Journal of Infection and Public Health最新文献

{"title":"Pertussis clinical profile shift, severity, prediction in a tertiary hospital: A comparative study before, during, and after COVID-19 in Southern China","authors":"Shufeng Tian ,&nbsp;Yulan Chen ,&nbsp;Qiru Su ,&nbsp;Biao Sun ,&nbsp;Zengrui Lin ,&nbsp;Yuchun Long ,&nbsp;Hongmei Wang ,&nbsp;Cuijuan Liao ,&nbsp;Ying Zhang ,&nbsp;Jinjun Zheng ,&nbsp;Lvjun Chen ,&nbsp;Song Guan ,&nbsp;Sen Wang ,&nbsp;Xinlei Xu ,&nbsp;Jingwen Ai ,&nbsp;Wenhong Zhang ,&nbsp;Jikui Deng","doi":"10.1016/j.jiph.2024.102610","DOIUrl":"10.1016/j.jiph.2024.102610","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze the epidemiological characteristics, clinical manifestations, antimicrobial resistance and develop a predictive model for severe pertussis spanning five years – before, during, and after the COVID-19 pandemic – in Shenzhen children’s hospital in southern China, aiming to provide insights into the pandemic impact and control measures on the pertussis disease profile.</div></div><div><h3>Methods</h3><div>Demographic, clinical, vaccination, and laboratory data were collected for patients who tested positive for pertussis by polymerase chain reaction and/or culture from January 1, 2019, to March 30, 2024. Analysis included changes in demographic and clinical features, indicators of severe cases, and resistance patterns over the study period.</div></div><div><h3>Results</h3><div>During this period, 3963 patients were diagnosed, with 79 severe (PICU admitted) cases; 1433 isolates underwent antimicrobial susceptibility testing. In late 2023, pertussis cases began to increase. From 2019 to 2024, the proportion of cases among 4–6 year olds rose from 4.9 % to 28.6 %, and among 7–11 year olds from 0.7 % to 21.2 %. Macrolide resistance surged from 46.5 % in 2019 to 97.3 % in 2024, with 80 % of resistant hospitalized cases initially treated with macrolides. Clinical severity and co-infection increased post-pandemic, with a larger number of cases necessitating antibiotic changes and enhanced supportive care. Vaccination protected against severe disease. Indicators such as white blood cell count, lymphocyte to neutrophil ratio, platelet count, cyanosis and pneumonia predicted disease severity.</div></div><div><h3>Conclusions</h3><div>Post-pandemic, pertussis cases shifted from infants to school-aged children, with increased clinical severity and high macrolide resistance. Urgent measures are needed to optimize vaccination schedules and develop management strategies addressing and changing epidemiological patterns.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102610"},"PeriodicalIF":4.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional heterogeneity of malaria healthcare seeking and diagnosis in China (2017–2022): Implications in preventing re-establishment of malaria transmission","authors":"Jian-hai Yin ,&nbsp;Li Zhang ,&nbsp;Bo-yu Yi ,&nbsp;Shui-sen Zhou ,&nbsp;Zhi-gui Xia","doi":"10.1016/j.jiph.2024.102601","DOIUrl":"10.1016/j.jiph.2024.102601","url":null,"abstract":"<div><h3>Background</h3><div>Enhancing regional collaboration in malaria prevention and control is a pivotal strategy for malaria control and elimination in China. The objective of this study is to examine the regional heterogeneity of malaria healthcare-seeking behaviors and diagnosis across various regions in China from 2017 to 2022.</div></div><div><h3>Methods</h3><div>Individual case data from national malaria surveillance databases were utilized. An analysis was conducted to discern the regional variations in the healthcare-seeking behaviors and diagnosis among regions.</div></div><div><h3>Results</h3><div>From 2017 to 2022, a total of 10,943 malaria cases were reported in China, predominantly imported cases (10,929), with significant variations in the distribution of different <em>Plasmodium</em> species among regions (<em>P</em> &lt; 0.001) and annually (<em>P</em> &lt; 0.001). There was a notable lack of timeliness in healthcare seeking (56.1 %) and case confirmation (67.3 %) with substantial regional disparities (<em>P</em> &lt; 0.001). These delays predominantly occurred in county and prefectural-level medical institutions (<em>P</em> &lt; 0.001), where misidentification of <em>Plasmodium</em> species was also prevalent (<em>P</em> &lt; 0.001). Furthermore, an initial diagnosis of malaria was observed in 76.6 % of cases (<em>P</em> &lt; 0.001), yet 87.8 % of malaria cases were ultimately confirmed correctly (<em>P</em> &lt; 0.001). Notably, <em>P. ovale</em> (21.0 %) and <em>P. malariae</em> (10.8 %) were easily misidentified as <em>P. vivax</em> (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The development of regional-specific interventions is essential to raise public awareness regarding malaria-related knowledge and to enhance the vigilance of health workers and their capacity of malaria testing. This will strengthen the nation’s malaria surveillance and response system. Concurrently, fostering technological innovations for the rapid and precise identification of <em>Plasmodium</em> species, along with effective coordination of cross-regional mechanisms, is imperative to prevent re-establishment of malaria transmission in China.