Journal of integrative neuroscience最新文献

{"title":"Correlation Analysis Between 3D and Plane DAT Binding Parameters of ¹¹C-CFT PET/CT and the Clinical Characteristics of Patients with Parkinson's Disease.","authors":"Xiaodong Wu, Ziyuan Li, Jing Gan, Feng Wei, Ping Wu, Sheng Liang, Yufei Ma, Lin Ding, Chuantao Zuo, Zhenguo Liu, Hui Wang, Yafu Yin","doi":"10.31083/JIN24440","DOIUrl":"https://doi.org/10.31083/JIN24440","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the correlation between dopamine transporter (DAT) positron emission tomography (PET)/computed tomography (CT) and the clinical characteristics and rating scales of Parkinson's disease (PD) patients. Additionally, we sought to assess the scientific validity and feasibility of integrating 3D-dopaminergic binding parameters into the clinical scoring system for PD.</p><p><strong>Methods: </strong>A total of 75 patients with PD who underwent ¹¹C-methyl-N-2β-methyl ester-3β-(4-fluorophenyl) tropane (¹¹C-CFT) PET/CT from April, 2019 to June, 2021 were retrospectively analyzed. Clinical characteristics, including age, sex, and disease duration, as well as the modified Hoehn-Yahr (H-Y) scale, Unified Parkinson's Disease Rating Scale (UPDRS) parts II and III (II-III), and Mini-Mental State Examination (MMSE) scores of PD patients during the corresponding time periods were collected. DAT binding parameters and their derived parameters based on plane and 3D images in the neostriatum were analyzed for consistency with plane and 3D parameters, and the correlation between DAT parameters and the clinical features of patients were assessed using SPSS software.</p><p><strong>Results: </strong>The DAT binding parameters derived from 3D images demonstrated good consistency with the plane parameters (<i>p</i> < 0.05). The asymmetry index (ai) of DAT binding parameters based on 3D and plane images showed good consistency in the anterior putamen (<i>p</i> < 0.05). The plane parameters of the anterior and posterior putamen were statistically correlated with the UPDRS II-III score and H-Y score of PD patients (<i>p</i> < 0.05), whereas those of the caudate nucleus were correlated with UPDRS II and MMSE scores. The 3D parameters in the neostriatum showed good statistical correlation with disease duration, UPDRS II-III score, H-Y score, and H-Y stage of PD patients (<i>p</i> < 0.05), and the ai was significantly correlated with MMSE score (<i>p</i> < 0.05). The 3D parameters in the putamen and posterior putamen exhibited significant statistical correlation with the UPDRS II-III score, H-Y score, and H-Y stage in PD patients (<i>p</i> < 0.05). The ai in the putamen showed statistical correlation with UPDRS III and MMSE scores, and the ai in the posterior putamen showed statistical correlation with UPDRS II score (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Quantitative parameters based on plane and 3D images of ¹¹C-CFT PET/CT showed good consistency. Moreover, 3D parameters in the neostriatum had a stronger correlation with activities of daily living, UPDRS motor scores, disease severity and duration, and cognition compared with plane parameters in PD patients.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"24440"},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Endovascular Revascularization on Functional Connectivity and Cognition in Symptomatic Chronic Internal Carotid Artery Occlusion Patients: A Preliminary Exploratory Study.","authors":"Renjie Ji, Shixin Zhang, Hanfeng Chen, Chunlan Deng, Ziqi Xu, Jie Zhang, Benyan Luo","doi":"10.31083/JIN36330","DOIUrl":"10.31083/JIN36330","url":null,"abstract":"<p><strong>Background: </strong>Symptomatic chronic internal carotid artery occlusion (CICAO) may lead to stroke and cognitive decline. Although endovascular recanalization has been proven to reduce the risk of future strokes, the effect on cognition remains controversial and requires further exploration. We explored alterations in functional connectivity (FC) and their associations with cognition in patients with symptomatic CICAO before and after carotid revascularization.</p><p><strong>Methods: </strong>Eighteen patients with unilateral CICAO and fifteen healthy controls (HCs) were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological assessment were performed on all participants, before and after 6 months post-recanalization in the patient group. FC alterations in multiple brain networks and their correlations with cognitive scores were analyzed.