Drug Testing and Analysis最新文献_第5页

Response to the Critical Comments on the Article "Infant Death due to Cannabis Ingestion". 对“因吸食大麻导致婴儿死亡”一文中批评意见的回应。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-25 DOI: 10.1002/dta.70055

Donata Favretto, Antonello Cirnelli, Roberto Pertile, Raffaella Stimamiglio, Clara Cestonaro, Anna Pagliaro, Fabio Mattiazzi, Oriana Cuman, Cristina Basso, Maddalena Galeazzi

引用次数: 0

Positive Doping Test Linked to Crumb Rubber From Artificial Football Pitch: Case Report. 人造足球场橡胶屑兴奋剂检测呈阳性：案例报告。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-25 DOI: 10.1002/dta.70067

Astrid Gjelstad, Geir Holden, Per Ole M Gundersen, Yvette Dehnes, Magnus Tvedte, Maren Levernæs, Åse Kjustad Eriksson, Fredrik Lauritzen

引用次数: 0

Critical Comments on the Article "Infant Death due to Cannabis Ingestion" by Favretto et al. in Drug Testing and Analysis (October 2025). 对Favretto等人在《药物测试与分析》（2025年10月）上发表的文章“因摄入大麻导致婴儿死亡”的批评意见。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-25 DOI: 10.1002/dta.70019

Willi Schirmer, Vanessa Hofmann, Wolfgang Weinmann

引用次数: 0

Application of Novel Patent-Based Effervescent Tablet as a Selective Filter for Removing Hazardous Chemical Materials in Hookah Smoke: Determination and Comparison of Toxic Chemical Compounds in Hookah Smoke Versus Cigarette Smoke 新型专利泡腾片选择性过滤水烟烟雾中有害化学物质的应用：水烟烟雾与卷烟烟雾中有毒化学物质的测定与比较。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2026-01-20 DOI: 10.1002/dta.70025

Arastou Raoufi

{"title":"Application of Novel Patent-Based Effervescent Tablet as a Selective Filter for Removing Hazardous Chemical Materials in Hookah Smoke: Determination and Comparison of Toxic Chemical Compounds in Hookah Smoke Versus Cigarette Smoke","authors":"Arastou Raoufi","doi":"10.1002/dta.70025","DOIUrl":"10.1002/dta.70025","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel patent-based effervescent tablet was developed and evaluated as a selective filter for reducing hazardous chemical compounds in hookah smoke. The study combined gas chromatography–mass spectrometry (GC–MS) and atomic absorption spectroscopy (AAS) to identify and quantify major toxicants. Hookah smoke was trapped using cellulose nanofiber–based solvent chambers and latex puff chambers, followed by analysis of volatile organic compounds (nicotine, propylene oxide, formaldehyde, crotonaldehyde, acrolein, acetaldehyde, 1,3-butadiene, benzopyrene, pyridine, phenol, benzene) and potentially toxic trace elements (PTEs) such as lead, mercury, cadmium, and chromium. Detection limits (LODs) ranged from 0.003 to 0.04 mg/g, with relative standard deviations (RSDs) below 13%. The effervescent tablet reduced > 81% of hazardous compounds while selectively lowering nicotine and flavor by approximately 15%, maintaining user acceptability. Compared with cigarette smoke, unfiltered hookah smoke contained significantly higher levels of aldehydes and polycyclic aromatic hydrocarbons, whereas filtered hookah smoke showed markedly lower contaminant concentrations than both cigarette and e-cigarette smoke. The proposed method demonstrates innovation by integrating a user-friendly, selective effervescent tablet with high recovery (92%–102%) and accuracy, offering a practical strategy for harm reduction in hookah smoking.</p>\u0000 </div>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"383-392"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay 巴拉圭农村社区科洛尼亚圣胡安儿童头发中的农药污染。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2025-12-26 DOI: 10.1002/dta.70020

Stela Benitez Leite, Alba Iglesias-Gonzalez, Mirta Noemí Mesquita, María Luisa Macchi, Robin Mesnage, Brice M. R. Appenzeller

