Journal of Medical Biochemistry最新文献

{"title":"Evaluation of the analytical and clinical characteristics of the siemens immulite®2000 tsi method for determining thyrotropin receptor antibodies.","authors":"Neda Milinković, Marija Sarić, Ana Ružanović, Miloš Žarković, Jasmina Ćirić, Iva Perović Blagojević, Ana-Marija Mastilović, Svetlana Ignjatović, Biljana Nedeljković Beleslin","doi":"10.5937/jomb0-55873","DOIUrl":"10.5937/jomb0-55873","url":null,"abstract":"<p><strong>Background: </strong>Despite commercially improved, standardised routine methods used in medical laboratories, precision laboratory medicine lacks harmonisation of results to make the laboratory result useful for its intended purpose. Furthermore, to obtain reliable laboratory results and precise diagnoses, it is important and recommended that each laboratory confirms the analytical and clinical characteristics of the method used. This study aimed to evaluate the analytical and clinical performance of the IMMULITE®2000 TSI bridge immunoassay to determine autoreactive thyroid stimulating hormone receptor antibodies (SH-R-Ab).</p><p><strong>Methods: </strong>A total of 86 patients with clinically present Graves' orbitopathy and 23 healthy volunteers as a control group were included in the study. The total TSH-R-Ab concentration was determined using an ECLIA (Elecsys Anti-TSHR Immunoassay Roche Diagnostics, GmbH, Mannheim, Germany) on the Cobas e411 analyser (Roche, Diagnostics, GmbH). The TSH-R-Ab concentration was measured using a CLIA method (IMMULITE TSI 2000, Siemens Healthcare Diagnostics, UK). The inaccuracy of the method was investigated using two levels of commercial control samples (low and high analyte concentration).</p><p><strong>Results: </strong>The results obtained meet the general minimum requirements for the analytical performance of laboratory methods (CV<5%). The overall laboratory inaccuracy was acceptable according to FDA guidelines (CV<20%). The results showed a statistically significant correlation between the analysed methods (r=0.9041, p < 0.0001) but with a relative bias of 24.5%. The best ratio of sensitivity and specificity determined by the ROC analysis (93.3% and 100%, respectively) was obtained for a cut-off value of 0.1215 IU/L, which is significantly lower compared to the cut-off value specified by the manufacturer (0.55 IU/L).</p><p><strong>Conclusions: </strong>The IMMULITE 2000 TSI bridge immunoassay for TSH-R-Ab quantification confirmed adequate precision, which is essential for routine use. However, further studies are required to evaluate its analytical specificity.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"438-446"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of serological markers and immune indicators combined with early warning scoring system for prognosis in pediatric acute respiratory infections.","authors":"Peng Zhou, Shanlin Wang, Xinyuan Huang, Caixia Xiang, Xiaoxia Qian, Yaping Shen, Yanyan Zhu","doi":"10.5937/jomb0-53846","DOIUrl":"10.5937/jomb0-53846","url":null,"abstract":"<p><strong>Background: </strong>The objective was to evaluate the combined utility of alertness-vigilance-pain-unresponsiveness (AVPU) scoring and serological factors in predicting outcomes for children with acute respiratory infections (ARIs) in the emergency department.</p><p><strong>Methods: </strong>This retrospective cohort study with a case-control design included 100 children with ARIs admitted to a pediatric department from May 2022 to May 2024. Patients were divided into the good prognosis group (GPG) and the poor prognosis group (PPG) based on their outcomes. Clinical data, vital signs, alertness-vigilance-pain-unresponsiveness (AVPU) scores, serum inflammatory markers (SIMs), immunoglobulin levels, and immune cell counts were compared between the two groups.</p><p><strong>Results: </strong>The GPG had significantly lower WBC, CRP, IL-6, and PCT levels than the PPG. AVPU scores were substantially lower in the PPG. Pearson correlation analysis revealed no notable correlation between AVPU scores and SIMs. Receiver operating characteristic (ROC) curve analysis showed that AVPU scores had higher sensitivity and specificity for predicting unfavourable outcomes than SIMs.