Journal of Inflammation Research最新文献

{"title":"Clinical Characteristics and Mechanism Discussion of Peripheral Nerve Injury in 2 Cases of Severe Viral Meningoencephalitis.","authors":"Xiaosu Guo, Mengyi Zheng, Zibin Wei, Jianghua Song, Xue Wang, Zhiyuan Shen, Xin Guo, Nan Zhang, Yuan Xing, Yaxin Zhang, Wei Zhang, Runxuan Du, Bo Qiu, Shujuan Tian, Zhiwei Wang","doi":"10.2147/JIR.S505159","DOIUrl":"10.2147/JIR.S505159","url":null,"abstract":"<p><strong>Purpose: </strong>Peripheral neuropathy(PN) secondary to central nervous system(CNS) infections is rare in clinical practice. This study analyze the prognosis, clinical characteristics, and outcomes of patients with PN secondary to CNS infections to aid early diagnosis and improve prognosis.</p><p><strong>Methods: </strong>Clinical data from two patients admitted to our Neurology Department with PN secondary to severe viral meningoencephalitis were collected, summarized, and analyzed. Using diagnostic tools like body fluid tests, imaging, EEG, and EMG, and based on the criteria of the International Encephalitis Consortium, encephalitis was diagnosed in Case 1 and Case 2. The European Academy of Neurology/Peripheral Nerve Society recommendations were applied to confirm patients' PN diagnosis.</p><p><strong>Results: </strong>Patient 1 was diagnosed with encephalitis, presenting with elevated serum IL-6 levels, and received IVIG treatment upon admission. One week later, the infection remitted and IL-6 levels decreased. Physical and EMG examinations revealed peripheral nerve demyelination damage. After treatment, the nerve damage improved, and the patient had a good prognosis post-discharge. Upon admission, Patient 2 exhibited viral meningoencephalitis symptoms, with elevated serum IL-8 and normal IL-6 levels; limb muscle strength and tone were normal. Five days later, the infection deteriorated, accompanied by reduced lower limb strength, and elevated IL-6 and IL-8 in serum and CSF, with a striking peak of CSF IL-6. EMG confirmed peripheral nerve demyelination and axonal damage. Following 5-day IVIG treatment, IL-6 and IL-8 levels in serum and CSF declined. Peripheral nerve injury recovery was modest despite treatment, and the patient's prognosis remained moderate.</p><p><strong>Conclusion: </strong>This study reported two rare cases of PN following CNS infection. Comparative analysis of symptoms, cytokine in body fluids, treatments, disease courses, and prognosis indicates that elevated peripheral and/or central cytokines, particularly IL-6 and IL-8, correlate with the severity and prognosis of this complication. IVIG modulates inflammation, and its administration timing likely determines differential outcomes.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6397-6410"},"PeriodicalIF":4.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pan-Immune-Inflammation Value as a Prognostic Biomarker for Hepatocellular Carcinoma Patients Undergoing Hepatectomy.","authors":"Hongyuan Fu, Yubo Wang, Bangde Xiang","doi":"10.2147/JIR.S521603","DOIUrl":"10.2147/JIR.S521603","url":null,"abstract":"<p><strong>Purpose: </strong>Hepatocellular carcinoma (HCC) poses a substantial threat to global health, characterized by its high incidence and mortality rates. This research aims to assess the prognostic value of a systematic serum inflammation index, the pan-immune-inflammation value (PIV), in patients with HCC who have undergone hepatectomy.</p><p><strong>Patients and methods: </strong>A total of 1764 HCC patients who underwent surgery were included in the study. These patients were divided into two groups based on the median PIV value. The Cox regression model was utilized to ascertain the independent risk factors that influence the prognosis of patients. A PIV-based nomogram was constructed and its performance was evaluated by the C-index, calibration curve, ROC curve, and DCA curve. Finally, a comparison was made between the nomogram and existing staging models.