Journal of Investigative Surgery最新文献

{"title":"A Prospective Multi-Institutional Evaluation of Iatrogenic Urethral Catheterization Injuries.","authors":"Stefanie M Croghan,&nbsp;Leah Hayes,&nbsp;Eabhann M O'Connor,&nbsp;Mark Rochester,&nbsp;William Finch,&nbsp;Anne Carrie,&nbsp;Shane W Considine,&nbsp;Frank D'Arcy,&nbsp;Aisling Nic An Riogh,&nbsp;Wasim Mahmalji,&nbsp;Mohammed Elhadi,&nbsp;Helen Thursby,&nbsp;Ian Pearce,&nbsp;Vaibhav Modgil,&nbsp;Hosam Noweir,&nbsp;Eoin MacCraith,&nbsp;Aideen Madden,&nbsp;Rustom Manecksha,&nbsp;Eva Browne,&nbsp;Subhasis K Giri,&nbsp;Connor V Cunnane,&nbsp;John Mulvihill,&nbsp;Michael T Walsh,&nbsp;Niall F Davis,&nbsp;Hugh D Flood","doi":"10.1080/08941939.2022.2109226","DOIUrl":"https://doi.org/10.1080/08941939.2022.2109226","url":null,"abstract":"<p><strong>Objectives: </strong>To perform a multi-institutional investigation of incidence and outcomes of urethral trauma sustained during attempted catheterization.</p><p><strong>Patients & methods: </strong>A prospective, multi-center study was conducted over a designated 3-4 month period, incorporating seven academic hospitals across the UK and Ireland. Cases of urethral trauma arising from attempted catheterization were recorded. Variables included sites of injury, management strategies and short-term clinical outcomes. The catheterization injury rate was calculated based on the estimated total number of catheterizations occurring in each center per month. Anonymised data were collated, evaluated and described.</p><p><strong>Results: </strong>Sixty-six urethral catheterization injuries were identified (7 centers; mean 3.43 months). The mean injury rate was 6.2 ± 3.8 per 1000 catheterizations (3.18-14.42/1000). All injured patients were male, mean age 76.1 ± 13.1 years. Urethral catheterization injuries occurred in multiple hospital/community settings, most commonly Emergency Departments (36%) and medical/surgical wards (30%). Urological intervention was required in 94.7% (54/57), with suprapubic catheterization required in 12.3% (n = 7). More than half of patients (55.56%) were discharged with an urethral catheter, fully or partially attributable to the urethral catheter injury. At least one further healthcare encounter on account of the injury was required for 90% of patients post-discharge.</p><p><strong>Conclusions: </strong>This is the largest study of its kind and confirms that iatrogenic urethral trauma is a recurring medical error seen universally across institutions, healthcare systems and countries. In addition, urethral catheter injury results in significant patient morbidity with a substantial financial burden to healthcare services. Future innovation to improve the safety of urinary catheterization is warranted.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 10","pages":"1761-1766"},"PeriodicalIF":1.9,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing and Managing Pancreaticopleural Fistulas in Children.","authors":"Konstantina Dimopoulou,&nbsp;Anastasia Dimopoulou,&nbsp;Nikolaos Koliakos,&nbsp;Andrianos Tzortzis,&nbsp;Dimitra Dimopoulou,&nbsp;Nikolaos Zavras","doi":"10.1080/08941939.2022.2103603","DOIUrl":"https://doi.org/10.1080/08941939.2022.2103603","url":null,"abstract":"<p><p><b>Background:</b> Pancreaticopleural fistula, an abnormal communication between the pancreas and the pleural cavity, is a rare complication of pancreatic disease in children and is mainly associated with acute pancreatitis, chronic pancreatitis, trauma or iatrogenicinjury. The present review presents the current available data concerning the pathogenesis, clinical features, diagnosis and management of this unusual but difficult clinical problem among children, in order to shed light on its pathologic manifestation and raise clinical suspicion.<b>Methods:</b> The review of the literature was performed through a PubMed search of pediatric original articles and case reports, using the key words \"pancreaticopleural fistula\", \"pancreatitis\", \"pleural effusion\", \"pseudocyst\" and \"children\". The literature search revealed 47 cases of pediatric patients with pancreaticopleural fistula.