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102601"},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping trends and hotspots of research on COVID-19 vaccine effectiveness: A comprehensive bibliometric analysis of global research","authors":"Jomana W. Alsulaiman ,&nbsp;Abdallah Alzoubi ,&nbsp;Ahmad Alrawashdeh ,&nbsp;Arwa M. Al-Dekah ,&nbsp;Sara Abubaker ,&nbsp;Wajdi Amayreh ,&nbsp;Waleed M. Sweileh ,&nbsp;Hamed M. Alzoubi ,&nbsp;Khalid A. Kheirallah","doi":"10.1016/j.jiph.2024.102597","DOIUrl":"10.1016/j.jiph.2024.102597","url":null,"abstract":"<div><h3>Background</h3><div>With an ever growing and expanding body of literature on the newly developed vaccines against the COVID-19, there is an urgent need for a comprehensive analysis of the current state of research on vaccine effectiveness (VE). This study conducted a comprehensive bibliometric analysis to critically examine the productivity and impact of retrieved publications on COVID-19 VE and to predict the future directions of research in the field.</div></div><div><h3>Methods</h3><div>The global literature on COVID-19 VE from 2021 to 2024 was extracted from the VIEW-hub website. Using bibliometric analysis tools, specifically Microsoft Excel, the R package \"bibliometrix, biblioshiny\" and VOSviewer, we analyzed publications for trends in productivity, citations, and global collaboration. Key metrics assessed include publication and citation trends, influential authors, collaborative networks, and thematic evolution, offering a comprehensive view of the research landscape on COVID-19 VE.</div></div><div><h3>Results</h3><div>A total of 490 publications were authored by 5031 authors from 934 institutions and 78 countries and published in 119 journals. Most retrieved publications were original articles (99.6 %). The United States was the most productive country with 205 publications (41.8 %). Global research collaborations were mainly within developed countries. Analysis of the thematic evolution of the field illustrated changing research focus over three distinct time clusters. Throughout 2021, studies were focused on outlining infection prevention and control measures, as well as examining the efficacy of novel mRNA vaccines. In 2022, the linchpin of research was shifted towards dissecting the epidemiological correlates of the pandemic in light of the widespread use of vaccines. The final cluster showed special emphasis on the new variants of COVID-19 and the long-term outcomes of vaccines.</div></div><div><h3>Conclusion</h3><div>Our study identified geopolitical disparities and weak engagement from developing countries in the ongoing efforts regarding COVID-19 VE. This study can inform researchers, policymakers, and funding agencies as they assess ongoing research and future directions in COVID-19 VE.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102597"},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world assessment of reinfection with SARS-CoV-2: Implications for vaccines","authors":"Kuang-Hung Tseng ,&nbsp;Jeng-Yuan Chioua ,&nbsp;Shiow-Ing Wang","doi":"10.1016/j.jiph.2024.102599","DOIUrl":"10.1016/j.jiph.2024.102599","url":null,"abstract":"<div><h3>Background</h3><div>There have been over 670 million confirmed cases of SARS-CoV-2 infection globally, resulting in over 6.87 million deaths. With approximately 0.1 %−6.8 % experiencing reinfection. This retrospective cohort study aimed to compare the risk of short-term circulatory and respiratory sequelae between SARS-CoV-2 reinfection and initial infection, and assess the impact of vaccination.</div></div><div><h3>Method</h3><div>Data from the TriNetX US Collaborative network (2020–2022) were used to create two cohorts based on reinfection status. The main outcome assessed were medical utilization, circulatory and respiratory symptoms, and circulatory and respiratory diseases. The Kaplan-Meier method was used to compare the risks between two cohorts. Four subgroup analyses (vaccination status, age, sex, race) and six sensitivity analyses (rigorous definition, modified exclusion criteria, treatment, different COVID-19 variants timeline, address survivorship bias, and E-value calculation) were also conducted.