</p><p><strong>Conclusions: </strong>AVPU scores and SIMs are valuable predictors of unfavourable outcomes in pediatric ARIs. Combined testing of AVPU scores and SIMs may improve predictive performance. These findings can inform early identification and timely intervention for children with ARIs at risk of unfavourable outcomes.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"544-552"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diagnostic value plasma procalcitonin (PCT) and serum amyloid A protein (SAA) in children with mycoplasma pneumonia.","authors":"Baoyue Wang, Yao Zheng, Linnan Jia","doi":"10.5937/jomb0-53616","DOIUrl":"10.5937/jomb0-53616","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the diagnostic value of pulmonary ultrasound combined with plasma procalcitonin (PCT) and serum amyloid A protein (SAA) in children with Mycoplasma pneumoniae pneumonia (MPP).</p><p><strong>Methods: </strong>Clinical data of 80 children with community-acquired pneumonia who underwent lung ultrasound examinations and were admitted to our hospital from January 2023 to December 2023 were collected. Children with MPP were divided into an MPP group and a non-MPP group on the grounds of whether they were MPP patients. Meanwhile, PCT and SAA levels were checked, and lung ultrasound and PCT and SAA examination results were collected and compared. The ROC curve was used to evaluate the value difference of the three alone and in combination in diagnosing mycoplasma pneumonia.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"534-543"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effectiveness of combined CT angiography, MMP-9, and PAF testing in the assessment of vascular restenosis in acute coronary syndromes after atorvastatin combined with tirofiban therapy.","authors":"Jia Sun, Yiling Gao, Jing Ma, Minghui Zhu, Kefei Li, Yiyong Hou, Huan Zhang, Chunqiao Xie","doi":"10.5937/jomb0-54706","DOIUrl":"10.5937/jomb0-54706","url":null,"abstract":"<p><strong>Background: </strong>Acute Coronary Syndrome (ACS) is a very common cardiovascular disease in clinical practice with a very high risk of death. In this study, we observed the effectiveness of CT angiography (CTA), matrix metalloproteinase-9 (MMP-9) and platelet-activating factor (PAF) in the assessment of ACS.</p><p><strong>Methods: </strong>A total of 124 patients with ACS admitted to our hospital from June 2022 to March 2024 were enrolled as study subjects. All study subjects were examined using coronary angiography (CAG) and CTA. To compare the detection rate of ACS by CAG and CTA and the difference in effectiveness in assessing coronary plaque stenosis and plaque calcification. In addition, the levels of MMP-9 and PAF were detected in the patients to analyze their relationship with the degree of stenosis and plaque grade. Subsequently, the effect of the three combined tests, CTA, MMP-9 and PAF, was analyzed to assess postoperative vessel restenosis. Finally, we examined the factors associated with poor CTA image quality.</p><p><strong>Results: </strong>There was no difference in the effectiveness of CTA in detecting ACS, assessing coronary plaque stenosis and plaque calcification compared with CAG (P>0.05). There was a positive correlation between MMP-9, PAF and the degree of coronary stenosis and plaque severity (P<0,05). The diagnostic accuracy of the combination of CTA, MMP-9, and PAF in diagnosing stenosis in postoperative ACS was 97.58% (Kappa=0.946). It was determined that 124 patients and 21 patients had poor CTA images, and logistic regression analysis showed that shorter breath-hold time and arrhythmia were independent risk factors for poor CTA image quality.</p><p><strong>Conclusions: </strong>CTA, MMP-9 and PAF are excellent for diagnosing stenosis after ACS, and shorter breath-hold time and arrhythmia are all independent risk factors for poor CTA image quality.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"603-613"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of matrix metalloproteinases and adhesive molecules with important aspects of carotid artery stenosis.","authors":"Ana Ružanović, Marija Sarić-Matutinović, Neda Milinković, Snežana Jovičić, Andreja Dimić, David Matejević, Ognjen Kostić, Branko Gaković, Igor Končar, Svetlana Ignjatović","doi":"10.5937/jomb0-51391","DOIUrl":"10.5937/jomb0-51391","url":null,"abstract":"<p><strong>Background: </strong>Symptom risk assessment in carotid artery stenosis (CAS) could be improved by parameters that reflect additional risk aspects such as chronic inflammation rate, and atherosclerotic activity on a systemic level. In light of that, we investigated the association of serum matrix metalloproteinases-2,7,9 (MMP-2,7,9), vascular cell adhesion molecule-1 (VCAM-1) and selectins-P and E with symptomatic status, stenosis degree and plaque morphology in CAS patients in order to select parameters that associate to important clinical determinants of the symptom development risk.