Journal of integrative neuroscience最新文献

{"title":"Feasibility of an Objective Approach Using Acoustic Change Complex for Evaluating Spectral Resolution in Individuals with Normal Hearing and Hearing Loss.","authors":"Soojin Kang, Jihwan Woo, Kyung Myun Lee, Hye Yoon Seol, Sung Hwa Hong, Il Joon Moon","doi":"10.31083/JIN25911","DOIUrl":"https://doi.org/10.31083/JIN25911","url":null,"abstract":"<p><strong>Background: </strong>Identifying the temporal and spectral information in sound is important for understanding speech; indeed, a person who has good spectral resolution usually shows good speech recognition performance. The spectral ripple discrimination (SRD) test is often used to behaviorally determine spectral resolution capacity. However, although the SRD test is useful, it is difficult to apply to populations who cannot execute the behavioral task, such as younger children and people with disabilities. In this study, an objective approach using spectral ripple (SR) stimuli to evoke the acoustic change complex (ACC) response was investigated to determine whether it could objectively evaluate the spectral resolution ability of subjects with normal hearing (NH) and those with hearing loss (HL).</p><p><strong>Method: </strong>Ten subjects with NH and eight with HL were enrolled in this study. All subjects completed the behavioral SRD test and the objective SR-ACC test. Additionally, the HL subjects completed speech perception performance tests while wearing hearing aids.</p><p><strong>Results: </strong>In the SRD test, the average thresholds were 6.48 and 1.52 ripples per octave (RPO) for the NH and HL groups, respectively, while in the SR-ACC test, they were 4.90 and 1.35 RPO, respectively. There was a significant difference in the average thresholds between the two groups for the SRD (<i>p</i> < 0.001) and the SR-ACC (<i>p</i> < 0.001) tests. A significant positive correlation was observed between the SRD and SR-ACC tests (ρ = 0.829, <i>p</i> < 0.001). In the HL group, there was a statistically significant relationship between speech recognition performance in noisy conditions and the SR-ACC threshold (ρ = 0.911, <i>p</i> < 0.001 in Sentence score of Korean Speech Audiometry (KSA)).</p><p><strong>Conclusions: </strong>The results supported the feasibility of the SR-ACC test to objectively evaluate auditory spectral resolution in individuals with HL. This test has potential for use in individuals with HL who are unable to complete the behavioral task associated with the SRD test; therefore, it is proposed as a more inclusive alternative to the SRD test.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25911"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Complications of Seizures and Migraines.","authors":"Josef Finsterer","doi":"10.31083/JIN26768","DOIUrl":"https://doi.org/10.31083/JIN26768","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26768"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role of Astrocytes in Learning and Memory Recall.","authors":"Kecan Li, Yihui Cui","doi":"10.31083/JIN38721","DOIUrl":"https://doi.org/10.31083/JIN38721","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"38721"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus.","authors":"Leigh M Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood","doi":"10.31083/JIN26508","DOIUrl":"https://doi.org/10.31083/JIN26508","url":null,"abstract":"<p><strong>Background: </strong>The study investigated the neural correlates of mind wandering using eyeblink rate (EBR) and variability (EBV) proxies. Dopamine, a neurotransmitter integral to the brain's reward system, has been implicated in regulating both task-unrelated and task-focused thinking. This study sought to clarify the relationships between dopaminergic function and cognitive control during a task by utilizing EBR and EBV as proxy measures.</p><p><strong>Methods: </strong>Vertical electrooculogram and brain event-related potential (ERP) data were gathered from 24 adult participants while they performed a computerized cognitive task. During the task (3-stimulus visual oddball procedure), participants discriminated between an infrequently seen target stimulus, an infrequent novel stimulus (for evaluating task engagement and distraction), and a commonly occurring nontarget stimulus. A retrospective questionnaire (Dundee Stress State Questionnaire, DSSQ) assessed task-unrelated (TUT) and task-related (TRT) thinking directly after task completion. The P3a ERP brain indexes at the Cz and Fz scalp electrode sites were also considered as a secondary proxy measure of dopamine function.</p><p><strong>Results: </strong>The main finding revealed that higher EBR was associated with higher TUT, suggesting a link between elevated dopaminergic activity and mind wandering. There was also a marginal negative correlation with P3a latency at the Fz scalp location and TUT, indicative of heightened responsiveness to distraction in general. For TRT, there was a positive correlation with P3a amplitudes at Fz, suggesting a role in task-related engagement and focus on all stimuli during the task. Regarding behavior, EBR and EBV were negatively correlated with Sigma ex-Gaussian task reaction time (RT), suggesting that more stable cognitive states are associated with higher blink rates and variability. Tau RT positively correlated with blink variability and P3a amplitudes at Fz and Cz, indicative of attentional lapse. Regression analyses showed that EBR and Mu RT predicted TUT, while TRT was predicted by P3a amplitude at Fz. More blinks and slower responses were related to TUT, whereas greater focus on the task stimuli (P3a amplitude) was related to TRT.