Journal of Mass Spectrometry最新文献

{"title":"Analysis of Amine Drugs Dissolved in Methanol by High-Resolution Accurate Mass Gas Chromatography Mass Spectrometry, GC-Orbitrap","authors":"Chee-Leong Kee,&nbsp;Xiaowei Ge,&nbsp;Min-Yong Low,&nbsp;Laura A. Ciolino","doi":"10.1002/jms.5127","DOIUrl":"https://doi.org/10.1002/jms.5127","url":null,"abstract":"<div>\u0000 \u0000 <p>The fragmentation pathways for amines dissolved in methanol (CH₃OH) or deuterated methanol (CD₃OD) have been investigated by high-resolution accurate mass gas chromatography mass spectrometry (HRAM-GCMS) or GC-Orbitrap. Primary and secondary amines used in this study were 1,3-dimethylamylamine (1,3-DMAA) and ephedrine hydrochloride (Eph), respectively. For isotopic labeling experiment, <i>1S</i>, 2<i>R</i> (+) ephedrine-D₃ hydrochloride (D₃-Eph) was used. Under splitless injection mode at an inlet temperature of 250°C, formaldehyde and its deuterated form were generated from CH₃OH and CD₃OD, respectively. This was evidenced by the oxonium ions generated from each solvent. When 1,3-DMAA was dissolved in CH₃OH or CD₃OD, distinct separation between the unreacted amine and condensation product fragments was observed, specifically methylene-imine (M + 12) and deuteromethylene-imine (M + 14) artifacts. More complex condensation patterns for Eph and D₃-Eph were observed, attributed to the labile hydrogen/deuterium exchange and gradual deuteration from CH₃OH to CD₃OD. The fragmentation pathways were supported by the presence of oxazolidine intermediates before forming smaller condensation product fragments. Despite their close retention time and mass, the HRAM data distinguished the isobaric unreacted amine and condensation product fragments produced by Eph and D₃-Eph in the coeluting region.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the Metabolic Mechanism of the Principal Components From Moringa oleifera (Lam) Seed by MALDI-IMS","authors":"Tao Wang,&nbsp;Jinglin Wang,&nbsp;Saifei Yang,&nbsp;Jinchao Wei,&nbsp;Yuanyuan Sun,&nbsp;Rui Chen","doi":"10.1002/jms.5125","DOIUrl":"https://doi.org/10.1002/jms.5125","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, the components of <i>Moringa oleifera</i> (Lam) seed were extracted using an ultrasonic-assisted extraction technique with 70% methanol solution as the solvent. The antioxidant properties of the extract were evaluated through its scavenging abilities against DPPH^. and ABTS. The antiproliferative effects of this extract on breast cancer MDA-MB-231, colon cancer SW480, leukemia HL-60, liver cancer SMMC-7721, and lung cancer A549 were assessed using the MTS assay. The distribution of MA, D-trehalose, and rbGlu in the heart, kidney, liver, and spleen of mice in various intervals was visually investigated using MALDI-IMS. In particular, the metabolic pathways of rbGlu were further elucidated. The result shows that rbGlu is metabolized to rbot-Glu in mice within 1 h. This approach further substantiates the use of MALDI-MSI technique in situ for studying the pharmacological mechanisms of bioactive component in natural products.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Rapid Liquid Chromatography–Tandem Mass Spectrometry Method for the Quantitation of Vitamin K Metabolites in Different Matrices","authors":"Danchen Wang,&nbsp;Yichen Ma,&nbsp;Honglei Li,&nbsp;Xiaoli Ma,&nbsp;Yutong Zou,&nbsp;Songlin Yu,&nbsp;Ling Qiu","doi":"10.1002/jms.5120","DOIUrl":"https://doi.org/10.1002/jms.5120","url":null,"abstract":"<div>\u0000 \u0000 <p>Adequate vitamin K is crucial for optimal health. Although vitamin K detection methods have been established using liquid chromatography–tandem mass spectrometry (LC–MS/MS), some limitations remain. Therefore, we aimed to establish a stable and rapid LC–MS/MS method that can quantify phylloquinone (VK1), menaquinones-4 (MK-4), and menaquinones-7 (MK-7) in serum and cerebrospinal fluid and explore its clinical applications. We developed an LC–MS/MS method with atmospheric pressure chemical ionization to quantify and validate its performance according to Clinical Laboratory and Standard Institution standards (C62-Ed2). Serums from 50 healthy individuals and cerebrospinal fluid from 15 patients were collected for clinical application. Sample preparation involved lipase incubation, protein precipitation with ethanol, and liquid–liquid extraction with hexane/ethyl; optimization was performed for sample preparation and LC separation. Linearity was 50–10 000 pg/mL for VK1, MK-4, and MK-7. The total coefficient of variation (%) for VK1, MK-4, and MK-7 ranged from 8.5% to 10.4%, 8.0% to 10.4%, and 7.0% to 11.1%, respectively. Recovery of VK1, MK-4, and MK-7 was 82.3%–110.6%, 92.3%–110.6%, and 89.5%–117.8%, respectively. VK1 and MK-7 were detected in the serum of all 50 healthy subjects, whereas MK-4 was detected in only 13 (26%) subjects. Approximately 53.3% (8/15) had no detectable vitamin K in their cerebrospinal fluid. The developed method exhibited satisfactory performance and was applicable for detecting VK1, MK-4, and MK-7 in serum and cerebrospinal fluid.