</p><p><strong>Methods: </strong>The study included 119 CAS patients and 46 healthy subjects. Carotid arteries were examined by color flow Doppler and B-mode Duplex ultrasound. Serum parameters were assessed using commercially available enzyme-linked immunosorbent assays (ELISA). Difference was tested by Mann-Whitney U, Kruskal-Wallis and Chi-square tests, and Spearman's correlation was tested.</p><p><strong>Results: </strong>MMP-7 and selectin-P levels were higher in CAS than in controls (p<0.001). Positive correlation with stenosis degree was found for MMP-7 (r=0.155, p=0.007), VCAM-1 (r=0.127, p=0.029) and selectin-P (r=0.269, p<0.001). MMP-7 and selectin-P were higher in subjects with Grey-Weale 2, comparing to subjects with Grey-Weale 3 plaques (p=0.036, p=0.009). Selectin-P was lower in the presence of Grey-Weale 4 than in Grey-Weale 2 (p=0.045).</p><p><strong>Conclusions: </strong>Concurrent association of MMP-7 and selectin-P with both stenosis degree and carotid plaque morphology shows the joint influence of these important determinants of symptom risk that is reflected in serum parameters. This indicates that they can supply additional information outside ultrasound CAS assessment only, and their integration in a future multiscale approach for CAS risk prediction could be beneficial.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"553-560"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pestle needle combined with six healing sounds Qi Gong on inflammatory factors in patients with lumbar disc herniation.","authors":"Junzhu Chen, Xiaohui Huang, Chaofan Liu, Yue Feng, Shurong Zhang, Qi Wang, Fang Wang","doi":"10.5937/jomb0-55195","DOIUrl":"10.5937/jomb0-55195","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the impact of combining Pestle needle therapy with Six Healing Sounds Qi Gong exercises on serum inflammatory markers in patients with lumbar disc herniation.</p><p><strong>Methods: </strong>Ninety-six patients with lumbar disc herniation (LDH) were randomly assigned to three groups with 32 patients in each group. Group A received standard LDH treatment and care, while Group B received Pestle needle therapy in addition to the standard treatment of Group A. Group C incorporated the Six Healing Sounds Qi Gong in addition to the treatments in Group B. All three groups underwent treatment for four weeks. Comparisons of serum levels of IL-1b, IL-6, TNF-a, and CRP, as well as evaluations using the VAS, the ODI, and JOA score, were conducted among the groups before and after treatment.</p><p><strong>Results: </strong>Following treatment, the levels of serum inflammatory markers, as well as VAS score and ODI score, in both Group B and Group C, were significantly reduced compared to their pre-treatment levels (P < 0.05). Additionally, the JOA score in these groups was significantly increased compared to pre-treatment values (P < 0.05). These improvements were notably greater than those observed in Group A (P < 0.05). Except for IL-1b, the improvements in the other indices in Group C were significantly better than those in Group B (P < 0.05).</p><p><strong>Conclusions: </strong>The combination of pestle needle and Six Healing Sounds Qi Gong exercise therapy can effectively reduce serum levels of serum inflammatory markers in patients with LDH. This approach helps alleviate lumbar pain and improve lumbar function.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"422-431"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum TNF-a and biomarkers levels after tenofovir therapy in patients with serum HBeAg-positive chronic hepatitis B.","authors":"Xijie Lai, Guosheng Gao, Xiunong Jiang","doi":"10.5937/jomb0-56238","DOIUrl":"10.5937/jomb0-56238","url":null,"abstract":"<p><strong>Background: </strong>Chronic hepatitis B (CHB) remains a wide-spread and serious infectious disease, with its pathogenesis still not fully understood. Tenofovir Amibufenamide, a pro-drug of tenofovir, belongs to the class of nucleoside reverse transcriptase inhibitors and is used in the treatment of CHB. This study aimed to evaluate the efficacy and safety of Tenofovir Amibufenamide in treating HBeAg-positive CHB.