Journal of integrative neuroscience最新文献

{"title":"Peripheral Nervous System Complications after COVID-19 Vaccination.","authors":"Seyed Sepehr Khatami, Samaneh Ghorbani Shirkouhi, Poul Flemming Høilund-Carlsen, Mona-Elisabeth Revheim, Abass Alavi, Morten Blaabjerg, Sasan Andalib","doi":"10.31083/JIN26632","DOIUrl":"https://doi.org/10.31083/JIN26632","url":null,"abstract":"<p><p>While vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains crucial, neurological complications have been detected following the coronavirus disease 2019 (COVID-19) vaccination. The neurological complications of COVID-19 vaccination can be seen in both the central nervous system (CNS) and the peripheral nervous system (PNS). In this study, we reviewed PNS complications after COVID-19 vaccination, their underlying mechanisms, diagnosis, and management. Inflammatory polyneuropathy, small fiber neuropathy, Parsonage-Turner syndrome (PTS), cranial mononeuropathies, and myasthenia gravis (MG) have been reported following COVID-19 vaccination. Inflammatory polyneuropathy following COVID-19 vaccination should be diagnosed early based on clinical presentation and treated with supportive care, and immunoglobulin or plasmapheresis to prevent respiratory distress if required. It is important to differentiate peripheral from central facial paralysis after COVID-19 vaccination to rule out upper motor neuron damage, including stroke. Diagnosis of small fiber neuropathy in the setting of COVID-19 vaccination should be suspected in patients with dysesthesia, dysautonomia, and lower extremity paresthesia. A skin biopsy of the proximal or distal lower limb should generally be considered for diagnosing small fiber neuropathy following COVID-19 vaccination. Even though pain at the injection site is one of the most common symptoms after COVID-19 vaccination, shoulder pain lasting more than 3 weeks should raise the suspicion of severe complications such as PTS. In addition to a proper physical examination as a reliable diagnosis tool, needle electromyography can be considered to help the diagnosis of PTS following COVID-19 vaccination. In our opinion, despite complications after COVID-19 vaccination, the benefit of vaccination immunity should not be forgotten.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26632"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Brain Injury with Special Reference to Astrocytes as a Therapeutic Target.","authors":"Caiping Wang, Xingjuan Fan, Yunwei Shi, Fengru Tang","doi":"10.31083/JIN25907","DOIUrl":"https://doi.org/10.31083/JIN25907","url":null,"abstract":"<p><p>Radiotherapy is one of the primary modalities for oncologic treatment and has been utilized at least once in over half of newly diagnosed cancer patients. Cranial radiotherapy has significantly enhanced the long-term survival rates of patients with brain tumors. However, radiation-induced brain injury, particularly hippocampal neuronal damage along with impairment of neurogenesis, inflammation, and gliosis, adversely affects the quality of life for these patients. Astrocytes, a type of glial cell that are abundant in the brain, play essential roles in maintaining brain homeostasis and function. Despite their importance, the pathophysiological changes in astrocytes induced by radiation have not been thoroughly investigated, and no systematic or comprehensive review addressing the effects of radiation on astrocytes and related diseases has been conducted. In this paper, we review current studies on the neurophysiological roles of astrocytes following radiation exposure. We describe the pathophysiological changes in astrocytes, including astrogliosis, astrosenescence, and the associated cellular and molecular mechanisms. Additionally, we summarize the roles of astrocytes in radiation-induced impairments of neurogenesis and the blood-brain barrier (BBB). Based on current research, we propose that brain astrocytes may serve as potential therapeutic targets for treating radiation-induced brain injury (RIBI) and subsequent neurological and neuropsychiatric disorders.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25907"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclic Alternating Pattern of EEG Activities and Heart Rate Variability in Parkinson's Disease Patients during Deep Sleep.","authors":"Zilin Cheng, Qi Li, Xueliang Zou, Zhijun Zhong, Qian Ouyang, Chunmei Gan, Fang Yi, Yaxing Luo, Yuhao Mao, Dongyuan Yao","doi":"10.31083/JIN26397","DOIUrl":"https://doi.org/10.31083/JIN26397","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbance and autonomic dysfunction are often found in Parkinson's disease (PD) patients, but little is known about changes in cyclic alternating patterns (CAPs) of electroencephalographic (EEG) activities and heart rate variability (HRV) during deep sleep in PD patients.