Journal of Geriatric Psychiatry and Neurology最新文献

{"title":"The Association Between Bilingual Animal Naming and Memory Among Bilingual Mexican American Older Adults.","authors":"Emily M Briceño, Miguel Arce Rentería, Barbara Mendez Campos, Roshanak Mehdipanah, Wen Chang, Lisa Lewandowski-Romps, Nelda Garcia, Xavier F Gonzales, Deborah A Levine, Kenneth M Langa, Steven G Heeringa, Lewis B Morgenstern","doi":"10.1177/08919887241302109","DOIUrl":"10.1177/08919887241302109","url":null,"abstract":"<p><p>BackgroundMonolingual cognitive assessments are standard for bilinguals; the value of bilingual assessment is unknown. Since declines in animal naming accompany memory declines in dementia, we examined the association between bilingual animal naming and memory among bilingual Mexican American (MA) older adults.MethodsBilingual MA (n = 155) completed the Harmonized Cognitive Assessment Protocol (HCAP) in a Texas community study. Regressions included HCAP memory score (English) as the outcome and English and Spanish animal naming trials as independent variables; demographics and language dominance were covariates.ResultsEnglish animal naming (<i>b</i> = 0.06, <i>P</i> = 0.004) was more reliably associated with memory than Spanish (<i>b</i> = 0.05, <i>P</i> = 0.06). Considered together, only English (<i>b</i> = 0.05, <i>P</i> = 0.02) was associated with memory, not Spanish (<i>b</i> = 0.01, <i>P</i> = 0.63). Conclusions: Spanish animal naming did not uniquely add to English animal naming in its association with memory among bilingual older MA.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"286-294"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Traumatic Brain Injury and Mild Behavioral Impairment With Cognitive Function and Dementia.","authors":"Lisa N Richey, Nicholas O Daneshvari, Lisa Young, Michael J C Bray, Rebecca F Gottesman, Thomas Mosley, Keenan A Walker, Andrea L C Schneider, Matthew E Peters","doi":"10.1177/08919887251317726","DOIUrl":"10.1177/08919887251317726","url":null,"abstract":"<p><p>ObjectiveTraumatic Brain Injury (TBI) may contribute additional complexity to the clinical picture of mild behavioral impairment (MBI). MBI, a behavioral analog to mild cognitive impairment (MCI), is comprised of five neuropsychiatric domains: decreased motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, and abnormal perception/thought content. We investigated (1) if cross-sectional associations of cognitive status with MBI symptoms differ by TBI status and (2) if prospective associations of MBI domain positivity with incident dementia risk differ by TBI status.Methods2246 participants without dementia from the Atherosclerosis Risk in Communities Study were included (mean age = 75.6 years, 59.0% female). TBI was defined by self-report/ICD-9/10 codes, MBI via an established algorithm based on the Neuropsychiatric Inventory Questionnaire, and baseline cognitive status/incident dementia using neuropsychological tests, informant interviews, and hospital/death certificate codes.ResultsCross-sectionally, although MCI status was associated with greater odds of MBI, this did not differ based on TBI status (MCI with TBI: OR = 2.04, 95% CI = 1.44-2.88, MCI without TBI: OR = 1.60, 95% CI = 1.20-2.14). Individuals with MCI (with or without TBI) were more likely to have decreased motivation, affective dysregulation, and impulse dyscontrol. Prospectively, positivity in 1+ MBI domains was associated with increased risk of incident dementia, not differing by TBI status (no TBI and MBI: HR = 2.15, 95% CI = 1.55-2.99, TBI and MBI: HR = 2.62, 95% CI = 1.81-3.80).ConclusionsNeither cross-sectional associations between cognitive status and MBI domain positivity nor prospective associations of MBI domain positivity with incident dementia risk differed by TBI status. How TBI may relate to neuropsychiatric symptomatology in the context of neurodegenerative processes requires further clarification.