Journal of Inflammation Research最新文献

{"title":"Dual Effects of Sodium Houttuyfonate Against Acute Rhinosinusitis: Antibacterial Action and Epithelial Barrier Repair Through the p38 MAPK/ERK Pathway.","authors":"Yang Fang, Huixia Zhou, WeiYi Li, Lu Bai, Xinchen Sun, KaiYuan He, Shanshan Xue, Yongjun Wu","doi":"10.2147/JIR.S539966","DOIUrl":"10.2147/JIR.S539966","url":null,"abstract":"<p><strong>Background: </strong><i>Houttuynia cordata</i> Thunb, a traditional medicinal herb, is the source of sodium houttuyfonate (SH), a stabilized derivative with antibacterial, antiviral, and anti-inflammatory activities. Acute rhinosinusitis (ARS) comprises viral, post-viral, and bacterial forms; bacterial ARS causes severe inflammation and epithelial barrier disruption. Despite wide clinical use, the mechanisms of SH in ARS remain unclear.</p><p><strong>Methods: </strong>Network pharmacology was applied to identify SH-associated targets and pathways. An ARS rat model was induced by inserting Staphylococcus aureus-soaked Merocel sponges into the nasal cavity. Rats received low, medium, or high doses of SH, with control and positive drug groups. Symptom scoring, CT, histopathology, hematology, ELISA, qRT-PCR, and immunohistochemistry were conducted. In vitro, human nasal epithelial cells (HNEpCs) were stimulated with lipopolysaccharide (LPS) and treated with SH, with or without MAPK modulators SB203580 (inhibitor) or Anisomycin (activator). Cell viability, cytokine expression, and ERK/p38 MAPK phosphorylation were assessed.</p><p><strong>Results: </strong>SH improved nasal symptoms, reduced epithelial injury, and normalized nasal pH in ARS rats. It downregulated IL-1β, IL-6, TNF-α, and ICAM-1 while upregulating IL-4. Transmission electron microscopy showed restoration of ciliary and mitochondrial integrity. In HNEpCs, 60 μM SH was optimal by CCK-8 assay. In LPS-stimulated cells, SH suppressed IL-1β/IL-6 mRNA and inhibited ERK and p38 MAPK phosphorylation; these effects were reversed by Anisomycin, confirming pathway involvement.</p><p><strong>Conclusion: </strong>SH alleviates sinonasal inflammation in ARS by inhibiting bacterial activity and restoring epithelial integrity through p38 MAPK/ERK suppression. These findings support SH as a potential therapy for upper airway inflammatory diseases.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13433-13452"},"PeriodicalIF":4.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Butyric Acid and Microorganisms in Chronic Inflammatory Diseases and Microbiome-Based Therapeutics.","authors":"Zhilin Liu, Yonghong Jiang, Qiuyue Fan, Sai Li, Yanni Wang","doi":"10.2147/JIR.S540163","DOIUrl":"10.2147/JIR.S540163","url":null,"abstract":"<p><p>Butyric acid, produced by gut microbiota fermentation, has gained significant attention over the past decade. It shows strong therapeutic potential in both experimental and clinical treatments for inflammatory diseases across multiple systems. However, factors such as the host's environment, genetics, and microbial lineage transmission influence gut microecology and butyric acid metabolism, resulting in variable and sometimes opposing, therapeutic effects. Consequently, precise personalized medicine is essential for diseases related to microbes and butyric acid. This review first introduces the fundamentals of butyric acid, focusing on its immune mechanisms and its effects on early-life microbiota. It then summarizes how microbes and butyric acid contribute to the treatment of systemic inflammatory diseases (eg, autoimmune diseases (AIDs), asthma, metabolic syndrome) and discusses the concept of Microbial Precision Therapy (MPT). Understanding butyric acid provides deeper insight into managing inflammatory diseases and supports precise medication and personalized therapy. This approach may offer more effective and safer strategies for multi-system inflammatory disorders.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13465-13487"},"PeriodicalIF":4.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Validation of a Novel Nutritional-Immune-Inflammatory Score Model for Predicting Survival Prognosis in Hepatocellular Carcinoma Patients Treated with PD-1 Inhibitors.","authors":"Kan Liu, Yaqin Lv, Shumin Fu, Ye Mao, Yongkang Xu, Shenglan Huang, Jianbing Wu","doi":"10.2147/JIR.S546164","DOIUrl":"10.2147/JIR.S546164","url":null,"abstract":"<p><strong>Purpose: </strong>Immune checkpoint inhibitors, particularly PD-1 inhibitors, are widely used in hepatocellular carcinoma therapy, many received PD-1 inhibitors beyond first-line, but heterogeneous treatment responses require reliable biomarkers. The interaction of immune function, nutritional status, and inflammatory responses affects tumor progression and survival, yet their prognostic value in PD-1 inhibitor-treated HCC patients remains unclear. This study developed a novel nutritional-immune-inflammatory score (NIIS) to evaluate its prognostic value in HCC patients receiving PD-1 inhibitors.