</p><p><strong>Objectives: </strong>To investigate changes in EEG activities and HRV during CAPs and non-CAPs (NCAPs) of N3 sleep in PD patients.</p><p><strong>Methods: </strong>Polysomnographic (PSG) examinations were carried out on 18 PD patients and 18 healthy controls, and power spectral analysis of EEG activities and HRV during CAPs and NCAPs (the segment of sleep without CAPs for more than 60 seconds) of N3 sleep were carried out.</p><p><strong>Results: </strong>The percentages of N3 sleep with CAPs and CAP A1, as well as the CAP A1 index in the PD patients, were significantly smaller compared with the healthy controls. In addition, the power of α waves in NCAPs was significantly higher, while the powers of δ waves in Phase A and B of CAP A1 and A3, and NCAPs were significantly smaller. Furthermore, the durations of total δ waves and δ waves with an amplitude ≥75 μV were significantly shorter, and the low frequency (LF) power of HRV during CAPs and the LF/high frequency (HF) HRV ratio during both CAPs and NCAPs were significantly smaller.</p><p><strong>Conclusions: </strong>The changes documented in EEG activities and HRV in PD patients during CAPs and NCAPs of N3 sleep compared with healthy controls suggest that N3 sleep quality and sympathetic function are compromised in PD patients.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26397"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential Role of Neurogranin in Alzheimer's Disease.","authors":"Xin Zhou, Xiao-Jun Jing, Hua Zhang","doi":"10.31083/JIN25368","DOIUrl":"https://doi.org/10.31083/JIN25368","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is the most common form of dementia and is characterized by the excessive deposition of amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles. Numerous new studies also indicate that synaptic damage and loss play crucial roles in AD and form the basis of cognitive impairment. In recent years, synaptic-related proteins have emerged as important biomarkers for the early diagnosis of AD. Among these proteins, neurogranin (Ng), a postsynaptic protein widely present in the dendritic spines of the associative cortex in the brain, plays a significant role in memory, learning, synaptic plasticity, and long-term potentiation (LTP). This review aims to reveal the link between Ng and AD, as well as the potential for the diagnosis of AD, the prediction of the development of the disease, and the identification of a therapeutic target for AD.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25368"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Activation following Transcranial Magnetic Stimulation in Neurotypical Adult Readers.","authors":"Adianes Herrera-Diaz, Ewelina Bledniak, Rachael M Harrington, Robin Morris, C Nikki Arrington","doi":"10.31083/JIN26365","DOIUrl":"https://doi.org/10.31083/JIN26365","url":null,"abstract":"<p><strong>Background: </strong>Transcranial magnetic stimulation (TMS) is considered a promising technique to noninvasively modulate cortical excitability and enhance cognitive functions. Despite the growing interest in using TMS to facilitate reading performance in learning disabilities, the immediate TMS-induced effects on brain activity during reading and language tasks in adults with typically developed reading skills remain to be further investigated. In the current study, we explored how a single offline session of intermittent theta burst stimulation (iTBS) delivered to core left-hemisphere nodes of the dorsal and ventral reading network changes brain activity during a spoken and written reading task.</p><p><strong>Methods: </strong>A total of 25 adults with typically developed reading skills participated in a sandwich design TMS-functional magnetic resonance imaging (fMRI) study, which was comprised of a baseline fMRI picture-word identification task that involved matching written or spoken words to picture cues, a single transcranial magnetic stimulation (TMS) session to either the left supramarginal gyrus (SMG) or the left middle temporal gyrus (MTG), followed by a post-stimulation fMRI session. A whole-brain analysis based on the general lineal model (GLM) was used to identify overall activated regions during the processing of spoken and written words. To identify differences between pre-and post-stimulation fMRI sessions, a paired sample <i>t</i>-test was conducted for each group separately (SMG and MTG groups).</p><p><strong>Results: </strong>Significant differences were found between pre-and post-stimulation fMRI sessions, with higher functional activation (post > pre) for spoken words only following SMG stimulation, and for both spoken and written words following MTG stimulation, in regions associated with the reading network and additional cognitive and executive control regions.