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precursor Resolution via Ion Z-State Manipulation: A Tandem Mass Spectrometry Approach for the Analysis of Mixtures of Multiply-Charged Ions","authors":"Nicolas J. Pizzala,&nbsp;Hsi-Chun Chao,&nbsp;Boukar K. S. Faye,&nbsp;Scott A. McLuckey","doi":"10.1002/jms.5124","DOIUrl":"https://doi.org/10.1002/jms.5124","url":null,"abstract":"<p>Electrospray ionization (ESI) is often the ionization method of choice, particularly for high-mass polar molecules and complexes. However, when analyzing mixtures of analytes, charge state ambiguities and overlap in mass-to-charge (<i>m/z</i>) can arise from species with different masses and charges. While solution-phase conditions can sometimes be optimized to produce relatively low charge states—thereby reducing charge-state ambiguity and <i>m/z</i> overlap—gas-phase methods offer greater control over charge state reduction. For complex mixtures, however, charge state reduction alone often fails to resolve individual components in the mixture. Incorporating a mass-selection step prior to charge state manipulation can simplify the mixture and significantly improve the separation of the components. This general tandem mass spectrometry approach is referred to here as <b>p</b>recursor <b>r</b>esolution via <b>i</b>on <b>z</b>-state <b>m</b>anipulation (<b>PRIZM</b>). Examples of variations of PRIZM experiments date back roughly 25 years and have involved ion/molecule proton transfer reactions, ion/ion proton transfer reactions, ion/ion electron transfer reactions, electron capture reactions, and multiply-charged ion attachment reactions. This tutorial review describes the PRIZM approach and provides illustrative examples using each of the charge state manipulation approaches mentioned above.</p>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jms.5124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast Nonlinear Damping Identification Method to Determine Size, Mass, and Charge of Lycopodium clavatum Spores in a Paul Trap","authors":"Shcherbinin D.P.,&nbsp;Rybin V.V.,&nbsp;Semynin M.S.,&nbsp;Slepneva E.E.,&nbsp;Ivanov A.V.,&nbsp;Rudyi S.S.","doi":"10.1002/jms.5123","DOIUrl":"https://doi.org/10.1002/jms.5123","url":null,"abstract":"<div>\u0000 \u0000 <p>In the present work, we have first applied the fast nonlinear damping identification (NDI) method to nondestructively and simultaneously determine the values of mass, size, and charge of biological micro-objects trapped in a quadrupole Paul trap. Here, we used well-studied <i>Lycopodium clavatum</i> individual spores as a test object. For the nondestructive determination of spore parameters, we analyzed their extended orbit trajectory implemented in the nonlinear regime of viscous friction while trapping in a quadrupole Paul trap. The article discusses the prospects of the method proposed for investigating a wide class of biological objects.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and Behaviors of TEMPO Derivatives in Seven Mass Spectrometry Ionization Methods","authors":"Kin-ichi Oyama,&nbsp;Seanghai Hor,&nbsp;Masaki Tsukamoto,&nbsp;Hedong Zhang","doi":"10.1002/jms.5122","DOIUrl":"10.1002/jms.5122","url":null,"abstract":"<p>Four 2,2,6,6-tetramethylpiperidinyloxyl (TEMPO) derivatives with molecular weights of 339–1131 Da were synthesized to investigate their ionization behaviors in fast atom bombardment (FAB), electron ionization (EI), direct analysis in real time (DART), electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). These include 4-dodecanoylamino-2,2,6,6-tetramethyl-1-piperidinyloxy (<b>1</b>), 4-dodecylamino-2,2,6,6-tetramethyl-1-piperidinyloxy (<b>2</b>), <i>N</i>,<i>N</i>′-bis(2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl)dodecanediamide (<b>3</b>), and bis-cholesterol TEMPO derivative <b>4</b>. For TEMPO derivatives <b>1</b> and <b>2</b> (molecular weights: 353 Da and 339 Da), [M]⁺, [M+H]^+•, and [M+2H]⁺ peaks were detected. TEMPO derivative <b>3</b>, containing two TEMPO moieties, showed [M]^+•, [M+H]⁺, [M+2H]^+•, and [M+3H]⁺ peaks. EI was optimal for smaller derivatives, as molecular ion peaks were predominant. For larger analytes, molecular ion intensities weakened, favoring hydrogen adduct peaks. EI and DART-MS failed to detect bis-cholesterol TEMPO derivative <b>4</b>. Under APCI and APPI-MS, N–O bond cleavage was observed. MALDI-MS detected only hydrogen adduct peaks. FAB, ESI, APCI, and APPI-MS detections varied with scan numbers, unlike EI, DART, and MALDI-MS.