<b>Results:</b> Diagnosis is based on the patient's medical history, physical examination and imaging, while the cornerstone of diagnosis is the presence of high pleural effusion amylase levels. The management of this disorder includes conservative, endoscopic and surgical treatment options. If treated promptly and properly, this clinical entity could have a lower rate of complications.<b>Conclusions:</b> The incidence of pancreaticopleural fistula in children may be underestimated in the literature, due to a reduced degree of clinical suspicion. A more heightened awareness of this entity is needed to improve the quality of life in children that suffer from this condition, as early diagnosis is essential for effective treatment and improved outcome.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1704-1710"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40623423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erector Spinae Plane Block versus Transversus Abdominis Plane Block for Postoperative Analgesia in Abdominal Surgery: A Systematic Review and Meta-Analysis.","authors":"Lin Liheng,&nbsp;Cai Siyuan,&nbsp;Cai Zhen,&nbsp;Wu Changxue","doi":"10.1080/08941939.2022.2098426","DOIUrl":"https://doi.org/10.1080/08941939.2022.2098426","url":null,"abstract":"<p><strong>Background: </strong>Regional anesthesia technique has been reported to exert excellent analgesic efficacy for various surgeries. Erector spinae plane block (ESPB) and transversus abdominis plane (TAP) block are good ways to relieve postoperative pain after abdominal surgery. However, the analgesic efficacy between them remains controversial. This meta-analysis evaluated the analgesic effect between these two blocks in abdominal surgery with statistical and clinical interpretation.</p><p><strong>Methods: </strong>PubMed, Web of Science, the Cochrane Library, ClinicalTrials.gov register, and Embase databases were systematically searched by two independent investigators from the inception to December 2021.</p><p><strong>Results: </strong>10 randomized controlled trials (RCTs) comprising 570 patients were included in the final meta-analysis. Meta-analysis revealed that ESPB decreased the opioid consumption and improved the pain scores during the first 24 postoperative hours compared with TAP groups statistically, while the magnitude of this difference did not reach the clinically significant threshold (10 mg of intravenous morphine consumption and 1.3 cm on the VAS scale). In addition, ESPB prolonged blockade duration and decreased the occurrence of postoperative nausea and vomiting (PONV). However, it did not improve the patients' satisfaction.</p><p><strong>Conclusions: </strong>Although ESPB does not provide better clinical analgesia than the TAP block, it could be a comparable nerve block technique for abdominal wall analgesia.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1711-1722"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40594895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Infrared Autofluorescence Imaging in Thyroid Surgery: A Systematic Review and Meta-Analysis.","authors":"Wei Lu,&nbsp;Qiang Chen,&nbsp;Pei Zhang,&nbsp;Anping Su,&nbsp;Jingqiang Zhu","doi":"10.1080/08941939.2022.2095468","DOIUrl":"https://doi.org/10.1080/08941939.2022.2095468","url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis aimed to assess the position of near-infrared autofluorescence (NIRAF) imaging in the recognition and protection of the parathyroid gland (PG) during thyroidectomy.</p><p><strong>Methods: </strong>The PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Library databases were searched up to June 2021. The primary outcome was to evaluate the rates of postoperative hypocalcemia, inadvertent PG resection, and autotransplantation of PG when adopting NIRAF imaging compared with standard naked-eye (N-E) surgery.</p><p><strong>Results: </strong>Eight studies with 2,889 patients were enrolled in the analysis. Our analysis showed that the incidence of transient hypocalcemia was 7.11% (60/844) in the NIRAF group and 22.40% (458/2045) in the N-E group (<i>p</i> < 0.0001) and the rate of transient hypoparathyroidism was 28.31% (126/445) and 33.36% (496/1487) in the NIRAF and N-E groups (<i>p</i> = 0.0008). The rate of inadvertent resection of PGs was 7.65% (55/719) in the NIRAF group and 14.39% (132/917) in the N-E group (<i>p</i> < 0.0001). No significant difference was observed in other indexes including the pooled proportion of permanent hypocalcemia and rate of PG autotransplantation.