听觉工作记忆中背外侧前额叶皮层的失活。

IF 2.7 4区 医学 Q3 NEUROSCIENCES
Bethany Plakke, Katryna Skye Kevelson, Charles Leyens, Lizabeth M Romanski
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引用次数: 0

摘要

背景:背外侧前额叶皮层(DLPFC)是工作记忆(WM)神经回路中的一个关键节点,通过对人类和非人类灵长类动物的神经生理学、神经心理学和神经影像学研究建立起来。虽然DLPFC在WM中的作用的大多数神经生理学证据来自于视觉空间WM范式,但它在听觉WM中的作用的证据已经被非人类灵长类动物的大面积外侧前额叶皮层病变导致听觉辨别缺陷这一事实所证明。此外,DLPFC神经元在听觉WM期间表现出任务相关的神经元反应。相比之下,其他研究提出腹侧前额叶皮层(VLPFC)在听觉和视听加工、整合和记忆加工中起着关键作用,因为VLPFC神经元对复杂的声刺激有反应,并且在听觉WM任务中非常活跃。此外,VLPFC的失活会损害视听WM。在这些失活研究中,由于皮质冷却而失活的皮层区域包括腹侧12/47、45和46区。可能包括46腹侧区可以解释先前在VLPFC失活时观察到的听觉WM表现缺陷,因此需要进一步的实验。方法:在本研究中,我们研究了恒河猴DLPFC(包括46v区、46d区和9区)的短暂失活是否会影响听觉WM。当两只恒河猴执行听觉工作记忆任务时,皮层冷却使DLPFC失活。随后进行永久性伊博滕酸损伤,并评估损伤后的行为表现。结果:我们的实验表明,通过皮质冷却使两只猕猴的DLPFC失活并没有导致听觉WM任务的表现显著下降。在一个实验对象中,失活导致在任务的后半段,视线下降事件增加,这可能是由于注意力或动机的丧失。ibotenic酸损伤的DLPFC没有显著改变听觉WM任务的表现。结论:我们的研究结果表明,皮层冷却和伊博tenic酸损伤导致的DLPFC短暂失活并没有显著改变听觉工作记忆的整体表现,这与VLPFC失活时所见的损伤不同。我们的数据表明,DLPFC和VLPFC在听觉工作记忆中可能起着不同的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inactivation of Dorsolateral Prefrontal Cortex During Auditory Working Memory.

Background: The dorsolateral prefrontal cortex (DLPFC) is a critical node in the working memory (WM) neural circuit, established through neurophysiology, neuropsychology, and neuroimaging studies in humans and nonhuman primates. While most of the neurophysiological evidence for the role of the DLPFC in WM comes from visuospatial WM paradigms, evidence for its role in auditory WM has been suggested by the fact that large lateral prefrontal cortex lesions in nonhuman primates cause auditory discrimination deficits. Moreover, DLPFC neurons demonstrate task-related neuronal responses during auditory WM. In contrast, other studies have proposed that the ventrolateral prefrontal cortex (VLPFC) plays a pivotal role in auditory and audiovisual processing, integration, and mnemonic processing, since VLPFC neurons are responsive to complex acoustic stimuli and are robustly active during auditory WM tasks. Furthermore, inactivation of the VLPFC impairs audiovisual and auditory WM. In these inactivation studies the cortical region that was inactivated by cortical cooling included areas 12/47, 45 and 46 ventral. It is possible that inclusion of area 46 ventral may account for the auditory WM performance deficit previously observed while inactivating VLPFC so further experiments are needed.

Methods: In the present study we examined whether transient inactivation of the DLPFC, including areas 46v and 46d, and 9, in rhesus macaques would effect auditory WM. The DLPFC was inactivated by cortical cooling while two rhesus macaques performed an auditory working memory task. This was followed by permanent ibotenic acid lesions and assessment of behavioral performance post-lesion.

Results: Our experiments demonstrated that inactivation of DLPFC by cortical cooling in two macaques did not result in a significant decrease in performance of an auditory WM task. The inactivation resulted in an increase in dropped gaze events during the latter half of the task, in one subject, which could be due to a loss of attention or motivation. The ibotenic acid lesions of the DLPFC did not significantly alter performance on the auditory WM task.

Conclusions: Our results showed that DLPFC transient inactivation with cortical cooling and ibotenic acid lesions did not significantly alter overall auditory working memory performance, which differs from the impairment seen when the VLPFC is inactivated. Our data suggest that the DLPFC and VLPFC may play different roles in auditory working memory.

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来源期刊
CiteScore
2.80
自引率
5.60%
发文量
173
审稿时长
2 months
期刊介绍: JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.
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