</p>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an LC–MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma","authors":"Andrew Cothrell,&nbsp;Ravi S. Orugunty,&nbsp;Leif Smith","doi":"10.1002/jms.5121","DOIUrl":"10.1002/jms.5121","url":null,"abstract":"<p>Fungal infections are caused by opportunistic pathogens that can be life threatening and have been growing in prevalence. Many clinically relevant pathogens have resistance to or are developing resistance to the commonly used antifungal treatments. Occidiofungin (OCF) is a unique cyclic lipoglycopeptide with a novel structure that includes noncanonical amino acid in its covalent structure. It exhibits broad spectrum antifungal activity and has activity against drug resistant <i>Candida</i> species. Occidiofungin is a fungicidal compound that has a novel mechanism of action in which it disrupts higher order actin structures. Currently, occidiofungin is being developed for use in treating vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC). This study describes the development and application of a bioanalytical method for the quantification of occidiofungin in rabbit plasma. Method development was performed to quantify occidiofungin in rabbit plasma after intravaginal administration of a hydrogel containing occidiofungin. The method was validated with a linear range of 30–15 000 ng/mL in rabbit plasma. Precision, accuracy, calibration curve linearity, and stability of drug in plasma were established in quality controls. Extract stability, matrix effects, and recovery of drug in the extract were also determined. This study supported a repeat dose toxicity study in rabbits to determine occidiofungin pharmacokinetics and toxicokinetics. The pharmacokinetic and toxicokinetic primarily showed plasma concentrations of occidiofungin below the limit of quantification (BLOQ), suggesting that OCF-B does not readily cross the vaginal epithelial membrane.</p>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 4","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro and In Vivo Assessment of Antidiabetic Activity of Cupressus torulosa D. Don Needles, Their LCQTOFMS Assisted Metabolite Profiling, and Implications for Diabetes Management","authors":"Radhika Khanna,&nbsp;H. R. Chitme,&nbsp;Khushaboo Bhadoriya,&nbsp;Y. C. Tripathi,&nbsp;V. K. Varshney","doi":"10.1002/jms.5117","DOIUrl":"https://doi.org/10.1002/jms.5117","url":null,"abstract":"<div>\u0000 \u0000 <p>Diabetes mellitus (DM) is a prevalent metabolic disorder attributed to insulin secretion and action defects, affecting a growing adult population with hyperglycemia expected to reach 578 million by 2030. This study explores the antidiabetic potential of 25% aqueous methanol extract of <i>Cupressus torulosa</i> needles, utilizing in vitro and in vivo assays. In the <i>α</i>-glucosidase inhibition assay, the extract exhibited significant in vitro antidiabetic activity with an IC₅₀, 123.45 ± 1.8 μg/mL, comparable to the standard drug acarbose (IC₅₀, 58.21 ± 3.1 μg/mL). Toxicity assessment indicated non-toxic nature of the extract at 2000 mg/kg b.w. In STZ-induced diabetic mice, it displayed dose-dependent antihyperglycemic effects, evident at the fourth hour and 14th day, paralleling the positive control glibenclamide. In the chemical profiling of the extract using UPLC-QTOF-MS, the mobile phases consisted of 0.1% formic acid in water (Solvent A) and 100% methanol (Solvent B). The gradient elution started with 5% B (0 to 2 min) and gradually increased to 95% B by 25 min, followed by a post-run time of 2 min. Preliminarily, 50 constituents were identified, predominantly phenolics, with hypoglycemic effects attributed to flavonoids like (−)-epicatechin, amentoflavone, and cupressuflavone, as well as iridoid <i>O</i>-glycoside, exemplified by haprpagoside. Further studies are needed to assess the long-term efficacy, safety, and molecular mechanisms of the extract of <i>C. torulosa</i> needles in diabetes management.