</p><p><strong>Results: </strong>Patients with elevated PIV exhibited diminished OS and RFS compared to those with lower PIV. Univariate and multivariate Cox analyses revealed that PIV is an independent predictor of prognosis. The PIV-based nomogram demonstrated excellent discrimination, calibration, and clinical net benefit. The proposed nomogram outperformed the other existing staging systems, as evidenced by a higher AUC value.</p><p><strong>Conclusion: </strong>PIV exhibits potential as a prognostic factor for both OS and RFS in patients with HCC who have undergone hepatectomy. The PIV-based nomogram can serve as an additional tool in conjunction with the existing liver cancer staging system, thereby facilitating more personalized treatment decisions for clinicians.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6411-6425"},"PeriodicalIF":4.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Based Mortality Risk Prediction Model in Patients with Sepsis.","authors":"Ye Zhang, Chen Li, Yilin Ji, Bing Wei, Shubin Guo, Xue Mei, Junyu Wang","doi":"10.2147/JIR.S502837","DOIUrl":"10.2147/JIR.S502837","url":null,"abstract":"<p><strong>Objective: </strong>The aim of our study was to establish and validate a machine learning-based predictive model for mortality risk in elderly patients with sepsis. By integrating traditional biomarkers, novel biomarkers, clinical data, and established scoring systems, the model seeks to enhance predictive accuracy and thereby improve clinical outcomes in high-risk patient population.</p><p><strong>Methods: </strong>Conducted at Beijing Chao-Yang Hospital from August 2021 to August 2023, our study included 180 emergency department patients meeting Sepsis 3.0 diagnostic criteria. Data collected included patient demographics, vital signs, laboratory parameters, disease-related scores, major comorbidities, and the 28-day mortality. Variables were analyzed using univariate analysis and LASSO regression, and the machine learning model was constructed using R statistical software and validated internally via bootstrap resampling and calibration curves.</p><p><strong>Results: </strong>The model identified seven significant variables: SOFA, APACHE II, MAP, ALB, PCT, LTB, and VEGF. These variables constituted our final prediction model, which achieved an AUC of 0.845 (95% CI: 0.786, 0.905), with a sensitivity of 75.9% and a specificity of 85.0%. Internal validation yielded a bootstrap-corrected AUC of 0.857 (95% CI: 0.799, 0.912), confirming the model's statistical robustness. The nomogram provided a visual tool for predicting 28-day mortality risk, and decision curve analysis demonstrated strong potential for clinical utility.</p><p><strong>Conclusion: </strong>The predictive model, which incorporates SOFA, APACHE II, MAP, ALB, PCT, LTB, and VEGF, shows significant potential in predicting the 28-day mortality risk for elderly sepsis patients. It provides a convenient and rapid tool for clinical use. Further research with larger sample sizes and external validation is warranted to confirm these findings and enhance the model's applicability.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6427-6437"},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>CLEC3B</i> as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes.","authors":"Kai Nan, Lei Zhang, Yulong Peng, Jing Huang, Su Yin, Yujia Zou, Kaikai He, Ming Zhang","doi":"10.2147/JIR.S517595","DOIUrl":"10.2147/JIR.S517595","url":null,"abstract":"<p><strong>Background: </strong>Despite the emergence of in vitro and in vivo experiments validating the connection between <i>CLEC3B</i> and various cancers, a comprehensive pan-cancer investigation remains elusive. In this study, we explored the potential roles of <i>CLEC3B</i> as a tumor suppressor and in immune function across multiple cancer types.</p><p><strong>Methods: </strong>We visualized outcomes derived from Gene Expression Omnibus (GEO) and diverse online databases. The relationship between tumor-infiltrating cells, gene set enrichment analysis (GSEA) and CLEC3B expression and was examined using R. Additionally, we explored the potential role of CLEC3B in tumor malignant behavior by using siRNA-mediated knockdown.