</p><p><strong>Conclusions: </strong>These data underscore the importance of dopamine during mind wandering and task focus. In addition, this study argues for using ex-Gaussian analysis to understand the complex dynamics of attentional control during mind wandering.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26508"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG Microstate Dynamics during Different Physiological Developmental Stages and the Effects of Medication in Schizophrenia.","authors":"Shihai Ling, Lingyan Du, Xi Tan, Guozhi Tang, Yue Che, Shirui Song","doi":"10.31083/JIN27059","DOIUrl":"https://doi.org/10.31083/JIN27059","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SCZ) is associated with abnormal neural activities and brain connectivity. Electroencephalography (EEG) microstate is a voltage topographical representation of temporary brain network activations. Most research on EEG microstates in SCZ has focused on differences between patients and healthy controls (HC). However, changes in EEG microstates among SCZ patients across various stages of physiological and cognitive development have not been thoroughly assessed. Consequently, we stratified patients with SCZ into four age-specific cohorts (20-29 years (brain maturation), 30-39 years (stabilization), 40-49 years (early aging), and 50-59 years (advanced aging)) to evaluate EEG microstate alterations. Additionally, we assessed changes in EEG microstates in first-episode psychosis (FEP) before and after an 8-week treatment period.</p><p><strong>Methods: </strong>We acquired 19-channel resting-state EEG from 140 chronic SCZ patients, aged 20 to 59 years, as well as from 19 FEP and 20 healthy controls. FEP patients underwent an 8-week inpatient follow-up. After pre-processing, EEG data from different groups were subjected to microstate analysis, and the K-Means clustering algorithm was applied to classify the data into 4 microstates. Subsequently, templates of these microstates were used to fit EEG signals from each patient, and the collected microstate parameters were analyzed.</p><p><strong>Results: </strong>Patients with SCZ aged 20 to 29 years demonstrated an increased time coverage of microstate class D compared to other age cohorts. In individuals aged 30-39 years, the parameters of microstate class B-specifically time coverage and occurrence-exhibited significant reductions relative to those in the 40-49 and 50-59 years age groups. Compared to healthy controls, microstates class A parameters were significantly reduced in SCZ patients, while microstates class C parameters were prolonged; after 8 weeks of treatment, microstates class A parameters increased and microstates class C parameters decreased.</p><p><strong>Conclusions: </strong>Alterations in microstate dynamics were observed among SCZ patients across developmental stages, suggesting potential changes in brain activity patterns. Changes in microstates A and C may serve as potential biomarkers for evaluating treatment efficacy, establishing a foundation for personalized therapeutic approaches.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"27059"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Intermittent Theta-Burst Stimulation Reverses Neurodegeneration in the Somatosensory Motor Cortex after Spinal Cord Transection in Rats.","authors":"Zhenghong Chen, Yujian Lin, Jing Xu, Jiawei Sun, Rui Liu, Yue Yang, Zhen Chen, Mingyu Lv, Biqin Lai, Ling Zhang","doi":"10.31083/JIN26731","DOIUrl":"https://doi.org/10.31083/JIN26731","url":null,"abstract":"<p><strong>Background: </strong>Complete spinal cord injury (SCI) leads to a disconnection between the brain and the body below the injury level, resulting in the functional silencing, degeneration, and apoptosis of sensorimotor cortex (SMC) neurons, which is of crucial importance to the pathological process.</p><p><strong>Methods: </strong>In this study, a rat model of spinal cord transection was employed to explore the activation of neurons in the SMC and the reversal of neurodegeneration after the rats were treated with transcranial intermittent theta-burst stimulation (T-iTBS).</p><p><strong>Results: </strong>The results demonstrated that the expression of the immediate early gene <i>c-Fos</i> and the synaptic plasticity-associated activity-regulated cytoskeleton (<i>Arc</i>) gene in the neurons of the SMC was increased in the T-iTBS group 4 weeks after SCI. Transcriptome sequencing revealed that neuronal activation-, neuronal metabolism-, synaptic activity-, and neural regeneration-related genes were significantly upregulated in the T-iTBS group compared with those of the sham-iTBS group, but the expression was similar to that in the normal group. Western blot analysis indicated that the expression of Cle-caspase-3 (CC3) in the SMC was significantly reduced in the T-iTBS group, and the number of CD68-positive cells in the SMC was close to that of normal rats but significantly less than that in the sham-iTBS and SCI groups. These results are in line with those of the transcriptome sequencing. Correlation analysis of the expression rate between c-Fos and Arc, CC3, and CD68 further suggested that T-iTBS improved the immune microenvironment and prevented neurodegeneration by regulating the activation and synaptic plasticity of SMC neurons in the early stages of injury.