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass Spectrometry–Based Proteomics in Clinical Diagnosis of Amyloidosis and Multiple Myeloma: A Review (2012–2024)","authors":"Katerina Kratka,&nbsp;Pavel Sistik,&nbsp;Ivana Olivkova,&nbsp;Pavlina Kusnierova,&nbsp;Zdenek Svagera,&nbsp;David Stejskal","doi":"10.1002/jms.5116","DOIUrl":"https://doi.org/10.1002/jms.5116","url":null,"abstract":"<p>Proteomics is nowadays increasingly becoming part of the routine clinical practice of diagnostic laboratories, especially due to the advent of advanced mass spectrometry techniques. This review focuses on the application of proteomic analysis in the identification of pathological conditions in a hospital setting, with a particular focus on the analysis of protein biomarkers. In particular, the main purpose of the review is to highlight the challenges associated with the identification of specific disease-causing proteins, given their complex nature and the variety of posttranslational modifications (PTMs) they can undergo. PTMs, such as phosphorylation and glycosylation, play critical roles in protein function but can also lead to diseases if dysregulated. Proteomics plays an important role especially in various medical fields ranging from cardiology, internal medicine to hemato-oncology emphasizing the interdisciplinary nature of this field. Traditional methods such as electrophoretic or immunochemical methods have been mainstay in protein detection; however, these techniques are limited in terms of specificity and sensitivity. Examples include the diagnosis of multiple myeloma and the detection of its specific protein or amyloidosis, which relies heavily on these conventional methods, which sometimes lead to false positives or inadequate disease monitoring. Mass spectrometry in this respect emerges as a superior alternative, providing high sensitivity and specificity in the detection and quantification of specific protein sequences. This technique is particularly beneficial for monitoring minimal residual disease (MRD) in the diagnosis of multiple myeloma where traditional methods fall short. Furthermore mass spectrometry can provide precise typing of amyloid proteins, which is crucial for the appropriate treatment of amyloidosis. This review summarizes the opportunities for proteomic determination using mass spectrometry between 2012 and 2024, highlighting the transformative potential of mass spectrometry in clinical proteomics and encouraging its wider use in diagnostic laboratories.</p>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jms.5116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CID-Induced Formation of Deprotonated Cyclic Peptide Ions From Anionic Adducts","authors":"Maciej Modzel,&nbsp;Piotr Stefanowicz","doi":"10.1002/jms.5114","DOIUrl":"https://doi.org/10.1002/jms.5114","url":null,"abstract":"<div>\u0000 \u0000 <p>MS analysis of cyclic peptides in negative ion mode has been a challenge, in particular if the peptide does not contain acidic functional groups. In this paper, we present a way to easily produce negative ions from anionic peptide adducts, utilising collision-induced dissociation (CID)-mediated elimination. Using two different mass spectrometers, we have generated series of adducts of three cyclic and one linear peptide with various anions. They were then isolated and subjected to CID with a range of collision energies. The deprotonation percentage was then calculated from the resultant spectrum, and compared between the spectrometers, as well as with an external reference—proton affinity values. The susceptibility to deprotonate by detaching a HX moiety is proportional to the proton affinity of the X⁻ species. Also, the linear peptide deprotonated more readily than the cyclic ones. On the other hand, lack of amino or acidic groups resulted in higher collision voltage (CV) necessary for the formation of deprotonated species. Moreover, the exact propensity for neutral loss depends on the ion temperature, which differs between mass spectrometers. We have developed a facile method for generating peptide anions for MS analysis of cyclic peptides, which works even if the peptide in question does not have easily ionisable groups. The deprotonated species generated in this way can be fragmented again in order to identify the peptide.</p>\u0000 </div>","PeriodicalId":16178,"journal":{"name":"Journal of Mass Spectrometry","volume":"60 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}