Journal of integrative neuroscience最新文献

{"title":"Cognitive Impairment in MASLD is associated with Amygdala-Related Connectivity Dysfunction in the Prefrontal and Sensory Cortex.","authors":"Yihan Jin, Ruoyu Tang, Liqiang Wu, Kuanghui Xu, Xiaofei Chen, Yaxin Zhu, Junping Shi, Jie Li","doi":"10.31083/j.jin2312215","DOIUrl":"https://doi.org/10.31083/j.jin2312215","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolism-related multisystem clinical disorder, often accompanied by a high comorbidity of mild cognitive impairment (MCI). Increasing evidence suggests that the amygdala is crucial in cognitive processing during metabolic dysfunction. Nevertheless, the role of the amygdala in the neural mechanisms of MASLD with MCI (MCI_MASLD) remains unclear.</p><p><strong>Methods: </strong>A total of 74 MASLD patients (43 with MCI_MASLD and 31 without MCI [nonMCI_MASLD]) and 62 demographic-matched healthy controls (HC) were enrolled. All participants underwent resting-state functional magnetic resonance imaging scans and psychological scale assessments. Liver fat content and blood index measurements were performed on the patients. Using the bilateral amygdala as seeds, the seed-based functional connectivity (FC) maps were calculated and one-way analysis of covariance with post hoc tests was performed to investigate the difference among the three groups.</p><p><strong>Results: </strong>Compared to nonMCI_MASLD patients, MCI_MASLD patients demonstrated enhanced FC between the right amygdala and the medial prefrontal cortex (mPFC), while reduced FC between the left amygdala and the left supplementary motor area (SMA). Interestingly, the FC values of the mPFC were correlated with the Montreal Cognitive Assessment Scale (MoCA) scores and liver controlled attenuation parameters, and the FC values of the SMA were also correlated with the MoCA scores. Furthermore, the FC values between the bilateral amygdala and regions within the frontal-limbic-mesencephalic circuits were higher in MASLD patients when compared to HC.</p><p><strong>Conclusions: </strong>Aberrant FC of the amygdala can provide potential neuroimaging markers for MCI in MASLD, which is associated with amygdala-related connectivity disturbances in areas related to cognition and sensory processing. Moreover, visceral fat accumulation may exacerbate brain dysfunction.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 12","pages":"215"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Effect of Exercise on Glial Cells: Focus on Ependymal Cells.","authors":"Grazia Maugeri, Alessandra Amato, Giuseppe Evola, Velia D'Agata, Giuseppe Musumeci","doi":"10.31083/j.jin2312216","DOIUrl":"10.31083/j.jin2312216","url":null,"abstract":"<p><p>A growing body of research highlights the positive impact of regular physical activity on improving physical and mental health. On the other hand, physical inactivity is one of the leading risk factors for noncommunicable diseases and death worldwide. Exercise profoundly impacts various body districts, including the central nervous system. Here, overwhelming evidence exists that physical exercise affects neurons and glial cells, by promoting their interaction. Physical exercise directly acts on ependymal cells by promoting their proliferation and activation, maintaing brain homeostasis in healthy animals and promote locomotor recovery after spinal cord injury. This review aims to describe the main anatomical characteristics and functions of ependymal cells and provide an overview of the effects of different types of physical exercise on glial cells, focusing on the ependymal cells.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 12","pages":"216"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress on the Role of the Interleukin Family in the Pathogenesis of Cerebral Palsy in Children.","authors":"Mingbo Hu, Chao Bai, Hong Zhao, Junjie Wu, Xinping Luan","doi":"10.31083/j.jin2312213","DOIUrl":"10.31083/j.jin2312213","url":null,"abstract":"<p><p>Cerebral palsy (CP), a common neurological disorder in children, remains a significant research focus. The interleukin (IL) family, pivotal mediators in inflammatory responses, shows increased expression in various neuroinflammatory diseases, markedly influencing their onset and progression. Elevated IL levels in the brains of children with CP, in contrast to healthy peers, reflect similar elevations in neurological conditions linked to CP, indicating a strong association between CP and the IL family. Anti-inflammatory therapies, particularly those targeting ILs, have shown effectiveness in animal models, diverging from traditional CP management methods. This shift suggests IL modulation as a promising therapeutic strategy in pediatric CP. This review consolidates recent findings on the IL family's role in CP, illuminating their evolving relationship.