</p><p><strong>Conclusions: </strong>Our results showed how a single-offline TMS session can modulate brain activity at ~20 minutes post-stimulation during spoken and written word processing. The selective contribution of the SMG stimulation for auditory (spoken) word processing provides further evidence of the distinct role of the dorsal and ventral streams within the reading network. These findings could contribute to the development of neuromodulatory interventions for individuals with reading and language impairments.</p><p><strong>Clinical trial registration: </strong>No: NCT04041960. Registered 29 July, 2019, https://clinicaltrials.gov/study/NCT04041960?cond=NCT04041960&rank=1 .</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26365"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech Perception and Discrimination in Noise for Long-term Bilateral Hearing Aids Users: An ERP Study.","authors":"Yu-Xin Zhang, Yu-Lu Liu, Quan-Zheng Li, Ying Yang","doi":"10.31083/JIN26070","DOIUrl":"https://doi.org/10.31083/JIN26070","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the characteristics of auditory event-related potentials (AERP) evoked by vowel and consonant contrasts in prelingual deafness adults, who fitted with bilateral hearing aids (HA) in quiet and noisy environments.</p><p><strong>Methods: </strong>Standard stimuli /ba/ (75%) and deviant stimuli (/ga/ and /bu/, 12.5% each) were presented using a passive oddball paradigm in quiet and noisy (+10 decibel [dB] signal-to-noise ratio [SNR]) conditions. Eighteen young adults aged 18-23 years with long-term bilateral HA, and 20 age-matched normal hearing (NH) individuals participated in the study.</p><p><strong>Results: </strong>The hearing loss (HL) group showed lower N1-P2 and mismatch negativity (MMN) amplitudes and longer N1 and MMN latencies than the NH group. Both groups showed reduced N1-P2 amplitudes and longer MMN latencies in noise. The consonant contrast (/ga/-/ba/) induced lower and delayed MMN than the vowel contrast (/bu/-/ba/).</p><p><strong>Conclusions: </strong>Young adult bilateral HA users with prelingual severe to profound HL have poorer abilities in processing consonant-vowel syllables than people with NH, especially in noisy conditions and consonant contrast differences. Long-term auditory compensation provided by bilateral HA for people with prelingual severe and profound HL does not seem to enable adequate development of the auditory cortex.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26070"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The Role of the Autonomic Nervous System in Epilepsy and Migraine: A Narrative Review\"- Authors' Reply.","authors":"Daniela D'Agnano, Federica Cernigliaro, Alessandro Ferretti, Salvatore Lo Cascio, Edvige Correnti, Gianluca Terrin, Andrea Santangelo, Giulia Bellone, Vincenzo Raieli, Vittorio Sciruicchio, Pasquale Parisi","doi":"10.31083/JIN36288","DOIUrl":"https://doi.org/10.31083/JIN36288","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"36288"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.","authors":"Ling Chen, Wenxiu Cui, Jiyao Qin, Manmin Zhu, Haiqing Zhang, Juan Yang, Zucai Xu, Hao Huang","doi":"10.31083/JIN25710","DOIUrl":"https://doi.org/10.31083/JIN25710","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy, the world's third most prevalent chronic brain disorder, significantly affects patients' quality of life and increases the economic burden on families and society. Previous studies have demonstrated that FK506-binding protein 51 (FKBP51) plays a crucial role in synaptic plasticity. However, FKBP51 exhibits different functions under various physiological and pathological conditions. Our study explored the relationship between FKBP51 and epilepsy and its possible mechanism of action. We also analyzed the expression levels of postsynaptic density-95 (PSD95) and synaptophysin (SYP) in the hippocampus to examine the pathophysiology of epilepsy.</p><p><strong>Methods: </strong>A chronic epileptic kindling model was established by injecting pentylenetetrazole (PTZ) intraperitoneally, and a spontaneous seizure model was created by injecting kainic acid (KA) into the dentate gyrus using a stereotaxic apparatus. Endogenous FKBP51 expression was inhibited using adeno-associated virus (AAV)-FKBP51-Small hairpin RNAs (shRNA). The expression of FKBP51, PSD95, and SYP in the hippocampus and synaptosomes was measured through western blotting. Golgi staining and electron microscopy were used to examine spines and synaptic structures.