Journal of Inflammation Research最新文献

{"title":"Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease.","authors":"Jianhua Gong, Zhijie Qin, Yihao Xiao, Jixue Li, Qing Wang, Liping Lei, Jiangfa Li","doi":"10.2147/JIR.S525168","DOIUrl":"10.2147/JIR.S525168","url":null,"abstract":"<p><strong>Objective: </strong>To assess causal links between senescence-related genes and non-alcoholic fatty liver disease (NAFLD) using summary-data Mendelian randomization (SMR) and colocalization analyses.</p><p><strong>Methods: </strong>Our study examined the relationship between senescence and NAFLD by integrating DNA methylation, gene expression, and protein quantitative trait loci (mQTL, eQTL, and pQTL) data. Summary statistics for NAFLD were sourced from a previous study (discovery) and the FinnGen database (replication), with additional cohorts for nonalcoholic steatohepatitis and liver fibrosis. Genetic variants near senescence-related genes were used as instrumental variables to assess causal relationships. Colocalization analysis was performed to confirm shared causal variants and liver-specific eQTL data were used for validation. Furthermore, we validated findings using cell and mouse models of NAFLD. Cell models were treated with oleic acid, and NAFLD mice were induced using a high-fat diet.</p><p><strong>Results: </strong>We identified 40 mQTLs, 9 eQTLs, and 3 pQTLs significantly linked to NAFLD in the discovery cohort. Multi-omics data highlighted three genes-<i>S100A6, ENDOG</i>, and <i>TP53I3</i>-as potential causal contributors. Notably, S100A6 was confirmed at both the methylation sites (cg24155129 and cg01910639) and gene expression levels, with methylation at these CpG sites significant regulating its expression. Liver-specific validation revealed that <i>ENDOG</i> expression was negatively associated with NAFLD, consistent with findings in blood. Finally, differential expression of all three genes was confirmed in cell models, with S100A6 and <i>ENDOG</i> further validated in a mouse model.</p><p><strong>Conclusion: </strong>Our findings suggest that <i>S100A6, ENDOG</i>, and <i>TP53I3</i> are associated with NAFLD, providing insights for further research into the disease's underlying etiology.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8821-8833"},"PeriodicalIF":4.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction for Acute Biliary Pancreatitis After Laparoscopic Cholecystectomy.","authors":"Dacheng Yue, Shixiang Hu","doi":"10.2147/JIR.S531707","DOIUrl":"10.2147/JIR.S531707","url":null,"abstract":"<p><strong>Background: </strong>Acute biliary pancreatitis (ABP), caused by biliary stones, is a severe inflammatory condition with high mortality rates. ABP recurrence is often linked to gallstones, necessitating effective treatment strategies. Despite recent advancements, the prediction of ABP occurrence following LC continues to present challenges, indicating the need for ongoing research and model refinement.</p><p><strong>Purpose: </strong>This study aims to develop a predictive model for assessing the risk of post- Laparoscopic cholecystectomy pancreatitis in patients with gallstones.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 968 patients who underwent LC. The patients were divided into the training set and validation set to develop and validate the predictive model. Demographic, clinical, and laboratory data were collected, and univariate and multivariate logistic regression analyses identified risk factors for ABP. A nomogram was constructed, and model performance was assessed using ROC curves, calibration, and decision curve analysis.</p><p><strong>Results: </strong>The incidence of ABP was 9.07% in the training set and 14.43% in the validation set. Significant predictors of post-LC pancreatitis included baseline APACHE II score, choledocholithiasis, number of intubation attempts, timing of cholecystectomy, and biochemical markers (C-reactive protein, white blood cell, red cell distribution width, D-dimer, neutrophils, triglycerides). The predictive model demonstrated high discriminative ability with a receiver operating characteristic value of 0.949 (training set), of folds 1-5 ranged from 0.855 to 0.962 (5-fold cross-validation), and 0.922, (external validation set). Calibration curves confirmed stable prediction performance, and decision curve analysis indicated high net benefit across a range of threshold probabilities.