</p><p><strong>Conclusions: </strong>Collectively, our findings offer support for the utilization of T-iTBS, a non-invasive neural stimulation treatment, to prevent SMC degeneration following severe SCI.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26731"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Xenon on the Developing Brain: Current Insights from Pre-clinical and Clinical Studies.","authors":"Qinfang Shi, Gerhard Rammes, Ping Wang, Chengkun Xia, Fangfang Mou, Jing Zhu, Haidong Guo, Shuijin Shao, Xingxing Wang","doi":"10.31083/JIN26388","DOIUrl":"https://doi.org/10.31083/JIN26388","url":null,"abstract":"<p><p>Research has indicated that general anesthetics may potentially induce neuroapoptosis, resulting in long-term neurological deficits in the developing brain. Fortunately, xenon, a noble gas, emerges as a promising candidate for an ideal anesthetic due to its favorable properties, offering neuroprotection and mitigating the neurotoxic effects of other general anesthetics during early life stages. Nevertheless, it is important to highlight that xenon has also been observed to cause neuroapoptosis in the neonatal brain, suggesting that xenon possesses both neuroprotective qualities (as evidenced by pre-clinical and clinical studies) and neurotoxic potential (based mainly on pre-clinical evidence) during brain development. To gain a comprehensive understanding the effects xenon, this review will explore the anesthetic properties of xenon, examine its effects on anesthesia, and elucidate its mechanisms of potential neuroprotection and neurotoxicity in the developing brain. The primary emphasis will be on xenon's application in the context of anesthetic-induced developmental neurotoxicity (AIDN), hypoxic-ischemic encephalopathy (HIE), and teratogenicity, aiming to provide valuable insights for pediatricians, pediatric anesthesiologists, and other healthcare professionals involved in the use and study of xenon anesthesia.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26388"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratification of the Extent of Visual Impairment Identifies Sex-Specific Degenerative Changes in Retinal Structure and Function during Aging.","authors":"Genea Edwards, Sean M Riordan, Caitlin Buchholz, Marc Mardelli, Carlyn P Euritt, Rodrigo Perez-Magnelli, Ariej Rafiq, Avery Engelmeyer, Peter Koulen","doi":"10.31083/JIN25805","DOIUrl":"https://doi.org/10.31083/JIN25805","url":null,"abstract":"<p><strong>Background: </strong>Initial manifestations of neurodegenerative ocular conditions, including age-related macular degeneration (AMD) and glaucoma, often remain undetected in the early stages and can begin after the age of 50 years with the likelihood gradually increasing each year thereafter. This study aimed to explore variances in visual and retinal function and anatomy among C57BL/6J mice, aiming to pinpoint differences between biological age and sex factors that potentially lead to the onset of vision impairment.</p><p><strong>Methods: </strong>A longitudinal study evaluated visual acuity (VA) and contrast sensitivity (CS) using optomotor reflex (OMR), and retinal function, encompassing scotopic and photopic measurements, was recorded by electroretinogram (ERG) at 12 months of age. Tissue was subsequently harvested for histological analysis, complementing the <i>in vivo</i> findings. Disparities in visual function were observed between individual male and female mice, necessitating categorization of visual impairment levels to investigate further sex-specific differences in the study's aging population. Comparisons between sex and the degree of visual impairment were conducted using ANOVA followed by Tukey's or Bonferroni's post-hoc corrections and unpaired <i>t</i>-tests. Pearson correlation analysis determined the association between biological factors.</p><p><strong>Results: </strong>Sex-related disparities were found in the visual function of male (n = 13) and female (n = 18) mice aged 5-12 months. Eyes were categorized by vision impairment: normal vision, or low, moderate, or severe vision loss at the end of the study. Male and female mice differed in mean contrast sensitivity, indicating less sensitivity to fine detail and moving stimuli in female mice (11-12 months old, <i>p</i> < 0.001). Spectral-domain optical coherence tomography (SD-OCT) revealed a thinner retinal outer nuclear layer in male mice (<i>p</i> < 0.0001), although this did not vary across different levels of vision impairment. ERG indicated slower retinal responses in male mice (<i>p</i> < 0.05), while histology showed a significant reduction in the inner plexiform layer thickness in male mice with severe vision loss (<i>p</i> < 0.0001). Conversely, female mice exhibited greater thinning in the photoreceptor layer when vision was unimpaired (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The study shows that sex and extent of vision impairment influence visual and retinal health, with individual retinal layers differentially changing in thickness over time.