</p><p><strong>Conclusions: </strong>The application of NIRAF imaging in thyroidectomy can help lower the incidence of inadvertent PG resection and reduce the risk of postoperative hypocalcemia and hypoparathyroidism compared with N-E recognition.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1723-1732"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40469411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Comparison of Postoperative Analgesic Efficacy of Ultrasound-Guided Paravertebral Block and Mid-Point Transverse Process Pleura Block in Mastectomy Surgeries: A Randomized Study.","authors":"Agâh Abdullah Kahramanlar,&nbsp;Mehmet Aksoy,&nbsp;Ilker Ince,&nbsp;Aysenur Dostbıl,&nbsp;Erdem Karadenız","doi":"10.1080/08941939.2022.2098544","DOIUrl":"https://doi.org/10.1080/08941939.2022.2098544","url":null,"abstract":"<p><strong>Purpose/aim of the study: </strong>The purpose of this triple-blind randomized study is to compare the postoperative analgesic efficacy of Mid-Point Transverse Process Pleura Block (MTP) and Paravertebral Block (PVB) in patients undergoing breast surgery.</p><p><strong>Materials and methods: </strong>The study was retrospectively registered on ClinicalTrials.gov (NCT05332028). A total of 64 patients undergoing unilateral simple mastectomy operation due to breast cancer were included in the study. Before the anesthesia procedure, participants were randomly assigned to one of two groups: Group 1: Participants undergoing PVB or Group 2: Participants undergoing MTP block. All block applications were performed using 20 mL of 0.25% bupivacaine. Routine general anesthesia protocol was performed on all patients. In the postanesthetic care unit, fentanyl infusion was given to all patients postoperatively via a patient-controlled analgesia device. Postoperative fentanyl consumption, time to the first request for analgesia, VAS score values at rest and in motion, and blocked dermatome areas were recorded.</p><p><strong>Results: </strong>Postoperative total opioid consumption, the number of patients given rescue analgesia, the time requiring postoperative supplemental analgesia, postoperative pain scores at rest and in motion, and blocked dermatome areas at both anterior and posterior lower and upper limits were not different between groups (<i>p</i> > 0.05, for all).</p><p><strong>Conclusions: </strong>It was concluded that ultrasound-guided PVB and MTP blocks have similar postoperative analgesic efficacy in patients undergoing breast surgery. The MTP block may be preferred as an alternative to PVB for breast surgeries with less risk of complications.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1694-1699"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40601829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Dimensional in Vivo Anatomical Study of Female Iliac Vein Variations.","authors":"Wenling Zhang,&nbsp;Chunlin Chen,&nbsp;Guidong Su,&nbsp;Hui Duan,&nbsp;Zhiqiang Li,&nbsp;Ping Shen,&nbsp;Jiaxin Fu,&nbsp;Ping Liu","doi":"10.1080/08941939.2022.2095469","DOIUrl":"https://doi.org/10.1080/08941939.2022.2095469","url":null,"abstract":"<p><strong>Objective: </strong>To investigate female iliac vein variations by using the computed tomography angiography (CTA) three-dimensional (3 D) reconstruction technique.</p><p><strong>Methods: </strong>We retrospectively studied 1623 patients undergoing abdominal and pelvic CTA scanning for gynecological diseases from December 2009 to December 2018. Accurate digital 3 D models of the iliac vein were constructed using Mimics 19.0 software and used to study the morphology and variations. Variations in the common iliac vein (CIV), external iliac vein (EIV) and internal iliac vein (IIV) were classified as type I, abnormal number of veins; type II, abnormal communicating branches; or type III, other variations.