</p><p><strong>Results: </strong>Our study identifies <i>CLEC3B</i>'s low expression in majority of cancers compared with adjacent normal tissues. Reduced <i>CLEC3B</i> expression correlated with advanced clinical stages, inferior overall survival (OS) and DNA methylation levels. We observed significant positive associations between <i>CLEC3B</i> expression and infiltration levels of various immune cell subtypes. Furthermore, markers linked with immune checkpoints, immunomodulation and RNA modification exhibited a favorable correlation with <i>CLEC3B</i> expression. Intriguingly, silencing <i>CLEC3B</i> (si-<i>CLEC3B</i>) augmented the migratory capabilities of pancreatic adenocarcinoma (PAAD) cells. Additionally, <i>CLEC3B</i> expression was notably enriched in metastatic PAAD endothelial cells and extracellular vesicles, potentially implicating its involvement in tumor vascular function by way of extracellular vesicle.</p><p><strong>Conclusion: </strong>In conclusion, our initial pan-cancer analyses of <i>CLEC3B</i> provide insights into its associations with clinical prognosis, DNA methylation, immune cell infiltration, and tumor mutation burden, highlighting its potential as a tumor suppressor and mediator of immune infiltration in pan-cancer.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6381-6396"},"PeriodicalIF":4.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Fatty Acid Metabolism Disorder-Related Gene Signature in Septic Cardiomyopathy.","authors":"Liman Li, Tiancong Zhang, Chuan Yang, Qiang Meng, Shuang Wang, Yang Fu","doi":"10.2147/JIR.S477110","DOIUrl":"10.2147/JIR.S477110","url":null,"abstract":"<p><strong>Background: </strong>Septic cardiomyopathy (SCM) is a prevalent complication of sepsis and a primary contributor to mortality in patients with sepsis. Although fatty acid metabolism (FAM) is known to regulate cardiac function, its specific role in the pathogenesis of SCM remains unclear.</p><p><strong>Methods: </strong>The SCM datasets were obtained from the NCBI GEO database. Differentially expressed genes (DEGs) were subjected to GO and KEGG pathway analyses. The fatty acid metabolism-related genes were obtained from the MSigDB database. CytoHubba and machine learning algorithms identified hub FAM-DEGs. Associated transcriptional factors and miRNAs of hub FAM-DEGs were predicted using Cytoscape software and miRWalk 3.0 database. The immune infiltration pattern in SCM was analyzed using the ImmuCellAI tool. The relationship between hub FAM-DEGs and immune infiltration abundance was investigated using Spearman method. Hub FAM-DEGs expression levels were validated in clinical samples and mouse models.</p><p><strong>Results: </strong>Five hub FAM-DEGs associated with SCM were identified, including <i>Hsd17b7, Dhcr24, Cyp1a1, Ephx1</i> and <i>Hmgcs2</i>. Immune analysis revealed significantly increased infiltrations of granulocytes, monocytes, M1 macrophage and neutrophils in the SCM group. Spearman analysis demonstrated that the hub FAM-DEGs were positively associated with the infiltration of pro-inflammatory immune cells. In Vivo, Down-regulations of Dhcr24 mRNA and protein levels in cardiac tissues were observed in the SCM mouse group. Clinically, the plasma concentration of DHCR24 was significantly decreased in patients with SCM.</p><p><strong>Conclusion: </strong>This study revealed fatty acid metabolism played a crucial role in SCM and identified DHCR24 may act as a potential diagnostic biomarker and therapeutic target in SCM.