</div></div><div><h3>Results</h3><div>The reinfection cohort showed a significant reduction in medical utilization [ Hazard ratio, HR: 0.867, (95 % confidence interval, CI:0.839–0.896) for hospitalization, 0.488 (0.418–0.570) for critical care services, and 0.476 (0.360–0.629) for mechanical ventilation], lower risk of circulatory diseases [ HR: 0.701 (95 % CI:0.637–0.772), 0.695 (0.583–0.829), 0.660 (0.605–0.719), 0.741 (0.644–0.854), 0.614 (0.535–0.705), and 0.758 (0.656–0.876) for ischemic heart disease, inflammatory heart disease, dysrhythmias, venous thromboembolism, other cardiac disorders, and cerebrovascular diseases, respectively], and lower risk of respiratory diseases such as pneumonia, other acute lower respiratory infections, asthma, and hypoxemia [HR: 0.302 (95 % CI: 0.273–0.333), 0.811 (0.686–0.958), 0.791 (0.735–0.850), and 0.392 (0.338–0.455), respectively]. The vaccinated reinfection cohort showed no significant differences in medical utilization, circulatory diseases, or respiratory conditions but had a higher risk of breathing abnormalities. breathing abnormalities [HR: 1.195 (95 % CI:1.087–1.313)].</div></div><div><h3>Conclusions</h3><div>The individuals who experienced reinfection exhibited milder short-term sequelae in the circulatory and respiratory systems. Vaccine administration protects against cardiovascular or respiratory systems.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102599"},"PeriodicalIF":4.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the genomic potential of Kytococcus schroeteri for antibacterial metabolites against multi-drug resistant Mycobacterium tuberculosis","authors":"Fatiha Khan ,&nbsp;Deng Li ,&nbsp;Iqra Ahmad ,&nbsp;Sumra Wajid Abbasi ,&nbsp;Umar Nishan ,&nbsp;Sheheryar Sheheryar ,&nbsp;Arlindo Alencar Moura ,&nbsp;Riaz Ullah ,&nbsp;Mohamed A. Ibrahim ,&nbsp;Mohibullah Shah ,&nbsp;Wangshu Li","doi":"10.1016/j.jiph.2024.102598","DOIUrl":"10.1016/j.jiph.2024.102598","url":null,"abstract":"<div><div>The versatile bacterium <em>Kytococcus schroeteri</em> is known for producing putative secondary metabolites. These include antimicrobials and other therapeutically significant compounds. The emergence of antibiotic-resistant pathogens has necessitated the exploration of possible sources for novel drug candidates. This study focuses on the genome mining of <em>Kytococcus schroeteri</em> to explore its secondary metabolites through biosynthetic gene clusters. It analyzes their drug-like properties through <em>in-silico</em> methods and evaluates their potential as antimicrobial agents. Eight biosynthetic gene clusters were identified in two strains (H01 and UMB1298) of this bacterium. Among the unique 49 metabolites from these clusters, 13 metabolites were selected according to the Lipinski rule of five. Physiochemical properties, pharmacokinetic analysis, toxicity profiles, and human target predictions of these metabolites were performed, and they were examined for crucial interactions with <em>M. tuberculosis’s</em> RpfB protein, the causative agent of latent tuberculosis. All metabolites were predicted to be non-toxic and did not inhibit any human proteins. Several metabolites, including a subset of brasilanes, exhibited both low acute toxicity and promising interactions with GLU292, the critical residue of the RpfB protein. The interaction affinity of the ligands with RpfB was validated by subjecting one of the complexes to a 100 ns MD simulation. The RMSD, RMSF, and binding energy calculations indicated a stable interaction of the ligand with the receptor protein, which raised the possibility of novel drugs to combat antibiotic resistance. The putative metabolites identified in this study not only exhibit molecular properties but also possess characteristics that support physiological compatibility. It also heightens their potential effectiveness as therapeutic antibacterial alternates. The experimental validation of our computational results may open an avenue to explore the potential of <em>K. schroeteri</em> for producing novel compounds to combat the antibiotic resistance in <em>M. tuberculosis.</em></div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102598"},"PeriodicalIF":4.