</p><p><strong>Results: </strong>The FC of the CICAO group were markedly lower relative to the HC group for the following: the dorsal attention network (DAN) with the ipsilateral (occlusion side, right) middle frontal gyrus and frontal pole; the default mode network (DMN) with the ipsilateral angular gyrus; the visual network (VN) with the ipsilateral fusiform gyrus; and the frontoparietal network (FPN) with middle temporal gyrus on the side contralateral to the occlusion. The decreased FC of the DAN exhibited a positive association with the total score of the Mini-Mental State Examination (MMSE, r = 0.499, <i>p</i> = 0.049), Montreal Cognitive Assessment (MoCA, r = 0.515, <i>p</i> = 0.041), and Backward Digit Span Test (BDST, r = 0.594, <i>p</i> = 0.015), and negatively correlated with the score of Trail Making Test (TMT)-A (r = -0.563, <i>p</i> = 0.023) and TMT-B (r = -0.602, <i>p</i> = 0.014). The CICAO group exhibited significantly increased FC of the DMN seed region with the middle occipital gyrus ipsilateral to the occlusion. Additionally, the VN seed region demonstrated increased FC with the fusiform gyrus ipsilateral to the occlusion following endovascular recanalization. The preoperative FC values of the DMN exhibited a strong positive association with the improvement in TMT-A score (r = 0.629, <i>p</i> = 0.021).</p><p><strong>Conclusion: </strong>Our exploratory study found that FC disruption may induce cognitive decline in symptomatic CICAO patients. Endovascular recanalization may improve FC within key brain networks, supporting cognitive improvement. The baseline DMN FC was significantly associated with the postoperative improvement in TMT-A scores, suggesting that preoperative DMN FC could serve as a potential predictor of cognitive recovery.</p><p><strong>Clinical trial registration: </strong>NCT05292729. Registered 1 December 2021, https://clinicaltrials.gov/study/NCT05292729?intr=NCT05292729&rank=1.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"36330"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis in Alzheimer's Disease: The Regulatory Role of Glial Cells.","authors":"Jingyi Xu, Rongjing Shen, Mengting Qian, Zhengjun Zhou, Bingqing Xie, Yong Jiang, Yang Yu, Wei Dong","doi":"10.31083/JIN25845","DOIUrl":"https://doi.org/10.31083/JIN25845","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a neurodegenerative disease characterized by the formation of amyloid plaques, neurofibrillary tangles and progressive cognitive decline. Amyloid-beta peptide (Aβ) monoclonal antibody therapeutic clinical trials have nearly failed, raising significant concerns about other etiological hypotheses about AD. Recent evidence suggests that AD patients also exhibit persistent neuronal loss and neuronal death accompanied by brain iron deposition or overload-related oxidative stress. Ferroptosis is a type of cell death that depends on iron, unlike autophagy and apoptosis. Inhibiting neuronal ferroptosis function is effective in improving cognitive impairment in AD. Notably, new research shows that ferroptosis in AD is crucially dependent on glial cell activation. This review examines the relationship between the imbalance of iron metabolism, the regulation of iron homeostasis in glial cells and neuronal death in AD pathology. Finally, the review summarizes some current drug research in AD targeting iron homeostasis, many novel iron-chelating compounds and natural compounds showing potential AD-modifying properties that may provide therapeutic targets for treating AD.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"25845"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Cytokines in Postherpetic Neuralgia.","authors":"Yunyan Shen, Ping Lin","doi":"10.31083/JIN25829","DOIUrl":"https://doi.org/10.31083/JIN25829","url":null,"abstract":"<p><p>Nerve injury is a significant cause of postherpetic neuralgia (PHN). It is marked by upregulated expression of cytokines secreted by immune cells such as tumor necrosis factor alpha, interleukin 1 beta (IL-1β), IL-6, IL-18, and IL-10. In neuropathic pain (NP) due to nerve injury, cytokines are important for the induction of neuroinflammation, activation of glial cells, and expression of cation channels. The release of chemokines due to nerve injury promotes immune cell infiltration, recruiting inflammatory cytokines and further amplifying the inflammatory response. The resulting disequilibrium in neuroimmune response and neuroinflammation leads to a reduction of nerve fibers, altered nerve excitability, and neuralgia. PHN is a typical NP and cytokines may induce PHN by promoting central and peripheral sensitization. Currently, treating PHN is challenging and research on the role of cytokine signaling pathways in PHN is lacking. This review summarizes the potential mechanisms of cytokine-mediated PHN and discusses the cytokine signaling pathways associated with the central and peripheral sensitization of PHN. By elucidating the mechanisms of cytokines, the cells and molecules that regulate cytokines, and their signaling systems in PHN, this review reveals important research developments regarding cytokines and their signaling pathways mediating PHN, highlighting new targets of action for the development of analgesic drugs.