</p><p><strong>Conclusion: </strong>The developed model effectively predicts the risk of post-LC pancreatitis in patients with gallstones, offering valuable guidance for clinical decision-making. Early identification of high-risk patients could improve treatment outcomes and reduce recurrence rates.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8835-8849"},"PeriodicalIF":4.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Targeted Therapeutic Strategies in Sepsis-Induced Myocardial Dysfunction: The Role of NLRP3 Inflammasome-Mediated Inflammation.","authors":"Yuan-Yuan Yu, Rong Wang, Guo-Qing Chen, Yu-Fang Gui, Juan Ma, Jin-Hai Ma, Shu-Jing Li","doi":"10.2147/JIR.S521655","DOIUrl":"10.2147/JIR.S521655","url":null,"abstract":"<p><p>Sepsis is a systemic inflammatory response syndrome triggered by infection, in which excessive immune responses can lead to multiple organ failure and shock. The heart, as one of the critical target organs in sepsis, is significantly impaired, which substantially increases the risk of mortality. Recent studies have increasingly highlighted the role of dysregulated inflammatory responses in the pathogenesis and progression of sepsis-induced myocardial dysfunction (SIMD). Among the key molecular mechanisms regulating various pathophysiological processes and modulating inflammation is the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3(NLRP3) inflammasome. This study aims to explore the role of the NLRP3 inflammasome in the pathogenesis of SIMD, with a focus on its involvement through pathways such as pyroptosis, oxidative stress, autophagy, mitochondrial damage, exosome release, and endoplasmic reticulum stress in the development of SIMD. Furthermore, the research seeks to uncover the potential key roles of the NLRP3 inflammasome in the underlying pathophysiological mechanisms of SIMD. Finally, the study will investigate NLRP3 inflammasome-based therapeutic strategies for targeting SIMD, providing theoretical support for the development of targeted management for SIMD.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8875-8897"},"PeriodicalIF":4.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danshensu Ethyl Ester Alleviates LPS-Induced Acute Lung Injury by Targeting the NLRP3 Inflammasome.","authors":"Wensi Ding, Sen Xu, Shuyang Xie, Yao Dong, Yujie Jiang, Ning Xie, Pingyu Wang, Jiankai Feng, Guiwu Qu","doi":"10.2147/JIR.S517701","DOIUrl":"10.2147/JIR.S517701","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether Danshensu ethyl ester (DEE) can attenuate acute lung injury (ALI) and explore the detailed mechanism.</p><p><strong>Methods: </strong>The ALI model was induced in mice using LPS. The effects of DEE on lung wet-to-dry weight ratio (W/D), bronchoalveolar lavage fluid (BALF) protein levels, and neutrophil infiltration (neutrophils) were assessed. In addition, molecular docking and molecular dynamics simulations were also carried out to determine the binding situation between DEE and NLRP3. We evaluated in both in vivo and in vitro models the expression of NLRP3-related proteins as well as the release of cytokines. The generation of reactive oxygen species (ROS) and the formation of ASC fluorescent specks in cells were also observed.</p><p><strong>Results: </strong>The results demonstrated that DEE significantly alleviated pulmonary edema and lung injury of mice. Molecular docking and simulations revealed that DEE directly targets and tightly binds to the NLRP3 protein. Furthermore, both in vivo and in vitro experiments showed that DEE suppressed activation of the NF-κB signaling pathway induced by LPS, and decreased the expression of NLRP3, ASC, and cleaved caspase-1, inhibiting the release of cytokines such as IL-1β, IL-6, and TNF-α. Additionally, DEE suppressed ROS generation and ASC specks formation, thereby inhibiting the assembly and activation of the NLRP3 inflammasome.</p><p><strong>Conclusion: </strong>DEE exerts an inhibitory influence on the LPS-induced inflammatory response by suppressing the activation of the NLRP3 inflammasome. This study provides the potential application of DEE in NLRP3-driven ALI therapy.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8767-8785"},"PeriodicalIF":4.