</p><p><strong>Methods: </strong>A total of 60 patients diagnosed with HBeAg-positive CHB were randomly assigned to two groups: an entecavir (ETV) group (0.5 mg) and a Tenofovir Amibufenamide (TMF) group (0.25 mg), with 30 patients in each. After 24 months of treatment, renal function (serum creatinine, glomerular filtration rate), liver function (ALT , AST , total bilirubin), and inflammatory markers (TNF-a levels) were measured to assess the antiviral efficacy and safety profiles of the two treatments.</p><p><strong>Results: </strong>Patients in the TMF group exhibited smaller changes in serum creatinine and glomerular filtration rate, indicating less renal impairment compared to the ETV group. Furthermore, the TMF group demonstrated greater reductions in alanine aminotransferase (ALT) and total bilirubin (TBIL) levels, indicating superior improvement in liver function (P<0.05). TNF-a levels were significantly elevated in the ETV group, reflecting greater inflammatory activity, while the TMF group showed more controlled inflammation. Additionally, the TMF group experienced significantly lower hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA levels, showing superior antiviral efficacy. The incidence of adverse reactions was lower in the TMF group (3.3%) compared to the ETV group (13.3%), although the difference was not statistically significant (P>0.05).</p><p><strong>Conclusions: </strong>Tenofovir Amibufenamide demonstrated superior efficacy in improving liver function and reducing viral load in patients with HBeAg-positive CHB. Moreover, it had a minimal impact on renal function and presented a higher safety profile compared to entecavir. These findings suggest Tenofovir Amibufenamide as a promising alternative for the treatment of HBeAg-positive CHB.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"687-695"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytokine changes in nasal secretions after acute acoustic trauma.","authors":"Vanja Jovanović, Sonja Marjanović, Aleksandar Perić, Dejan Jovanović, Zoran Radojičić, Mirjana Đukić, Danilo Vojvodić","doi":"10.5937/jomb0-54742","DOIUrl":"10.5937/jomb0-54742","url":null,"abstract":"<p><strong>Background: </strong>Occupational noise-induced hearing loss poses a significant health risk, especially for military and law enforcement. Unlike steady, prolonged noise, impulse noise, such as gunfire, leads to more immediate and severe hearing impairment. This study explores the link between sensorineural hearing loss and cytokine levels in nasal secretions of male and female military cadets exposed to high-intensity gunfire noise.</p><p><strong>Methods: </strong>105 cadets (75 males and 30 females, aged 19-25) undergoing regular firearms training were included. Audiometric testing and measurement of IL-1b, TNF-a, GM-CSF, and IL-10 concentrations in nasal secretions were conducted at three time points: 24 hours before, immediately after and 24 hours following noise exposure.</p><p><strong>Results: </strong>Acute acoustic trauma affected the hearing of 39% of male and 21% of female participants. Among those with audiometric changes, IL-1b levels increased immediately after exposure, while both IL-1b and GM-CSF levels were elevated 24 hours later. Nasal IL-1b and GM-CSF levels significantly changed across all participants, with the most pronounced alterations seen in those with audiogram changes.</p><p><strong>Conclusions: </strong>Acoustic trauma associated with a certain degree of hearing loss due to noise exposure is linked to an increase in nasal pro-inflammatory cytokine levels, and this effect is more pronounced in men than in women.