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25805"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Diffusional Kurtosis Imaging on Normal-Appearing White Matter in Cerebral Small Vessel Disease.","authors":"Yue-Lin Guo, Si-Lan Chen, Hai-Bing Rao, Ling-Mei Kong, Wei-Jia Li, Qi-Ze Liu, Feng-Yu Liu, Yu Wang, Wen-Bin Zheng","doi":"10.31083/JIN25521","DOIUrl":"https://doi.org/10.31083/JIN25521","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the diagnostic potential of diffusional kurtosis imaging (DKI) parameters in detecting pathological alterations in the normal-appearing white matter (NAWM) associated with cerebral small vessel disease (CSVD).</p><p><strong>Methods: </strong>A total of 56 patients diagnosed with CSVD were enrolled, all exhibiting confirmed lacunar infarction in the corticospinal tract (CST) as verified by conventional magnetic resonance imaging. A control group of 24 healthy individuals who exhibited no discernible abnormalities on conventional magnetic resonance imaging (MRI) scans was also included. The following DKI parameters were recorded, including mean kurtosis (MK), axial kurtosis (Ka), and radial kurtosis (Kr). Regions of interest were placed at representative levels of the CST on the affected side, encompassing the pons, anterior part of the posterior limb of the internal capsule (PLIC), corona radiata, and subcortex.</p><p><strong>Results: </strong>Variations in MK, Ka, and Kr values in the pons, anterior part of the PLIC, corona radiata, and subcortex of the control group were observed. Notably, the MK and Kr values of the normal-appearing pons in CSVD patients were significantly elevated compared with the control group. The MK, Ka value of the normal-appearing anterior part of the PLIC was significantly higher in the CSVD group than in the control group. The Kr value of the normal-appearing corona radiata exhibited a significant elevation in CSVD patients compared with the control group. Lastly, patients with CSVD displayed lower Ka values and higher Kr values in the normal-appearing subcortex compared with the control group.</p><p><strong>Conclusions: </strong>DKI is an effective tool for assessing NAWM in patients with CSVD. These findings potentially offer novel insights into the prognosis of CSVD and serve as a foundational platform for future DKI studies on NAWM in other diffuse brain lesions.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 2","pages":"25521"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactylation of PLBD1 Facilitates Brain Injury Induced by Ischemic Stroke.","authors":"Faming Zhou, Guanghui Chen, Xiaoli Li, Xiaodong Yu, Yinyin Yang","doi":"10.31083/JIN25949","DOIUrl":"https://doi.org/10.31083/JIN25949","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke is a prevalent global condition and its associated brain damage poses a significant threat to patient survival and outcomes. The underlying mechanisms of ischemic stroke-induced brain injury remain elusive, necessitating further investigation.</p><p><strong>Methods: </strong>Ischemic stroke models were established using middle cerebral artery occlusion (MCAO) in animals and oxygen-glucose deprivation and reperfusion (OGD-R) in cells. Phospholipase B domain-containing protein 1 (PLBD1) expression in these models was assessed <i>via</i> western blotting analysis, reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), and cell immunofluorescence. A comprehensive evaluation, incorporating cellular lactate dehydrogenase (LDH) release assays, glycolysis metabolism kits, RT-qPCR, western blotting, triphenyl tetrazolium chloride (TTC) staining, neurological scoring, brain tissue water content measurement, and creatine kinase-MB (CK-MB) analysis, was conducted to determine the impact of PLBD1 on brain injury. Potential lactylation sites in PLBD1 were predicted using the DeepKla database, with western blotting and co-immunoprecipitation (Co-IP) confirming the lactylation site.</p><p><strong>Results: </strong>PLBD1 was significantly upregulated in the brain tissue of MCAO animal models and OGD-R-treated cells. PLBD1 knockdown markedly mitigated OGD-R-induced cellular injury, suppressed glycolysis <i>in vitro</i>, and reversed MCAO-induced brain damage <i>in vivo</i>. Furthermore, lactylation at the K155 site of PLBD1 enhanced its expression in response to elevated lactate levels following OGD-R treatment. These results indicated that the upregulation of PLBD1 <i>via</i> K155 site lactylation plays a pivotal role in exacerbating ischemic stroke-induced brain damage.</p><p><strong>Conclusion: </strong>Targeting the lactate/PLBD1 axis presents a promising therapeutic strategy for ischemic stroke management.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 2","pages":"25949"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}