</p><p><strong>Patients and methods: </strong>We analyzed 355 HCC patients treated with PD-1 inhibitors (training: n=249; validation: n=106), the cohort included 18.6% Child-Pugh B patients. Fourteen nutritional, immune, and inflammatory biomarkers were evaluated. Prognostic indicators were selected via univariate and LASSO Cox regression. The NIIS was constructed and validated for OS prediction. A nomogram integrating the NIIS with clinical variables was developed and validated based on calibration curves, AUC, and DCA, and compared with the BCLC staging system. The primary outcome assessed was OS from the initiation of PD-1 inhibitor therapy in HCC patients.</p><p><strong>Results: </strong>The NIIS (ALRI, APRI, PALBI, AAPR) showed strong prognostic stratification. High-risk patients had shorter OS (training: P =1.764×10^-8; verification: P=2.775×10^-6). Higher NIIS were significantly associated with advanced tumor stage, poor liver function grade, multiple and larger tumors, tumor thrombus, vascular invasion, and elevated AFP levels (P<0.05). Multivariate Cox analysis confirmed the NIIS as an independent prognostic factor for OS (training: HR=1.565, 95% CI: 1.273-1.925; verification: HR=1.341, 95% CI: 1.065-1.687). A nomogram integrating the NIIS with clinical variables was constructed for individualized prognosis prediction, demonstrating superior predictive performance compared to the conventional BCLC staging system.</p><p><strong>Conclusion: </strong>The NIIS and nomogram provide a clinically useful tool for risk stratification in HCC immunotherapy, this model outperforming conventional staging systems and may optimize patient selection for PD-1 inhibitor therapy. Prospective multicenter studies are warranted to validate its generalizability.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13397-13412"},"PeriodicalIF":4.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Characteristics of Nasal Tissues From Paediatric Patients with Chronic Rhinosinusitis and Nasal Polyps Requiring Revision Surgery.","authors":"Sheng-Feng Hsieh, Pei-Wen Wu, Cheng-Hsun Chiu, Yen-Lin Huang, Chien-Chia Huang","doi":"10.2147/JIR.S540300","DOIUrl":"10.2147/JIR.S540300","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic sinus surgery (ESS) is a safe and effective intervention for medically refractory pediatric chronic rhinosinusitis (CRS), particularly in older children and those with nasal polyposis. However, the histopathological characteristics associated with poor surgical outcomes in pediatric chronic rhinosinusitis with nasal polyposis (CRSwNP) have not been fully clarified. This study aimed to to identify histopathological characteristics of CRSwNP prognostic for revision surgery.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of 161 pediatric patients with CRSwNP including 22 patients with recurrent nasal polyps requiring revision surgery. The histopathological characteristics were compared between patients with and without revision surgery.</p><p><strong>Results: </strong>Histopathological analysis revealed that the degree of inflammation, interstitial-gland percentage, mucosal ulceration, and numbers of eosinophils and goblet cells were significantly higher in participants who underwent revision surgery than in those who did not (all P<0.05). The degree of inflammation (odds ratio [OR], 2.53; P=0.003), eosinophil count (OR, 1.03; P<0.001), goblet-cell count (OR, 1.19; P=0.002), interstitial-gland percentage (OR, 1.99; P=0.012), and mucosal ulceration (OR, 3.37; P=0.013) were significantly associated with revision surgery in the univariate regression analysis. Receiver operating characteristic curve analysis identified 2.5 goblet cells per high-power field as the optimal cutoff value for predicting revision surgery, with a sensitivity of 77.3% and a specificity of 67.6%.</p><p><strong>Conclusion: </strong>Histopathological features, including elevated eosinophil count, goblet-cell hyperplasia, marked mucosal inflammation, interstitial-gland hyperplasia, and mucosal ulceration, were associated with the need for revision in pediatric patients with CRSwNP. These findings could help clinicians stratify disease severity and tailor therapeutic approaches.