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"264-274"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Role of Sex and APOE4 status on Psychosis in Alzheimer's Disease.","authors":"Jonathan Fan, Nathan Churchill, Ayad Fadhel, Luis R Fornazzari, Vincenzo De Luca, Zahinoor Ismail, David G Munoz, Tom A Schweizer, Corinne E Fischer","doi":"10.1177/08919887241313225","DOIUrl":"10.1177/08919887241313225","url":null,"abstract":"<p><p>BackgroundPsychosis occurs in approximately 41% of patients living with Alzheimer's disease. Previous findings from our group based on analyses of a neuropathological cohort suggest that among AD patients with Lewy Body pathology, female APOE4 homozygotes are at significantly greater risk of psychosis. This study aims to replicate this finding in a clinical cohort using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.MethodsOur group used data from a sample of patients with AD in the ADNI database from the ADNI1, ADNI2, ADNI3, and ADNIGO studies. We defined psychosis status as experiencing hallucinations or delusions at one time point based on the Neuropsychiatric Inventory. We then used forward binary logistic regression to determine if sex and APOE4 status are predictors of AD + P.ResultsIn total there were 204 participants who met the inclusion criteria, 133 of which were male, and 71 of which were female. Fifty-six patients were <i>APOE4</i> non-carriers, 109 patients were <i>APOE4</i> heterozygote carriers, and 39 were <i>APOE4</i> homozygote carriers. In total, there were 59 patients with psychosis. When adjusting for mini mental state examination score, adjusted hippocampal volume, and age, we demonstrate that female APOE4 homozygotes have a significantly increased risk of psychosis compared to other groups (<i>P</i> = 0.0264, OR = 19.50).DiscussionThe results of our study demonstrate a significant association between psychosis risk and female APOE4 homozygotes, thus corroborating findings from a neuropathological cohort. The effects of <i>APOE</i> ε4 on psychosis risk are significant only in females, and not in males.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"235-240"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Tai Chi With Depression and Anxiety Among Older Adults: Nationwide Study Findings From a Network Perspective.","authors":"Meng-Yi Chen, Wei Bai, Ling Zhang, Sha Sha, Zhaohui Su, Teris Cheung, Gabor S Ungvari, Katrine K Wong, Todd Jackson, Feng Yuan, Yu-Tao Xiang","doi":"10.1177/08919887241313248","DOIUrl":"10.1177/08919887241313248","url":null,"abstract":"<p><p>Within the global population, depression and anxiety are common among older adults. Tai Chi is believed to have a positive impact on these disturbances. This study examined the network structures of depression and anxiety among older Tai Chi practitioners vs non-practitioners. Propensity score matching (PSM) was used to construct a non-practitioner group based on Chinese Longitudinal Healthy Longevity Survey (CLHLS) data. 346 Tai Chi practitioners and 1019 non-practitioners were included. The prevalence and severity rates of depression were significantly lower among Tai Chi practitioners compared to non-practitioners though there was no group difference for anxiety. Network analysis showed that, among Tai Chi practitioners, \"Felt sadness\", \"Uncontrollable worrying\" and \"Trouble relaxing\" were the most central symptoms. In contrast, among non-practitioners, the most central symptoms were \"Felt sadness\", \"Uncontrollable worrying\", and \"Nervousness\". Key bridge symptoms linking depressive and anxiety symptoms were \"Worry too much\", \"Bothered by things\" and \"Uncontrollable worrying\" in Tai Chi practitioners and \"Nervousness\", \"Felt nervous/fearful\" and \"Sleep quality\" in non-practitioners. This study underscored how practising Tai Chi is associated with reduced overall prevalence and severity of depression and different interactions of depressive and anxiety symptoms among older adults. Central and bridge symptoms differed between Tai Chi practitioners and non-practitioners.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"38 4","pages":"241-253"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Incident Hearing Loss and Subsequent Risk of Dementia: The Health and Retirement Study 2010-2018\".","authors":"","doi":"10.1177/08919887251352257","DOIUrl":"10.1177/08919887251352257","url":null,"abstract":"","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251352257"},"PeriodicalIF":2.