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 12","pages":"213"},"PeriodicalIF":2.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights in Perinatal Depression: Neuroplasticity and Psycho-Social Factors.","authors":"Sijia Liu, Guolin He, Bochao Cheng","doi":"10.31083/j.jin2312212","DOIUrl":"https://doi.org/10.31083/j.jin2312212","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 12","pages":"212"},"PeriodicalIF":2.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study.","authors":"Ksenia A Kobzeva, Denis E Gurtovoy, Alexey V Polonikov, Vladimir M Pokrovsky, Evgeny A Patrakhanov, Olga Y Bushueva","doi":"10.31083/j.jin2312211","DOIUrl":"https://doi.org/10.31083/j.jin2312211","url":null,"abstract":"<p><strong>Background: </strong>Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date, molecular genetic studies on the involvement of genes encoding proteins of the HSP40 family in IS have not yet been carried out.</p><p><strong>Aim: </strong>We sought to determine whether nine single nucleotide polymorphisms (SNPs) in genes encoding HSP40 family proteins (<i>DNAJB1</i>, <i>DNAJB2</i>, <i>DNAJA1</i>, <i>DNAJA2</i>, <i>DNAJA3</i> and <i>DNAJC7</i>) are associated with the risk and clinical features of IS.</p><p><strong>Methods: </strong>Using TaqMan-based polymerase chain reaction (PCR) and the MassArray-4 system, DNA samples of 2551 Russians - 1306 IS patients and 1245 healthy individuals - were genotyped.</p><p><strong>Results: </strong>SNP rs2034598 <i>DNAJA2</i> decreased the risk of IS exclusively in male patients (odds ratio = 0.81, 95% confidence interval 0.78-0.98, <i>p</i> = 0.028); rs7189628 <i>DNAJA2</i> increased the brain infarct size (<i>p</i> = 0.04); and rs6500605 <i>DNAJA3</i> lowered the age of onset of IS (<i>p</i> = 0.03). SNPs rs10448231 <i>DNAJA1</i>, rs7189628 <i>DNAJA2</i>, rs4926222 <i>DNAJB1</i> and rs2034598 <i>DNAJA2</i> were involved in the strongest epistatic interactions linked to IS; SNP rs10448231 <i>DNAJA1</i> is characterised by the most essential mono-effect (2.96% of IS entropy); all of the top SNP-SNP interaction models included the pairwise combination rs7189628 <i>DNAJA2</i>×rs4926222 <i>DNAJB1</i>, which was found to be a key factor determining susceptibility to IS. In interactions with the studied SNPs, smoking was found to have multidirectional effects (synergism, antagonism or additive effect) and the strongest mono-effect (3.47% of IS entropy), exceeding the mono-effects of rs6500605 <i>DNAJA3</i>, rs10448231 <i>DNAJA1</i>, rs2034598 <i>DNAJA2</i>, rs7189628 <i>DNAJA2</i> and rs4926222 <i>DNAJB1</i>, involved in the best G×E models and determining 0.03%-0.73% of IS entropy.</p><p><strong>Conclusions: </strong>We are the first to discover polymorphisms in genes encoding <i>HSP40</i> family proteins as a major risk factor for IS and its clinical manifestations. The comprehensive bioinformatics analysis revealed molecular mechanisms, underscoring their significance in the pathogenesis of IS, primarily reflecting the regulation of heat stress, proteostasis and cellular signalling.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 12","pages":"211"},"PeriodicalIF":2.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Modulatory Effect of Exogenous Orienting on Audiovisual Emotional Integration: An ERP Study.","authors":"Shengnan Li, Yueying Li, Ruizhi Li, Yan Li, Jinglong Wu, Weiping Yang, Zhilin Zhang","doi":"10.31083/j.jin2311210","DOIUrl":"https://doi.org/10.31083/j.jin2311210","url":null,"abstract":"<p><strong>Background: </strong>In this study, we explored the interplay between exogenous orienting attention and emotional audiovisual integration (AVI) via electroencephalography (EEG).