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease.","authors":"Jinhui Wu, Penghui Yang, Jing Zhang, Zhuo Chen, Yi Wei, Ya Su, Qijian Yi","doi":"10.2147/JIR.S519589","DOIUrl":"10.2147/JIR.S519589","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting children and is a leading cause of acquired heart disease in developed countries. Recently, an increasing number of studies have demonstrated the close correlations between inflammation and KD. Thymosin β4 (Tβ4) has been reported to play a role in cardiovascular protection and repair by modulating inflammation, angiogenesis, and endothelial function. However, its role in KD still remains poorly understood. This study aims to explore the potential involvement of Tβ4 in the pathogenesis of KD, with a particular focus on its relationship to inflammation and coronary artery lesions (CALs).</p><p><strong>Methods: </strong>Serum Tβ4 levels were measured using enzyme-linked immunosorbent assay (ELISA) in children with KD and age-matched healthy controls. The KD group was further categorized into patients with and without CALs. Correlation analyses were performed between Tβ4 levels and clinical or laboratory parameters.</p><p><strong>Results: </strong>Serum Tβ4 levels were significantly lower in patients with KD compared to healthy controls and were further reduced in patients with CALs. After intravenous immunoglobulin (IVIG) treatment, Tβ4 levels significantly increased. Tβ4 levels were negatively correlated with several pro-inflammatory (eg, TNF-α, IL-1β) and anti-inflammatory cytokines (eg, IL-4, IL-10).</p><p><strong>Conclusion: </strong>Tβ4 levels were significantly lower in children with KD, particularly in those with CALs. These findings suggest that Tβ4 may be involved in the inflammatory pathogenesis of KD and the progression of CALs, thus could represent a potential target for future diagnostic or therapeutic interventions.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8755-8765"},"PeriodicalIF":4.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Platelet-to-Lymphocyte Ratio and Tricuspid Regurgitation Velocity in Patients with Light-Chain Myocardial Amyloidosis.","authors":"Yingxin Zhu, Chen Gong, Jinglin Hu, Tiankuo Gao, Cuicui Feng, Chun Yang, Yini Wang","doi":"10.2147/JIR.S520998","DOIUrl":"10.2147/JIR.S520998","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the prognostic value of inflammatory indexes and novel echocardiographic parameters in light-chain myocardial amyloidosis (AL-CA) patients.</p><p><strong>Methods: </strong>We retrospectively collected clinical, laboratory, electrocardiography and echocardiographic parameters of patients. The prognostic value of inflammation indexes and echocardiographic parameters was assessed, and the association of inflammation indexes with cardiac function and the type of light chain (AL) was analyzed.</p><p><strong>Results: </strong>In total, 83 biopsy-proven AL-CA patients were studied (age: 61.42±10.7 years; 68.7% male). The inflammation indexes [PLR (Platelet-to-Lymphocyte ratio), NLR (Neutrophil-to-Lymphocyte ratio), NMLR ((Neutrophil+Monocyte)-to-Lymphocyte ratio), SIRI ((Monocyte × Neutrophil)-to-Lymphocyte ratio), SII ((Platelet × Neutrophil)-to-Lymphocyte ratio), (all P<0.001)] and echocardiographic parameter TRV (Tricuspid Regurgitation Velocity), (P=0.005) were significantly higher in deceased patients compared with survivors. Multivariate COX regression analysis indicated that PLR, TRV, Lymphocyte (LYM) and Left Ventricular Ejection Fraction (LVEF) were independent outcome predictors. The PLR, TRV, and the combined indicator (PLR+TRV) showed great value in predicting short-term prognosis. The likelihood ratio χ2 test showed that PLR and TRV added predictive values to the Mayo04, Mayo12, and Euro15 models. The Spearman correlation analysis demonstrated a positive correlation between the inflammation indexes and New York Heart Association (NYHA) class, Mayo04 stage, Mayo12 stage, and Euro15 stage. Additionally, the NLR (P<0.001), NMLR (P=0.002), SIRI (P=0.029), and SII (P<0.001) were higher in Lambda than in Kappa light-chain patients.</p><p><strong>Conclusion: </strong>Our study revealed that PLR and TRV were valid predictors of short-term survival in AL-CA, and the levels of several inflammation indexes correlated with the severity of cardiac involvement and AL subtype.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8787-8804"},"PeriodicalIF":4.