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violent Behaviors in Frontotemporal Dementia.","authors":"Othman Mounir Alaoui, Alexandra Fayel, Emmanuel Morain, Dominique De Blanchard, Claire Paquet, Emmanuel Cognat","doi":"10.1177/08919887251348933","DOIUrl":"https://doi.org/10.1177/08919887251348933","url":null,"abstract":"<p><p>BackgroundThis study assessed the prevalence, characteristics, and contributing factors of violent behaviors in patients with frontotemporal dementia (FTD) as reported by their caregivers.MethodsA nationwide survey was conducted in France targeting caregivers of FTD patients. The survey was disseminated online between July and September 2022 through the French FTD association communications channels. It collected data on the frequency, types and targets of violent behaviors, and associated behavioral and psychological symptoms of dementia (BPSD). Associations between violent behaviors, BPSD, and demographic factors were explored.Results167 answers were analyzed. Violent behaviors were reported in 56.29% of patients with FTD, predominantly verbal (83.2%), often directed at caregivers (68.1%). Factors associated with violence included higher proxy NPI, delusions, agitation/aggression, and irritability scores. Violent behaviors were underreported, with only 48.8% of caregivers having disclosed them to health professionals.ConclusionsViolent behaviors in patients suffering from FTD appear often underreported. Systematic screening during medical appointments is recommended to ensure early intervention and better management.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251348933"},"PeriodicalIF":2.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Ethical Dilemmas: Experiences, Views and Attitudes of Informal Caregivers of Individuals With Dementia in Albania.","authors":"Elona Gaxhja, Ilma Toci, Dorina Saja, Eliona Sula, Mitilda Gugu, Daniel Sperling","doi":"10.1177/08919887251343606","DOIUrl":"https://doi.org/10.1177/08919887251343606","url":null,"abstract":"<p><p>IntroductionCaregiving for people with dementia poses emotional, social, and ethical challenges, which are intensified by socio-cultural factors and limited external support.AimThis study explores the complex challenges, ethical dilemmas and socio-cultural factors, faced by informal caregivers of individuals with dementia in Albania, focusing on their experiences, views, and attitudes towards caregiving responsibilities and decision-making processes.MethodsQualitative research using interpretative phenomenological analysis, was conducted through in-depth, semi-structured interviews with 12 family caregivers.ResultsThree main themes emerged: (1) The Heavy Burden of Family Caregiving; (2) Balancing Autonomy, Safety, Dignity, and Well-being and (3) Injustice in Care: The Plight of Dementia Caregivers in Albania.ConclusionThis study underscores the necessity for systemic changes that prioritize the health and well-being of both caregivers and people with dementia highlighting the impact of cultural norms, family dynamics, and insufficient external support on caregivers.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251343606"},"PeriodicalIF":2.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity, Patient-Reported Outcomes, and Quality of Life in Parkinson's Disease.","authors":"James F Morley, Indu Subramanian, Joshua Farahnik, Leah Grout, Cristal Salcido, Josi Kurtzer, Laurie K Mischley","doi":"10.1177/08919887251346495","DOIUrl":"10.1177/08919887251346495","url":null,"abstract":"<p><p><b>Background:</b> Physical activity has been shown to improve motor symptoms in numerous Parkinson's Disease (PD) clinical trials. However, the relationship between physical activity (PA), patient-reported outcomes, and quality of life (QoL) in a community-dwelling cohort has not been well-characterized. <b>Methods:</b> To evaluate this association, data were obtained from the internet-based Modifiable Variables in Parkinsonism Study (n = 415). Patient-reported outcomes and QoL were assessed by the Patient-Reported Outcomes in Parkinson's Disease (PRO-PD) and Patient-Reported Outcomes Measurement Information System (PROMIS), respectively. Regression models controlled for age, sex, and disease duration. <b>Results:</b> As PA increased, PROMIS scores increased (<i>P</i> < 0.001) and motor and non-motor symptom PRO-PD scores decreased (<i>P</i> < 0.001) implying improved symptoms and QoL. The association between PA and symptom severity was significant in women, but not men. <b>Conclusions:</b> These data may imply improved symptoms and QoL with increased PA frequency in individuals with PD. Sex differences in the relationship between PA and PD outcomes warrant further investigation.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251346495"},"PeriodicalIF":2.