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13279-13289"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Profiling of Serum-Derived Exosomes in Oral Lichen Planus: FN1-C3-ECM Crosstalk as a Potential Novel Therapeutic Target.","authors":"Xue-Ying Wang, Yu-Fang Deng, Sheng-Jin Xue, Wei-Qun Guan","doi":"10.2147/JIR.S553682","DOIUrl":"10.2147/JIR.S553682","url":null,"abstract":"<p><strong>Objective: </strong>Oral lichen planus (OLP) is a chronic inflammatory disorder with malignant potential. The aim is to characterize serum exosome protein expression profiles in patients diagnosed with OLP and to identify potential disease-associated candidate proteins.</p><p><strong>Methods: </strong>Serum samples were collected from 30 participants, comprising erosive OLP patients, non-erosive OLP patients, and healthy controls (n = 10 per group). Serum exosome proteomes were compared across groups following validation of exosomal integrity using nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), and Western blotting. Label-free quantitative proteomic profiling was performed with Orbitrap Exploris 480 mass spectrometry, integrated with bioinformatics analyses to identify differentially expressed proteins.</p><p><strong>Results: </strong>About 138 differentially expressed proteins (DEPs, 39↑/99↓) in OLP patients vs controls, with subtype-specific profiles (70 DEPs in non-erosive, 99 in erosive). Gene Ontology (GO) enrichment analysis indicated that these proteins were predominantly associated with extracellular vesicles, protein binding, and immune response regulation. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted enrichment in the complement and coagulation cascade (<i>p</i> < 0.05), platelet activation, and focal adhesion pathways. Protein-protein interaction (PPI) network analysis identified central proteins including fibronectin 1 (FN1), complement component 3 (C3), integrin subunit beta 3 (ITGB3), vinculin (VCL), and SRC proto-oncogene (SRC). Among these, FN1 and C3 were implicated in mediating epithelial-extracellular matrix (ECM) separation and thromboinflammatory activity.</p><p><strong>Conclusion: </strong>The identified differentially expressed proteins in serum exosomes and their association with the complement and coagulation cascade pathway appear to contribute to the pathogenesis and progression of OLP. FN1 and C3 dysregulation directly contributes to OLP pathogenesis via immune-stromal crosstalk. Core proteins such as FN1 and C3 may serve as promising non-invasive diagnostic biomarkers and therapeutic targets, warranting further validation.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13359-13379"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Combined Detection of Systemic Inflammation Response Index and Prognostic Nutritional Index in Predicting Short-Term Prognosis of Myasthenia Gravis.","authors":"Ting Chen, Hui Chen, Yishuang Wen, Yanzhen Huang, Ziqun Lin, Qing Liang, Wen Huang","doi":"10.2147/JIR.S546111","DOIUrl":"10.2147/JIR.S546111","url":null,"abstract":"<p><strong>Purpose: </strong>Although systemic inflammation response index (SIRI) and prognostic nutritional index (PNI) are associated with prognosis in various diseases, their role in myasthenia gravis (MG) remains unclear. This study aims to evaluate the predictive value of SIRI combined with PNI for MG prognosis.</p><p><strong>Methods: </strong>260 MG patients were enrolled in this retrospective study and were categorized into clinical improvement and non-improvement groups based on changes in MG-ADL and QMG scores after 6 months' treatment. Lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), SIRI and PNI were calculated from admission blood indices. Clinical differences between groups were compared. Logistic regression was used to identify independent predictors of clinical non-improvement. The ROC curve was utilized to assess the prognostic predictive value of SIRI, PNI, and their combination. Interaction effects and stratified analyses were used to explore the relationship between SIRI, PNI and MG prognosis across distinct subgroups.