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6363-6380"},"PeriodicalIF":4.2,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Research on the P2X7 Receptor: A Bibliometric and Visualization Analysis.","authors":"Chao Ren, Jingjing Zhang, Ting Yang, Yao Wang, Xiaoyu Song, Hanrui Wang, Wanchen Liu, Yakui Mou, Xicheng Song","doi":"10.2147/JIR.S522380","DOIUrl":"10.2147/JIR.S522380","url":null,"abstract":"<p><p>The P2X7 receptor (P2X7R), activated by ATP, participates in mediating a variety of biological processes such as the release of inflammatory factors, thereby affecting the pathogenesis of numerous diseases. Despite its clinical significance, comprehensive bibliometric studies on P2X7R-related research remain scarce. To address this gap, we conducted a bibliometric investigation to quantify publication outputs, identify leading contributors, and map geographical distributions of P2X7R-related research, ultimately elucidating current research frontiers and emerging trends. Utilizing visualization techniques, complex bibliometric relationships were transformed into interpretable graphical representations. Our Web of Science query for \"P2X7R\" identified 4551 original research articles by 13,471 authors published since 1985. Publication volume demonstrated sustained growth, with China emerging as the predominant contributor in quantitative output (1871 articles) and the United States leading in international collaborations. Thematic mapping revealed two principal research areas: \"P2X7R, inflammation, microglia\" and \"P2X7R, apoptosis, purinergic\". Notably, \"P2X7R, P2 receptors, oxidative stress\" encompassed both motor and niche themes, thus representing the trajectory of future development potential. Through bibliometric and visualization analysis, we found that the literature related to P2X7R is on the rise and will enter a new stage of interdisciplinary integration development in the future.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6349-6362"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFN-γ Induces Pleural Mesothelial Cells to Recruit Immune Cells via CXCL10-CXCR3 Axis in a Mouse Pleurisy Model [Retraction].","authors":"","doi":"10.2147/JIR.S540101","DOIUrl":"https://doi.org/10.2147/JIR.S540101","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/JIR.S496037.].</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6347-6348"},"PeriodicalIF":4.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCL1 and CXCL2: Key Regulators of Host Defense Against <i>Phialophora verrucosa</i>.","authors":"Jiejie Lu, Qi Dong, Ruijun Zhang, Weiwei Wu, Huilan Yang","doi":"10.2147/JIR.S518653","DOIUrl":"10.2147/JIR.S518653","url":null,"abstract":"<p><strong>Purpose: </strong>Dematiaceous fungi, such as <i>Phialophora verrucosa</i> (<i>P. verrucosa</i>), cause persistent infections that are difficult to treat. The purpose of this study was to investigate the roles of chemokines CXCL1 and CXCL2 in the innate immune defense against <i>P. verrucosa</i> infections.</p><p><strong>Methods: </strong>A subcutaneous infection model was employed, in which live <i>P. verrucosa</i> conidia were administered into the footpads of wild-type C57BL/6 mice and their <i>Cxcl1</i> and <i>Cxcl2</i> knockout (KO) counterparts (equal numbers of male and female mice). The natural course of infection, pathological changes, and immune responses were monitored continuously over four weeks.</p><p><strong>Results: </strong>The current results show that both CXCL1 and CXCL2 deficiencies impair fungal clearance, leading to prolonged infection as evidenced by higher fungal loads and histopathology in <i>Cxcl1</i>/<i>Cxcl2</i> KO mice at week 4. In <i>Cxcl1</i> KO mice, increased levels of inflammatory cytokines IFN-γ, G-CSF, and IL-4 were observed, likely compensating for the immunological deficiencies caused by the lack of CXCL1. Conversely, <i>Cxcl2</i> KO mice exhibited impaired neutrophil infiltration early in infection, accompanied by a significant increase in macrophage infiltration.</p><p><strong>Conclusion: </strong>These findings highlight the critical roles of CXCL1 and CXCL2 in mounting an effective immune response against dematiaceous fungi and suggest their potential as therapeutic targets.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6319-6329"},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Immune-Related Transcription Control/Regulation in Intracranial Aneurysm Through KEGG Analysis and in-vivo Validation.","authors":"Jianjun Huang, Shuya Gao, Shunli Liu, Li Liu","doi":"10.2147/JIR.S506360","DOIUrl":"10.2147/JIR.S506360","url":null,"abstract":"<p><strong>Background: </strong>Intracranial aneurysms (IAs), a leading cause of subarachnoid hemorrhage, rank second only to cerebral thrombosis and hypertensive intracerebral hemorrhage among cerebrovascular diseases. However, the understanding of the regulatory mechanisms associated with IAs remains limited currently.