</p><p><strong>Results: </strong>The results showed a significant increase in FKBP51 expression in the hippocampal tissue of the PTZ- and KA-induced epilepsy model groups. Inhibition of FKBP51 expression through AAV-FKBP51-shRNA resulted in a shorter latency and an elevated seizure grade score in mice. Moreover, the suppression of FKBP51 expression enhanced the expression of synaptic plasticity-related proteins, increased the density of dendritic spines, and elevated the quantity of spherical synaptic vesicles in the presynaptic membrane in the hippocampus.</p><p><strong>Conclusions: </strong>FKBP51 may serve as an endogenous protective factor in epilepsy by regulating the expression of the synaptic plasticity-related protein PSD95, the density of dendritic spines, and the number of synaptic vesicles in the hippocampal CA1.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25710"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury.","authors":"Yugang Ma, Xuebin Wang, Yahui Li, Jing Zhao, Xue Zhou, Xingchen Wang","doi":"10.31083/JIN26458","DOIUrl":"https://doi.org/10.31083/JIN26458","url":null,"abstract":"<p><p>Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical thrombolysis remain the most significant and effective methods for relief of ischemia. Key elements of these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, and preserving the ischemic penumbra. However, in achieving the therapeutic goals of vascular recanalization, secondary damage to brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements in understanding the pathological processes associated with CIRI, effective interventions to prevent its onset and progression are still lacking. Recent research has indicated that mitophagy and ferroptosis are critical mechanisms in the development of CIRI, and significantly contribute to the onset and progression of IS and CIRI because of common targets and co-occurrence mechanisms. Therefore, exploring and summarizing the potential connections between mitophagy and ferroptosis during CIRI is crucial. In the present review, we mainly focused on the mechanisms of mitochondrial autophagy and ferroptosis, and their interaction, in the development of CIRI. We believe that the data show a strong relationship between mitochondrial autophagy and ferroptosis with interactive regulation. This information may underpin new potential approaches for the prevention and treatment of IS and subsequent CIRI.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26458"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TDCS Modulates Brain Functional Networks in Children with Autism Spectrum Disorder: A Resting-State EEG Study.","authors":"Jiannan Kang, Wenqin Mao, Juanmei Wu, Xinling Geng, Xiaoli Li","doi":"10.31083/JIN27314","DOIUrl":"https://doi.org/10.31083/JIN27314","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of transcranial direct current stimulation (tDCS) on brain functional networks in children with autism spectrum disorder (ASD).</p><p><strong>Methods: </strong>We constructed brain functional networks using phase-locking value (PLV) and assessed the temporal variability of these networks using fuzzy entropy. Graph theory was applied to analyze network characteristics. Resting-state electroencephalography (EEG) data were used to compare differences in brain functional connectivity, temporal variability, and network properties between children with ASD and typically developing (TD) children. Additionally, we examined the changes in functional connectivity, temporal variability, and network properties in children with ASD after 20 sessions of tDCS intervention.</p><p><strong>Results: </strong>The study revealed that children with ASD exhibited lower connectivity in the alpha band and higher connectivity in the beta band. In the delta and theta bands, ASD children demonstrated a mixed pattern of both higher and lower connectivity. Furthermore, ASD children exhibited higher temporal variability across all four frequency bands, particularly in the delta and beta bands. After tDCS intervention, the total score of the Autism Behavior Checklist (ABC) significantly decreased. Additionally, functional connectivity in the delta and alpha bands increased, while temporal variability in the delta and beta bands decreased, indicating positive changes in brain network characteristics.</p><p><strong>Conclusion: </strong>These results suggest that tDCS may be a promising intervention for modulating brain functional networks in children with ASD.</p><p><strong>Clinical trial registration: </strong>ChiCTR2400092790. Registered 22 November, 2024, https://www.chictr.org.cn/showproj.html?proj=249950.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"27314"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}