Journal of integrative neuroscience最新文献

{"title":"FKBP51 is Involved in Epileptic Seizure by Regulating PSD95 in a PTZ-Induced Epileptic Mouse Model.","authors":"Ling Chen, Wenxiu Cui, Jiyao Qin, Manmin Zhu, Haiqing Zhang, Juan Yang, Zucai Xu, Hao Huang","doi":"10.31083/JIN25710","DOIUrl":"10.31083/JIN25710","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy, the world's third most prevalent chronic brain disorder, significantly affects patients' quality of life and increases the economic burden on families and society. Previous studies have demonstrated that FK506-binding protein 51 (FKBP51) plays a crucial role in synaptic plasticity. However, FKBP51 exhibits different functions under various physiological and pathological conditions. Our study explored the relationship between FKBP51 and epilepsy and its possible mechanism of action. We also analyzed the expression levels of postsynaptic density-95 (PSD95) and synaptophysin (SYP) in the hippocampus to examine the pathophysiology of epilepsy.</p><p><strong>Methods: </strong>A chronic epileptic kindling model was established by injecting pentylenetetrazole (PTZ) intraperitoneally, and a spontaneous seizure model was created by injecting kainic acid (KA) into the dentate gyrus using a stereotaxic apparatus. Endogenous FKBP51 expression was inhibited using adeno-associated virus (AAV)-FKBP51-Small hairpin RNAs (shRNA). The expression of FKBP51, PSD95, and SYP in the hippocampus and synaptosomes was measured through western blotting. Golgi staining and electron microscopy were used to examine spines and synaptic structures.</p><p><strong>Results: </strong>The results showed a significant increase in FKBP51 expression in the hippocampal tissue of the PTZ- and KA-induced epilepsy model groups. Inhibition of FKBP51 expression through AAV-FKBP51-shRNA resulted in a shorter latency and an elevated seizure grade score in mice. Moreover, the suppression of FKBP51 expression enhanced the expression of synaptic plasticity-related proteins, increased the density of dendritic spines, and elevated the quantity of spherical synaptic vesicles in the presynaptic membrane in the hippocampus.</p><p><strong>Conclusions: </strong>FKBP51 may serve as an endogenous protective factor in epilepsy by regulating the expression of the synaptic plasticity-related protein PSD95, the density of dendritic spines, and the number of synaptic vesicles in the hippocampal CA1.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25710"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury.","authors":"Yugang Ma, Xuebin Wang, Yahui Li, Jing Zhao, Xue Zhou, Xingchen Wang","doi":"10.31083/JIN26458","DOIUrl":"10.31083/JIN26458","url":null,"abstract":"<p><p>Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical thrombolysis remain the most significant and effective methods for relief of ischemia. Key elements of these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, and preserving the ischemic penumbra. However, in achieving the therapeutic goals of vascular recanalization, secondary damage to brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements in understanding the pathological processes associated with CIRI, effective interventions to prevent its onset and progression are still lacking. Recent research has indicated that mitophagy and ferroptosis are critical mechanisms in the development of CIRI, and significantly contribute to the onset and progression of IS and CIRI because of common targets and co-occurrence mechanisms. Therefore, exploring and summarizing the potential connections between mitophagy and ferroptosis during CIRI is crucial. In the present review, we mainly focused on the mechanisms of mitochondrial autophagy and ferroptosis, and their interaction, in the development of CIRI. We believe that the data show a strong relationship between mitochondrial autophagy and ferroptosis with interactive regulation. This information may underpin new potential approaches for the prevention and treatment of IS and subsequent CIRI.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26458"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TDCS Modulates Brain Functional Networks in Children with Autism Spectrum Disorder: A Resting-State EEG Study.","authors":"Jiannan Kang, Wenqin Mao, Juanmei Wu, Xinling Geng, Xiaoli Li","doi":"10.31083/JIN27314","DOIUrl":"10.31083/JIN27314","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of transcranial direct current stimulation (tDCS) on brain functional networks in children with autism spectrum disorder (ASD).</p><p><strong>Methods: </strong>We constructed brain functional networks using phase-locking value (PLV) and assessed the temporal variability of these networks using fuzzy entropy. Graph theory was applied to analyze network characteristics. Resting-state electroencephalography (EEG) data were used to compare differences in brain functional connectivity, temporal variability, and network properties between children with ASD and typically developing (TD) children. Additionally, we examined the changes in functional connectivity, temporal variability, and network properties in children with ASD after 20 sessions of tDCS intervention.