptomatic chronic osteoporotic vertebral fractures (SCOVFs).Method: Thirty-one patients with SCOVFs were included in this retrospective study and divided into PFSUP (n = 14) and PSF + VP (n = 17) groups. Visual analog scores (VAS) and Oswestry Disability Index (ODI) were recorded before and after surgery and at the last follow-up. Besides, the local kyphosis angle (LKA) and sagittal vertical axis (SVA) were measured. The operation duration, number of X-ray exposures, amount of blood loss, bed rest duration, hospitalization duration, and presence of complications were recorded.Result: The VAS, ODI, LKA, and SVA after surgery and at the last follow-up were significantly improved in both groups compared to preoperative measurements. The PFSUP group experienced shorter operation duration (78.2 ± 13.1 vs. 124.7 ± 14.7, p < 0.001), less blood loss (31.1 ± 8.1 vs. 334.7 ± 70.9, p < 0.001), more X-ray exposures (92.1 ± 14.3 vs. 29.4 ± 5.5, p < 0.001), shorter bed rest duration (12.4 ± 3.8 vs. 43.4 ± 10.0, p < 0.001), shorter hospitalization (6.6 ± 2.4 vs. 10.9 ± 2.7, p < 0.001), lower complication rate (28.5% vs. 64.7%, p < 0.05), and higher cement leakage rate (42.9% vs. 5.8%, p < 0.05) than the PSF + VP group.Conclusion: During the treatment of SCOVFs, the combination of PFSUP and PSF + VP can restore spinal stability, improve kyphosis, and relieve pain. PFSUP can reduce blood loss and complications, early mobilization, and shorten the hospital stay, but it is associated with a higher cement leakage rate and more radiation exposure.","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"36 1","pages":"2257780"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49678389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0