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"576-586"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nutritional intervention combined with vitamin D on glucose metabolism, sex hormones and inflammatory factors in patients with polycystic ovary syndrome.","authors":"Xinqin Kang, Lin Liu","doi":"10.5937/jomb0-53948","DOIUrl":"10.5937/jomb0-53948","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome is a very common endocrine and metabolic disease in clinical practice. Most polycystic ovary syndrome patients are complicated with obesity, a condition associated with an elevated risk of long-term complications such as diabetes, hypertension, and endometrial cancer, seriously threatening the health of patients. The best way to treat this disease is to use drugs to promote ovulation, adjust the menstrual period, and restore pregnancy. However, the drugs used to treat obesity and polycystic ovary syndrome usually have entirely opposite effects, resulting in unsatisfactory rehabilitation.</p><p><strong>Methods: </strong>This study selected 102 obese or overweight PCOS patients treated in our hospital from July 2022 to July 2024 as the research subjects. Sex hormones: The levels of prolactin (PRL), testosterone (T), follicle-stimulating hormone (FSH), and luteinising hormone (LH) were measured by electrochemiluminescence. Inflammation: C-reactive protein (CRP), white blood cell count (WBC), and procalcitonin (PCT) were examined by an automated blood cell counter. 46 (control group) of the 102 were treated with a conventional treatment scheme, and the other 56 (experimental group) were intervened by nutritional intervention combined with vitamin D based on conventional treatment.</p><p><strong>Results: </strong>Both groups showed reductions in sex hormone levels after treatment, with the PRL, T, LH, and FSH in the experimental group being (5.12±0.51) ng/mL, (1.22±0.32) ng/mL, (9.14±1.61) mIU/mL, and (5.01±0.42) mIU/mL, respectively, all of which were lower compared with the control group (P<0.05).</p><p><strong>Conclusions: </strong>In this study, we intervened obese polycystic ovary syndrome patients with nutritional or conventional intervention and found that compared with conventional treatment, the posture, blood glucose metabolism, and lipid function of the patients who received nutritional intervention were more significantly metabolised, and the levels of inflammatory factors were more effectively inhibited, indicating the high clinical application value of nutritional intervention in obese polycystic ovary syndrome.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"595-602"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The BCLF's core objectives, mission, and logo symbolism.","authors":"Nuray N Ulusu, Nada Majkić-Singh","doi":"10.5937/jomb0-56486","DOIUrl":"10.5937/jomb0-56486","url":null,"abstract":"<p><p>The Balkan Clinical Laboratory Federation (BCLF) is important in advancing clinical laboratory practices and fostering collaboration across the Balkan region. This federation was established in 1992, the BCLF aims to unite medical biochemists from Balkan countries, promoting standardization, innovation, and professional development in clinical laboratory medicine. This personal view article explores the federation's growth, its impact on clinical biochemistry, and the process behind the creation of its logo. The BCLF's logo designed during a Congress in 2010 and accepted in 2011, symbolizes the unity and interconnectedness of the region. The blue section represents the sea, the orange symbolizes the Balkans, and the green section represents Turkey, collectively illustrating the federation's collaborative nature. The colors were chosen for their symbolic meanings: orange embodies optimism and enthusiasm, green signifies growth and new beginnings, and blue reflects grandeur and depth. The logo plays a significant role in visually representing the values and mission of the BCLF. The BCLF has successfully organized educational events, conferences, and workshops, facilitated knowledge exchange, and helped laboratory professionals stay current with new methodologies. Additionally, the federation advocates for improved healthcare policies and laboratory infrastructure, ensuring the sustainability of clinical laboratory services in the region. Through its dedication to unity, research, and knowledge sharing, the BCLF has elevated clinical biochemistry in the region, creating a foundation for continued growth and collaboration in the clinical biochemistry field.</p>","PeriodicalId":16175,"journal":{"name":"Journal of Medical Biochemistry","volume":"44 3","pages":"381-385"},"PeriodicalIF":1.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}