</p><p><strong>Methods: </strong>We designed a 2 (cue validity: valid, invalid) × 3 (emotion types: happiness, neutral and sadness) × 3 (modality: visual, auditory, audiovisual) discrimination task on the basis of the cue-target paradigm. Twenty-two participants (average age: 21.71 ± 1.84 years; 13 females, 9 males) were enrolled in this experiment. Participants were asked to respond to three emotional stimuli presented in different modalities by pressing a corresponding key.</p><p><strong>Results: </strong>The results indicated faster responses to multisensory stimuli than to unisensory stimuli and to the valid cue condition than to the invalid cue condition, which indicated multisensory advantage and cueing effect occurred. In addition, happiness stimuli induced the fastest response compared with neutral and sadness emotion stimuli. EEG findings indicated a reduction in audiovisual integration induced by valid exogenous orienting in the frontal, central and parietal lobe regions. Moreover, neutral emotional stimuli elicited greater audiovisual integration than stimuli expressing happiness and sadness did.</p><p><strong>Conclusions: </strong>Overall, valid exogenous cues and emotional processing decreased audiovisual integration. The present study sheds light on how exogenous attention modulates emotional audiovisual integration and highlights the complex interactions among attention, sensory processing, and the emotional context in multisensory perception.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 11","pages":"210"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insular Epilepsy: Functions, Diagnostic Approaches, and Surgical Interventions.","authors":"Felix R Ekman, Jorge A González-Martínez","doi":"10.31083/j.jin2311209","DOIUrl":"10.31083/j.jin2311209","url":null,"abstract":"<p><p>Epilepsy, a chronic neurological disorder characterized by recurrent seizures, affects a significant portion of the global population, with drug-resistant epilepsy (DRE) presenting a major treatment challenge. Insular epilepsy, originating from this complex region, exhibits a broad range of symptoms, making diagnosis particularly difficult. Advanced imaging techniques and invasive procedures like stereoelectroencephalography (SEEG) are often crucial for accurately localizing the epileptogenic zone. Surgical resection remains the primary treatment for DRE, with recent advancements in microsurgical techniques and neuroimaging improving outcomes. Additionally, minimally invasive approaches like laser interstitial thermal therapy (LITT) and radiofrequency thermocoagulation (RFTC) offer promising alternatives.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 11","pages":"209"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise 3D Localization of Intracerebral Implants Using a Simple Brain Clearing Method.","authors":"Julien Catanese, Tatsuya C Murakami, Adam Catto, Paul J Kenny, Ines Ibañez-Tallon","doi":"10.31083/j.jin2311207","DOIUrl":"10.31083/j.jin2311207","url":null,"abstract":"<p><strong>Background: </strong>Precise localization of intracerebral implants in rodent brains is required for physiological and behavioral studies, particularly if targeting deep brain nuclei. Traditional histological methods, based on manual estimation through sectioning can introduce errors and complicate data interpretation.</p><p><strong>Methods: </strong>Here, we introduce an alternative method based on recent advances in tissue-clearing techniques and light-sheet fluorescence microscopy. This method uses a simplified recipe of the Clear, Unobstructed Brain/Body Imaging Cocktails and Computational Analysis (CUBIC) method, which is a rapid clearing procedure using an aqueous-based solution compatible with fluorescence and fluorescence markers. We demonstrate the utility of this approach in anesthetized transgenic mice expressing channelrhodopsin-2 (ChR2) and enhanced yellow fluorescent fusion (EYFP) protein under the choline acetyltransferase (ChAT) promoter/enhancer regions (<i>ChAT-ChR2-EYFP</i> mice) with implanted linear silicon optrode probes into the midbrain interpeduncular nucleus (IPN).</p><p><strong>Results: </strong>By applying the red fluorescent DiD' dye (DiIC₁₈(5) solid (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine, 4-Chlorobenzenesulfonate Salt) to the electrode surface, we precisely visualize the electrode localization in the IPN of C<i>hAT-ChR2-EYFP</i> mice. Three-dimensional brain videos from different orientations highlight the potential of this method. Optogenetic responses recorded from electrodes placed in the IPN validate these findings.