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"25829"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Therapeutics in the Treatment of Substance Use Disorders: A Focus on GLP-1 Receptor Agonists, D3R Antagonists, and CRF Antagonists.","authors":"Khaled Draghmeh, Brian Fuehrlein","doi":"10.31083/JIN26361","DOIUrl":"https://doi.org/10.31083/JIN26361","url":null,"abstract":"<p><p>The prevalence and rising use of alcohol, opioids, and stimulants have led to substance use disorders (SUDs) that are a significant public health challenge. Traditional treatments offer some benefit; however, they often limited by efficacy, side effects, and accessibility, highlighting the urgent need for novel therapeutics. This review explores the current literature surrounding three different classes of novel treatments: glucagon-like peptide-1 (GLP-1) receptor agonists, dopamine D3 receptor (D3R) antagonists, and corticotropin-releasing factor (CRF) antagonists. These therapeutics collectively target different aspects of the addiction process, such as stress and relapse prevention, reward modulation, and the reduction of drug-seeking behavior, leading to a combined multifaceted approach to treating SUDs. This review includes preclinical and clinical evidence supporting the use of these therapies, highlighting their potential to reduce substance use and prevent relapse to alcohol, opioid, and stimulant use. Despite the potentially promising findings of these treatments, further research is necessary to fully understand their mechanisms, optimize their application, and confirm their efficacy in clinical settings.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"26361"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Static and Kinetic Disequilibrium are Central Neural Signs in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation.","authors":"Kunihisa Miwa","doi":"10.31083/JIN25488","DOIUrl":"10.31083/JIN25488","url":null,"abstract":"<p><strong>Background: </strong>Chronic fatigue syndrome is primarily caused by myalgic encephalomyelitis (ME)-associated dysfunction of the central nervous system. Postural instability or disequilibrium is a typical neural sign and is classified as static or kinetic.</p><p><strong>Methods: </strong>A total of 160 ME patients (53 males and 107 females) with a mean age of 37 ± 12 years were enrolled in this study. They underwent both the Romberg test for static disequilibrium and the tandem gait test with turn and return for kinetic disequilibrium.</p><p><strong>Results: </strong>Static disequilibrium was found in 40 (25%) patients who showed instability when standing with both feet together and eyes either open (n = 7, 4%) or closed (n = 33, 21%). Kinetic disequilibrium was found in 71 (44%) patients, with 57 (36%) being positive for the straight tandem gait test. Fourteen (9%) patients were negative for the straight tandem gait test, but showed a positive result after turning and returning. Almost all patients with static disequilibrium also had kinetic disequilibrium (39/40, 98%). Patients with static and/or kinetic disequilibrium had a significantly higher prevalence of orthostatic intolerance, diagnosed as failure to complete the 10-min standing test, compared with patients without disequilibrium. They also had a significantly higher median performance status score (0-9) for restricted activities of daily living. Both types of disequilibria were recovered in 11 (85%) of 13 patients treated with repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex and primary motor area in the brain, suggesting a central vestibular origin.</p><p><strong>Conclusions: </strong>Static disequilibrium related to orthostatic intolerance, and kinetic disequilibrium related to gait disturbance are both prevalent in patients with ME and are important central neural signs that restrict activities of daily living. rTMS treatment effectively alleviated these disequilibria.