Journal of Geriatric Psychiatry and Neurology最新文献

{"title":"Neuropsychologists' Engagement With and Cognitive Assessment in Parkinson's Disease: A Mixed Methods Australian Investigation.","authors":"James M King, Nadeeka N Dissanayaka, Deborah Brooks, Leander K Mitchell, Kumareshan Sivakumaran, Jihyun Yang, Deepa Sriram, Sharon L Naismith, Nancy A Pachana, Rebecca Gough, Dana Pourzinal","doi":"10.1177/08919887261462186","DOIUrl":"10.1177/08919887261462186","url":null,"abstract":"<p><p>ObjectiveA mixed methods study was conducted to investigate how clinical neuropsychologists engage with and provide cognitive assessment to persons living with Parkinson's disease (PD). Current practices were examined to identify service gaps and generate recommendations for future research.MethodAustralian neuropsychologists experienced in PD assessment were recruited to complete an online survey (N = 20) and semi-structured interviews (N = 5). Quantitative data was summarised descriptively. Qualitative data underwent coding reliability thematic analysis. Findings were combined through mixed methods integration to identify service gaps.ResultsIntegration revealed four service gaps for neuropsychologists when assessing persons living with PD. These were: (1) varied assessment practices across neuropsychologists; (2) infrequent engagement of neuropsychologists; (3) suboptimal test availability for PD assessment; and (4) limited integration of digital modalities within practice.ConclusionsThe findings provide preliminary observation into service gaps for neuropsychologists in PD assessment to help direct future research.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261462186"},"PeriodicalIF":2.8,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Immigration-Related Factors and Cognition Among Hispanics, the HABS-HD Study.","authors":"Shanshan Wang, Uyen-Sa Nguyen, Zhengyang Zhou, Stephanie Grasso, Sid E O'Bryant, Kristine Yaffe, Leigh Johnson, Rajesh R Nandy","doi":"10.1177/08919887261462181","DOIUrl":"https://doi.org/10.1177/08919887261462181","url":null,"abstract":"<p><p>ObjectivesTo examine associations between immigration-related factors and mild cognitive impairment (MCI) or dementia among Hispanics; and associations between immigration-related factors and cognitive performance among cognitively unimpaired Hispanics.MethodsData from the Health & Aging Brain Study-Health Disparities study were used. 1231 Hispanic participants were included. Six indicators, including time living in the US, nativity, age of migration, primary language, bilingualism, and acculturation level, were considered immigration-related factors. Both the three-category (dementia, MCI, and cognitively unimpaired) and binary (cognitively impaired and cognitively unimpaired) outcomes were used. The cognitive performance was evaluated by the Mini-Mental State Examination (MMSE). Multiple logistic, multinomial logistic, and linear regression models adjusted for age, sex, and education were applied.ResultsThe likelihood of cognitive impairment did not differ significantly between native-born and foreign-born Hispanics, whereas foreign-born cognitively unimpaired Hispanics had significantly lower global cognition than their native-born counterparts. When stratifying by age of migration, a significant association between time living in the US and cognitive impairment was observed among early-life immigrants. A higher acculturation level was associated with lower odds of both dementia and MCI among native-born Hispanics, but was insignificant in foreign-born Hispanics. Bilingualism was significantly associated with dementia or MCI in foreign-born Hispanics. Monolingual foreign-born cognitively unimpaired Hispanics had significantly lower MMSE scores than bilingual foreign-born Hispanics.ConclusionsForeign-born Hispanics might be more vulnerable to cognitive aging. Bilingualism may play a more important role in cognitive health in foreign-born Hispanics than in native-born Hispanics. Acculturation may have distinct effects on foreign-born and native-born Hispanics.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261462181"},"PeriodicalIF":2.