</p><p><strong>Results: </strong>Patients without clinical improvement exhibited significantly elevated SIRI, NLR, and PLR, whereas LMR and PNI were reduced (<i>p</i> < 0.001). Multivariate logistic regression demonstrated that both SIRI and PNI significantly predicted clinical non-improvement (OR = 9.108, 95% CI: 3.412-24.317, <i>p</i> < 0.001; OR = 0.695, 95% CI: 0.601-0.804, <i>p</i> < 0.001). The area under the curve (AUC) of SIRI combined with PNI for predicting clinical non-improvement in MG was 0.928 (95% CI:0.896-0.961, sensitivity: 0.873, specificity: 0.851), which is higher than SIRI (AUC: 0.841, 95% CI: 0.783-0.899, sensitivity: 0.772, specificity: 0.845) and PNI (AUC: 0.822, 95% CI: 0.770-0.875, sensitivity: 0.759, specificity: 0.740) alone. A statistically significant interaction was identified between SIRI and thymoma (<i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>SIRI and PNI are independently associated with MG prognosis, particularly in thymoma cases, where SIRI shows a stronger correlation. Furthermore, the combination of SIRI and PNI can serve as a valuable predictor of clinical non-improvement in MG.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13319-13333"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Single-Cell Analysis Reveals the Heterogeneity of Tumor-Associated Macrophages and Their Implications for Immunotherapy in Colorectal Cancer.","authors":"Guozeng Xu, Binglan Fang, Xiaobi Tang, Qingqing Wei, Jing Li","doi":"10.2147/JIR.S531641","DOIUrl":"10.2147/JIR.S531641","url":null,"abstract":"<p><strong>Background: </strong>Tumor-associated macrophages (TAMs) are one of the predominant cell components within the colorectal cancer (CRC) microenvironment, which display prominent and multifaceted roles in modulating tumor biology. The systematic subtypes and function analysis of TAMs remain elusive in CRC.</p><p><strong>Methods: </strong>We performed an integrated single-cell atlas of three American studies (GSE178341, GSE200997, and GSE231559) to establish the TAM subtypes in the CRC microenvironment. We adopted unsupervised clustering and manual cell annotation to categorize macrophage subtypes accurately, performed enrichment analysis and developmental trajectory analysis for three TAM subsets, and explored the cell-to-cell crosstalk of different TAM subsets with other cell types. Finally, we further performed an integrated single-cell atlas of five Asian studies (GSE132257, GSE132465, GSE144735, GSE221575, and GSE245552) to validate these characteristics of different TAM subtypes.</p><p><strong>Results: </strong>We identified three TAM subtypes, including CCL20⁺ TAMs with proinflammatory and anti-tumor properties, APOE⁺ TAMs with lipid-metabolism and pro-tumor properties, and SLC40A1⁺ TAMs with immunosuppressive and pro-tumor properties. APOE⁺ TAMs might be intermediate state during macrophage polarization and foster a desmoplastic niche by the fibroblast-derived collagen pathways. SLC40A1⁺ TAMs might play an immunosuppressive role by the fibroblast-derived MIF pathways and the high expression of LGALS9. CRC with enriched CCL20⁺ and APOE⁺ TAMs were characterized by high prevalence of deficient-mismatch repair (27.9%) and might achieve more benefit from immunotherapy.</p><p><strong>Conclusion: </strong>This single-cell study established an accurate classification system of CRC TAMs, unveiling their diverse roles in modulating tumor biology and assisting in treatment options of CRC patients.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13381-13396"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crosstalk Between Cell Death and the cGAS-STING Pathway in Sepsis-Associated Acute Lung Injury.","authors":"Xuelin Li, Min Wang, Yifan Li, Ying Huang, Xiangcheng Zhang","doi":"10.2147/JIR.S543273","DOIUrl":"10.2147/JIR.S543273","url":null,"abstract":"<p><p>Sepsis-associated acute lung injury (ALI) is a complex pathological condition characterized by dysregulated inflammatory responses and the activation of various cell death mechanisms. This review examines the interplay between cell death pathways and the cGAS-STING signaling pathway in sepsis-associated ALI. The cGAS-STING pathway, which recognizes pathogen-derived DNA to trigger innate immune responses, can exacerbate lung injury when dysregulated. Recent studies have revealed that apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, NETosis, and PANoptosis are all intricately linked to the cGAS-STING pathway. These cell death mechanisms interact synergistically to amplify inflammation and tissue damage. Targeting the cGAS-STING pathway has been shown to reduce both inflammation and cell death in sepsis-associated ALI. For instance, inhibiting the stimulator of interferon genes (STING) pathway can mitigate ferroptosis and inflammation in macrophages, suggesting its potential as a therapeutic target. Furthermore, exosome-based therapies that modulate immune responses and promote tissue repair are emerging as promising strategies for treating ALI. However, further research is needed to fully elucidate the specific mechanisms through which the cGAS-STING pathway regulates cell death and inflammation in ALI. Additionally, exploring combination therapies that integrate STING inhibitors with other treatments, such as anti-inflammatory agents, may offer improved clinical outcomes in sepsis-associated ALI.