</p><p><strong>Conclusions: </strong>This method allows for precise localization of brain implantation sites in transgenic mice expressing cell-specific fluorescence markers. It enables virtual brain slicing in any orientation, making it a useful tool for functional studies in mice.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 11","pages":"207"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-Negative Temporal Lobe Epilepsy: A Study of Brain Structure in Adults Using Surface-Based Morphological Features.","authors":"Yongjie He, Ying Huang, Zhe Guo, Haitao Zhu, Da Zhang, Chen Xue, Xiao Hu, Chaoyong Xiao, Xue Chai","doi":"10.31083/j.jin2311206","DOIUrl":"https://doi.org/10.31083/j.jin2311206","url":null,"abstract":"<p><strong>Background: </strong>This research aimed to delve into the cortical morphological transformations in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy (TLE-N), seeking to uncover the neuroimaging mechanisms behind these changes.</p><p><strong>Methods: </strong>A total of 29 individuals diagnosed with TLE-N and 30 healthy control participants matched by age and sex were selected for the study. Using the surface-based morphometry (SBM) technique, the study analyzed the three-dimensional-T1-weighted MRI scans of the participants' brains. Various cortical structure characteristics, such as thickness, surface area, volume, curvature, and sulcal depth, among other parameters, were measured.</p><p><strong>Results: </strong>When compared with the healthy control group, the TLE-N patients exhibited increased insular cortex thickness in both brain hemispheres. Additionally, there was a notable reduction in the curvature of the piriform cortex (PC) and the insular granular complex within the right hemisphere. In the left hemisphere, the volume of the secondary sensory cortex (OP1/SII) and the third visual area was significantly reduced in the TLE-N group. However, no significant differences were found between the groups regarding cortical surface area and sulcal depth (<i>p</i> < 0.025 for all, corrected by threshold-free cluster enhancement).</p><p><strong>Conclusions: </strong>The study's initial findings suggest subtle morphological changes in the cerebral cortex of TLE-N patients. The SBM technique proved effective in identifying brain regions impacted by epileptic activity. Understanding the microstructural morphology of the cerebral cortex offers insights into the pathophysiological mechanisms underlying TLE.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 11","pages":"206"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Regulatory Effect of Insulin-Like Growth Factor-2 on Hypothalamic Gonadotropin-Releasing Hormone Neurons during the Pubertal Period.","authors":"Xiaoli Dai, Yuanyuan He, Xinghui Han, Wen Sun, Jian Yu, Yating Lin, Yonghong Wang","doi":"10.31083/j.jin2311208","DOIUrl":"https://doi.org/10.31083/j.jin2311208","url":null,"abstract":"<p><strong>Background: </strong>The insulin-like growth factor (IGF) system plays a vital role in regulating gonadotropin-releasing hormone (GnRH), whether the IGF2 can act on the GnRH neurons during the pubertal period is unclear.</p><p><strong>Methods: </strong>Central precocious puberty (CPP) rats were induced by danazol, and when the rats met the first diestrus, they were euthanized and tissues were collected. GT1-7 cells were cultured and treated with 0, 1, 10 ng/mL IGF2 for 4 hours and the changes in GnRH were measured. Mice were injected intracerebroventricularly with IGF2 (15 ng/g, 5 μL) or with the same dose of phosphate buffered saline (PBS), after eight hours, they were euthanized and tissues collected.</p><p><strong>Results: </strong>CPP rats had increased expression of <i>IGF2</i> and <i>GnRH</i> mRNA and their respective proteins in the preoptic area (POA) of the hypothalamus. Treatment of GT1-7 cells with 10 ng/mL of IGF2 increased GnRH mRNA and protein expression, and GnRH concentration in the culture medium. Injection of IGF2 protein into the lateral ventricle of mice increased the expression of GnRH mRNA and protein in the POA.</p><p><strong>Conclusions: </strong>IGF2 may upregulate the synthesis of GnRH during the pubertal period, and may also take part in the pathology of CPP.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"23 11","pages":"208"},"PeriodicalIF":2.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}