</p><p><strong>Methods: </strong>We obtained the GSE122897 dataset and analyzed differential expression genes (DEGs) from control, Ruptured intracranial aneurysm (RIA) and Unruptured intracranial aneurysm (UIA) samples under varied conditions. The correlation and differences of immune cell types across groups were examined. TF-target genes were obtained from the hTFtarget database, five immune-related TFs were identified and their expression was normalized and validated in an IA mouse model via qRT-PCR and Western blot analysis.</p><p><strong>Results: </strong>1852 up-regulated and 971 down-regulated DEGs in Control vs RIA, 583 up-regulated and 389 down-regulated genes in Control vs UIA groups. Most DEGs enriched in immune response, such as circulating immunoglobulin, immunoglobulin mediated immune response and B cell mediated immunity. A TF-target regulatory network of these DEGs were predicted and suggested that TF RUNX3 has the most target genes, including SBDS, ARTN, LTA, GMFB and so on. qRT-PCR and Western blot validated the higher expression of DBP, NR3C2 and ZNF711, and lower expression of RUNX3 and ZFN711 in IA mice.</p><p><strong>Conclusion: </strong>5 key TFs DBP, RUNX3, SPIB, NR3C2 and ZNF711 were found to be related to immune response and their up/down-regulated expression were observed in IA mice. As RUNX3, SPIB and NR3C2 shared common target genes, they may involved in co-regulated pathway during IA progression.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6305-6317"},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between PhenoAgeAccel and Clinical Outcomes in Atrial Fibrillation Patients Undergoing Radiofrequency Catheter Ablation.","authors":"Zhihao Zhao, Xiaoqin Hu, Chaoqun Zhang, Chengzong Li, Fengyun Zhang, Yu Yang","doi":"10.2147/JIR.S517228","DOIUrl":"10.2147/JIR.S517228","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between phenotypic age (PhenoAge) and accelerated phenotypic age (PhenoAgeAccel) and recurrence of atrial fibrillation (AF) in patients after radiofrequency catheter ablation (RFCA).</p><p><strong>Patients and methods: </strong>Preoperative PhenoAge and PhenoAgeAccel were determined in AF patients undergoing RFCA. We used logistic regression models and subgroup analysis to study the relationship between PhenoAge and PhenoAgeAccel and the risk of AF recurrence. As for revealing the value of PhenoAgeAccel in predicting AF recurrence, the ROC curve analysis was performed. To further detect the enhancement role of in PhenoAgeAccel in the APPLE score and a model of established risk factors in predicting AF recurrence, C-statistics, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) was conducted.</p><p><strong>Results: </strong>A total of 322 patients with AF who underwent RFCA in our hospital were included in the present study. The mean follow-up period was 21 months. The frequency of AF recurrence increased gradually as the PhenoAgeAccel index rose. The optimal cut-off value of the PhenoAgeAccel index was -0.338. Patients with PhenoAgeAccel ≥ -0.338 had a significantly greater likelihood of experiencing recurrent AF than those with PhenoAgeAccel <-0.338 (OR 3.989, 95% CI 2.006-7.933, <i>p </i>< 0.001). The association was also reflected in each subgroup. Incorporating the PhenoAgeAccel into the APPLE score and the existing model of established risk factors for recurrence may result in enhancements to the C-statistics, NRI and IDI (<i>p</i><0.05), respectively.</p><p><strong>Conclusion: </strong>PhenoAgeAccel was positively and independently associated with AF recurrence following RFCA.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"6293-6304"},"PeriodicalIF":4.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}