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention Networks Connectivity After Cognitive Rehabilitation in Alzheimer's Disease.","authors":"Eric Salmon, Mohamed Ali Bahri, Sophie Kurth, Fabienne Collette, Christophe Phillips, Steve Majerus, Françoise Lekeu, Anne Quittre, Vinciane Wojtasik, Catherine Olivier, Vinciane Godichard, Christine Bastin","doi":"10.1177/08919887261462178","DOIUrl":"https://doi.org/10.1177/08919887261462178","url":null,"abstract":"<p><p>IntroductionCognitive rehabilitation (CR) enhances the autonomy of patients with Alzheimer's disease. Their daily activities are likely dependent on attention networks.MethodThis pilot resting-state fMRI study investigated the cerebral correlates of CR in participants with mild Alzheimer disease (n = 22), compared to a control intervention in patients (n = 21) and in healthy participants (n = 27). Connectivity changes between dorsal and ventral attention networks were expected after 3 months of rehabilitation.ResultsA mixed ANOVA comparing pre- and post-intervention data across groups revealed increased connectivity between the dorsal and the ventral attention network following CR (FDR-corrected <i>P</i> = .0072). A post hoc correlation analysis of post-intervention data in the CR group showed that greater autonomy in daily activities was associated with stronger functional relationship between the two attention networks (FDR-corrected <i>P</i> = .0001).ConclusionEnhanced connectivity between attention networks may be a characteristic of CR benefits in individuals with mild Alzheimer disease.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261462178"},"PeriodicalIF":2.8,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild Behavioural Impairment and Everyday Functioning in Cognitively Unimpaired Older Adults: Evidence From the CAN-PROTECT Study.","authors":"Maryam Ghahremani, Dylan X Guan, Clive Ballard, Byron Creese, Anne Corbett, Ellie Pickering, Eric E Smith, Zahinoor Ismail","doi":"10.1177/08919887261457447","DOIUrl":"https://doi.org/10.1177/08919887261457447","url":null,"abstract":"<p><p>BackgroundRecognizing early clinical signs of dementia is key to optimizing emerging therapies, including monoclonal antibodies. Mild behavioural impairment (MBI) characterizes later-life emergent and persistent nropsychiatric symptoms linked to greater dementia risk, representing a behavioural manifestation of the underlying neurodegenerative disease for some. The association of MBI with functional ability may therefore reveal subtle functional decline as an additional early risk marker in cognitively unimpaired (CU) older adults.MethodsBaseline data from 1714 CU participants from the CAN-PROTECT study were analyzed. MBI was assessed using the MBI Checklist (MBI-C) (continuous and dichotomized, MBI+ ≥8). Functional ability was assessed using the SAGEA scale capturing instrumental and basic activities. Negative binomial models examined associations between MBI and function, adjusting for demographics, cognition, and physical/sensory limitations.ResultsHigher MBI-C scores (count ratio [CR] = 1.07; 95%CI: 1.06-1.07) and MBI+ status (CR = 2.64; 95%CI: 2.36-2.95) were associated with greater global and domain-specific functional impairments.ConclusionFindings highlight the importance of assessing both behavioural and functional changes in CU adults to identify at-risk individuals for timely interventions.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261457447"},"PeriodicalIF":2.5,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing Agitation From Aggression in Neurocognitive Disorders: A Systematic Review of Conceptualization, Assessment and Correlates.","authors":"Pavel Kubíček, Jan Vevera","doi":"10.1177/08919887261459660","DOIUrl":"https://doi.org/10.1177/08919887261459660","url":null,"abstract":"<p><p>BackgroundAggressive behavior affects 30-50% of patients with dementia, yet agitation and aggression are frequently conflated despite distinct etiologies and treatment implications.ObjectivesTo examine how many recent studies define and distinguish agitation from aggression in adults with dementia or related disorders.MethodsA systematic review was conducted following a PROSPERO-registered protocol (CRD420251141548) and PRISMA guidelines. PubMed, Scopus, and Web of Science were searched for original studies published between 1st January 2017 and 28th February 2026. Definitions, assessment tools, and correlates were extracted. Study quality was appraised using CASP checklist.ResultsOf 236 identified studies, after deduplication 19 studies were reviewed in full. Only 5 studies distinguished agitation from aggression, all using the Cohen-Mansfield Agitation Inventory.ConclusionsFailure to distinguish agitation from aggression remains common and likely contributes to suboptimal management and overuse of antipsychotic medications in neurocognitive disorders.