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zhongfeng Xingnao Liquid Ameliorated the Early Impairment of Intracerebral Hemorrhage by Inhibiting NF-κB/NLRP3 Axis in Rats.","authors":"Heyu Yang, Bingqian Luo, Yifan Du, Jiafu Guo, Shiqi Zhang, Ping Wang, Yuan Dai, Yun Lu, Shijun Xu","doi":"10.2147/JIR.S528358","DOIUrl":"10.2147/JIR.S528358","url":null,"abstract":"<p><strong>Background: </strong>Perihematomal neuroinflammation serves as a pivotal pathogenic driver of secondary brain injury during the acute stage of intracerebral hemorrhage (ICH). The traditional Chinese medicine Zhongfeng Xingnao Liquid exhibits anti-neuroinflammatory effects. This study aims to elucidate the optimal timing for ZFXN administration within hours of symptom onset and its underlying mechanisms, focusing on NF-κB/NLRP3-mediated neuroinflammation.</p><p><strong>Methods: </strong>ICH was induced by injection of autologous arterial blood into the left caudal nucleus. Neurological deficits scores, hematoma volume, cerebral blood flow (CBF), H&E and Nissl staining were conducted at 24 hours following ICH. The levels of neuroinflammation response and NF-κB/NLRP3 axis surrounding the hematoma were measured using immunofluorescent staining and Western blot. The inhibition of ZFXN on NF-κB/NLRP3 axis was further confirmed in Lipopolysaccharide (LPS)-induced BV-2 cells.</p><p><strong>Results: </strong>Post-ICH pathology was characterized by progressive hematoma expansion, elevated neurological deficit scores, neuronal damage, and reduced CBF, accompanied by neuroinflammatory. Early ZFXN intervention within 6 hours post-ICH significantly reduced hematoma volume and improved neurological scores (mNSS, Bederson, Zea Longa) at 24 hours, while markedly alleviating perihematomal neuronal damage and enhancing CBF, with optimal efficacy observed following one-hour administration. The treatment also effectively suppressed IL-1β/TNF-α release and microglial activation through NF-κB/NLRP3 pathway inhibition. Consistently, ZFXN diminished NF-κB-p65 nuclear translocation and downregulated NLRP3 inflammasome components (ASC, Cleaved Caspase-1) in LPS-stimulated BV-2 cells.</p><p><strong>Conclusion: </strong>ZFXN emerges as a promising neuroprotective agent for ICH through targeted inhibition of the NF-κB/NLRP3 inflammatory axis, demonstrating optimal efficacy within the critical 6-hour hyperacute phase by mitigating secondary neuroinflammation and addressing current therapeutic gaps in ICH management.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8805-8819"},"PeriodicalIF":4.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling PANoptosis in Acute Kidney Injury: An Integrative Multi-Dimensional Approach to Identify Key Biomarkers.","authors":"Ning Wang, Lina Zhang, Ziyu Xu, Qin Xu, Yanfang Lu, Peiyuan Niu, Lei Yan, Limeng Wang, Huixia Cao, Fengmin Shao","doi":"10.2147/JIR.S525222","DOIUrl":"10.2147/JIR.S525222","url":null,"abstract":"<p><strong>Background: </strong>Programmed cell death and inflammatory responses are critical in the progression of acute kidney injury (AKI). PANoptosis, a highly regulated and complex form of programmed inflammatory cell death, integrates the molecular mechanisms of apoptosis, pyroptosis, and necroptosis. While this process has been implicated in various inflammatory conditions, its specific role in AKI remains unclear.</p><p><strong>Methods: </strong>The role of PANoptosis in AKI was investigated using single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data. Initially, scRNA-seq was utilized to identify differentially expressed genes (DEGs) associated with apoptosis, pyroptosis, and necroptosis in individual AKI cells. Through integrating these DEGs, a candidate gene set associated with PANoptosis was established. Several machine learning algorithms were employed to determine the optimal feature genes. The diagnostic potential of these genes was examined through receiver operating characteristic curve analysis. Gene set enrichment analyses were performed to explore their relationship with PANoptosis. Further validation was carried out using AKI animal models.</p><p><strong>Results: </strong>PANoptosis levels were significantly elevated in AKI. ScRNA-seq revealed heterogeneity in PANoptosis activity across cell types. Integration of transcriptomic data with machine learning algorithms led to the identification of five key upregulated genes: EGR1, CEBPD, HSPA1A, HSPA1B, and RHOB. The diagnostic potential of these genes was demonstrated with the area under curve values of 0.981 for EGR1, 0.920 for CEBPD, 0.968 for HSPA1A, 0.970 for HSPA1B, and 0.953 for RHOB. Functional enrichment analysis demonstrated a significant positive correlation between the expression of these biomarkers and PANoptosis activity. Validation through Western blot and immunohistochemistry further confirmed their roles in AKI pathogenesis.