</p><p><strong>Results: </strong>The study revealed that children with ASD exhibited lower connectivity in the alpha band and higher connectivity in the beta band. In the delta and theta bands, ASD children demonstrated a mixed pattern of both higher and lower connectivity. Furthermore, ASD children exhibited higher temporal variability across all four frequency bands, particularly in the delta and beta bands. After tDCS intervention, the total score of the Autism Behavior Checklist (ABC) significantly decreased. Additionally, functional connectivity in the delta and alpha bands increased, while temporal variability in the delta and beta bands decreased, indicating positive changes in brain network characteristics.</p><p><strong>Conclusion: </strong>These results suggest that tDCS may be a promising intervention for modulating brain functional networks in children with ASD.</p><p><strong>Clinical trial registration: </strong>ChiCTR2400092790. Registered 22 November, 2024, https://www.chictr.org.cn/showproj.html?proj=249950.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"27314"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of an Objective Approach Using Acoustic Change Complex for Evaluating Spectral Resolution in Individuals with Normal Hearing and Hearing Loss.","authors":"Soojin Kang, Jihwan Woo, Kyung Myun Lee, Hye Yoon Seol, Sung Hwa Hong, Il Joon Moon","doi":"10.31083/JIN25911","DOIUrl":"10.31083/JIN25911","url":null,"abstract":"<p><strong>Background: </strong>Identifying the temporal and spectral information in sound is important for understanding speech; indeed, a person who has good spectral resolution usually shows good speech recognition performance. The spectral ripple discrimination (SRD) test is often used to behaviorally determine spectral resolution capacity. However, although the SRD test is useful, it is difficult to apply to populations who cannot execute the behavioral task, such as younger children and people with disabilities. In this study, an objective approach using spectral ripple (SR) stimuli to evoke the acoustic change complex (ACC) response was investigated to determine whether it could objectively evaluate the spectral resolution ability of subjects with normal hearing (NH) and those with hearing loss (HL).</p><p><strong>Method: </strong>Ten subjects with NH and eight with HL were enrolled in this study. All subjects completed the behavioral SRD test and the objective SR-ACC test. Additionally, the HL subjects completed speech perception performance tests while wearing hearing aids.</p><p><strong>Results: </strong>In the SRD test, the average thresholds were 6.48 and 1.52 ripples per octave (RPO) for the NH and HL groups, respectively, while in the SR-ACC test, they were 4.90 and 1.35 RPO, respectively. There was a significant difference in the average thresholds between the two groups for the SRD (<i>p</i> < 0.001) and the SR-ACC (<i>p</i> < 0.001) tests. A significant positive correlation was observed between the SRD and SR-ACC tests (ρ = 0.829, <i>p</i> < 0.001). In the HL group, there was a statistically significant relationship between speech recognition performance in noisy conditions and the SR-ACC threshold (ρ = 0.911, <i>p</i> < 0.001 in Sentence score of Korean Speech Audiometry (KSA)).</p><p><strong>Conclusions: </strong>The results supported the feasibility of the SR-ACC test to objectively evaluate auditory spectral resolution in individuals with HL. This test has potential for use in individuals with HL who are unable to complete the behavioral task associated with the SRD test; therefore, it is proposed as a more inclusive alternative to the SRD test.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"25911"},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autonomic Complications of Seizures and Migraines.","authors":"Josef Finsterer","doi":"10.31083/JIN26768","DOIUrl":"https://doi.org/10.31083/JIN26768","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26768"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role of Astrocytes in Learning and Memory Recall.","authors":"Kecan Li, Yihui Cui","doi":"10.31083/JIN38721","DOIUrl":"https://doi.org/10.31083/JIN38721","url":null,"abstract":"","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"38721"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Blink Rates Predict Mind Wandering: Dopaminergic Insights into Attention and Task Focus.","authors":"Leigh M Riby, Lewis Marr, Lynn Barron-Millar, Joanna Greer, Colin Joseph Hamilton, Deborah McGann, Jonathan Smallwood","doi":"10.31083/JIN26508","DOIUrl":"10.31083/JIN26508","url":null,"abstract":"<p><strong>Background: </strong>The study investigated the neural correlates of mind wandering using eyeblink rate (EBR) and variability (EBV) proxies. Dopamine, a neurotransmitter integral to the brain's reward system, has been implicated in regulating both task-unrelated and task-focused thinking. This study sought to clarify the relationships between dopaminergic function and cognitive control during a task by utilizing EBR and EBV as proxy measures.