{"title":"Pesticide Contamination in the Hair of Children From Colonia San Juan, a Rural Community in Paraguay","authors":"Stela Benitez Leite, Alba Iglesias-Gonzalez, Mirta Noemí Mesquita, María Luisa Macchi, Robin Mesnage, Brice M. R. Appenzeller","doi":"10.1002/dta.70020","DOIUrl":"10.1002/dta.70020","url":null,"abstract":"<p>Chronic exposure to pesticides can cause carcinogenic, reproductive, neurological, and endocrine-disrupting effects. Hair analysis is a valuable biomonitoring tool to assess human exposure to pesticides. We determined the presence of pesticides, their metabolites, and other environmental pollutants in the hair of children in an agricultural area of Paraguay. We analyzed 152 pesticides and environmental chemicals in hair samples from 51 children (2–14 years, mean ± SD = 8.5 ± 3.3 years) living in Colonia San Juan, a rural community in Paraguay. The locality is surrounded by soybean crops, and the community engages primarily in family farming. Eighty of the 152 compounds (52.6%) were detected. Each child's sample contained an average of 55 ± 3.7 compounds (range 48–65), including organophosphates, pyrethroids, neonicotinoids, fungicides, herbicides, and endocrine disruptors such as bisphenol A and bisphenol S. Thirty-seven compounds were present in all samples. Children in this rural community are simultaneously exposed to numerous pesticides and pollutants, highlighting the urgent need for stricter environmental protections and preventive health measures.</p>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"354-369"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manhole Sampling at Gyms and Sports Centers in Denmark: A Pilot Study Using Wastewater Analysis as a Tool for Monitoring the Use of Performance-Enhancing Drugs 丹麦体育馆和体育中心的人孔取样：一项利用废水分析作为监测提高成绩药物使用的工具的试点研究。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2025-12-12 DOI: 10.1002/dta.70016

Pia Johansson Heinsvig, Katinka Rønnow Holler, Ask Vest Christiansen, Christian Lindholst

{"title":"Manhole Sampling at Gyms and Sports Centers in Denmark: A Pilot Study Using Wastewater Analysis as a Tool for Monitoring the Use of Performance-Enhancing Drugs","authors":"Pia Johansson Heinsvig, Katinka Rønnow Holler, Ask Vest Christiansen, Christian Lindholst","doi":"10.1002/dta.70016","DOIUrl":"10.1002/dta.70016","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we assess the feasibility of wastewater sampling from manholes as a potential monitoring tool for performance and image-enhancing drugs (PIEDs) at local gyms and general sports centers in Denmark. Wastewater samples from two gyms and two sports centers were analyzed using two LC–MS-based analytical methods (UPLC–MS/MS and UPLC-TOF-MS) to detect the presence of PIEDs. Samples were collected at 3-h intervals during the opening hours on three selected days of the week for each location. The study showed the presence of anabolic agents such as oxandrolone, stanozolol, and ostarine in wastewater sampled from the gyms. All three compounds are class C drugs in the United States, and likewise, illegal to sell and possess in Denmark. Other PIEDs, such as aromatase inhibitors and psychoactive drugs, were detected in several samples from both gyms and sports centers. However, gyms showed a higher occurrence of PIEDs, whereas general sports centers showed a lower occurrence. Although it cannot be used as a traditional prevalence measure, wastewater sampling from manholes is a useful tool for studying the occurrence of PIEDs among recreational athletes at specific locations or events. Wastewater analysis may be used as an easy and cost-effective tool to complement both preventive and control measures, such as information campaigns, surveys, or personal testing. However, not all locations are suitable for manhole sampling, and it is necessary to consider the legal, ethical, and practical aspects before using wastewater analysis to monitor communities or specific populations.</p>\u0000 </div>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"310-319"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Metabolites of Methyldienolone by In Vitro Human Liver Microsomes and Characterized Using LC/HRMS for Doping Control Purposes 甲基二烯诺酮在体外人肝微粒体中的新代谢物及LC/HRMS表征

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2025-12-12 DOI: 10.1002/dta.70017

Jinghua Hou, Xiya Yan, Lisi Zhang, Zhanliang Wang, Sheng Yang

{"title":"New Metabolites of Methyldienolone by In Vitro Human Liver Microsomes and Characterized Using LC/HRMS for Doping Control Purposes","authors":"Jinghua Hou, Xiya Yan, Lisi Zhang, Zhanliang Wang, Sheng Yang","doi":"10.1002/dta.70017","DOIUrl":"10.1002/dta.70017","url":null,"abstract":"<div>\u0000 \u0000 <p>Methyldienolone, a synthetic anabolic androgenic steroid (AAS), has been banned in sports by the World Anti-Doping Agency (WADA) because of its performance-enhancing properties. This study aimed to investigate the main metabolites using in vitro incubation with human liver microsomes (HLM) and to detect them through liquid chromatography-high-resolution mass spectrometry (LC-HRMS) for doping control purposes. A total of six groups of Phase I metabolites, including 17-epimerization, hydroxylation, C3-keto reduction, 18-nor modifications, reduction, and demethylation, as well as five different Phase II metabolites, such as glucuronide conjugates, were characterized, indicating extensive metabolism by HLM. Structural characterization of these metabolites was improved through derivatization with methoxylamine and hydroxylamine, which enabled their detection with higher sensitivity by LC-HRMS. These novel metabolites provide new insights into the metabolism of methyldienolone and may contribute to antidoping analysis. The synthesis of reference materials is necessary to confirm the structure of the proposed metabolites in the future.</p>\u0000 </div>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"320-331"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigations Into the Human Metabolism of Trestolone (7α-Methyl-19-Nortestosterone) Trestolone （7α-甲基-19-去甲睾酮）的人体代谢研究。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2025-12-17 DOI: 10.1002/dta.70018