</p><p><strong>Results: </strong>The overall variation rates of the iliac vein and CIV were 51.57% (837/1623) and 20.33% (330/1623), respectively. The main type of CIV variation was type II. The main type I CIV variation was the absence of the CIV (98.15%), which mostly occurred on the right side (64.81%, 35/54). Type II CIV variation was the most common, with abnormal communicating branches between the left CIV and right IIV (81.78%, 211/258). The overall variation rates of the EIV and IIV were 36.66% (595/1623) and 49.60% (805/1623), respectively, mainly on the right side. The main type of variation was type I. Among them, the division of the IIV into two branches plus convergence with the ipsilateral EIV was the most common (22.98%, 373/1623).</p><p><strong>Conclusion: </strong>In this study, approximately half of the patients had iliac vein variations. The preoperative identification of iliac vein variation may reduce vascular injury in pelvic surgery.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1679-1685"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40476097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Dermal Microcirculatory Changes after Topical Administration of Capsaicin: A Randomized Placebo-Controlled Study in 46 Subjects.","authors":"Ruth Christine Schäfer,&nbsp;Anna Sohn,&nbsp;Anabel Kersten,&nbsp;Amro Amr,&nbsp;Manuel Held,&nbsp;Andrea Wenger","doi":"10.1080/08941939.2022.2091694","DOIUrl":"https://doi.org/10.1080/08941939.2022.2091694","url":null,"abstract":"<p><strong>Background: </strong>Dermal blood flow is crucial for wound healing and survival of flaps in dermatologic surgery. To improve flap viability in cases of compromised perfusion topical agents can easily be applied. The aim of this placebo-controlled study was to characterize changes of DBF in healthy subjects by quantitatively assessing perfusion dynamics after application of capsaicin to establish a reference for measurements at injured sites.</p><p><strong>Methods: </strong>In 46 healthy subjects perfusion dynamics after local application with capsaicin and placebo was noninvasively assessed, determining cutaneous oxygen saturation, relative hemoglobin count and blood flow using an Oxygen-to-See device.</p><p><strong>Results: </strong>A significant raise in superficial (162% <i>p</i> = 0.000) and deep (144%, <i>p</i> = 0.000) skin oxygenation after 30 min was provoked. A highly significant raise in measurements of flow and velocity was present in superficial (523%, <i>p</i> = 0.000) and deep (242%, <i>p</i> = 0.000) sites.</p><p><strong>Conclusion: </strong>With the introduced model applied to observe changes in parameters of dermal blood flow in healthy subjects the authors can reliably monitor effects of topically administered capsaicin. This baseline can be used as reference for further studies in the settings of endangered flap survival or critically perfused wounds as has been proven in animal studies.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1673-1678"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40617330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Concepts in Treating Synchronous Liver Metastases Rectal Cancer Patients: Report of Six Cases.","authors":"Hao Zhang,&nbsp;Yinghu Jin,&nbsp;Rui Huang,&nbsp;Guiyu Wang","doi":"10.1080/08941939.2022.2088905","DOIUrl":"https://doi.org/10.1080/08941939.2022.2088905","url":null,"abstract":"<p><strong>Background: </strong>Rectal cancer patients with synchronous liver metastases (SLM) is common in clinical practice. However, the application of conventional natural orifice specimen extraction surgery (NOSES) and NOSES with specimen extraction via stoma/hepatectomy incision in the special population is rarely explored.</p><p><strong>Case report: </strong>Six SLM rectal cancer patients were treated with simultaneous surgical resection and the specimens were extracted via anal/stoma/hepatectomy incision. Respectively, intraoperative and postoperative data, anal function 3 months after surgery and long-term prognosis were reviewed.</p><p><strong>Results: </strong>Intraoperative and postoperative data and anal function were reliable for the six cases. Only one patient died of brain and bone metastases at 84 months after surgery and the other five patients were alive at their last follow-up.