</p><p><strong>Methods: </strong>Vertical electrooculogram and brain event-related potential (ERP) data were gathered from 24 adult participants while they performed a computerized cognitive task. During the task (3-stimulus visual oddball procedure), participants discriminated between an infrequently seen target stimulus, an infrequent novel stimulus (for evaluating task engagement and distraction), and a commonly occurring nontarget stimulus. A retrospective questionnaire (Dundee Stress State Questionnaire, DSSQ) assessed task-unrelated (TUT) and task-related (TRT) thinking directly after task completion. The P3a ERP brain indexes at the Cz and Fz scalp electrode sites were also considered as a secondary proxy measure of dopamine function.</p><p><strong>Results: </strong>The main finding revealed that higher EBR was associated with higher TUT, suggesting a link between elevated dopaminergic activity and mind wandering. There was also a marginal negative correlation with P3a latency at the Fz scalp location and TUT, indicative of heightened responsiveness to distraction in general. For TRT, there was a positive correlation with P3a amplitudes at Fz, suggesting a role in task-related engagement and focus on all stimuli during the task. Regarding behavior, EBR and EBV were negatively correlated with Sigma ex-Gaussian task reaction time (RT), suggesting that more stable cognitive states are associated with higher blink rates and variability. Tau RT positively correlated with blink variability and P3a amplitudes at Fz and Cz, indicative of attentional lapse. Regression analyses showed that EBR and Mu RT predicted TUT, while TRT was predicted by P3a amplitude at Fz. More blinks and slower responses were related to TUT, whereas greater focus on the task stimuli (P3a amplitude) was related to TRT.</p><p><strong>Conclusions: </strong>These data underscore the importance of dopamine during mind wandering and task focus. In addition, this study argues for using ex-Gaussian analysis to understand the complex dynamics of attentional control during mind wandering.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26508"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG Microstate Dynamics during Different Physiological Developmental Stages and the Effects of Medication in Schizophrenia.","authors":"Shihai Ling, Lingyan Du, Xi Tan, Guozhi Tang, Yue Che, Shirui Song","doi":"10.31083/JIN27059","DOIUrl":"10.31083/JIN27059","url":null,"abstract":"<p><strong>Background: </strong>Schizophrenia (SCZ) is associated with abnormal neural activities and brain connectivity. Electroencephalography (EEG) microstate is a voltage topographical representation of temporary brain network activations. Most research on EEG microstates in SCZ has focused on differences between patients and healthy controls (HC). However, changes in EEG microstates among SCZ patients across various stages of physiological and cognitive development have not been thoroughly assessed. Consequently, we stratified patients with SCZ into four age-specific cohorts (20-29 years (brain maturation), 30-39 years (stabilization), 40-49 years (early aging), and 50-59 years (advanced aging)) to evaluate EEG microstate alterations. Additionally, we assessed changes in EEG microstates in first-episode psychosis (FEP) before and after an 8-week treatment period.</p><p><strong>Methods: </strong>We acquired 19-channel resting-state EEG from 140 chronic SCZ patients, aged 20 to 59 years, as well as from 19 FEP and 20 healthy controls. FEP patients underwent an 8-week inpatient follow-up. After pre-processing, EEG data from different groups were subjected to microstate analysis, and the K-Means clustering algorithm was applied to classify the data into 4 microstates. Subsequently, templates of these microstates were used to fit EEG signals from each patient, and the collected microstate parameters were analyzed.</p><p><strong>Results: </strong>Patients with SCZ aged 20 to 29 years demonstrated an increased time coverage of microstate class D compared to other age cohorts. In individuals aged 30-39 years, the parameters of microstate class B-specifically time coverage and occurrence-exhibited significant reductions relative to those in the 40-49 and 50-59 years age groups. Compared to healthy controls, microstates class A parameters were significantly reduced in SCZ patients, while microstates class C parameters were prolonged; after 8 weeks of treatment, microstates class A parameters increased and microstates class C parameters decreased.