Thomas Piper, Gregor Fusshöller, Mario Thevis

{"title":"Investigations Into the Human Metabolism of Trestolone (7α-Methyl-19-Nortestosterone)","authors":"Thomas Piper, Gregor Fusshöller, Mario Thevis","doi":"10.1002/dta.70018","DOIUrl":"10.1002/dta.70018","url":null,"abstract":"<p>Already in the 1960s, the anabolic properties of Trestolone (7α-methyl-19-nortestosterone, MENT) were investigated in the context of cancer research, and MENT was found to be 10 times more potent regarding its anabolic properties compared to testosterone. The human metabolism of MENT was only investigated once in an antidoping context, and three urinary metabolites were identified, corroborating earlier findings from in vitro and animal experiments. Based on these metabolites, no doping control sample was reported to contain MENT or its metabolites in the last two decades albeit MENT is readily available via online distributors. One reason for the lack of adverse analytical findings in doping controls could be analytical challenges originating from the chromatographic properties of MENT and its urinary metabolites. Therefore, the human metabolism of MENT was reinvestigated employing an excretion study with deuterated MENT and metabolite detection based on hydrogen isotope ratio mass spectrometry in combination with high accuracy/high resolution mass spectrometry. Considering unconjugated, glucuronidated, and sulfated metabolites, 50 potential candidates were detected. In order to identify those metabolites suitable for sports drug testing, three volunteers administered a single oral dose of nondeuterated MENT, and all postadministration samples were investigated using triple quadrupole mass spectrometry-based determinations routinely employed in doping controls. From the 50 metabolites detected, two showed promising results with respect to their detection windows and suitability under routine measurement conditions. The specificity of the novel metabolites was ensured by the reanalysis of 200 routine doping control samples demonstrating the absence of potential coeluting compounds.</p>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"341-353"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12983052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emoxypine as a Potential Marker for Identifying Possible Cases of Unintended Meldonium Doping in Sports 艾莫西平作为识别运动中意外使用米屈肼的潜在标记物。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2026-01-29 DOI: 10.1002/dta.70031

Pavel V. Postnikov, Yulia A. Efimova, Igor A. Rodin

{"title":"Emoxypine as a Potential Marker for Identifying Possible Cases of Unintended Meldonium Doping in Sports","authors":"Pavel V. Postnikov, Yulia A. Efimova, Igor A. Rodin","doi":"10.1002/dta.70031","DOIUrl":"10.1002/dta.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>In recent years, a scenario involving milk contamination by biotransformation products of the veterinary drug Emidonol has received widespread publicity. Emidonol is intended for use in cattle under pathological conditions accompanied by hypoxia. The drug dissociates into two antihypoxants—meldonium, a metabolic modulator prohibited in sports, and emoxypine, which also has antioxidant properties. A small-scale pilot study involved three volunteers consuming a single 900-mL dose of unpasteurized cow's milk collected on the last (15th) day of treatment with the drug. The mean estimated urinary concentration of emoxypine peaked between 7- and 8.5-h postadministration (1360 ± 240 ng/mL), elimination time being approximately 50–54 h. The mean estimated urinary concentration of meldonium peaked between 5.8- and 9.0-h postadministration and was 322 ± 68 ng/mL, elimination time being approximately 35–45 h. The simultaneous presence of emoxypine and meldonium in urine samples may be indicative of the consumption of Emidonol-contaminated milk, which may facilitate the identification of cases of unintended doping in sport.</p>\u0000 </div>","PeriodicalId":160,"journal":{"name":"Drug Testing and Analysis","volume":"18 3","pages":"414-418"},"PeriodicalIF":2.7,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection and Longitudinal Monitoring of Cyclosporine in Horse Plasma and Urine After Ocular Implant Administration 眼植入后马血浆和尿液中环孢素的检测和纵向监测。

IF 2.7 3区医学

Drug Testing and Analysis Pub Date : 2026-03-13 Epub Date: 2026-01-18 DOI: 10.1002/dta.70026

Yat-Ming So, Wai Him Kwok, Charlynn Yap, Celia O. L. Wong, Samuel G. R. Smalley, Bronte S. Forbes, Derek W. Y. Chow, Emmie N. M. Ho

引用次数: 0