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Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

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Response to "Methodological Concerns on the Optimal Timing of Adjuvant S-1 After Pancreatectomy". 对“胰腺切除术后S-1辅助治疗最佳时机的方法学问题”的回应。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-09-05 DOI: 10.1002/jhbp.70181
Dongha Lee, Yoshihide Nanno, Shohei Komatsu
{"title":"Response to \"Methodological Concerns on the Optimal Timing of Adjuvant S-1 After Pancreatectomy\".","authors":"Dongha Lee, Yoshihide Nanno, Shohei Komatsu","doi":"10.1002/jhbp.70181","DOIUrl":"https://doi.org/10.1002/jhbp.70181","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence-Free Survival in Hepatocellular Carcinoma Patients. 白细胞介素-37增强肝NK细胞毒性，提高肝细胞癌患者无复发生存期。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-09-04 DOI: 10.1002/jhbp.70178
Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M Krams, Olivia M Martinez, Carlos O Esquivel, Kazunari Sasaki, Hideki Ohdan
{"title":"Interleukin-37 Enhances Liver NK Cell Cytotoxicity and Improves Recurrence-Free Survival in Hepatocellular Carcinoma Patients.","authors":"Yuki Imaoka, Masahiro Ohira, Yuka Tanaka, Toshihiro Nakayama, Miho Akabane, Shinichiro Yokota, Sheri M Krams, Olivia M Martinez, Carlos O Esquivel, Kazunari Sasaki, Hideki Ohdan","doi":"10.1002/jhbp.70178","DOIUrl":"https://doi.org/10.1002/jhbp.70178","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide, and postoperative recurrence continues to limit long-term survival. Liver-resident natural killer (NK) cells are key effectors of antitumor immunity in the hepatic microenvironment. Interleukin-37 (IL-37), an anti-inflammatory cytokine, has recently been shown to modulate immune responses and enhance NK-cell activity.</p><p><strong>Methods: </strong>Liver mononuclear cells were isolated from 24 deceased donors. For functional experiments, liver NK cells from six donors were cultured with interleukin-2 (IL-2) in the presence or absence of IL-37. Flow cytometry was used to evaluate activation markers, and cytotoxicity assays assessed NK cell-mediated tumor lysis. Serum IL-33 and IL-37 levels were measured in 120 patients undergoing liver resection for HCC, and their associations with oncological outcomes were analyzed.</p><p><strong>Results: </strong>IL-37 significantly enhanced NK-cell cytotoxicity, increasing TRAIL and NKp44 expression. Clinically, patients with higher serum IL-37 levels showed improved 5-year recurrence-free survival (35.5% vs. 20.1%, p = 0.02) and a lower incidence of early recurrence.</p><p><strong>Conclusion: </strong>IL-37 enhanced liver NK-cell cytotoxicity in experimental analyses, and higher preoperative serum IL-37 levels were associated with improved recurrence-free survival after liver resection for HCC.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pretreatment Contrast-Enhanced Harmonic EUS Predicts Pathological Response and Recurrence-Free Survival After Multimodal Treatment in Resectable Pancreatic Cancer. 预处理对比增强谐波EUS预测可切除胰腺癌多模式治疗后的病理反应和无复发生存期。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-09-03 DOI: 10.1002/jhbp.70180
Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Ryohei Kumano, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima
{"title":"Pretreatment Contrast-Enhanced Harmonic EUS Predicts Pathological Response and Recurrence-Free Survival After Multimodal Treatment in Resectable Pancreatic Cancer.","authors":"Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Ryohei Kumano, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima","doi":"10.1002/jhbp.70180","DOIUrl":"https://doi.org/10.1002/jhbp.70180","url":null,"abstract":"<p><strong>Objectives: </strong>Recurrence remains common in resectable pancreatic cancer (PC) despite multimodal treatment. We evaluated whether pretreatment contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) predicts pathological response and recurrence-free survival (RFS).</p><p><strong>Methods: </strong>We retrospectively analyzed 52 patients with resectable PC who underwent CH-EUS before standardized multimodal treatment (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy). Associations between CH-EUS enhancement patterns (iso- or hypoenhancement) at 20, 40, and 60 s and pathological response were assessed. Associations with RFS were analyzed using Kaplan-Meier and Cox regression analyses.</p><p><strong>Results: </strong>Hypoenhancement was associated with significantly lower pathological response rates at all phases. Median RFS was significantly shorter in the hypoenhancement group at 20 s (560 vs. 1296 days; p = 0.018), 40 s (683 days vs. not reached; p = 0.013), and 60 s (779 days vs. not reached; p = 0.034). In multivariate analysis, hypoenhancement at 20 s independently predicted shorter RFS (HR 2.49, 95% CI 1.01-6.09; p = 0.047).</p><p><strong>Conclusions: </strong>Pretreatment CH-EUS predicts pathological response and recurrence risk in resectable PC. In particular, 20-s enhancement provides a simple, reproducible imaging biomarker that may support pre-treatment risk stratification and potentially guide individualized management strategies.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Pure Laparoscopic Living Donor Right Hepatectomy: A Multifactorial Evolutional Learning Curve Analysis From a Single-Surgeon High-Volume Series". 评论“纯腹腔镜活体右肝切除术：来自单个外科医生高容量系列的多因素进化学习曲线分析”。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-31 DOI: 10.1002/jhbp.70175