</p><p><strong>Conclusions: </strong>Alterations in microstate dynamics were observed among SCZ patients across developmental stages, suggesting potential changes in brain activity patterns. Changes in microstates A and C may serve as potential biomarkers for evaluating treatment efficacy, establishing a foundation for personalized therapeutic approaches.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"27059"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial Intermittent Theta-Burst Stimulation Reverses Neurodegeneration in the Somatosensory Motor Cortex after Spinal Cord Transection in Rats.","authors":"Zhenghong Chen, Yujian Lin, Jing Xu, Jiawei Sun, Rui Liu, Yue Yang, Zhen Chen, Mingyu Lv, Biqin Lai, Ling Zhang","doi":"10.31083/JIN26731","DOIUrl":"10.31083/JIN26731","url":null,"abstract":"<p><strong>Background: </strong>Complete spinal cord injury (SCI) leads to a disconnection between the brain and the body below the injury level, resulting in the functional silencing, degeneration, and apoptosis of sensorimotor cortex (SMC) neurons, which is of crucial importance to the pathological process.</p><p><strong>Methods: </strong>In this study, a rat model of spinal cord transection was employed to explore the activation of neurons in the SMC and the reversal of neurodegeneration after the rats were treated with transcranial intermittent theta-burst stimulation (T-iTBS).</p><p><strong>Results: </strong>The results demonstrated that the expression of the immediate early gene <i>c-Fos</i> and the synaptic plasticity-associated activity-regulated cytoskeleton (<i>Arc</i>) gene in the neurons of the SMC was increased in the T-iTBS group 4 weeks after SCI. Transcriptome sequencing revealed that neuronal activation-, neuronal metabolism-, synaptic activity-, and neural regeneration-related genes were significantly upregulated in the T-iTBS group compared with those of the sham-iTBS group, but the expression was similar to that in the normal group. Western blot analysis indicated that the expression of Cle-caspase-3 (CC3) in the SMC was significantly reduced in the T-iTBS group, and the number of CD68-positive cells in the SMC was close to that of normal rats but significantly less than that in the sham-iTBS and SCI groups. These results are in line with those of the transcriptome sequencing. Correlation analysis of the expression rate between c-Fos and Arc, CC3, and CD68 further suggested that T-iTBS improved the immune microenvironment and prevented neurodegeneration by regulating the activation and synaptic plasticity of SMC neurons in the early stages of injury.</p><p><strong>Conclusions: </strong>Collectively, our findings offer support for the utilization of T-iTBS, a non-invasive neural stimulation treatment, to prevent SMC degeneration following severe SCI.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26731"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Xenon on the Developing Brain: Current Insights from Pre-clinical and Clinical Studies.","authors":"Qinfang Shi, Gerhard Rammes, Ping Wang, Chengkun Xia, Fangfang Mou, Jing Zhu, Haidong Guo, Shuijin Shao, Xingxing Wang","doi":"10.31083/JIN26388","DOIUrl":"10.31083/JIN26388","url":null,"abstract":"<p><p>Research has indicated that general anesthetics may potentially induce neuroapoptosis, resulting in long-term neurological deficits in the developing brain. Fortunately, xenon, a noble gas, emerges as a promising candidate for an ideal anesthetic due to its favorable properties, offering neuroprotection and mitigating the neurotoxic effects of other general anesthetics during early life stages. Nevertheless, it is important to highlight that xenon has also been observed to cause neuroapoptosis in the neonatal brain, suggesting that xenon possesses both neuroprotective qualities (as evidenced by pre-clinical and clinical studies) and neurotoxic potential (based mainly on pre-clinical evidence) during brain development. To gain a comprehensive understanding the effects xenon, this review will explore the anesthetic properties of xenon, examine its effects on anesthesia, and elucidate its mechanisms of potential neuroprotection and neurotoxicity in the developing brain. The primary emphasis will be on xenon's application in the context of anesthetic-induced developmental neurotoxicity (AIDN), hypoxic-ischemic encephalopathy (HIE), and teratogenicity, aiming to provide valuable insights for pediatricians, pediatric anesthesiologists, and other healthcare professionals involved in the use and study of xenon anesthesia.</p>","PeriodicalId":16160,"journal":{"name":"Journal of integrative neuroscience","volume":"24 3","pages":"26388"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}