</p><p><strong>Clinical trial registration: </strong>The study has been registered on https://jrct.mhlw.go.jp/ (registration number: jRCT1042240065; registration date: July 30, 2024).</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"25488"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling of Circulating Cell-free DNA Methylation Patterns Identifies Aberrant Methylated <i>CTBP1</i> Promotor Sites for Prediction of Alzheimer's Disease.","authors":"Zhiwu Dong, Kewen Zhao, Hongjun Gu, Wenwei Yang, Xin Zhang","doi":"10.31083/JIN36527","DOIUrl":"https://doi.org/10.31083/JIN36527","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is the most common neurodegenerative disease affecting the elderly, with its diagnosis at early stages crucial for effective intervention. Recent evidence increasingly supports the role of epigenetic alterations in AD pathogenesis, highlighting the need for innovative biomarkers that reflect these changes. This study aimed to characterize the genome-wide DNA methylation profiles of cell-free DNA in peripheral blood for potential biomarkers associated with AD.</p><p><strong>Methods: </strong>The Illumina Infinium array was utilized to detect the methylation patterns of circulating cell-free DNA from AD patients and healthy controls. The R Bioconductor Linear Models for Microarray Data (LIMMA) package was employed to identify methylation variable positions (MVPs), and Probe Lasso was used to pinpoint differentially methylated regions (DMRs) linked to AD. Bioinformatics enrichment analysis of the annotated genes was performed using EnrichR. A second cohort was recruited to validate the methylation changes at the C-terminal binding protein1 (<i>CTBP1</i>) promoter cytosine-phosphate-guanine (CpG) sites via pyrosequencing. Additionally, microarray data from the Gene Expression Omnibus (GEO) database were analyzed to further validate gene expression and immune infiltration.</p><p><strong>Results: </strong>A unique DNA methylation landscape in peripheral blood was characterized for AD patients and 4335 MVPs showed significant differential methylation (<i>p</i> < 0.01). Functional annotation and pathway enrichment analysis underscored processes and pathways inherent in the nervous system. Probe Lasso identified 68 DMRs annotated to 10 genes, with hypermethylation of CpG islands in the <i>CTBP1</i> TSS1500 promoter showing significant differences when AD and controls were compared (<i>p</i> < 0.01), with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.779. Analysis of immune cell infiltration revealed <i>CTBP1</i> expression is significantly correlated with altered distribution of immune cells (<i>p</i> < 0.001), underscoring its potential role in modulating immune responses in AD. Moreover, <i>CTBP1</i> expression levels significantly varied across multiple GEO datasets.</p><p><strong>Conclusions: </strong>AD displays distinct DNA methylation patterns in peripheral blood and <i>CTBP1</i> promoter hypermethylation represents a promising potential biomarker for AD diagnosis.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"36527"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between White Matter Hyperintensity and Cognitive Impairment in Cerebral Small Vessel Disease: The Frequency-dependent Role of Brain Functional Activity.","authors":"Dongqiong Fan, Tingting Wang, Haichao Zhao, Chang Liu, Chenhui Liu, Tao Liu, Yilong Wang","doi":"10.31083/JIN36303","DOIUrl":"10.31083/JIN36303","url":null,"abstract":"<p><strong>Background: </strong>Cognitive dysfunction in cerebral small vessel disease (CSVD) patients is associated with white matter hyperintensity (WMH), which demonstrates frequency-dependent correlations with brain functional activities. However, the neural mechanisms underlying the relationship between these structural and functional abnormalities and cognitive impairment remain unclear.</p><p><strong>Methods: </strong>We recruited 34 CSVD patients (mean age 63.74 ± 4.85 years, 19 males) and 45 age-matched healthy controls (mean age 63.69 ± 6.15 years, 15 males). All participants underwent magnetic resonance imaging (MRI) scanning and comprehensive cognitive assessments, including three behavioral tasks and a cognitive questionnaire battery. Regional brain activity and network topological properties were separately compared between the two groups for each of the three frequency bands (slow-4, slow-5, and typical band) using two-sample <i>t</i>-tests. Simple and multiple mediation analyses were performed to examine the relationships among WMH, functional brain measures, and global cognition.