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent public threat: Crimean-Congo hemorrhagic fever outbreak spikes during Eid-al-Adha in Afghanistan (Reported cases to National Surveillance System, 2015-2024)","authors":"Enayatullah Hamdard ,&nbsp;Ahmadullah Zahir ,&nbsp;Babrak Karwand ,&nbsp;Zabih Ullah Nazari ,&nbsp;Fangxiong Shi","doi":"10.1016/j.jiph.2024.102591","DOIUrl":"10.1016/j.jiph.2024.102591","url":null,"abstract":"<div><h3>Background</h3><div>Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with a Case Fatality Ratio (CFR) of 10–40 %. It spreads from livestock to humans primarily through tick bites. It is crucial to monitor the peak months of this endemic disease in Afghanistan. Currently, the country is grappling with a potential national outbreak of CCHF, facing limitations in both diagnostic and preventive measures. Therefore, this study aims to describe CCHF prevalence during spike months (June-September) from 2015 to 2024, coinciding with Eid-al-Adha, and assess CCHF familiarity among inhabitants in eight regions of Afghanistan.</div></div><div><h3>Method</h3><div>We have analyzed the National Surveillance System data (2015–2024) on retrospective basis. A structured questionnaire was developed to assess CCHF knowledge among inhabitants of eight regions. Data analysis included percentages, frequencies, chi-square tests, using SPSS and power BI.</div></div><div><h3>Results</h3><div>The national surveillance system recorded 1796 CCHF confirmed cases with 238 deaths during spike months from 2015 to 2024. The highest number of Reported cases was in 2023 (734 cases, 78 deaths), followed by 2022 (221 cases). During Eid-al-Adha months from 2015 to 2024, there were 804 CCHF cases and 176 deaths, with the most in 2023 (313 cases, 78 deaths) and the fewest in 2015 (7 cases, 2 deaths).</div><div>A survey of 1440 inhabitants (80 % male, 20 % female) across eight regions of Afghanistan showed knowledge of CCHF varied within regions. Correct responses were highest in the central region (394/815), followed by north (336/760). Incorrect responses were highest in central highlands (1039/1440), followed by west (450/881), indicating limited knowledge despite annual spikes in cases.</div></div><div><h3>Conclusion</h3><div>The surge in CCHF outbreaks during Eid-al-Adha in Afghanistan underscores the challenge posed by limited knowledge of the disease. Uncontrolled animal movement and self-slaughter during Eid festival emphasize the urgent need for targeted public health strategies by relevant ministries.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102591"},"PeriodicalIF":4.7,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling influenza sentinel surveillance in Pakistan 2008-2024: Epidemiological insights during the pre and post pandemic period of COVID-19","authors":"Nazish Badar ,&nbsp;Muhammad Salman ,&nbsp;Nadia Nisar ,&nbsp;Hamza Ahmed Mirza ,&nbsp;Abdul Ahad ,&nbsp;Faisal Ahmad ,&nbsp;Bisma Daud","doi":"10.1016/j.jiph.2024.102595","DOIUrl":"10.1016/j.jiph.2024.102595","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus pandemic has substantially influenced the transmission pattern of other respiratory viruses. However, screening and detecting other respiratory pathogens was unheeded during this time to combat the COVID-19 pandemic. High virulence and re assortment factors intensify the importance of influenza virus surveillance for effective disease management. Therefore, the present surveillance study was designed to determine the influenza positivity rate from 2008–24. This study will provide integral support in depicting a panoramic representation of two respiratory-pandemic periods, 2010–11 and 2019–2021, for influenza and COVID-19 pandemics, respectively.</div></div><div><h3>Methods</h3><div>An inferential cross-sectional study was conducted from 2008 to 2024 by collecting influenza surveillance data from twelve sentinel sites in Pakistan. Clinical and demographic data was recorded at sample collection time. Specimens were collected through nasopharyngeal/throat swabs and stored in viral transport medium (VTM) at the sentinel site laboratory at 2‐4 °C. Viral RNA was isolated from the samples using KingFisher TM Flex Purification System and MagMAX™ Viral/Pathogen Nucleic Acid Extraction Kit.</div></div><div><h3>Results</h3><div>Within 16 years, 78118 samples were tested for influenza, of which 7999 (10.2 %) appeared positive. The positivity rate appeared very low in recent years, with only a 3.5 % positivity rate observed in 2020. Influenza A strain H1N1pdm09 seemed to be the prominent strain (n = 3407, 42.6 %), followed by influenza B (n = 2125, 26.6 %). Conclusion: The positivity of influenza samples was 10.2 % and recorded in patients where typical clinical representation of influenza was absent. Fewer samples were reported during the coronavirus pandemic, which might be because influenza screening was hindered and overlooked to combat the SARS-CoV-2 virus, and the patient threshold was very high for COVID-19 virus screening.