</p><p><strong>Conclusion: </strong>By integrating scRNA-seq and transcriptomic data, along with the application of innovative methodologies, five key PANoptosis-related genes associated with AKI were identified. Our study offers new insights into the role of PANoptosis in AKI and highlights potential biomarkers for clinical evaluation and therapeutic targeting.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8735-8754"},"PeriodicalIF":4.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Patients with Hepatocellular Carcinoma Receiving HAIC-Based Conversion Hepatectomy: A Dual-Center Retrospective Cohort Study.","authors":"Dong Li, Youwen Fan, Benyi He, Yajun Tang, Gang Deng, Rongping Guo, Min Deng, Di Tang","doi":"10.2147/JIR.S523194","DOIUrl":"10.2147/JIR.S523194","url":null,"abstract":"<p><strong>Background: </strong>Clinical tools for predicting prognosis are limited for patients with hepatocellular carcinoma (HCC) undergoing hepatic arterial infusion chemotherapy (HAIC)-based hepatectomy. This study evaluated the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) in patients with HCC who received HAIC-based hepatectomy.</p><p><strong>Methods: </strong>This dual-center retrospective study included 390 patients who received HAIC-based conversion resection to investigate the relationship of NLR and LMR with survival outcomes, adverse events, and risk factors.</p><p><strong>Results: </strong>A total of 390 patients with HCC who received HAIC-based conversion liver resection were included. Patients with NLR ≥ 5 exhibited a significantly shorter overall survival (OS) and recurrence-free survival (RFS) compared to those with NLR < 5 (<i>P</i> = 0.0181 and <i>P</i> = 0.0164, respectively). Patients with LMR ≥ 3 exhibited favorable OS and RFS rates compared to those with LMR < 3 (<i>P</i> = 0.0195 and <i>P</i> = 0.0225, respectively). Similar results were observed in patients who achieved an objective response. NLR ≥ 5 and LMR < 3 were significantly associated with decreased OS and RFS compared to NLR < 5 and LMR ≥ 3 (<i>P</i> = 0.0131, <i>P</i> = 0.0104, <i>P</i> = 0.0055, and <i>P</i> = 0.0329, respectively).</p><p><strong>Conclusion: </strong>NLR and LMR have an effective predictive capability in prognosis for patients with HCC who received HAIC-based conversion surgery. These findings may help surgeons and patients make decisions regarding HAIC-based conversion hepatectomy.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8675-8688"},"PeriodicalIF":4.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Health and Diabetic Cardiomyopathy: Mechanisms, Biomarkers, and Early Screening Approaches.","authors":"Junhao Fang, Yanlin Wu, Han Wang, Jiale Zhang, Liangzhen You","doi":"10.2147/JIR.S521430","DOIUrl":"10.2147/JIR.S521430","url":null,"abstract":"<p><p>Diabetic Cardiomyopathy (DCM) is a common cardiovascular complication in patients with diabetes. In recent years, the association between oral health and diabetic heart disease has gained increasing attention. This perspective reviews the potential mechanisms of oral diseases in diabetic heart disease, oral indicators for early screening of diabetic heart disease, and proposes future research directions. The potential mechanisms of oral diseases in diabetic heart disease primarily involve abnormal activation of inflammatory responses, dysregulation of the oral microbiome, and immune system disorders. In the context of early screening for diabetic heart disease, oral health indices, salivary biomarkers, and the oral microbiome serve as critical oral indicators with significant clinical value for early diagnosis. Future research should promote interdisciplinary diagnosis and collaboration, develop non-invasive early screening technologies, integrate multimodal and multi-omics oral data, leverage large-scale multicenter clinical data to comprehensively evaluate the association between oral health indicators and diabetic cardiomyopathy, and simultaneously train and validate precise artificial intelligence models. This perspective integrates existing research findings on the role of oral health in diabetic heart disease, highlights current research limitations, and emphasizes the need for further studies to clarify causal relationships and facilitate widespread clinical application.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8689-8704"},"PeriodicalIF":4.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}