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261459660"},"PeriodicalIF":2.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Myth of Tithonus: Ageing and Dementia in Ancient Greek Thought.","authors":"Victor Calil, Leonardo Cruz de Souza, Lucas Porcello Schilling","doi":"10.1177/08919887261459700","DOIUrl":"https://doi.org/10.1177/08919887261459700","url":null,"abstract":"<p><p>In Greek mythology, Tithonus was the husband of Eos, the goddess of dawn. Granted immortality without the gift of eternal youth, Tithonus became an illustration of senescence without physical or cognitive wellbeing, characterised by not only physical but also cognitive decline - this is one of the earliest literary representations of dementia in Western civilisation. As myths mirror the values and concerns of a society, the depictions of Tithonus across the eras are an interesting window into how the Ancient Greek society dealt with the process of ageing and cognitive decline. In this paper, we discuss what the myth of Tithonus reveals about senescence and its challenges in the classical world. Remarkably, we conclude that many of the contemporary views and burdens of old age and dementia date from Antiquity, suggesting that ageing and its burdens are inherent human concerns, not merely products of the modern context.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261459700"},"PeriodicalIF":2.5,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Late-Life Depression a Comprehensive Review of Clinical, Pathophysiological, and Therapeutic Considerations.","authors":"Thomas Fraccalini, Beatrice Tarozzo, Thomas Roberts, Andrea Trogolo, Grazia Ceravolo, Alessandro Maraschi, Julia Michelin Vecchini, Laura Santos Ribeiro, Valerio Piras, Elisa Binello, Arianna Mianulli, Roberta Vacchelli, Ivana Finiguerra, Salvatore Di Gioia, Davide Minniti, Giuseppe Maina, Valerio Ricci, Giovanni Volpicelli","doi":"10.1177/08919887261449835","DOIUrl":"https://doi.org/10.1177/08919887261449835","url":null,"abstract":"<p><p>Geriatric depression presents distinct clinical challenges, often manifesting atypically through cognitive decline, somatic symptoms, and apathy rather than classic mood disturbances. This review synthesizes current understanding of its unique pathophysiology - including vascular contributions and frontostriatal dysfunction - and presents evidence to argue the diagnostic pitfalls in applying youth-centric criteria to elderly populations. We examine epidemiological trends, evidence-based treatment considerations, and emerging research directions, emphasizing the urgent need for age-specific diagnostic frameworks and personalized therapeutic approaches to address this underrecognized yet debilitating condition in aging populations.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261449835"},"PeriodicalIF":2.5,"publicationDate":"2026-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reported Driving Behaviours and the Relationship With Sleepiness in Subjective Cognitive Decline and Mild Cognitive Impairment.","authors":"Tiffany Y T Lo, Jessica E Manousakis, Melinda L Jackson, Michael Woodward, Sharon L Naismith, Clare Anderson","doi":"10.1177/08919887261452231","DOIUrl":"https://doi.org/10.1177/08919887261452231","url":null,"abstract":"<p><p>BackgroundDriving promotes independence in older adults, yet age-related changes in cognition and sleepiness may reduce driver safety. We examined associations between sleepiness and driving in older adults with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).MethodsA cross-sectional/observational study of older drivers (60-80 years), classified as cognitively healthy (n = 21), SCD (n = 26), or MCI (n = 13), completing the Manchester Driver Behaviour Questionnaire (DBQ), and a 2-week driving diary including the Sleepiness Symptoms Questionnaire (SSQ).ResultsFor DBQ, MCI drivers reported 2.26x more driving lapses (eg, memory/attention failures) than healthy, while SCD reported 2.54x more driving violations than MCI. For diaries, SCD drivers reported 7.51x more inattention events than healthy, and higher SSQ (<i>P</i> = .002). Higher SSQ was associated with increased inattention events for SCD and MCI groups (<i>P</i> ≤ .018).ConclusionSleepiness impacts poorer driving outcomes in SCD and MCI, providing an intervention opportunity to support continued driving.