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102595"},"PeriodicalIF":4.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of multidrug-resistant E. coli ST8346 isolates carrying three distinct plasmids with NDM-5, KPC-2, and OXA-181","authors":"Ping-Yuan Chen ,&nbsp;Yu-Chin Chen ,&nbsp;Che-Ming Chiang ,&nbsp;Chi-Chung Chen ,&nbsp;Chih-Cheng Lai ,&nbsp;Chia-Hung Tsai ,&nbsp;Chung-Han Ho ,&nbsp;Po-Yu Chen ,&nbsp;Hung-Jen Tang ,&nbsp;Julie Chi Chow ,&nbsp;Tu-Hsuan Chang","doi":"10.1016/j.jiph.2024.102596","DOIUrl":"10.1016/j.jiph.2024.102596","url":null,"abstract":"<div><h3>Background</h3><div><em>E. coli</em> ST8346 is a unique strain associated with the potential carriage of multiple carbapenemases. Three unique <em>E. coli</em> ST8346 isolates were identified, each concurrently harboring multiple carbapenemases, including <em>bla</em>_NDM-5, <em>bla</em>_KPC-2, and/or <em>bla</em>_OXA-181. This study aimed to characterize the genetic and plasmid structures of these isolates to understand their transmission and resistance mechanisms.</div></div><div><h3>Methods</h3><div>Antibiotic resistance profiles, genetic relatedness, and plasmid structures were determined using antibiotic susceptibility testing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), S1 nuclease PFGE, and long-read sequencing.</div></div><div><h3>Results</h3><div>All the strains were carbapenem resistant. PFGE revealed close genetic relationships among the isolates, despite the lack of geographical or epidemiological connections. <em>bla</em>_NDM-5, <em>bla</em>_KPC-2, and <em>bla</em>_OXA-181 were located on separate plasmids. Plasmids harboring <em>bla</em>_NDM-5 showed genetic similarities to <em>bla</em>_NDM-5-bearing IncF plasmids in the United Kingdom. The IncA/C plasmids harboring <em>bla</em>_KPC-2 had identical sequences resembling a plasmid from a <em>K. pneumoniae</em> strain in Taiwan, except for the <em>bla</em>_KPC-2 region, which matched a strain from China, indicating a hybrid plasmid.</div></div><div><h3>Conclusion</h3><div>This study is the first to identify and characterize the coexistence of <em>bla</em>_NDM-5, bla_KPC-2, and <em>bla</em>_OXA-181 in <em>E. coli</em> ST8346 isolates. The spread appears to be due to independent acquisition events. We identified the putative origins of these plasmids and detected a possible recombination event in a novel IncA/C plasmid. These findings emphasize the importance of ongoing surveillance and further investigations.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102596"},"PeriodicalIF":4.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox Global Research: A Comprehensive Analysis from Emergence to Present (1961-2023) for innovative prevention and control approaches","authors":"Nader Kameli ,&nbsp;Abdullah Algaissi ,&nbsp;Manal Mohamed Elhassan Taha ,&nbsp;Edrous Alamer ,&nbsp;Abdulaziz Alhazmi ,&nbsp;Waleed Hakami ,&nbsp;Badreldin S. Rahama ,&nbsp;Anwar M. Hashem ,&nbsp;Siddig Ibrahim Abdelwahab","doi":"10.1016/j.jiph.2024.102593","DOIUrl":"10.1016/j.jiph.2024.102593","url":null,"abstract":"<div><div>The current study aims to identify research hotspots and trends in Monkeypox (MPX). A total of 2655 MPX-related articles published from 1961 to 2023 were extracted from the Scopus database. Data were analyzed using Scopus Analytics, Microsoft Excel, Bibliometrix, and VOSviewer. The number of MPX papers has been increasing annually, particularly since the most recent outbreak. The United States and India have been productive in this area. The most cited and productive scholar in the field is Inger K. Damon. The MPX research theme map shows clusters with various centralities and densities, focusing on deep learning, molecular docking, and orthopoxviruses. Over the last decade, key terms include \"transmission,\" \"pandemic,\" \"deep learning,\" \"docking,\" \"Democratic Republic of Congo,\" \"Ebola,\" \"virulence,\" \"modified vaccinia Ankara,\" and \"orthopoxvirus.\" Researchers can utilize existing findings to steer future research on this illness, prepare for potential pandemics, and address bioterrorist threats.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102593"},"PeriodicalIF":4.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surging antimicrobial resistance mortality rates in Africa: Spotlight on antibiotic misuse in Nigeria","authors":"Oche Joseph Otorkpa,&nbsp;Onifade Adefunmilola Adebola ,&nbsp;Chinenye Oche Otorkpa","doi":"10.1016/j.jiph.2024.102594","DOIUrl":"10.1016/j.jiph.2024.102594","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 1","pages":"Article 102594"},"PeriodicalIF":4.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}