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13291-13312"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreasing Procalcitonin and Its Ratio to Albumin Predict Mortality in Patients with Abdominal Sepsis.","authors":"Qiang Li, Zhuo-Chen Lyu, Le-Le Zhang, Yi-Ran Li, Jia-Ying Chen, Ya-Wei Yuan","doi":"10.2147/JIR.S523827","DOIUrl":"10.2147/JIR.S523827","url":null,"abstract":"<p><strong>Purpose: </strong>Abdominal sepsis may act as a life-threatening disease characterized by a dysregulated inflammatory response and nutritional deficits. Given the complex interplay between inflammation and malnutrition, integrating these biomarkers may provide a more comprehensive understanding of patients' outcomes and improve early prognosis in the intensive care unit (ICU). Herein, we report the predictive value of procalcitonin (PCT) and its ratio to albumin (ALB) for mortality of abdominal sepsis patients, aiming to provide more references for clinical disease management.</p><p><strong>Patients and methods: </strong>This is a retrospective study involving one hundred and twenty-four patients diagnosed with abdominal sepsis. Kaplan-Meier survival analysis was utilized to analyze the 30- and 90-day mortality of patients. Univariable and multivariable Cox regression analyses were conducted to confirm the prognostic factors. In addition, ROC analyses were performed to evaluate the diagnostic efficiency.</p><p><strong>Results: </strong>An 80% decrease of PCT within 4 days was identified as a cutoff to predict the 30-day (<i>P</i> = 0.032) and 90-day mortality (<i>P</i> = 0.030) with the help of Kaplan-Meier analysis. In the multivariate Cox regression analysis, the PCT decrease/ALB was an independent prognostic factor for 30-day mortality (<i>P</i> <0.05) and 90-day mortality (<i>P</i> <0.05) before and after adjustment for age, gender, and BMI. Moreover, ROC analysis revealed the significance of PCT and PCT decrease/ALB in predicting 30-day and 90-day mortality.</p><p><strong>Conclusion: </strong>In conclusion, the decrease in PCT and the ratio of PCT decrease/ALB are promising biomarkers to predict mortality in patients with abdominal sepsis.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13413-13422"},"PeriodicalIF":4.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged Acute Kidney Injury and Symmetrical Peripheral Gangrene: A Rare Case Report of Acute Promyelocytic Leukemia.","authors":"Yu-Ke Kong, Hong Shu, Wen-Jun Zhang, Chong-Yang Wu","doi":"10.2147/JIR.S533309","DOIUrl":"10.2147/JIR.S533309","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is a serious complication of acute promyelocytic leukemia (APL). However, symmetric peripheral gangrene (SPG) and AKI have rarely been reported in this disease. Here we present the case of a patient who developed life-threatening APL complicated by AKI and SPG. Laboratory investigations revealed disseminated intravascular coagulation (DIC), respiratory failure, renal insufficiency, hepatic insufficiency, cardiac failure, and infection with multiple pathogens, including: novel coronavirus disease (COVID-19), candida monda, saccharomyces capitis, aspergillus fumigatus, candida lusitaniae, aspergillus flavus. One month later, the patient was off the ventilator, but his renal function needed hemodialysis. He also developed SPG, particularly the fingers of the hands and feet. After two months, the patient was discharged from hospital with normal liver and heart function. Four months after discharge, the patient's APL was on the mend, but some of the gangrenous sites had undergone autoamputation. Therefore, AKI and SPG are complex clinical complications in APL that pose significant challenges to clinicians. In addition to coagulopathy, the presence of COVID-19 and DIC worsened the clinical outcomes. At the same time, we extensively reviewed the literature to provide a comprehensive analysis of the pathogenesis and management strategies of these complications.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"13313-13318"},"PeriodicalIF":4.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}