Optimized Minimally Invasive Jejunoileal Bypass Compared to Traditional Minimally Invasive Jejunoileal Bypass in the Treatment of Type 2 Diabetes: A Retrospective Cohort Study.

Objective: The efficacy and safety of optimized minimally invasive jejunoileal bypass (OM-JIB) compared to traditional minimally invasive jejunoileal bypass (TM-JIB) in the treatment of type 2 diabetes mellitus (T2DM) were evaluated.

Methods: The included patients were placed into two groups (TM-JIB group [n = 49] and OM-JIB group [n = 48]) based on the surgical method. The surgical parameters, basic information, the laboratory results, 1-y postoperative outcomes, and postoperative complication rates were compared.

Results: The operative time was longer for the OM-JIB group compared to the TM-JIB group (p < 0.05) with no differences in the intraoperative blood loss and length of hospital stay (p > 0.05). Both groups exhibited significant reductions in BMI, fasting plasma glucose, 2-hour plasma glucose, and glycated hemoglobin over time (p < 0.05). The OM-JIB group achieved a similar efficacy rate to the TM-JIB group at the 1-y follow-up evaluation (p > 0.05). However, the postoperative complication rate was significantly lower in the OM-JIB group than the TM-JIB group (2.08% vs. 16.33%, p < 0.05).

Conclusion: OM-JIB treatment of T2DM patients was shown to be as effective as TM-JIB, but with significantly fewer complications than TM-JIB, thus enhancing patient safety.