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety Profile of Istradefylline in Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials and Disproportionality Analysis Using FAERS.","authors":"Beema T Yoosuf, Suhani Jain, Muhammed Favas Kt, Dipika Bansal","doi":"10.1177/08919887251343608","DOIUrl":"https://doi.org/10.1177/08919887251343608","url":null,"abstract":"<p><p>BackgroundIstradefylline, a selective adenosine A2A receptor antagonist, is used as an adjunct therapy to levodopa to improve motor symptoms in Parkinson's disease (PD) patients, particularly those experiencing wearing-off phenomena. This study integrates safety data on istradefylline for the treatment of PD from randomized controlled trials (RCTs) and the FDA Adverse Event Reporting System (FAERS).MethodsWe performed a systematic search of PubMed, EMBASE, Ovid, MEDLINE, and ClinicalTrials.gov for RCTs on istradefylline safety in PD patients up to September 2024. A random-effects meta-analysis estimated the Peto odds ratio (OR) with 95% confidence intervals (CIs). FAERS data were analyzed through disproportionality measures, including the proportional reporting ratio (PRR) and reporting odds ratio (ROR), with signal refinement to primary suspect cases.ResultsThe safety meta-analysis, encompassing data from 8 RCTs, reveals a significant association between istradefylline treatment and an increased risk of dyskinesia (odds ratio [OR] 1.77, 95% CI 1.32-2.36; <i>P</i> = 0.01), hallucinations (OR 2.08, 95% CI 1.11-3.90; <i>P</i> = 0.02), and nausea, when compared with placebo. In the FAERS database, 2597 patients were identified with adverse events (AEs) linked to istradefylline. Disproportionality analysis of istradefylline revealed 39 AEs strongly associated with its use, all of which were substantiated through signal refinement. The most commonly reported AEs were primarily associated with nervous system and psychiatric disorders.ConclusionThis study highlights distinct AE patterns for istradefylline in trials vs real-world data, underscoring the importance of post-marketing surveillance to detect underreported AEs and validate new safety signals effectively.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251343608"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods.","authors":"Tammy T Hshieh, Benjamin A Chapin, Wingyun Mak, Guoquan Xu, Eva M Schmitt, Edward R Marcantonio, Hannah Shanes, Cole Heine, Jordan Helfand, Catherine Price, Kenneth S Boockvar, Eran D Metzger, Tamara G Fong, Richard N Jones, Sharon K Inouye","doi":"10.1177/08919887251343604","DOIUrl":"10.1177/08919887251343604","url":null,"abstract":"<p><p>PurposeDelirium is a common yet preventable complication of hospitalization, surgery and illness that is associated with poor outcomes. Older adults with Alzheimer's Disease and Related Dementias (ADRD) are especially vulnerable to delirium and experience greater delirium severity, yet no existing assessment tool is specifically designed to evaluate this vulnerable population. This study will validate two new delirium severity instruments, the Delirium Severity (DEL-S) rating for all older adults and the Delirium Severity Rating in ADRD (DEL-S-AD) for patients with dementia.Design/Setting and ParticipantsThe Better ASsessment of ILlness II (BASIL II) study is an innovative prospective cohort study that measures cognitive function, delirium, delirium severity, demographics, clinical and functional variables and clinical outcomes. Participants include older adults from 3 unique yet complementary clinical sites: medical inpatients, elective surgery inpatients, or skilled nursing facility residents.MethodsPerformance of DEL-S and DEL-S-AD items in older adults with cognition ranging from no impairment to moderate impairment will be determined. Analyses will include psychometric characteristics of DEL-S and DEL-S-AD items, harmonization of the two scales and validation against reference standard diagnoses.Conclusions and ImplicationsResults from this study will help accurately measure delirium severity, a critically important, graded outcome. The DEL-S-AD instrument holds broad applications in persons with and without ADRD to monitor delirium severity in clinical settings, and as an outcome measure in future clinical treatment trials and pathophysiologic studies. Ultimately, the DEL-S and DEL-S-AD have the potential to improve health care for the vulnerable, growing population of older adults with cognitive impairment worldwide.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887251343604"},"PeriodicalIF":2.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}