Rumaisa Siddiqui, Sarah Zafar, Ayesha Rahman Khan
{"title":"Comment on \"Pure Laparoscopic Living Donor Right Hepatectomy: A Multifactorial Evolutional Learning Curve Analysis From a Single-Surgeon High-Volume Series\".","authors":"Rumaisa Siddiqui, Sarah Zafar, Ayesha Rahman Khan","doi":"10.1002/jhbp.70175","DOIUrl":"https://doi.org/10.1002/jhbp.70175","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: "Biologically Refined Oncological Resectability for Hepatocellular Carcinoma". 评论：“肝癌的生物学精细化肿瘤可切除性”。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-31 DOI: 10.1002/jhbp.70179
Imen Ben Ismail, Mariem Marzouki
{"title":"Comment on: \"Biologically Refined Oncological Resectability for Hepatocellular Carcinoma\".","authors":"Imen Ben Ismail, Mariem Marzouki","doi":"10.1002/jhbp.70179","DOIUrl":"https://doi.org/10.1002/jhbp.70179","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Comment on "Pure Laparoscopic Living Donor Right Hepatectomy: A Multifactorial Evolutional Learning Curve Analysis From a Single-Surgeon High-Volume Series". 回复：关于“纯腹腔镜活体右肝切除术：单个外科医生高容量系列的多因素进化学习曲线分析”的评论。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-27 DOI: 10.1002/jhbp.70173
Flavio Milana, Sang Hoon Kim, Ki-Hun Kim
{"title":"Reply to: Comment on \"Pure Laparoscopic Living Donor Right Hepatectomy: A Multifactorial Evolutional Learning Curve Analysis From a Single-Surgeon High-Volume Series\".","authors":"Flavio Milana, Sang Hoon Kim, Ki-Hun Kim","doi":"10.1002/jhbp.70173","DOIUrl":"https://doi.org/10.1002/jhbp.70173","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biliary Radiofrequency Ablation-Assisted Removal of a Multi-Hole Metallic Stent for Malignant Hilar Biliary Obstruction. 胆道射频消融辅助多孔金属支架移除治疗恶性肝门胆道梗阻。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-25 DOI: 10.1002/jhbp.70172
Masanari Sekine, Taku Mizutani, Ryo Hashimoto, Goya Sasaki, Azumi Sato, Shu Kojima, Mina Morino, Naruaki Takahashi, Takeshi Uehara, Hirosato Mashima
{"title":"Biliary Radiofrequency Ablation-Assisted Removal of a Multi-Hole Metallic Stent for Malignant Hilar Biliary Obstruction.","authors":"Masanari Sekine, Taku Mizutani, Ryo Hashimoto, Goya Sasaki, Azumi Sato, Shu Kojima, Mina Morino, Naruaki Takahashi, Takeshi Uehara, Hirosato Mashima","doi":"10.1002/jhbp.70172","DOIUrl":"https://doi.org/10.1002/jhbp.70172","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Ben Ismail et al. 回复Ben Ismail等人。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-24 DOI: 10.1002/jhbp.70174
Kenta Aso, Yoshinori Takeda, Akio Saiura
{"title":"Reply to Ben Ismail et al.","authors":"Kenta Aso, Yoshinori Takeda, Akio Saiura","doi":"10.1002/jhbp.70174","DOIUrl":"https://doi.org/10.1002/jhbp.70174","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “Multicenter Validation Study of the Clinical Diagnostic Criteria for IgG4-Related Sclerosing Cholangitis 2020 in Japan” 《2020年日本igg4相关硬化性胆管炎临床诊断标准多中心验证研究》点评
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-18 Epub Date: 2026-03-06 DOI: 10.1002/jhbp.70098
Palavardhan Peddapalegani, Raghav Gupta, Priyanka Bansal
{"title":"Comment on “Multicenter Validation Study of the Clinical Diagnostic Criteria for IgG4-Related Sclerosing Cholangitis 2020 in Japan”","authors":"Palavardhan Peddapalegani,&nbsp;Raghav Gupta,&nbsp;Priyanka Bansal","doi":"10.1002/jhbp.70098","DOIUrl":"10.1002/jhbp.70098","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 8","pages":"e61-e62"},"PeriodicalIF":2.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Letter: Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis 回复信件：紧急ERCP对急性胆管炎并发急性胆石性胰腺炎临床结局的影响：倾向评分匹配分析。
IF 2.5 3区 医学
Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2026-08-18 Epub Date: 2026-03-15 DOI: 10.1002/jhbp.70105
Mustafa Comoglu, Fatih Acehan, Ihsan Ates
{"title":"Response to Letter: Effect of Urgent ERCP on Clinical Outcomes in Acute Cholangitis With Concurrent Acute Gallstone Pancreatitis: A Propensity Score Matching Analysis","authors":"Mustafa Comoglu,&nbsp;Fatih Acehan,&nbsp;Ihsan Ates","doi":"10.1002/jhbp.70105","DOIUrl":"10.1002/jhbp.70105","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":"33 8","pages":"e67-e68"},"PeriodicalIF":2.5,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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