</p><p><strong>Conclusions: </strong>Simultaneous surgical resection with the concept of conventional NOSES and NOSES with specimen extraction via stoma/hepatectomy incision is safety for SLM rectal patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1700-1703"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Diameter of Perforator in Pedicle and Different Managements of Intermediate Non-Pedicle Perforator on Flap Survival in Rats.","authors":"Donghong Liu,&nbsp;Fang Fang,&nbsp;Yuehong Zhuang","doi":"10.1080/08941939.2022.2097345","DOIUrl":"https://doi.org/10.1080/08941939.2022.2097345","url":null,"abstract":"<p><strong>Backgrounds: </strong>The quantified relationship between perforator diameter and flap length can be supported, and the impact of different strategies of managements of a non-pedicled perforator with two major subfascial divisions on flap survival has never been explored.</p><p><strong>Materials and methods: </strong>This study was divided into two parts. In Part I, 48 Sprague-Dawley rats underwent flap harvesting based on six perforators with a diameter gradient. Then, the flap length and perforator diameter were measured for establishment of an equation. In Part II, 32 rats underwent harvest of a transverse flap based on the right superficial epigastric perforator. In 16 rats the right intermediate iliolumbar perforator was severed in a distal-to-division approach, whereas, in the other 16 rats, it was severed with in a proximal-to-division approach. Necrosis rates and blood perfusion were also compared.</p><p><strong>Results: </strong>The equation y = 13.02 × x + 2.29 could be established between the perforator diameter in the pedicle (x) and the flap length (y) that could be supported with R²=0.8963 and P < 0.001.The transverse flap with a distal-to-division management of the intermediate iliolumbar perforasome was weaker in perfusion and had a necrosis rate of 49±4%, whereas the flap with a proximal-to division management had a significantly stronger perfusion and a lower necrosis rate of 21±2% (P<0.001).</p><p><strong>Conclusions: </strong>The safe flap length that can be estimated based on a perforator with a known diameter can be calculated using y=13.02× x +2.29. A short segment of the stem of an intermediate perforator with two major subfascial branches should be preserved to augment flap survival.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 9","pages":"1686-1693"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40519707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis?","authors":"Murat Biyik,&nbsp;Zeynep Biyik,&nbsp;Mehmet Asil,&nbsp;Muharrem Keskin","doi":"10.1080/08941939.2022.2084187","DOIUrl":"https://doi.org/10.1080/08941939.2022.2084187","url":null,"abstract":"<p><strong>Objectives: </strong>The inflammatory response is critically important in acute pancreatitis (AP). Systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI), which are novel inflammatory markers, have been linked to determining outcomes in various diseases. The goal of the current study was to examine the relation of the SII index and SIRI with disease severity and acute kidney injury (AKI) in subjects with AP.</p><p><strong>Methods: </strong>A total of 332 subjects with AP were analyzed retrospectively. SII index was calculated using the formula; platelet (P)×neutrophil (N)/lymphocyte (L), while SIRI was calculated as N × monocyte (M)/L count. Multivariate regression (MR) was done to determine the independent risk factors for AKI and severe AP (SAP).</p><p><strong>Results: </strong>Statistical analyses showed that both median SII index and median SIRI increased gradually with higher AP severity (<i>p</i> < 0.001). Both SII index and SIRI were higher in subjects with AKI compared to controls (<i>p</i> < 0.001). Using MR analysis, the SII index was found to independently predict both SAP (OR = 1.004, 95% CI: 1.001-1.008, <i>p</i> = 0.018) and AKI (OR = 1.005, 95% CI: 1.003-1.008, <i>p</i> < 0.001). ROC analysis showed that the SII index could accurately differentiate SAP (AUC = 0.809, <i>p</i> < 0.001) and AKI (AUC = 0.820, <i>p</i> = 0.001) in patients with acute pancreatitis. ROC analysis also showed that SIRI could also accurately differentiate SAP (0.782, <i>p</i> < 0.001) and AKI (AUC = 0.776, <i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>SIRI and the SII indexes can be used as potential biomarkers in predicting both disease severity and AKI development in subjects with AP.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"35 8","pages":"1613-1620"},"PeriodicalIF":1.9,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}