</p><p><strong>Results: </strong>CSVD patients exhibited frequency-specific alterations in regional activity and reduced global functional organization in the slow-4 band. Frequency-dependent functional measures in the slow-4 band significantly mediated the relationship between deep WMH and cognitive performance.</p><p><strong>Conclusion: </strong>Our findings demonstrate the frequency-specific mediating role of abnormal brain functions in the pathophysiological pathway linking WMHs to cognitive impairment. This study provides new insight into the pathological mechanisms underlying WMH-related cognitive dysfunction.</p><p><strong>Clinical trial registration: </strong>ChiCTR2100043346, 02 November 2021, https://www.chictr.org.cn/showproj.html?proj=52285.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"36303"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Neutrophil Extracellular Traps: A Potential Therapeutic Strategy for Hemorrhagic Stroke.","authors":"Rasit Dinc, Nurittin Ardic","doi":"10.31083/JIN26357","DOIUrl":"https://doi.org/10.31083/JIN26357","url":null,"abstract":"<p><p>Stroke is a major health problem with high mortality and morbidity rates, partly due to limited treatment options. Inflammation has a critical role in the secondary damage that occurs following a stroke event. Neutrophil extracellular traps (NETs) are released by neutrophils and contribute to the progression of neuroinflammation that further worsens brain damage. The prevention of NET formation at sites of brain damage has been reported to prevent neuroinflammation and improve neurological deficits. The aim of this article was to assess the importance of NETs as a treatment target for hemorrhagic stroke in light of the available evidence. NETs are network structures that consist of decondensed DNA strands coated with granule proteins such as citrullinated histones, neutrophile esterase (NE), myeloperoxidase (MPO), and high mobility group protein B1 (HMGB1). Peptidyl arginine deiminase type-IV (PAD4) plays a key role in the formation of NETs. Inhibitors of NET formation, such as the PAD4-specific inhibitor GSK484, are effective at preventing inflammation and thus ultimately reducing brain damage after stroke. In conclusion, inhibition of NETs offers a potential therapeutic strategy for hemorrhagic stroke, although further research is needed to clarify the role of NETs in this condition.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"26357"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Auditory Evoked Potentials in Neuromyelitis Optica Spectrum Disorder.","authors":"Lucas Pinto Mielle, Liliane Aparecida Fagundes Silva, Dayane Aparecida Nascimento Barbosa, Glauciene Amaral Martins, Alessandra Giannella Samelli, Carla Gentile Matas","doi":"10.31083/JIN27733","DOIUrl":"https://doi.org/10.31083/JIN27733","url":null,"abstract":"<p><strong>Background: </strong>Neuromyelitis optica spectrum disorder (NMOSD) is a recurrent demyelinating neuroinflammatory disorder of the central nervous system. This study aimed to evaluate the neural conduction and sound information processing in individuals with NMOSD, through the analysis of auditory brainstem responses (ABRs) and cortical auditory evoked potentials (CAEPs).</p><p><strong>Methods: </strong>Twenty-four individuals (9-21 years old) were distributed into two groups: the study group (SG), diagnosed with NMOSD, and the control group, healthy individuals. Their ABRs and CAEPs were evaluated, and the results were examined alongside data from cranial magnetic resonance imaging (MRI).</p><p><strong>Results: </strong>Abnormal ABRs were observed in 33% of the SG and increased I-III interpeak was the most prevalent finding. The CAEPs showed abnormalities in 58% of the SG, mainly to P1 latency. SG subjects presented longer P1, N1, and N2 latencies and lower N2-P3 amplitude. MRI showed alterations mostly in the pons, midbrain, and IV ventricle.</p><p><strong>Conclusions: </strong>Alterations in neural conduction and sound information processing were observed in individuals with NMOSD when compared with their peers. Auditory evoked potentials are important instruments to identify central auditory dysfunction in this population as well as to monitor disease evolution.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 4","pages":"27733"},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}