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261452231"},"PeriodicalIF":2.5,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Alzheimer Disease Detection Using Neuropsychiatric Symptoms: The Role of Mild Behavioural Impairment in the Revised NIA-AA Research Framework.","authors":"Rebeca Leon, Maryam Ghahremani, Dylan X Guan, Eric E Smith, Henrik Zetterberg, Zahinoor Ismail","doi":"10.1177/08919887251366634","DOIUrl":"10.1177/08919887251366634","url":null,"abstract":"<p><p>BackgroundAs the prevalence of Alzheimer disease (AD) rises, early identification of at-risk individuals is essential for effective intervention. Mild behavioral impairment (MBI), which captures emergent and persistent neuropsychiatric symptoms (NPS) in later life, may enhance early detection of AD; however, its associations with 2024 NIA-AA Core 1 biomarkers remain unexplored. We investigated associations between MBI and cerebrospinal fluid (CSF) amyloid β-42 (Aβ42) and phosphorylated tau-181 (p-tau181).MethodBaseline data from 1327 dementia-free Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed. Participants were classified as MBI, non-MBI NPS, or no NPS. Gaussian mixture modeling defined biomarker positivity. Logistic and multinomial logistic regressions modeled associations between NPS status and biomarker positivity or biomarker profiles, adjusting for age, sex, education, and cognition.ResultsMBI was associated with Aβ42+ (aOR = 2.26; 95% CI = 1.71-2.99), p-tau181+ (aOR = 1.72; 95% CI = 1.30-2.28), and AD continuum profile (aOR = 2.33; 95% CI = 1.73-3.14), but not with non-AD pathology. Non-MBI NPS showed no associations.ConclusionMBI may serve as a behavioral marker of AD pathology.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"277-287"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Escitalopram and Citalopram for Agitation in Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Anderson Matheus Pereira da Silva, Luciano Falcão, Filipe Virgilio Ribeiro, Kenzo Ogasawara Donato, Pedro Lucas Machado Magalhães, Maria da Vitória Santos Nascimento, Marianna Leite, Mariana Lee Han, Daniel Gonçalves Quiroga, Eryvelton de Souza Franco, Maria Bernadete de Sousa Maia","doi":"10.1177/08919887251369893","DOIUrl":"10.1177/08919887251369893","url":null,"abstract":"<p><p>BackgroundAgitation is a frequent and distressing neuropsychiatric symptom in patients with Alzheimer's disease (AD), often leading to increased caregiver burden, institutionalization, and healthcare costs. While antipsychotics are commonly prescribed, their use is limited by safety concerns. Selective serotonin reuptake inhibitors (SSRIs), such as citalopram and escitalopram, have emerged as alternative treatments with a more favorable safety profile. This study aimed to evaluate the efficacy and safety of these agents in the management of agitation in AD.MethodsWe conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing citalopram or escitalopram with placebo or other pharmacological treatments in older adults with AD and clinically defined agitation. Primary outcomes included changes in agitation severity, assessed by the Neuropsychiatric Inventory-Clinician Rating (NPI-C) and the Neurobehavioral Rating Scale (NBRS). Secondary outcomes included cognitive function (MMSE), anxiety symptoms, and adverse events. Standardized mean difference (SMD) and risk ratio (RR) were pooled using a random-effects model.ResultsFour RCTs comprising 502 patients were included. Pooled analysis showed no significant improvement in agitation severity (SMD -0.67; 95% CI -2.58, 1.25; I² = 98.3%) or cognitive outcomes (SMD 2.43; 95% CI -2.55, 7.41). Rates of serious adverse events (RR 0.85; 95% CI 0.50, 1.45) and treatment discontinuation (RR 1.05; 95% CI 0.80, 1.37) were similar between groups. However, SSRI use was associated with an increased risk of falls (RR 1.78; 95% CI 1.15, 2.75; I² = 0%).ConclusionEscitalopram and citalopram do not significantly reduce agitation in AD but are generally well tolerated. Increased fall risk warrants cautious clinical use.Registration PROSPERO protocol numberCRD420251055237.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"249-260"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}